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2 results on '"S, De Medeiros"'

1. Structure-Based Molecular Networking for the Target Discovery of Oxahomoaporphine and 8-Oxohomoaporphine Alkaloids from .

Author

Paz, Weider H. P., de Oliveira, Rodolfo N., Heerdt, Gabriel, Angolini, Célio F. F., S. de Medeiros, Lívia, Silva, Valdenizia R., Santos, Luciano S., Soares, Milena B. P., Bezerra, Daniel P., Morgon, Nelson H., Almeida, Jackson R. G. S., da Silva, Felipe M. A., Costa, Emmanoel V., Koolen, Hector H. F., Angolini, Célio F F, and S de Medeiros, Lívia

Published
2019
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2. Structure-Based Molecular Networking for the Target Discovery of Oxahomoaporphine and 8-Oxohomoaporphine Alkaloids from Duguetia surinamensis

Author

Paz, Weider H. P., de Oliveira, Rodolfo N., Heerdt, Gabriel, Angolini, Célio F. F., S. de Medeiros, Lívia, Silva, Valdenizia R., Santos, Luciano S., Soares, Milena B. P., Bezerra, Daniel P., Morgon, Nelson H., Almeida, Jackson R. G. S., da Silva, Felipe M. A., Costa, Emmanoel V., and Koolen, Hector H. F.

Abstract

In addition to seven known alkaloids (2, 6–11) and 1,2,4-trimethoxybenzene (1), three isoquinoline-derived alkaloids (3–5), namely, duguetinine (3), a compound based on an unprecedented oxahomoaporphine scaffold, and two new 8-oxohomoaporphine alkaloids, duguesuramine (4) and 11-methoxyduguesuramine (5), and a new asarone-derived phenylpropanoid (10) were isolated from the bark of Duguetia surinamensis. The isolation workflow was guided by HPLC-HRESIMS/MS and molecular networking-based analyses. Twenty-four known alkaloids were dereplicated from the D. surinamensisalkaloid-rich fraction network and were assigned by manual MS/MS interpretation. Their cytotoxic potential was evaluated.

Published
2019
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