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IoT devices typically encompass objects or devices equipped with software and internet connectivity, allowing them to collect data. They have limited processing power, memory, and storage. These limitations can make it difficult to secure these devices, as traditional security measures may not be practical. Implementing security for IoT devices can be challenging due to these characteristics, but several steps can be taken to mitigate these challenges. Elliptic Curve Cryptography (ECC) can secure resource constrained IoT devices by providing a more efficient method of encryption and authentication than traditional methods such as RSA. In this paper, we analyzed the lightweight cryptographic algorithm ECC for securing resource-constrained devices such as IoT and evaluated its performance compared to the RSA cryptosystem. The analysis result indicates that ECC is considered to provide stronger security than RSA for the same key length. The CoAP protocol is applied to devices with limited resources, and an examination of its impact is conducted, considering three key performance metrics: CPU usage, bandwidth efficiency, and message communication latency. [ABSTRACT FROM AUTHOR]

Purpose: We examined the relationship between comorbid medical conditions and changes in cognition over the course of rehabilitation following acquired brain injury. In particular, we compared outcomes between traumatic brain injury (TBI) and non-TBI using a retrospective inpatient rehabilitation dataset. We hypothesized that differences by diagnosis would be minimized among subgroups of patients with common comorbid medical conditions. Materials and Methods: We used the Functional Independence Measure (FIM)-cognition subscale to index changes in cognition over rehabilitation. A decision tree classifier determined the top 10 comorbid conditions thatmaximally differentiated TBI and non-TBI. Ten subsets of patients were identified by matching on these conditions, in rank order. Data from these subsets were submitted to repeated-measures logistic regression to establish the minimum degree of commonality in comorbid conditions that would produce similar cognitive rehabilitation, regardless of etiology. Results: The TBI group demonstrated a greater increase in ordinal scores over time relative to non-TBI, across all subscales of the FIM-cognition. When both groups were matched on the top 3 symptoms, there were no significant group differences in rehabilitation trajectory in problem-solving and memory domains (Cohen's d range: 0.2-0.4). Conclusion: Comorbid medical conditions explain differences in cognitive rehabilitation trajectories following acquired brain injury beyond etiology. [ABSTRACT FROM AUTHOR]

Background: Imaging‐based markers of cerebrovascular disease are associated with adverse health events, including incident dementia. However, only infarcts ≥3mm are typically considered in clinical and research settings. Recent evidence demonstrates that smaller infarcts in individuals during mid‐life, particularly when co‐occurring with larger infarcts, may be clinically relevant to cognitive decline, incident stroke, and stroke mortality. We aimed to determine if there was a similar compounding of risk for incident dementia among those with both smaller and larger infarcts at midlife. Method: The ARIC study is a multi‐site longitudinal cohort study which began in 1987. At visit 3 (1993‐95), brain 1.5T MRI scans were completed in 1881 participants with self‐reported Black/White race and no history of stroke (Mean age=62.9±4.9, 40% Male, 50% Black). Infarcts were identified on T2 and proton density weighted images, with smaller infarcts defined as those <3mm and larger infarcts defined as ≥3mm. All participants were followed prospectively for incident dementia using a combination of medical record surveillance, telephone interviews, in‐person assessments, and expert adjudicated dementia status at three in‐person exams (2011‐2013, 2015‐17, 2018‐19). Cox regression was used to determine the association between infarct group [none(referent), smaller only, larger only, both] and incident dementia adjusted for age, sex, education, site‐race, APOE4, and competing risk of mortality. Result: Among 1881 participants, 539 incident dementia cases were identified over 25 years of follow‐up. 1611 participants were infarct‐free, 50 participants had only smaller infarcts, 185 had only larger infarcts, and 35 participants had both. Compared to those with no infarcts, participants with both smaller and larger infarcts were over 2.5 times more likely to develop dementia [Hazard Ratio(HR)=2.61; 95% Confidence Interval(CI)=1.44, 4.72]. Associations were in similar directions but had wider and indeterminate confidence intervals when comparing the smaller infarcts only (HR=1.22; 95%CI=0.70, 2.13) or larger infarcts only (HR=1.27; 95%CI=0.92, 1.74) to the no infarct group. Of the 35 participants with both smaller and larger infarcts, all but two either died or developed dementia. Conclusion: A midlife infarct burden including both smaller and larger lesions may represent a vulnerability to dementia beyond the risk conferred by either smaller or larger infarcts alone. [ABSTRACT FROM AUTHOR]