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Objective: The aim of this study was to investigate the relationship between specific subtests of the Mini-Mental State Examination-Second Edition (MMSE-2) and activities of daily living (ADL) functions in people with dementia. Methods: A cross-sectional design study was conducted to collect data from two teaching hospitals in northern Taiwan between March 2019 and March 2020. One hundred and twenty-five people with dementia were recruited and assessed with the MMSE-2, Barthel Index (BI), Self-Perceived Difficulty Scale, Ability Scale, and Lawton Instrumental Activities of Daily Living Scale (Lawton IADL) once. Results: The subtests of registration, language, MMSE-2: Standard Version total score, story memory, processing speed, and MMSE-2: Expanded Version (MMSE-2: EV) total score of theMMSE-2were significantly correlated with the BI, Self-Perceived Difficulty Scale, and Ability Scale (r = .31-.35, p < .001). In addition, the subtests of orientation,MMSE-2: Brief Version total score, and visual-constructional ability were significantly correlated with the Ability Scale (r = .32-.33, p < .001). All, except for registration subtest, were significantly correlated with the Lawton IADL (r = .29-.57, p < .001). The registration and language subtests were two important predictors of the BI, while the processing speed subtest was the only predictor for the Self-Perceived Difficulty Scale and Ability Scale. The MMSE-2: EV total score was an important predictor of the Lawton IADL. Conclusions: The overall findings from our study demonstrates that the relationship between the MMSE-2 and ADL functions is not simply general, but that specific aspects of the MMSE-2 do in fact correlate more significantly and strongly with certain ADL functions. The findings of this study could help with the early detection of people with dementia and may provide useful information for early interventions to maintain patients' independence. [ABSTRACT FROM AUTHOR]

INTRODUCTION: Cardiovascular fat is a novel risk factor that may link to dementia. Fat volume and radiodensity are measurements of fat quantity and quality, respectively. Importantly, high fat radiodensity could indicate healthy or adverse metabolic processes. METHODS: The associations of cardiovascular fat (including epicardial, paracardial, and thoracic perivascular adipose tissue [PVAT]) quantity and quality assessed at mean age of 51 with subsequent cognitive performance measured repeatedly over 16 years of follow‐up were examined using mixed models among 531 women. RESULTS: Higher thoracic PVAT volume was associated with a higher future episodic memory (β[standard error (SE)] = 0.08 [0.04], P = 0.033), while higher thoracic PVAT radiodensity with lower future episodic (β[SE] = −0.06 [0.03], P = 0.045) and working (β[SE] = −0.24 [0.08], P = 0.003) memories. The latter association is prominent at higher volume of thoracic PVAT. DISCUSSION: Mid‐life thoracic PVAT may have a distinct contribution to future cognition possibly due to its distinct adipose tissue type (brown fat) and anatomical proximity to the brain circulation. HIGHLIGHTS: Higher mid‐life thoracic perivascular adipose tissue (thoracic PVAT) volume is related to a better future episodic memory in women.Higher mid‐life thoracic PVAT radiodensity is related to worse future working and episodic memories.Negative association of high thoracic PVAT radiodensity with working memory is prominent at higher thoracic PVAT volume.Mid‐life thoracic PVAT is linked to future memory loss, an early sign of Alzheimer's disease.Mid‐life women's epicardial and paracardial fat are not related to future cognition. [ABSTRACT FROM AUTHOR]

Copyright of Avances en PsicologÍa Latinoamericana is the property of Colegio Mayor de Nuestra Senora del Rosario and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: We investigated associations between neighborhood racial/ethnic segregation and cognitive change. Methods: We used data (n = 1712) from the Multi‐Ethnic Study of Atherosclerosis. Racial/ethnic segregation was assessed using Getis‐Ord (Gi*) z‐scores based on American Community Survey Census tract data (higher Gi* = greater spatial clustering of participant's race/ethnicity). Global cognition and processing speed were assessed twice, 6 years apart. Adjusted multilevel linear regression tested associations between Gi* z‐scores and cognition. Effect modification by race/ethnicity, income, education, neighborhood socioeconomic status, and neighborhood social support was tested. Results: Participants were on average 67 years old; 43% were White, 11% Chinese, 29% African American/Black, 17% Hispanic; 40% had high neighborhood segregation (Gi* > 1.96). African American/Black participants with greater neighborhood segregation had greater processing speed decline in stratified analyses, but no interactions were significant. Discussion: Segregation was associated with greater processing speed declines among African American/Black participants. Additional follow‐ups and comprehensive cognitive batteries may further elucidate these findings. Highlights: A study of neighborhood racial/ethnic segregation and change in cognition.Study was based on a racially and geographically diverse, population‐based cohort of older adults.Racial/ethnic segregation (clustering) was measured by the Getis‐ord (Gi*) statistic.We saw faster processing speed decline among Black individuals in segregated neighborhoods. [ABSTRACT FROM AUTHOR]

Background: Falls and fear of falling (FoF) inhibit healthy longevity and have been suggested to be associated with cognitive function. However, the domains of cognitive function that are associated with them remain controversial. It is speculated that clarifying this will help in the assessment of health status and interventions in the community. Aim: To analyse the associations between fall history and FoF and multidimensional cognitive function in independent community-dwelling older adults. Methods: The data from 9759 (73.3 ± 5.4 years, 59.9% women) older individuals enrolled in the cross-sectional ORANGE study were analysed. Simple questions were used to assess fall history in the past year and current FoF. Assessments of multidimensional cognitive function were performed using the National Center for Geriatrics and Gerontology-Functional Assessment Tool (NCGG-FAT) to evaluate memory, attention, executive function, and processing speed. The independent associations of fall history and FoF with multidimensional cognitive function were assessed using multivariate linear regressions adjusted for potential confounding variables. Results: A total of 18.3% and 35.4% of participants presented with fall history and FoF, respectively. Fall history (p = 0.008) and FoF (p = 0.002) were significantly associated with memory. FoF, but not fall history was associated with attention (p = 0.004), executive function (p < 0.01), and processing speed (p < 0.01). Conclusion: In independent community-dwelling older adults, fall history was associated only with the memory domain; in contrast, fear of falling was associated with multidimensional cognitive function. This study provides weak evidence suggesting the need to assess falls and FoF in all situations involving independent community-dwelling older adults. [ABSTRACT FROM AUTHOR]

Developmental difficulties in many cognitive domains are common in children with sickle cell anaemia (SCA). Children with stroke are most affected but delayed or atypical cognitive function has been reported in children with SCA and silent infarcts (SCI), vasculopathy, and normal brain MRI. However, very few studies of cognition have been conducted in Africa, a continent with 75% of the SCA burden. We therefore investigated cognitive profiles in Tanzanian children with SCA and examined the impact of age, SCI, vasculopathy, and haemoglobin concentration (Hb). Children aged 6–16 years with and without SCA were eligible for this cross-sectional study. Cognitive assessment was performed using Raven's Matrices, assessing fluid, non-verbal intelligence and subtests from the Wechsler Intelligence Scales for Children (WISC-IV), assessing processing speed (PS), perceptual reasoning (PR), and working memory (WM) as these tests are less culture-bound. Magnetic resonance imaging (MRI) and angiography (MRA) were also completed to assess the presence of SCI and vasculopathy. Hb was collected in both SCA children and their non-SCA siblings. Seventy-three children with SCA and 71 healthy siblings (Mean ages 11.9, SD = 2.8 and 11.1, SD = 2.9 years respectively) were recruited. Compared with healthy siblings, children with SCA had lower PS (Mean diff 7.35 points; p =.002). Older children had higher performance scores on all tests in relation to their ages. Lowest cognitive scores were observed on the PS subtest, where patients with SCI (SCI+) had lowest mean values as compared to children with no SCI (SCI-) and healthy siblings (i.e., SCI+ < SCI- < healthy siblings, p =.028). On post-hoc analysis the difference was between SCI+ and healthy siblings SCI+ < non-SCA siblings (p =.015); there was no difference between SCI+ and SCI- patient groups. PS was significantly lower in SCA patients with no vasculopathy as compared to healthy siblings. The mean difference from healthy siblings was -8.352 and -0.752 points for VASC- and VASC + respectively (p =.004). There was a significant positive effect of Hb on PSI (p =.001) in both patients and controls and a trend level significant positive effect of Hb on PR (p =.050) and WM (p =.051). In this Tanzanian study, cognitive performance was reduced in children with SCA with or without SCI on MRI or vasculopathy. Cognitive performance improved with increasing age. Lower Hb was associated with lower cognitive performance in both patients with SCA and their non-SCA siblings. SCI and vasculopathy do not appear to have an impact on cognitive function. [ABSTRACT FROM AUTHOR]

L'objectif de la présente recherche est de déterminer dans quelle mesure l'effet de fréquence du voisinage orthographique dans une tâche de catégorisation de couleur de mots est modifié lors du vieillissement lorsque la vitesse de traitement des participants est prise en compte. Deux conditions de mots colorés ont été comparées dans une tâche de catégorisation de couleurs réalisée par un groupe d'adultes jeunes (M âge = 21,62) et un groupe d'adultes âgés (M âge = 66,04). La moitié des mots ne possédaient pas de voisin orthographique (ex., pistil), l'autre moitié avaient un voisin plus fréquent (ex., tirade/tirage). Les résultats ont montré que l'effet de fréquence du voisinage sur les temps de catégorisation de couleur variait différemment dans chaque groupe d'âge selon la vitesse de traitement. Ces données sont discutées dans le cadre des théories du vieillissement cognitif et de la reconnaissance des mots écrits. The objective of this research was to determine to what extent the effect of higher-frequency orthographic neighbourhood in a word colour-categorization task is changed during aging when processing speed is taken into account. In addition, the effect of the lexicality of the stimuli on colour categorization was examined, as well as its variation according to age and processing speed. Fifty-two young adults (M age = 21.62) and 52 older adults (M age = 66.04) participated in this study. For each age group, two sub-groups were created according to the processing speed of the participants as measured by the WAIS Coding subtest. Two conditions of words (written in red, yellow, green or blue) were presented in a colour-categorization task. Half of the words did not have any orthographic neighbours (e.g., pistil [pistil]), while the other half had a higher-frequency neighbour (e.g., tirade [tirade]/TIRAGE [draw]). A control condition with a series of Xs was added to test the influence of the effect of the lexicality of words on the colour-categorization times. As a whole, the results showed slower colour-categorization times for words compared to a series of Xs, which did not vary with age and processing speed. Importantly, the results showed that orthographic neighbourhood frequency interacted with age and processing speed, on colour categorization response times. More precisely, the neighbourhood frequency effect was found to vary differently according to processing speed in each age group. For the fastest young adults, the facilitatory effect of higher-frequency orthographic neighbourhood was obtained, whereas no such effect was found for the slowest young adults. The fastest older adults did not exhibit any effect of higher-frequency orthographic neighbourhood whereas a facilitatory effect was observed for the slowest older adults. Therefore, these data suggest that both aging and the processing speed of the participants influence the interference effect of reading on colour categorization. These findings are discussed in the context of cognitive aging theories and models of written word recognition. [ABSTRACT FROM AUTHOR]

Objective: Slowed processing speed and executive dysfunction are associated with poor outcomes in Late Life Depression (LLD), though it is unclear why. We investigated whether these variables interfere with the development of positive treatment expectancies in an antidepressant trial.Methods: Depressed older subjects were randomized to Open (intended to increase patient expectancy) or Placebo-controlled (termed 'Hidden,' intended to decrease expectancy) administration of antidepressant medication for 8 weeks. Analysis of covariance analyzed the between-group difference on expectancy (Credibility and Expectancy Scale [CES]) and depression (Hamilton Rating Scale for Depression [HRSD], Clinical Global Impressions [CGI] Severity). Moderator analyses examined whether these Open versus Hidden differences varied based on higher versus lower processing speed and executive function.Results: Among the 108 participants, a significant between-group difference was observed on expectancy (effect size [ES, Cohen's d] = 0.51 on CES Item 2; ES = 0.64 on Item 4), indicating the manipulation was effective. Processing speed as measured by the Stroop Color-Word Test (number color-words named in congruent condition) was a significant moderator of the Open versus Hidden effect on expectancy. Depressive symptom improvement was greater on average for Open versus Hidden participants who received active drug (CGI-severity ES = 1.25, HRSD ES = 0.41), but no neurocognitive moderators of the between-group difference reached statistical significance.Conclusions: Slowed processing speed impairs the development of expectancies in antidepressant trials for LLD, which may help explain lower antidepressant response among older adults. Future studies may address whether interventions to optimize treatment expectancies are capable of improving treatment outcomes. [ABSTRACT FROM AUTHOR]

Background: Physical fitness is an important contributor to healthy aging that improves cognition. Older adults who engage in cardiorespiratory fitness activities show less cognitive decline. Aims: To examine whether physical fitness acts as a potential protective mechanism shielding against the negative associations between age and cognition. Specifically, we examined whether physical fitness mediates the relationship between age and processing speed. Methods: 114 (M = 63.80, SD = 10.63) senior executives completed a computerized cognitive battery composed of four processing speed tasks. Level of physical fitness was assessed on a treadmill stress test and reported in metabolic equivalents (METs). Results: Older age was associated with slower processing speed (r = 0.25, p = 0.007), whereas greater physical fitness was associated with faster processing speed (r = −0.30, p = 0.001). Path analysis indicated that the association between age and processing speed was fully mediated by the level of physical fitness (Indirect effect: β = 0.10, p = 0.008; Direct effect: β = 0.16, p = 0.20). Conclusions and discussion: The findings indicate that physical fitness is a strong mediator of the relationship between age and processing speed and imply that physical fitness makes a major contribution to cognitive reserve during the aging process. The results may suggest that the decrease in physical fitness during aging may partially account for slower cognitive processing. [ABSTRACT FROM AUTHOR]

To investigate early and late effects of planned surgically acquired homonymous hemianopias on visual search in children and adolescents. This prospective study included five patients (5y 5 m–18y 0 m; 2 girls) with pharmaco-refractory epilepsies in whom one visual hemifield was sacrificed as part of the surgical strategy, and, as controls, seven patients (5y 11 m–18y 0 m; 6 girls) undergoing epilepsy surgeries not affecting the visual fields. Visual search was studied using the "Table Test", which is an everyday life-like visual search test. General processing speed was studied using a standard IQ subtest. All five patients with newly acquired homonymous hemianopias showed a relative disadvantage of visual search times for objects in their newly blind hemifields immediately after the surgery. Six months later, this relative disadvantage had recovered completely in all patients. Nevertheless, compared with the preoperative situation, overall search times were still prolonged in the hemianopic patients, but this effect could be mitigated or even overcompensated by improvements in processing speed. Children with homonymous hemianopias inflicted by epilepsy surgery develop effective compensation strategies to minimize the relative disadvantage of visual search in their blind hemifields. For changes in overall visual search times between the preoperative and the six-month follow-up examination, we could demonstrate overlapping effects of (a) deterioration by hemianopia and (b) amelioration by improved processing speed as part of the cognitive improvements achieved by amelioration of the epilepsy. • Prospective study (pre/post) on visual search in newly acquired iatrogenic hemianopia. • New hemianopia causes visual search disadvantage in the newly blind hemifield. • Six months later, this relative disadvantage is compensated. [ABSTRACT FROM AUTHOR]

Objective: Despite the losses commonly associated with aging, older adults seem to possess particularly preserved emotional regulation. To further understand this phenomenon, the authors examined longitudinal trajectories between age, depressive symptoms, brain structure, and cognition.Methods: Seven hundred and sixteen functionally intact older adults (age M = 67.9, 56.8% female), followed longitudinally (visit range: 1-13, M = 2.5), completed cognitive testing and the Geriatric Depression Scale (GDS). A subset (N = 327) underwent 3T brain MRI. Mixed-effects linear regression models were conducted controlling for sex, education, and total intracranial volume.Results: There was a significant interaction between age and time on GDS, such that GDS improved with increasing age over time, but attenuated around age 71 (age*time b = 0.10, p <0.001). Fractional anisotropy (FA) and mean diffusivity interacted with age to predict longitudinal changes in GDS (FA: b = -0.02, p = 0.01; MD: b = 0.03, p = 0.007), such that age-related benefits on GDS were attenuated in those with declining FA. Executive function (EF) and processing speed also interacted with age to predict longitudinal changes in GDS (EF: b = -0.04, p = 0.03; speed: b = 0.04, p = 0.04). Again, the positive effect of age on GDS attenuated in those with worsening EF and speed. There were no associations with memory, semantic fluency, or gray matter (p values >0.05).Conclusion: EF, processing speed, and white matter integrity moderated the longitudinal relationship between age and mood. Previous studies demonstrate the link between positivity and better cognitive control, leading to improved mood in older adults. Our results are not only consistent, but establish a potential neurobiological correlate. Future research further exploring biological mechanisms driving psychological processes may have important therapeutic implications. [ABSTRACT FROM AUTHOR]

We investigated processing speed for deservingness-relevant versus deservingness-irrelevant information. Female students read stories involving deserved, undeserved, or neutral outcomes. We recorded participants' reaction time (RT) in processing the outcomes. We also measured individual differences in "belief in a just world" as a proxy for deservingness schematicity. RTs for deserved and undeserved outcomes were faster than for neutral outcomes, B = -8.45, p = .011, an effect that increased the stronger the belief in a just world (e.g., B = -3.18, p = .006). These findings provide novel evidence that the construct of deservingness is central in human social relations, and suggest both universal and particularistic schemas for deservingness. [ABSTRACT FROM AUTHOR]

Objective: Sluggish cognitive tempo refers to a constellation of symptoms that include slowed behavior/thinking, reduced alertness, and getting lost in one's thoughts. Despite the moniker "sluggish cognitive tempo," the evidence is mixed regarding the extent to which it is associated globally with slowed (sluggish) mental (cognitive) information processing speed (tempo). Method: A well-characterized clinical sample of 132 children ages 8–13 years (M = 10.34, SD = 1.51; 47 girls; 67% White/non-Hispanic) were administered multiple, counterbalanced neurocognitive tests and assessed for sluggish cognitive tempo symptoms via multiple-informant reports. Results: Bayesian linear regressions revealed significant evidence against associations between sluggish cognitive tempo and computationally modeled processing speed (BF01 > 3.70), and significant evidence for associations with slower working memory manipulation speed. These findings were consistent across parent and teacher models, with and without control for attention-deficit/hyperactivity disorder inattentive symptoms and IQ. There was also significant evidence linking faster inhibition speed with higher parent-reported sluggish cognitive tempo symptoms. Conclusions: These findings provide strong evidence against characterizing children with sluggish cognitive tempo symptoms as possessing a globally sluggish cognitive tempo. Instead, these symptoms appear to be related, to a significant extent, to executive dysfunction characterized by working memory systems that are too slow and inhibition systems that are too fast. Behaviorally, these findings suggest that requiring extra time to rearrange the active contents of working memory delays responding, whereas an overactive inhibition system likely terminates thoughts too quickly and therefore prevents intended behaviors from starting or completing, thereby giving the appearance that children are absent-minded or failing to act when expected. This study indicates that the syndrome called "sluggish cognitive tempo" is not associated with the globally sluggish (slow) processing speed implied by its name. Instead, the syndrome appears to be characterized by disruptions in the speed of specific cognitive abilities that involve mentally reordering information and inhibiting behavior. [ABSTRACT FROM AUTHOR]

Background: In older adults hospitalized with heart failure (HF), cognitive impairment is associated with increased hospital readmission and mortality risk. There is no consensus on an objective, scalable method of cognitive screening in this population. Objective: The aim of this project was to determine the feasibility, test-retest reliability, and convergent validity of the Processing Speed Test (PST), a test of information processing, attention, and working memory administered on an iPad in older adults hospitalized with HF. Methods: Patients hospitalized with HF (n = 30) and age-, sex-, and education-matched controls (n = 30) participated in the study. To determine test-retest reliability, the PST was administered on an iPad on 2 occasions, separated by 12 to 48 hours. The Symbo lDigit Modalities Test was administered at the first testing time point to determine convergent validity. Results: Test-retest reliability of the PST was 0.80 and 0.92 in individuals with HF and controls, respectively. Convergent validity was 0.72 and 0.90 for individuals with HF and controls, respectively. Time to complete the PST was similar for both individuals with HF and controls (<5 minutes). Conclusion: The iPad-based deployment of the PST was a feasible, reliable, and valid cognitive screen for older adults hospitalized with HF. Using a tablet-based self-administered cognitive screen in older adults with HF provides a method of cognitive assessment that is amenable to widespread clinical utilization. [ABSTRACT FROM AUTHOR]

• Processing speed deficits are common in secondary progressive multiple sclerosis. • Little is known about the neural correlates of this function in this disease. • Frontal white matter integrity supports this function in this disease. • Associative and callosal tracts with information integration roles are involved. • These white matter tracts are crucial to support fast cognitive computations. Processing speed (PS) deficits have been consistently observed in secondary progressive multiple sclerosis (SPMS). However, the underlying neural correlates have not been clarified yet. The present study aimed to investigate the relationship between macrostructural and microstructural white matter (WM) integrity and performance on different cognitive measures with prominent PS load. Thirty-one patients with SPMS were recruited and underwent neurological, neuropsychological, and MRI assessments. The associations between a composite index of PS abilities and scores on various tests with prominent PS load and T1-weighted and diffusion tensor image parameters were tested. Analyses were carried out using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS). VBM results showed that only the semantic fluency task correlated with grey matter (GM) volume in a range of cortical and subcortical areas bilaterally as well as the corpus callosum and the superior longitudinal fasciculus. TBSS analysis revealed consistent results across all the cognitive measures investigated, showing a prominent role of commissural and frontal associative WM tracts in supporting PS-demanding cognitive operations. In patients with SPMS, PS abilities are mainly dependent on the degree of both macrostructural and microstructural WM integrity. Preservation of associative WM tracts that support information integration seems crucial to sustain performance in tasks requiring fast cognitive processes. [ABSTRACT FROM AUTHOR]

• Physical activity and sedentary behavior may be important targets in MS. • Working memory/processing speed was related to a combination of activity metrics. • Energy expenditure, moderate-to-vigorous activity, and steps linked to cognition. • Cognition was negatively linked to longer sitting bouts and disease severity. • Cognition may improve from walking/moderate activity and shorter sitting periods. Cognitive dysfunction is a pervasive symptom of multiple sclerosis (MS). Correlational evidence on the relationships between physical activity, sedentary behavior, and cognition has been mixed and limited to a few activity measures. The collinearity of accelerometry-based metrics has precluded an assessment of the full activity spectrum. Here, we aimed to examine the rich set of activity measures using analytic approaches suitable for collinear metrics. We investigated the combination of physical activity, sedentary, and clinicodemographic measures that explain the most variance in composite scores of working memory/processing speed, visual memory, and verbal memory. We analyzed baseline accelerometry and neuropsychological data (n = 80) from a randomized controlled trial of pedometer tracking. Using partial least squares regression (PLSR), we built three models to predict latent scores on the three domains of cognition using 12 activity metrics, sex, education, and Expanded Disability Status Scale (EDSS) scores. Significance was assessed using linear regression models with model component scores as predictors and cognitive composites as outcomes. The latent component was significant for working memory/processing speed but was not significant for visual memory and verbal memory after Bonferroni correction. Working memory/processing speed was positively associated with average kilocalories, moderate-to-vigorous physical activity (MVPA), steps, and sex (i.e., higher scores in males) and negatively related to duration of long sedentary bouts and EDSS. These findings suggest that increasing overall energy expenditure through walking and MVPA, while decreasing prolonged sedentary time may positively benefit working memory/processing speed in people with MS. This RCT #NCT03244696 was registered on Clinicaltrials.gov (https://www.clinicaltrials.gov/ct2/show/NCT03244696). [ABSTRACT FROM AUTHOR]

Neuropsychological (NP) performance has been associated with psychosocial treatment outcomes in nonpain conditions, but has never been investigated in chronic pain. We performed a secondary analysis on the association of baseline NP performance with treatment outcomes among veterans with chronic pain (N = 117) undergoing an 8-week acceptance and commitment therapy (ACT) intervention. Participants completed measures of pain interference, pain severity, quality of life, activity levels, depression, and pain-related anxiety at baseline, midtreatment, and post-treatment. Executive functioning, working memory, processing speed, learning, and verbal memory were assessed at baseline. All study measures significantly improved from baseline to post-treatment. NP performance was related to changes in depression and pain-related anxiety during treatment. Specifically, relatively lower executive functioning and processing speed was associated with greater decreases in depressive symptoms, and relatively lower processing speed was associated with greater decreases in pain-related anxiety. Consistent with research in nonpain conditions, those with relatively lower NP functioning received greater benefit from psychosocial treatment, although most study outcomes did not differ as a function of NP performance. Our results suggest relatively lower NP functioning is not contraindicated for participation in psychosocial interventions like ACT but instead may be associated with greater relief. Perspective This study suggests that NP functioning is unrelated to changes in pain interference associated with ACT, and that those with relatively lower NP functioning may experience greater reductions in depressive symptoms and pain-related anxiety. This article contains important information for researchers and clinicians interested in cognition and chronic pain. [ABSTRACT FROM AUTHOR]

Introduction: Diffusion tensor imaging detects early tissue alterations in Alzheimer's disease and cerebral small vessel disease (SVD). However, the origin of diffusion alterations in SVD is largely unknown. Methods: To gain further insight, we applied free water (FW) imaging to patients with genetically defined SVD (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy [CADASIL], n = 57), sporadic SVD (n = 444), and healthy controls (n = 28). We modeled freely diffusing water in the extracellular space (FW) and measures reflecting fiber structure (tissue compartment). We tested associations between these measures and clinical status (processing speed and disability). Results: Diffusion alterations in SVD were mostly driven by increased FW and less by tissue compartment alterations. Among imaging markers, FW showed the strongest association with clinical status (R2 up to 34%, P <.0001). Findings were consistent across patients with CADASIL and sporadic SVD. Discussion: Diffusion alterations and clinical status in SVD are largely determined by extracellular fluid increase rather than alterations of white matter fiber organization. [ABSTRACT FROM AUTHOR]

Objective: Posttraumatic stress disorder (PTSD), history of mild traumatic brain injury (mTBI), and executive function (EF) difficulties are prevalent in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans. We evaluated the contributions of injury variables, lower-order cognitive component processes (processing speed/attention), and psychological symptoms to EF. Participants: OEF/OIF Veterans (N = 65) with PTSD and history of mTBI were administered neuropsychological tests of EF and self-report assessments of PTSD and depression. Results: Those impaired on one or more EF measures had higher PTSD and depression symptoms and lower processing speed/attention performance than those with intact performance on all EF measures. Across participants, poorer attention/processing speed performance and higher psychological symptoms were associated with worse performance on specific aspects of EF (eg, inhibition and switching) even after accounting for injury variables. Although direct relationships between EF and injury variables were equivocal, there was an interaction between measures of injury burden and processing speed/attention such that those with greater injury burden exhibited significant and positive relationships between processing speed/attention and inhibition/switching, whereas those with lower injury burden did not. Conclusion: Psychological symptoms as well as lower-order component processes of EF (attention and processing speed) contribute significantly to executive dysfunction in OEF/OIF Veterans with PTSD and history of mTBI. However, there may be equivocal relationships between injury variables and EF that warrant further study. Results provide groundwork for more fully understanding cognitive symptoms in OEF/OIF Veterans with PTSD and history of mTBI that can inform psychological and cognitive interventions in this population. [ABSTRACT FROM AUTHOR]

To compare subjective and objective cognitive functions among patients at the following three stages of treatment for colorectal cancer (CRC): new diagnosis (Group A), ≤2 years since chemotherapy completion (Group B), and >2 years since chemotherapy completion (Group C). A comparative cross-sectional approach was used in this study. The Functional Assessment of Cancer Therapy-Cognitive Function questionnaire and neuropsychological assessments were used to assess patients' subjective cognitive function, attention, memory, and executive functions. A total of 63 patients with stage I to III CRC were recruited from a medical center in northern Taiwan. We performed one-to-one-to-one propensity score matching to identify 36 individuals as eligible for this study. A generalized estimating equation was used to compare subjective and objective cognitive functions. We observed no significant between-group differences in subjective cognitive function and objective performance in overall cognition and memory. Group B had significantly longer reaction time in attention and processing speed than did Group A. Adjuvant chemotherapy had significantly deleterious effects on attention and processing speed in patients with CRC. These cognitive symptoms last for approximately 2 years after the completion of chemotherapy. The early detection of cancer-related cognitive impairment is necessary for managing symptom distress. Future studies with a large sample size and longitudinal design may elucidate the trajectory of specific cognitive functions. Developing nursing interventions aimed at improving attention and executive function in patients with CRC are needed. [ABSTRACT FROM AUTHOR]

Background The Symbol Digit Modalities Test (SDMT) is a sensitive measure of impaired cognition in people with MS. While the SDMT is primarily considered a test of information processing speed, other components such as visual scanning and oral-motor ability have also been linked to performance. The objective of this study was to determine the role of memory in the performance of the SDMT. Methods Two version of a modified computerized SDMT (c-SDMT) were employed, a fixed and a variable. For each group 50 MS and 33 healthy control (HC) participants were recruited. In the fixed c-SDMT, the symbol-digit code is kept constant for the entire test whereas in the variable version, it changes eight times. Unlike the traditional SDMT which records the correct number of responses, the c-SDMT presented here measures the mean response time (in seconds) for the eight trials. Results MS participants were slower than HC on the fixed (p < 0.001) and variable (p = 0.005) c-SDMT. Trend analysis showed performance improvement on the fixed, but not on the variable c-SDMT in both MS and HC groups. Furthermore, immediate visual memory recall was associated with the fixed (β = −0.299, p = 0.017), but not variable (B = −0.057, p = 0.260) c-SDMT. Immediate verbal memory was not associated with either versions of the c-SDMT. Conclusions Given that the fixed and variable c-SDMTs are identical in every way apart from the fixity of the code, the ability of participants to speed up responses over the course of the fixed version only points to the contribution of incidental visual memory in test performance. [ABSTRACT FROM AUTHOR]

Objectives: Bipolar disorder (BD) is associated with compromised white matter (WM) integrity and deficits in processing speed (PS). Few studies, however, have investigated age relationships with WM structure and cognition to understand possible changes in brain health over the lifespan. This investigation explored whether BD and healthy counterpart (HC) participants exhibited differential age-related associations with WM and cognition, which may be suggestive of accelerated brain and cognitive aging.Design: Cross-sectional study.Setting: University of California San Diego and the Veterans Administration San Diego Healthcare System.Participants: 33 euthymic BD and 38 HC participants.Measurements: Diffusion tensor imaging was acquired as a measure of WM integrity, and tract-specific fractional anisotropy (FA) was extracted utilizing the Johns Hopkins University probability atlas. PS was assessed with the Number and Letter Sequencing conditions of the Delis-Kaplan Executive Function System Trail Making Test.Results: BD participants demonstrated slower PS compared with the HC group, but no group differences were found in FA across tracts. Multiple linear regressions revealed a significant group-by-age interaction for the right uncinate fasciculus, the left hippocampal portion of the cingulum, and for PS, such that older age was associated with lower FA values and slower PS in the BD group only. The relationship between age and PS did not significantly change after accounting for uncinate FA, suggesting that the observed age associations occur independently.Conclusions: Results provide support for future study of the accelerated aging hypothesis by identifying markers of brain health that demonstrate a differential age association in BD. [ABSTRACT FROM AUTHOR]

Copyright of Mechanics & Advanced Technologies is the property of National Technical University of Ukraine KPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: This study investigates the independent and combined potential of slowed gait speed and slowed processing speed as predictors of adverse health outcomes. The role of depressive symptoms in these associations is also investigated.Methods: In the prospective cohort study, using the Longitudinal Aging Study Amsterdam database, three study samples for each outcome variable were defined: persistent cognitive decline (PCD; N = 1,271, 13 years of follow-up), falls (N = 1,282, 6 years of follow-up), and mortality (N = 1,559, age 74.9 ± 5.8, 21 years of follow-up). At baseline, gait speed (6-m walk with a turn at 3 m), processing speed (coding task), depressive symptoms (Center for Epidemiologic Studies Depression Scale), and basic demographic data were assessed. Also, time to PCD, falls, and mortality were assessed. Cox (for PCD and mortality) and stratified Cox (for falls) regression models were used.Results: Slowed processing speed predicted PCD (HR: 7.8; 95% CI: 3.3-18.8), slowed gait speed predicted falls (HR: 1.3; 95% CI: 1.0-1.5), and both measures predicted mortality (gait speed HR: 2.1; 95% CI: 1.6-2.6; processing speed HR: 1.9; 95% CI: 1.6-2.4). Each association remained significant after adjusting for the other slowing symptom. Slowed processing speed only predicted falls in the presence of slowed gait (interaction). A slowing sum score that combines both slowing symptoms predicted all three outcomes. The associations were not influenced by depressive symptoms.Conclusion: Slowing of thought is as relevant as slowing of movement to predict adverse health outcomes, because they seem to represent separate underlying pathologies. [ABSTRACT FROM AUTHOR]

Objectives How practice effect influences cognitive testing measured by monthly Symbol Digit Modalities Test (SDMT) during natalizumab treatment, and what factors confound such effect. Methods Eighty patients were examined monthly with SDMT for 26.2 ± 8.4 months. After 26.0±8.1 months, SDMT was also performed with a rearranged key in 59 cases. Results of SDMTs with the rearranged and previous regular key were compared. We examined if gender, age, Extended Disability Status Scale (EDSS), relapses, and disability progression/improvement influence SDMT performed with the regular and the rearranged key, respectively. We also explored if natalizumab applied before regular monthly SDMT may influence practice effect and cognition. Results SDMT performance improved by 1.2 points/test during the first six months and by 0.4 points/test thereafter. Rearranging the symbols of the key after 26.0±8.1 months returned SDMT scores to baseline indicating a practice effect. Such practice effect was more significant after longer testing period, but was not influenced by gender, age, relapses, disability progression and prior natalizumab treatment. Although the change from baseline to 2.5 years was significant in subgroups with EDSS 0–3, 3.5–5.5 and 6–7.5, this was higher in patients with EDSS 0–3 compared to 6–7.5. Conclusions Practice effect significantly contributes to continuous improvement in SDMT performance during natalizumab treatment: to test cognition, a change in key is required. Practice effect is less pronounced in patients with advanced disease. Cognition remains stable even in patients with progressive disease during more than 2 years of natalizumab treatment indicated by scores corresponding to baseline after changing the key. [ABSTRACT FROM AUTHOR]

Application-level traffic classification is an essential requirement for stable network operation and resource management. The payload signature-based classifier is considered a reliable method for Internet traffic classification. However, with this system, processing speeds are slower when high volumes of traffic are being classified in high-speed networks in real time. In this paper, we propose a method for server IP-port pair cachebased traffic classification, with the aim of increasing the processing speed and completeness of payload signature-based traffic classification. This approach takes application traffic locality into consideration. Moreover, we propose a cache data management method that has the purpose of minimizing the utilization of cache memory and processing speed and maximizing level of completeness. When our proposed method was applied to a campus network, we observe 10 times improvement in processing speed and 10% increasing in completeness against the payload signature-based classifier without a server IP-Port pair cache. [ABSTRACT FROM AUTHOR]

Background and aims Besides motor function the cerebellum subserves frontal lobe functions. Thus, we investigated executive functions in pediatric posterior fossa tumor survivors. Methods We tested information processing, aspects of attention, planning and intelligence in 42 pediatric posterior fossa tumor survivors (mean age 14.63 yrs, SD 5.03). Seventeen low-grade tumor patients (LGCT) were treated with surgery only and 25 high-grade tumors patients (HGCT) received postsurgical adjuvant treatment. We evaluated simple reaction time, executive functioning, i.e. visuospatial memory, inhibition, and mental flexibility using the Amsterdam Neuropsychological Tasks program, whereas forward thinking was assessed with the Tower of London-test. Intelligence was determined using the Wechsler Intelligence Scale. Ataxia was assessed with the International Cooperative Ataxia Rating Scale. Results About one third of each patient group showed forward thinking scores below one standard deviation of the norm. Impaired forward thinking correlated significantly with degree of ataxia ( r = −0.39, p = 0.03) but not with fluid intelligence. Both patient groups exhibited executive function deficits in accuracy and reaction speed in more difficult tasks involving information speed and attention flexibility. Still, HGCT patients were significantly slower and committed more errors. Working memory was inferior in HGCT patients. Conclusion Pediatric cerebellar tumor survivors with different disease and treatment related brain damage exhibit similar patterns of impairment in executive functioning, concerning forward thinking, inhibition and mental flexibility. The deficits are larger in high-grade tumor patients. The pattern of function loss seen in both groups is most probably due to comparable lesions to cerebro-cerebellar circuits that are known to modulate critical executive functions. [ABSTRACT FROM AUTHOR]

The Symbol Digit Modalities Test (SDMT), the most reliable and sensitive measure of cognition in people with multiple sclerosis (PwMS), is increasingly used in clinical trials and care. We aimed to establish how SDMT performance is influenced by repeating forms and frequency of use in PwMS. A retrospective analysis was completed on a large database of PwMS (n = 740) with multiple SDMT administrations. Change in SDMT performance was analyzed, accounting for frequency of tests and utilization of alternate- versus same-form conditions. SDMT administrations ranged from 2 to 14 per subject over a mean (SD) of 5.9 (4.5) years. Accounting for demographics, the mixed effects model revealed a significant main effect of SDMT exposures (1.8 point improvement per repetition, p = 0.001) and an interaction between time since previous SDMT and whether the same test form was administered in the previous administration (estimate=-1.1, p = 0.037). As well, SDMT decline is observed when testing intervals exceed two years (F = 9.69, p <0.001). Improvements in SDMT performance with repeated exposure, likely reflecting practice effects, were greatest when repeating the same SDMT form over briefer intervals. We recommend the use of alternate forms or analogous versions of timed symbol-digit coding particularly where samples are saturated with many administrations. [ABSTRACT FROM AUTHOR]

• Cross-Cultural Dementia (CCD) is a novel cognitive screening test. • We validated the CCD for cognitive impairment identification in MS. • CCD evaluates episodic memory, mental speed, and executive function. Several batteries have been developed for the cognitive assessment of people with multiple sclerosis (MS). However, all these tests have some limitations in general clinical practice and from a cross-cultural perspective. In this study, we aimed to validate a novel cognitive screening test, the Cross-Cultural Dementia screening test (CCD), in pwMS. Seventy-five participants with relapsing-remitting MS and 75 healthy controls were enrolled and completed a comprehensive neuropsychological battery and the CCD. Intergroup comparisons, effect sizes, and correlations with previously validated tests were calculated for a majority and a pilot study of a minority sample. ROC curves were estimated, and random forest classification models were developed. There were statistically significant differences between cognitively impaired MS (MS-CI) group and healthy controls, and between MS-CI and non-cognitively impaired MS group in all subtests of CCD with medium to large effect sizes. Correlations with standardized neuropsychological tests were moderate to high, supporting concurrent validity. These results were replicated in the minority sample. The random forest models showed a very accurate classification using the CCD. This test showed good psychometric properties compared with SDMT. Our study validates the CCD for cognitive impairment screening in MS, showing advantages over other routinely used cognitive tests. [ABSTRACT FROM AUTHOR]

Objective: To examine whether cerebrovascular risk, executive function, and processing speed are associated with acute treatment outcome of psychotic depression in older adults.Methods: The authors analyzed data from 142 persons aged 60 years or older with major depression with psychotic features who participated in a 12-week randomized controlled trial (RCT) comparing olanzapine plus sertraline with olanzapine plus placebo. The independent variables were baseline cerebrovascular risk (Framingham Stroke Risk Score), baseline executive function (Stroop interference score and the initiation/perseveration subscale of the Mattis Dementia Rating Scale), and baseline processing speed (color and word reading components of the Stroop). The outcome variable was change in severity of depression, measured by the 17-item Hamilton Depression Rating Scale total score, during the course of the RCT.Results: Greater baseline cerebrovascular risk was significantly associated with less improvement in depression severity over time, after controlling for pertinent covariates. Neither executive function nor processing speed predicted outcome.Conclusion: This study suggests an association of cerebrovascular risk, but not executive function or processing speed, with treatment outcome of major depression with psychotic features in older adults. [ABSTRACT FROM AUTHOR]

We investigated the relationship between vascular disease and risk factors versus cognitive decline cross-sectionally and longitudinally in normal older control, mild cognitive impairment, and mild Alzheimer disease (AD) dementia subjects. A total of 812 participants (229 normal older control, 395 mild cognitive impairment, 188 AD) underwent cognitive testing, brain magnetic resonance imaging, and clinical evaluations at baseline and over a period of 3 years. General linear, longitudinal mixed-effects, and Cox proportional hazards models were used. Greater homocysteine level and white matter hyperintensity volume were associated with processing speed impairment (homocysteine: P=0.02; white matter hyperintensity: P<0.0001); greater Vascular Index score was associated with memory impairment (P=0.007); and greater number of apolipoprotein E ∈4 (APOE4) alleles was associated with global cognitive impairment (P=0.007) at baseline. Apolipoprotein E ∈4 was associated with greater rate of increase in global cognitive impairment (P=0.002) and processing speed impairment (P=0.001) over time, whereas higher total cholesterol was associated with greater rate of increase in global cognitive impairment (P=0.02) and memory impairment (P=0.06) over time. These results suggest a significant association of increased vascular disease and risk factors with cognitive impairment at baseline and over time in the AD spectrum in a sample that was selected to have low vascular burden at baseline. [ABSTRACT FROM AUTHOR]

Background The effects of sleep disturbances on cognitive performance under distraction in multiple sclerosis (MS) are not known. The objective of the present study was to explore the association between an index of sleep (i.e. daytime somnolence), distractibility and the hallmark cognitive deficit in people with MS (i.e. processing speed). Methods MS participants (n=102) were recruited from outpatient neurology clinics. All participants completed the traditional Symbol Digit Modalities Test (SDMT). In addition, half the sample (n=52) completed a computerized version with distracters (c-SDMT) and half (n=50) without distracters. Excessive daytime sleepiness was explored with the Epworth Sleepiness Scale. Mood, anxiety and fatigue were also assessed. A linear regression analyses was conducted to determine predictors of cognitive performance. Results Participants with excessive daytime sleepiness performed significantly slower on the distracter c-SDMT than those with normal sleepiness (p=0.01). No significant differences were found on the c-SDMT without distracters or the traditional SDMT. Depression and excessive daytime sleepiness predicted performance on the distracter c-SDMT, whereas only the former predicted performance on the traditional test. Conclusions Excessive daytime sleepiness in people with MS adversely influences their processing speed in the presence of real-world distracters. This finding suggests that a more complete understanding of processing speed deficits in people with MS should entail a closer look at sleep and the relationship with distractibility. [ABSTRACT FROM AUTHOR]

Light is a powerful zeitgeber that synchronizes our endogenous circadian pacemaker with the environment and has been previously described as an agent in improving cognitive performance. With that in mind, this study was designed to explore the influence of exposure to blue-enriched white light in the morning on the performance of adolescent students. 58 High school students were recruited from four classes in two schools. In each school, one classroom was equipped with blue-enriched white lighting while the classroom next door served as a control setting. The effects of classroom lighting on cognitive performance were assessed using standardized psychological tests. Results show beneficial effects of blue-enriched white light on students׳ performance. In comparison to standard lighting conditions, students showed faster cognitive processing speed and better concentration. The blue-enriched white lighting seems to influence very basic information processing primarily, as no effects on short-term encoding and retrieval of memories were found. [ABSTRACT FROM AUTHOR]

Processing speed deficit, ascertained by digit-symbol substitution test (DSST), is considered as a fundamental impairment in schizophrenia. Clinical correlates of processing speed abnormalities, especially using the parametric version of DSST is yet to be evaluated comprehensively. In this study, we examined schizophrenia patients (N=66) and demographically matched healthy controls (N=72) using computer-administered parametric DSST (pDSST) with fixed (pDSSTF) as well as random (pDSSTR) conditions and analysed the relationship between pDSST performance and clinical symptoms. Psychopathology was assessed using Scale for Assessment of Positive Symptoms (SAPS)/Negative Symptoms (SANS) with good inter-rater reliability. In comparison with healthy controls, patients demonstrated significantly lesser number of correct responses (CN) in pDSSTF (t=8.0; p<0.001) and pDSSTR (t=7.8; p<0.001) as well as significantly prolonged reaction time in pDSSTF (t=7.1; p<0.001) and pDSSTR (t=7.0; p<0.001). The difference in CN between pDSSTF and pDSSTR [ΔCN] was significantly lesser in patients than healthy controls (t=2.61; p=0.01). The pDSST reaction time had significant positive correlation with negative syndrome scores as well as bizarre behaviour score. Significantly greater processing speed deficits in pDSST suggest potential relational memory/visual scanning abnormalities in schizophrenia. Furthermore, pDSST deficits demonstrated a significant association with the psychopathology, especially with the various negative symptoms and bizarre behaviour. [ABSTRACT FROM AUTHOR]

Abstract: The main goal of this study was to investigate differences and similarities in general cognitive functioning between adults with schizophrenia and autism, because this has not been systematically investigated. We used a cross-sectional design to compare adults with schizophrenia (n =27), with autism (n =114) and a healthy control group (n =30). Schizophrenia diagnoses were based on the Structured Clinical Interview for the DSM-IV Axis I (SCID-I) and behavioral symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS). Autism was diagnosed with a DSM-IV questionnaire for autism spectrum disorders and the Autistic Diagnostic Interview, revised version. The Wechsler Adult Intelligence Scale, third version (WAIS-III) was used to assess cognitive functions. All participants were between 18 and 65 years of age and had a minimum full scale intelligence of 80. Results showed that patients with schizophrenia scored significantly lower on processing speed than patients with autism and the healthy control group. Differences on other index scales were not found. In participants with schizophrenia a correlation was found between processing speed impairment and negative symptoms. Diagnosis could be predicted correctly with WAIS-III profile in 70.4% of the cases with schizophrenia compared to 56.7% of the healthy control group and 22.8% of the autism group. [Copyright &y& Elsevier]

In a quasi-experimental evaluation of the possible role of stereotype threat in the academic performance of college students with learning disabilities (LD), students with (N = 29) and without (N = 62) identified LD took a simulated Verbal GRE® task in one of two conditions modeled after those used in past stereotype threat (ST) research. The task was presented as either a measure of verbal reasoning and reading abilities (ST condition) or as a measure of problem-solving style (Reduced-Threat condition; [RT]). The traditional ST-related performance differences in accuracy were not found in the sample of undergraduates with LD; however, marginally significant differences in the efficiency with which students with LD completed test items in the RT condition relative to the ST condition suggest the need for follow-up research, given the frequency with which the accommodation of extra time on exams is granted to and is used by undergraduates with LD. Potential limitations due to size and representativeness of the sample are addressed. [ABSTRACT FROM AUTHOR]

Abstract: Purpose: The purpose of our study is to describe intellectual functioning in three common childhood epilepsy syndromes – frontal lobe epilepsy (FLE), childhood absence epilepsy (CAE) and benign epilepsy with centro-temporal spikes (BECTS). And also to determine the influence of epilepsy related variables, type of epilepsy, age at epilepsy onset, duration and frequency of epilepsy, and treatment on the scores. Methods: Intellectual functioning was examined in a group of 90 children with epilepsy (30 FLE, 30 CAE, 30 BECTS), aged 6–15 years, and compared with a control group (30). All subjects obtained a Full Scale IQ≥70 and they were receiving no more than two antiepileptic medications. Participants completed the Wechsler Intelligence Scale for Children – Third Edition. The impact of epilepsy related variables (type of epilepsy, age at epilepsy onset, duration of epilepsy, seizure frequency and anti-epileptic drugs) on intellectual functioning was examined. Results: Children with FLE scored significantly worse than controls on WISC-III Verbal IQ, Full Scale IQ and Processing Speed Index. There was a trend for children with FLE to have lower intelligence scores than CAE and BECTS groups. Linear regression analysis showed no effect for age at onset, frequency of seizures and treatment. Type of epilepsy and duration of epilepsy were the best indicators of intellectual functioning. Conclusion: It is crucial that children with FLE and those with a longer active duration of epilepsy are closely monitored to allow the early identification and evaluation of cognitive problems, in order to establish adequate and timely school intervention plans. [Copyright &y& Elsevier]

We investigated individuation - attribute-based impressions associated with each unique individual rather than their categorical membership - as a moderator of impressions formed when slower versus faster processors encounter conflicting social category conjunctions. Descriptions of incongruent (e.g., female bricklayer), but not congruent category conjunctions (e.g., female nurse) were moderated by individuation in the application of emergent attributes (novel attributes associated exclusively with the category conjunction and not the constituents). However, this was only the case for slow processors. These findings suggest that the means by which slower processors relative to faster processors form impressions for poorly correlated category conjunctions vary systematically. Individuated impressions lead to emergent attribute application for perceivers with slower processing ability. We discuss the implications of these findings. [ABSTRACT FROM AUTHOR]

Objectives: This study investigated white matter alterations in the corpus callosum (CC) and centrum semiovale (CSO), using diffusion tensor imaging and magnetization transfer imaging, in participants with severe traumatic brain injury (TBI) and related these changes to processing speed measures. Participants and Methods: Fourteen adult participants with severe TBI underwent neuroimaging and assessment, using the Symbol Digit Modalities Test and Trail-Making Test, Part B, at approximately 6 months postinjury. Thirteen demographically similar, neurologically intact adults were imaged for comparison. Results: The TBI group demonstrated lower fractional anisotropy (FA) for the right CSO and higher apparent diffusion coefficient (ADC) for the CSO bilaterally than the control group. Lower FA and higher ADC were noted in all CC regions. Magnetization transfer imaging revealed smaller magnetization transfer ratios (MTRs) in the right and left CSO and CC genu and splenium. Written Symbol Digit Modalities Test performance was related to right CSO FA, bilateral CSO ADC, CC FA, and right CSO MTR, whereas oral Symbol Digit Modalities Test was related to right CSO FA, ADC, and MTR. Trail-Making Test, Part B, was related to right CSO FA and MTR. Conclusions: Advanced neuroimaging modalities such as diffusion tensor imaging and magnetization transfer imaging demonstrate significant alterations in white matter, which are related to processing speed. These techniques may be useful in quantifying the extent of injury even in normal appearing white matter after TBI. [ABSTRACT FROM AUTHOR]

The article discusses research in geriatric psychiatry, with a focus on an investigation of the effects of cognitive performance and depression on functional impairment in older people with mild cognitive impairment (MCI). Topics include measurement of memory impairment and cognitive processing speed, executive functioning and dysfunction, and depressive symptoms.

Copyright of Eesti Rakenduslingvistika Ühingu Aastaraamat is the property of Eesti Rakenduslingvistika Uhing (ERU) / Estonian Association for Applied Linguistics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and aims: It is well known that tip-of-the-tongue (ToT) states, which are due to failure in the phonological activation of words, especially proper names, are more common in older than in younger adults. Nevertheless, the relationship between increased numbers of ToTs and cognitive aging remains unclear. The aim of the present study was to clarify this relationship by examining ToT production and the performance of cognitive tasks such as working memory and processing speed tests. Methodology: In order to study the relationships between these constructs, the performance of 133 participants in different language, working memory and processing speed tasks was analysed by use of LISREL software. Results: The best fit model included direct and indirect effects of age, mediated by cognitive variables, on lexical production variables. The model incorporated the indirect effects of age on vocabulary through working memory and also the indirect effect of age on ToT through processing speed. Conclusion: The results indicate negative modulation of slowed processing in the age-related increase of ToT and positive modulation of working memory in vocabulary, as well as an absence of any relation between vocabulary and ToT. Assuming that ToT events involve controlled processes, the relationship between slowed processing and ToT in aging could be interpreted as reflecting controlled compensatory mechanisms. [ABSTRACT FROM AUTHOR]

Objectives: To explore the relationship between specific aspects of cognition, white matter hyperintensities (WMHs), and cardiovascular autonomic parameters in late-life depression (LLD). Design: Cross-sectional analysis. Setting: Secondary care psychiatry. Participants: Forty-one individuals older than 60 years, with current or previous history of major depression, and 32 age-matched comparison subjects. Measurements: Cognition was assessed by a standardized computer battery of tasks (Cognitive Drug Research) that measured processing speed, attention, episodic memory, and working memory. Cardiovascular autonomic parameters were estimated by a noninvasive device that calculated blood pressure, heart rate variability, and baroreflex sensitivity (Task Force Monitor). Magnetic resonance imaging was performed on a 3-T magnetic resonance imaging system, and WMH volume was estimated using an automated validated method. Results: As expected, cognitive deficits in all tested domains were present in LLD subjects compared with comparison subjects. In the LLD group, processing speed was correlated with scores on memory and working memory tasks. Attentional deficits were correlated with total and periventricular WMH volume, and episodic memory was associated with heart rate variability. There were no associations between cognitive variables and traditional vascular risk factors or between cognitive variables and any of these parameters in the comparison subjects. Conclusions: This study suggests that processing speed may be an important factor underlying deficits in LLD, but it also indicates that other factors, including those related to vascular disease, are important and thus provide further support for the vascular depression hypothesis. [ABSTRACT FROM AUTHOR]

Abstract: Patients with fibromyalgia frequently report cognitive complaints. In this study we examined performance on 2 cognitive inhibition tests, the Stroop Color-Word Test (SCWT) and the Multi-Source Interference Test (MSIT), in 35 female patients with fibromyalgia and 35 age-matched healthy female controls. Experimental pressure pain thresholds (PPT) were determined, and fibromyalgia patients rated their current pain on a visual analog scale and completed the pain and fatigue subscales of the Fibromyalgia Impact Questionnaire. Further, all subjects completed questionnaires assessing symptoms of pain catastrophizing, depression, and anxiety. Significant group differences were found for SCWT and MSIT performance in both the neutral (N) and interference (I) conditions with slower reaction times in patients versus controls. However, no significant group differences were found for the difference (I–N) or proportion (I/N) scores, or on the number of errors made. For patients, pain experienced during PPT correlated significantly to several indices of cognition. Psychosocial variables were not related to cognitive test performance. Fibromyalgia patients performed worse on both tests but to a similar extent for the neutral condition and the interference condition, indicating that there is no specific problem in cognitive inhibition. Evidence of decreased mental processing and/or psychomotor speed was found in patients with fibromyalgia. Perspective: Fibromyalgia patients performed worse on interference tests, but no specific problem in cognitive inhibition was found. Decreased reaction time performance may instead point to an underlying problem of psychomotor or mental processing speed in fibromyalgia. Future studies should examine potential deficits in psychomotor function in fibromyalgia patients in more detail. [Copyright &y& Elsevier]

Abstract: Recent findings of neurological functioning in autism spectrum disorder (ASD) point to altered brain connectivity as a key feature of its pathophysiology. The cortical underconnectivity theory of ASD (Just et al., 2004) provides an integrated framework for addressing these new findings. This theory suggests that weaker functional connections among brain areas in those with ASD hamper their ability to accomplish complex cognitive and social tasks successfully. We will discuss this theory, but will modify the term underconnectivity to ‘disrupted cortical connectivity’ to capture patterns of both under- and over-connectivity in the brain. In this paper, we will review the existing literature on ASD to marshal supporting evidence for hypotheses formulated on the disrupted cortical connectivity theory. These hypotheses are: 1) underconnectivity in ASD is manifested mainly in long-distance cortical as well as subcortical connections rather than in short-distance cortical connections; 2) underconnectivity in ASD is manifested only in complex cognitive and social functions and not in low-level sensory and perceptual tasks; 3) functional underconnectivity in ASD may be the result of underlying anatomical abnormalities, such as problems in the integrity of white matter; 4) the ASD brain adapts to underconnectivity through compensatory strategies such as overconnectivity mainly in frontal and in posterior brain areas. This may be manifested as deficits in tasks that require frontal–parietal integration. While overconnectivity can be tested by examining the cortical minicolumn organization, long-distance underconnectivity can be tested by cognitively demanding tasks; and 5) functional underconnectivity in brain areas in ASD will be seen not only during complex tasks but also during task-free resting states. We will also discuss some empirical predictions that can be tested in future studies, such as: 1) how disrupted connectivity relates to cognitive impairments in skills such as Theory-of-Mind, cognitive flexibility, and information processing; and 2) how connection abnormalities relate to, and may determine, behavioral symptoms hallmarked by the triad of Impairments in ASD. Furthermore, we will relate the disrupted cortical connectivity model to existing cognitive and neural models of ASD. [Copyright &y& Elsevier]

Abstract: Psychopathology of obsessive compulsive disorder (OCD) that has been characterized by a conflict between the ego and superego on one hand, and aggressive and sexual impulses emerging from the id on the other, and employment of characteristic defenses to combat intense conflicts being connected with ones’ biological disposition from the psychoanalytic school of thought now gets empirical foundation from neuroimaging research. The findings disregard the psychological construct, exclusively establishing the neurobiology of the disorder. With the objective to study the impact of sexual and aggressive impulses on the executive functions and processing speed in the patient group, 20 OCD patients (11 males, 9 females) and 20 normal control subjects, matched for all relevant variables including age, sex, educational level and handedness were studied. Sexual impulse and guilt was assessed on the Sex Guilt Rating Scale (SGRS), aggressive impulses were tested using State-Trait Anger Expression Inventory (STAXI), the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was used to assess symptom severity, executive functions were assessed through Wisconsin Card Sorting Test (WCST), and processing speed was assessed by employing the Processing Speed Index (PSI) – from WAIS III. It was found that the OCD group differed significantly from the controls, attaining significantly lower percentiles on Processing Speed Index and for all variables of WCST under consideration, namely, perseverative response, perseverative error, non-perseverative error, conceptual level response and number of categories completed. They reported higher scores on subscales of STAXI, specifically related to trait anger and lower scores on anger expression. On the items of SGRS, the OCD group significantly differed with the controls, expressing greater sexual inhibition. In conclusion, we propose an explanation of psychopathology of OCD, which addresses instinctual impulses, executive functions and neural substrates. Our findings contribute to understanding instinctual impulses from the neuropsychological perspective. The findings have implications for better eclectic understanding of the pathogenesis of OCD. [Copyright &y& Elsevier]

The rapid automatized naming task (RAN) is a well-established tool to evaluate risk of developmental disorders. Its potential use with 3-year-olds who are at risk for learning difficulties and factors affecting its dependent measures are not yet understood. This study investigated the effects of neonatal central nervous system compromise grouping (five levels, N = 617) on RAN task adapted for 3-year-olds, using two levels of information load and two presentation orders. Results showed that increased errors and slowed speed in toddlers are expected subsequent to severe neonatal CNS compromise. Furthermore, collaborative information may have a beneficial effect on processing speeds of toddlers born with severe, but not with moderate, neonatal CNS compromise. Finally, the study highlights the feasability of evaluating RAN performance in toddlers who are at a developmental risk for learning disabilities and the conditions of RAN that may facilitate performance of severely affected participants. [ABSTRACT FROM AUTHOR]