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1. Abacavir induces loading of novel self-peptides into HLA-B57

Author

Norcross, Michael A., Luo, Shen, Lu, Li, Boyne, Michael T., Gomarteli, Mary, Rennels, Aaron D., Woodcock, Janet, Margulies, David H., McMurtrey, Curtis, Vernon, Stephen, Hildebrand, William H., and Buchli, Rico

Abstract

Abacavir drug hypersensitivity in HIV-treated patients is associated with HLA-B57:01 expression. To understand the immunochemistry of abacavir drug reactions, we investigated the effects of abacavir on HLA-B57:01 epitope-binding in vitroand the quality and quantity of self-peptides presented by HLA-B57:01 from abacavir-treated cells.

Published
2012
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