157 results on '"SATO, KAZUKI"'
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2. Phase of Illness at the time of being referred to the hospital palliative care team and changes after the intervention.
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Ohinata, Hironori, Hirayama, Hideyuki, Aoyama, Maho, Satomi, Eriko, Kizawa, Yoshiyuki, Miyazaki, Mayuko, Tagami, Keita, Sekine, Ryuichi, Suzuki, Kozue, Yotani, Nobuyuki, Sugano, Koji, Abo, Hirofumi, Sakashita, Akihiro, Sato, Kazuki, Nakagawa, Sari, Nakazawa, Yoko, Hamano, Jun, and Miyashita, Mitsunori
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PALLIATIVE treatment ,MEDICAL quality control ,SECONDARY analysis ,RESEARCH funding ,SCIENTIFIC observation ,QUESTIONNAIRES ,HOSPITAL care ,DESCRIPTIVE statistics ,SEVERITY of illness index ,LONGITUDINAL method ,RESEARCH ,MEDICAL needs assessment ,HEALTH outcome assessment ,SOCIODEMOGRAPHIC factors ,TERMINAL care ,COMPARATIVE studies ,HEALTH care teams ,MEDICAL referrals - Abstract
Palliative care is provided according to patient needs. Healthcare providers can use the Phase of Illness to assess patient needs and improve palliative care. However, patients' phase changes after the palliative care team's intervention remain unknown. This study clarified the Phase of Illness of patients referred to palliative care teams at hospitals and the changes in their phase after the intervention. Our study was a secondary analysis of a multicenter survey involving patient-reported outcomes. This study was conducted between February and August 2021 at eight facilities with palliative care teams. The participants were patients for whom the palliative care team received a new request for intervention during the patient enrollment period. Out of the 310 patients, 68 (21.9%) were in the stable phase, 141 (45.5%) in the unstable phase, 87 (28.1%) in the deteriorating phase, and 14 (4.5%) in the terminal phase at the time of referral. The total score for symptom distress at the time of referral was the highest in the deteriorating phase (65.7), followed by the unstable (54.1), terminal (47.5), and stable phases (40.5). Furthermore, 20.4% of patients in the unstable phase at the time of referral moved to the stable phase after one week of the intervention. This study identified the distribution and changes in the Phase of Illness of patients referred to palliative care teams. Assessments for the Phase of Illness must be standardized in palliative care teams to set benchmarks. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Parameter and Topology Optimizations for Wireless Power Transfer Device Considering Magnetic and Circuit Properties
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Otomo, Yoshitsugu, Sato, Kazuki, Onozaka, Ken, and Igarashi, Hajime
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This article proposes a novel optimization method to design the transmitting and receiving coils of a wireless power transfer (WPT) device considering its magnetic and circuit properties. In the proposed optimization, the coil shapes are determined by parameter optimization (PO) for manufacturability, whereas the magnetic core shapes introduced near them are determined by topology optimization (TO). The power transfer efficiencies of the optimized WPT device are evaluated using the SPICE simulation considering the coupling with an electronic circuit. The circuit parameters of the optimized coils are computed using the homogenization-based finite element method (FEM), which can effectively evaluate the eddy current loss in the coil windings. It is shown that the optimized WPT device has a power transfer efficiency higher than 90% even when there is a misalignment.
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- 2024
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4. Synthesis of P‑Modified DNA from Boranophosphate DNA as a Precursor via Acyl Phosphite Intermediates.
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Takahashi, Yuhei, Kakuta, Kiyoshi, Namioka, Yukichi, Igarashi, Ayumi, Sakamoto, Taiichi, Iwata Hara, Rintaro, Sato, Kazuki, and Wada, Takeshi
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- 2023
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5. Detection of Modified Histones from Oral Mucosa of a Patient with DYT-KMT2BDystonia
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Sugeno, Naoto, Hasegawa, Takafumi, Haginoya, Kazuhiro, Kubota, Takafumi, Ikeda, Kensuke, Nakamura, Takaaki, Ishiyama, Shun, Sato, Kazuki, Yoshida, Shun, Koshimizu, Eriko, Uematsu, Mitsugu, Miyatake, Satoko, Matsumoto, Naomichi, and Aoki, Masashi
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Introduction:DYT-KMT2Bis a rare childhood-onset, hereditary movement disorder typically characterized by lower-limb dystonia and subsequently spreads into the craniocervical and laryngeal muscles. Recently, KMT2B-encoding lysine (K)-specific histone methyltransferase 2B was identified as the causative gene for DYT-KMT2B, also known as DYT28. In addition to the fact that many physicians do not have sufficient experience or knowledge of hereditary dystonia, the clinical features of DYT-KMT2Boverlap with those of other hereditary dystonia, and limited clinical biomarkers make the diagnosis difficult. Methods:Histone proteins were purified from the oral mucosa of patients with de novo KMT2Bmutation causing premature stop codon, and then trimethylated fourth lysine residue of histone H3 (H3K4me3) which was catalyzed by KMT2B was analyzed by immunoblotting with specific antibody. We further analyzed the significance of H3K4me3 in patients with DYT-KMT2Busing publicly available datasets. Results:H3K4me3 histone mark was markedly lower in the patient than in the control group. Additionally, a reanalysis of publicly available datasets concerning DNA methylation also demonstrated that KMT2Bremained inactive in DYT-KMT2B. Discussion:Although only one case was studied due to the rarity of the disease, the reduction of H3K4me3 in the patient’s biological sample supports the dysfunction of KMT2B in DYT-KMT2B.Together with informatics approaches, our results suggest that KMT2Bhaploinsufficiency contributes to the DYT-KMT2Bpathogenic process.
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- 2023
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6. Error analysis of approximate operators for a particle method based on Voronoi diagram
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Koba, Hajime and Sato, Kazuki
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This paper considers several approximate operators used in a particle method based on a Voronoi diagram. We introduce and study our approximate operators on gradient and Laplace operators. We derive error estimates for these approximate operators by applying our weight functions. The key idea of deriving our error estimates is to divide the integration region into a ring-shaped area and some areas. In the appendix, we give an exemplary application of the main results of this paper.
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- 2023
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7. Solid-Phase Synthesis of Glycosyl Phosphate Repeating Units via Glycosyl Boranophosphates as Stable Intermediates.
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Sato, Kazuki, Muramoto, Kazumasa, Hagio, Tomoya, I. Hara, Rintaro, and Wada, Takeshi
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- 2023
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8. Synthesis of P-Modified DNA from Boranophosphate DNA as a Precursor via Acyl Phosphite Intermediates
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Takahashi, Yuhei, Kakuta, Kiyoshi, Namioka, Yukichi, Igarashi, Ayumi, Sakamoto, Taiichi, Iwata Hara, Rintaro, Sato, Kazuki, and Wada, Takeshi
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In this study, we successfully synthesized several kinds of P-modified nucleic acids from boranophosphate DNAs via an acyl phosphite intermediate in solution and on a solid support. In the solution-phase synthesis, phosphorothioate diester, phosphotriester, and phosphoramidate diester were synthesized in a one-pot reaction from boranophosphodiester via the conversion of an acyl phosphite as a key intermediate. In addition, doubly P-modified nucleic acid derivatives which were difficult to synthesize by the phosphoramidite and H-phosphonate methods were also obtained by the conversion reaction. In the solid-phase synthesis, a boranophosphate derivative was synthesized on a solid support using the H-boranophosphonate method. Then, an acyl phosphite intermediate was formed by treatment with pivaloyl chloride in pyridine, followed by appropriate transformations to obtain the P-modified derivatives such as phosphotriester and phosphorothioate diester. Notably, it was suggested that the conversion reaction of a boranophosphate to a phosphorothioate diester proceeded with retention of the stereochemistry of the phosphorous center. In addition, a phosphorothioate/phosphate chimeric dodecamer was successfully synthesized from a boranophosphate/phosphate chimeric dodecamer using the same strategy. Therefore, boranophosphate derivatives are versatile precursors for the synthesis of P-modified DNA, including chimeric derivatives.
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- 2023
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9. Total elbow arthroplasty using an augmented reality–assisted surgical technique.
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Tanji, Atsushi, Nagura, Takeo, Iwamoto, Takuji, Matsumura, Noboru, Nakamura, Masaya, Matsumoto, Morio, and Sato, Kazuki
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Precision placement of implants in total elbow arthroplasty (TEA) using conventional surgical techniques can be difficult and riddled with errors. Modern technologies such as augmented reality (AR) and 3-dimensional (3D) printing have already found useful applications in many fields of medicine. We proposed a cutting-edge surgical technique, augmented reality total elbow arthroplasty (ARTEA), that uses AR and 3D printing to provide 3D information for intuitive preoperative planning. The purpose of this study was to evaluate the accuracy of humeral and ulnar component placement using ARTEA. Twelve upper extremities from human frozen cadavers were used for experiments performed in this study. We scanned the extremities via computed tomography prior to performing TEA to plan placement sites using computer simulations. The ARTEA technique was used to perform TEA surgery on 6 of the extremities, whereas conventional (non-ARTEA) techniques were used on the other 6 extremities. Computed tomography scanning was repeated after TEA completion, and the error between the planned and actual placements of humeral and ulnar components was calculated and compared. For humeral component placement, the mean positional error ± standard deviation of ARTEA vs. non-ARTEA was 1.4° ± 0.6° vs. 4.4° ± 0.9° in total rotation (P =.002) and 1.5 ± 0.6 mm vs. 8.6 ± 1.3 mm in total translation (P =.002). For ulnar component placement, the mean positional error ± standard deviation of ARTEA vs. non-ARTEA was 5.5° ± 3.1° vs. 19.5° ± 9.8° in total rotation (P =.004) and 1.5 ± 0.4 mm vs. 6.9 ± 1.6 mm in total translation (P =.002). Both rotational accuracy and translational accuracy were greater for joint components replaced using the ARTEA technique compared with the non-ARTEA technique (P <.05). Compared with conventional surgical techniques, ARTEA had greater accuracy in prosthetic implant placement when used to perform TEA. [ABSTRACT FROM AUTHOR]
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- 2022
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10. Effect of varying storage conditions on diagnostic test outcomes of SARS-CoV-2.
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Oguri, Satoshi, Fujisawa, Shinichi, Kamada, Keisuke, Nakakubo, Sho, Yamashita, Yu, Nakamura, Junichi, Horii, Hiroshi, Sato, Kazuki, Nishida, Mutsumi, Teshima, Takanori, Ohiro, Yoichi, Takada, Ayato, and Konno, Satoshi
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- 2021
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11. A Case of Coronal Intra-articular and Epiphyseal Fractures of the Metacarpal Head in Early Adolescence
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Kato, Tomoyuki, Iwamoto, Takuji, Suzuki, Taku, Matsumura, Noboru, Nakamura, Masaya, Matsumoto, Morio, and Sato, Kazuki
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- 2021
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12. A woman complicated by sudden cardiac arrest owing to spontaneous coronary artery dissection after stillbirth.
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Numasawa, Yohei, Yokokura, Souichi, Maeda, Takashi, Daigo, Kyohei, Sakata, Shingo, Hashimoto, Ryota, Taruoka, Akira, Sato, Kazuki, Haginiwa, Sho, Kojima, Hidenori, and Tanaka, Makoto
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Spontaneous coronary artery dissection (SCAD) is the most important cause of acute coronary syndrome in pregnant women. Pregnancy-associated SCAD frequently occurs in the third trimester or postpartum period. However, little is known regarding the relationship between the occurrence of SCAD and stillbirth. We describe here a 41-year-old woman complicated by sudden cardiac arrest owing to SCAD in the distal segment of the right coronary artery 13 days after stillbirth. After contacting emergency medical services, she was resuscitated by an automated external defibrillator because the initial electrocardiographic waveform was ventricular fibrillation. After cardiopulmonary resuscitation, the diagnosis of SCAD was confirmed by coronary angiography and intracoronary imaging, including intravascular ultrasound and optical coherence tomography. The patient was managed with conservative medical therapy because the culprit lesion was present in the distal segment of the right coronary artery and coronary blood flow was preserved. No major adverse cardiovascular events, including recurrent ventricular arrhythmia, were observed during hospitalization. Our findings indicate that pregnancy-associated SCAD leading to sudden cardiac arrest may occur in the postpartum period, even after stillbirth. Intravascular imaging plays a pivotal role in diagnosing SCAD. < Learning objective: Pregnancy-associated spontaneous coronary artery dissection (SCAD) is a relatively rare but well-known cause of acute coronary syndrome in pregnant or postpartum women. However, whether the risk of pregnancy-associated SCAD in the postpartum period is different between normal birth and stillbirth remains unknown. Pregnancy-associated SCAD leading to sudden cardiac arrest owing to acute myocardial ischemia may occur in postpartum women, regardless of fetal survival.> [ABSTRACT FROM AUTHOR]
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- 2021
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13. Restricted Wrist Rotation after an Ulnar Head Fracture: A Report of Two Cases
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Kato, Tomoyuki, Abe, Koji, Sato, Kazuki, and Nakamura, Toshiyasu
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- 2021
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14. Evaluation of Dynamic Carpal Arch Stability following Carpal Tunnel Release Using Four-Dimensional Computed Tomography
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Kimura, Hiroo, Sato, Kazuki, Matsumura, Noboru, Suzuki, Taku, Iwamoto, Takuji, Ohori, Kuniaki, Yamada, Yoshitake, Matsumoto, Morio, Nakamura, Masaya, Jinzaki, Masahiro, and Nagura, Takeo
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- 2021
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15. 0138 Effects of Slow Oscillation Enhancement During NREM Sleep Using Closed-loop Auditory Stimulation on Anxiety
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Suzuki, Yoko, Ding, Ning, Sato, Kazuki, Wang, Zishan, Suzuki, Yurina, Oiwa, Yumeka, Kanbayashi, Takashi, and Abe, Takashi
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- 2024
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16. FUGIN hot core survey. I. Survey method and initial results for l= 10°–20°
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Sato, Kazuki, Hasegawa, Tetsuo, Umemoto, Tomofumi, Saito, Hiro, Kuno, Nario, Seta, Masumichi, and Sakamoto, Seiichi
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We have developed a method to make a spectral-line-based survey of hot cores, which represent an important stage of high-mass star formation, and applied the method to the data of the FUGIN (FOREST Unbiased Galactic plane Imaging survey with the Nobeyama 45 m telescope) survey. First, we select hot core candidates by searching the FUGIN data for the weak hot core tracer lines (HNCO and CH3CN) by stacking, and then we conduct follow-up pointed observations on these candidates in C34S, SO, OCS, HC3N, HNCO, CH3CN, and CH3OH J= 2–1 and J= 8–7 lines to confirm and characterize them. We applied this method to the l= 10°–20° portion of the FUGIN data and identified 22 “HotCores” (compact sources with more than two significant detections of the hot core tracer lines, i.e., SO, OCS, HC3N, HNCO, CH3CN, or CH3OH J= 8–7 lines) and 14 “DenseClumps” (sources with more than two significant detection of C34S, CH3OH J= 2–1, or the hot core tracer lines). The identified HotCores are found to be associated with signposts of high-mass star formation such as ATLASGAL clumps, WISE H iiregions, and Class II methanol masers. Many of the FUGIN HotCores are identified with the Herschel Hi-GAL clumps with a median mass of 6.8 × 102M⊙and a median bolometric luminosity of 7.4 × 103L⊙. Five of the seven HotCores with stronger CH3CN lines exhibit elevated gas temperatures of 50–100 K. These observations suggest that FUGIN HotCores are closely related to the formation of stars with medium to high mass. For those associated with ATLASGAL clumps, their bolometric luminosity to clump mass ratios are consistent with the star formation stages centered at the hot core phase. The catalog of FUGIN HotCores provides a useful starting point for further statistical studies and detailed observations of high-mass star forming regions.
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- 2021
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17. Range of Motion after the Sauvé–Kapandji and Darrach Procedures without Extensor Tendon Rupture
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Kato, Tomoyuki, Suzuki, Taku, Kameyama, Makoto, Okazaki, Masato, Morisawa, Yasushi, Nishiwaki, Masao, Nakamura, Toshiyasu, Sato, Kazuki, and Iwamoto, Takuji
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- 2021
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18. Causes of Procedural Failures of Closed Reductions using an Extension-Block Pin for Bony Mallet Finger
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Suzuki, Taku, Iwamoto, Takuji, Matsumura, Noboru, Kimura, Hiroo, Nakamura, Masaya, Matsumoto, Morio, and Sato, Kazuki
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- 2021
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19. Quality of dying and death in patients with interstitial lung disease compared with lung cancer: an observational study
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Koyauchi, Takafumi, Suzuki, Yuzo, Sato, Kazuki, Hozumi, Hironao, Karayama, Masato, Furuhashi, Kazuki, Fujisawa, Tomoyuki, Enomoto, Noriyuki, Nakamura, Yutaro, Inui, Naoki, Yokomura, Koshi, Imokawa, Shiro, Nakamura, Hidenori, Morita, Tatsuya, and Suda, Takafumi
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BackgroundThere is limited knowledge regarding the quality of dying and death (QODD) and end-of-life interventions in patients with interstitial lung disease (ILD). Hence, differences in QODD and end-of-life interventions between patients with ILD and those with lung cancer (LC) remain poorly understood.MethodsThe primary aim of this study was to explore the differences in QODD and end-of-life interventions among patients dying with ILD versus those dying with LC. We performed a mail survey to quantify the QODD of a bereaved family’s perspective using the Good Death Inventory (GDI) score. Moreover, we examined the end-of-life interventions by medical chart review.ResultsOf 361 consecutive patients analysed for end-of-life interventions, 167 patients whose bereaved families completed questionnaires were analysed for QODD. Patients with ILD had lower GDI scores for QODD than those with LC (p=0.04), particularly in domains related to ‘physical and psychological distress relief’ and ‘prognosis awareness and participation in decision making’ (p=0.02, respectively). In end-of-life interventions, patients with ILD were less likely to receive specialised palliative care services (8.5% vs 54.3%; p<0.001) and opioids (58.2% vs 73.4%; p=0.003). Additionally, lower frequencies of participation of patients with ILD in end-of-life discussion were also observed (40.8% vs 62.4%; p=0.007).ConclusionPatients with ILD had lower QODD and poorer access to palliative care and decision making than those with LC. Additional efforts to improve QODD in patients with ILD, particularly in symptom relief and decision-making processes, are urgently warranted.
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- 2021
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20. Causes of Procedural Failures of Closed Reductions using an Extension-Block Pin for Bony Mallet Finger
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Suzuki, Taku, Iwamoto, Takuji, Matsumura, Noboru, Kimura, Hiroo, Nakamura, Masaya, Matsumoto, Morio, and Sato, Kazuki
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This retrospective study evaluated procedural failures of closed reductions using an extension-block Kirschner wire (K-wire) for bony mallet finger. A total of 132 patients who underwent a closed reduction for bony mallet finger in a procedure using an extension-block K-wire were radiographically assessed. Radiographs were used to evaluate (1) postoperative displacement of the reduction before or after K-wire removal and (2) inaccurate reduction of the fragment immediately after surgery. The causes of procedural failure and bone union were evaluated using radiographs and medical records of the intraoperative findings. Out of 132 patients, 17 with procedural failure were enrolled. Displacement of the reduction before and after K-wire removal occurred in seven and six cases, respectively. Inaccurate reduction immediately after surgery occurred in four cases. The most common cause of procedural failure was inaccurate insertion of the K-wire to fix the distal interphalangeal joint (eight cases) followed by inaccurate insertion of the extension-block pin (five cases). All patients had bone union regardless of the displacement of the reduction or inaccurate reduction of the fragment. Caution should be exercised during the reduction and fixation when an extension-block K-wire is used in a closed reduction procedure.
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- 2021
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21. Evaluation of Dynamic Carpal Arch Stability following Carpal Tunnel Release Using Four-Dimensional Computed Tomography
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Kimura, Hiroo, Sato, Kazuki, Matsumura, Noboru, Suzuki, Taku, Iwamoto, Takuji, Ohori, Kuniaki, Yamada, Yoshitake, Matsumoto, Morio, Nakamura, Masaya, Jinzaki, Masahiro, and Nagura, Takeo
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Introduction This study aimed to assess the carpal arch dynamics during active finger and wrist motion following carpal tunnel release using four-dimensional computed tomography (4D-CT).
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- 2021
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22. A Case of Coronal Intra-articular and Epiphyseal Fractures of the Metacarpal Head in Early Adolescence
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Kato, Tomoyuki, Iwamoto, Takuji, Suzuki, Taku, Matsumura, Noboru, Nakamura, Masaya, Matsumoto, Morio, and Sato, Kazuki
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Intra-articular metacarpal head fracture is relatively rare. We report a case of coronal intra-articular and epiphyseal fractures of Salter–Harris type IV injury in the metacarpal head of the index finger. Surgery was performed by a dorsal approach. The volar fragment that was displaced proximally was gently reduced while bending the metacarpophalangeal (MP) joint, and it was fixed with cortical screws inserted proximal to the articular cartilage facilitating early rehabilitation. We consider the mechanism of injury to be a force applied from the distal phalanx that was transmitted unevenly to the volar side when the MP joint was slightly flexed. A three-dimensional computed tomography scan was useful in making the precise diagnosis, confirming the fracture pattern and planning fixation of the fracture.
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- 2021
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23. Hypertrophic Pisiform: A Case of Osteoid Osteoma
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Hori, Keiko, Nakamura, Toshiyasu, Sato, Kazuki, Ikegami, Hiroyasu, and Toyama, Yoshiaki
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- 2020
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24. Solid-Phase Synthesis of Phosphate/Boranophosphate Chimeric DNAs Using the H‑Phosphonate–H‑Boranophosphonate Method.
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Sato, Kazuki, Imai, Hiroki, Shuto, Tomohito, Hara, Rintaro Iwata, and Wada, Takeshi
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- 2019
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25. Identification of Blood–Brain Barrier-Permeable Proteins Derived from a Peripheral Organ: In Vivo and in Vitro Evidence of Blood-to-Brain Transport of Creatine Kinase.
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Sato, Kazuki, Tachikawa, Masanori, Watanabe, Michitoshi, Miyauchi, Eisuke, Uchida, Yasuo, and Terasaki, Tetsuya
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- 2019
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26. Chinese herbal medicine Qing-Dai-induced pulmonary arterial hypertension in a patient with ulcerative colitis: A case report and experimental investigation.
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Sato, Kazuki, Ohira, Hiroshi, Horinouchi, Takahiro, Nakaya, Toshitaka, Mazaki, Yuichi, Sugimoto, Ayako, Watanabe, Taku, Tsujino, Ichizo, and Nishimura, Masaharu
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Abstract A recent case report described a case of pulmonary arterial hypertension (PAH) associated with use of the Chinese herbal medicine Qing-Dai; however, the clinical course and possible mechanisms have not been characterized. We present the case of a man with ulcerative colitis who was diagnosed with idiopathic PAH. After initiating oral beraprost therapy, the patient showed significant hemodynamic improvements and an unusual course of clinical recovery. In 2016, the Japanese Ministry of Health, Labour, and Welfare issued a warning regarding the possible side effects of Qing-Dai. We learned that our patient had been taking self-purchased Qing-Dai for 2 years. Therefore, we performed an experimental study and determined that Qing-Dai may cause PAH through a mechanism involving nitric oxide synthase inhibition and pulmonary artery endothelial dysfunction. [ABSTRACT FROM AUTHOR]
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- 2019
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27. Identification of Blood–Brain Barrier-Permeable Proteins Derived from a Peripheral Organ: In Vivo and in Vitro Evidence of Blood-to-Brain Transport of Creatine Kinase
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Sato, Kazuki, Tachikawa, Masanori, Watanabe, Michitoshi, Miyauchi, Eisuke, Uchida, Yasuo, and Terasaki, Tetsuya
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Certain proteins, such as inflammatory cytokines, that are released from injured or diseased organs are transported from the circulating blood through the blood–brain barrier (BBB) into the brain and contribute to the pathogenesis of related central nervous system dysfunctions. However, little is known about the protein transport mechanisms involved in the central nervous system dysfunctions. The aims of the present study were to identify BBB-permeable protein(s) derived from liver and to clarify their transport characteristics at the BBB. After administration of biotin-labeled liver cytosolic protein fraction to mice in vivo, we identified 9 biotin-labeled proteins in the brain. Among them, we focused here on creatine kinase (CK). In vitro uptake studies with human brain microvessel endothelial cells (hCMEC/D3 cells) showed preferential uptake of muscle-type CK (CK-MM) compared with brain-type CK (CK-BB) at the BBB. Integration plot analysis revealed that CK-MM readily penetrated into brain parenchyma from the circulating blood across the BBB. The uptake of CK-MM by hCMEC/D3 cells was decreased at 4 °C and in the presence of clathrin- and caveolin-dependent endocytosis inhibitors. These results indicate that entry of CK into the brain is mediated by a transport system(s) at the BBB.
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- 2024
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28. Computed tomography–based 3-dimensional preoperative planning for unlinked total elbow arthroplasty.
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Iwamoto, Takuji, Suzuki, Taku, Oki, Satoshi, Matsumura, Noboru, Nakamura, Masaya, Matsumoto, Morio, and Sato, Kazuki
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Hypothesis Three-dimensional (3D) surgical planning for unlinked total elbow arthroplasty (TEA) would be helpful for estimation of the implant size and accurate placement of implants. Methods We included 28 patients who underwent TEA with an unlinked total elbow implant in this study. All patients underwent computed tomography scans of the elbow before surgery, and a 3D digital model of the elbow was reconstructed. After the appropriate size and position of the prosthesis were determined, 10 points around the bone tunnel (4 on the humerus and 6 on the ulna) were measured to plan the insertion of the humeral and ulnar stems. Two-dimensional planning was also performed using anteroposterior and lateral radiographs. Intraoperatively, the surgeon measured the planned parameters using a slide gauge to reproduce the 3D planned position of the stem insertion. Results The stem sizes were accurately estimated in 57% of patients for the humerus and 68% for the ulna with 2-dimensional planning and in 86% for the humerus and 96% for the ulna with 3D planning. The mean differences between the positions of the prostheses after surgery with reference to the planned positions were 0.8° of varus and 1.5° of flexion for the humeral component and 0.7° of varus and 2.9° of flexion for the ulnar component. We did not evaluate rotational positioning in this study. Conclusions The 3D surgical planning allowed accurate estimation of the implant size and appropriate placement of implants. This method may contribute to a reduced incidence of complications and improved long-term outcomes from TEA. [ABSTRACT FROM AUTHOR]
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- 2018
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29. A New Baseline Subtraction Method for Di-hadron Correlations in High-multiplicity Small System Collisions.
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Han, Seyoung, Esumi, ShinIchi, Sato, Kazuki, Nakagawa, Itaru, and Todoroki, Takahito
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- 2018
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30. Solid-Phase Synthesis of Phosphate/Boranophosphate Chimeric DNAs Using the H-Phosphonate–H-Boranophosphonate Method
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Sato, Kazuki, Imai, Hiroki, Shuto, Tomohito, Hara, Rintaro Iwata, and Wada, Takeshi
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Boranophosphate (PB) DNAs are promising antisense oligonucleotide candidates because of their attractive features, such as high nuclease resistance and low toxicity. However, a full boranophosphate backbone modification to antisense DNAs causes reduced duplex formation with complementary RNAs and reduced antisense activity. In this study, an efficient solid-phase synthesis of phosphate/boranophosphate (PO/PB) chimeric DNA was achieved by the combination of the H-phosphonate and H-boranophosphonate methods. The physiological and biological properties of the synthesized PO/PB chimeric DNAs were also evaluated. The strategy employed herein can facilitate the design and synthesis of PO/PB chimeric DNAs containing site-specific boranophosphate modifications.
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- 2019
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31. Continuous Catheter Irrigation for the Treatment of Purulent Tenosynovitis during Two-Stage Flexor Tendon Reconstruction
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Fujita, Megumi, Iwamoto, Takuji, Suzuki, Taku, Matsumura, Noboru, Sato, Kazuki, Nakamura, Masaya, and Matsumoto, Morio
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- 2019
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32. Prediction of tablet characteristics based on sparse modeling for residual stresses simulated by the finite element method incorporating Drucker-Prager cap model
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Takayama, Kozo, Sato, Tsubasa, Sato, Kazuki, Todo, Hiroaki, Obata, Yasuko, and Sugibayashi, Kenji
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Effects of residual stresses on the mechanical characteristics of tablets such as tensile strength (TS) and disintegration time (DT) were investigated. The residual stresses were simulated using the finite element method (FEM), in which the powder compaction was represented by a Drucker-Prager cap (DPC) model under unconstrained condition. As model tablet formulations, we employed powder mixtures comprising various quantities of lactose (LAC), corn starch (CS), and microcrystalline cellulose (MCC). Key parameters of DPC model were well predicted as a function of quantity ratio of LAC, CS, and MCC. A clear difference was observed in the residual stress distributions between the flat and convex tablets. Strong stresses remained in the convex tablets, while they were rather weak in the flat tablets. For a sparse modeling, an elastic-net (ENET) regression was employed to identify specific stress sites in the tablets. Consequently, the ENET regression revealed specific significant sites in the tablet affecting the TS and DT values. Both quantity and direction of the remaining stresses acting at specific sites close to the die wall were crucial in the convex tablets to predict the TS and DT values; however, no such tendency was seen in the flat tablet.
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- 2019
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33. Development and Validity of the Nursing Care Scale and Nurse’s Difficulty Scale in Caring for Dying Patients With Cancer and Their Families in General Hospitals in Japan
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Kanno, Yusuke, Sato, Kazuki, Shimizu, Megumi, Funamizu, Yuko, Andoh, Hideaki, Kishino, Megumi, Senaga, Tomomi, Takahashi, Tetsu, and Miyashita, Mitsunori
- Abstract
This study develops and examines the validity and reliability of 2 scales, respectively, for evaluating nursing care and the experience of difficulties providing nursing care for dying patients with cancer and their families. A cross-sectional anonymous questionnaire was administered to nursing staff caring for dying patients with cancer and their families in 4 general hospitals and a university hospital in Japan. The instruments assessed were the Nursing Care Scale for Dying Patients and Their Families (NCD) and the Nurse’s Difficulty Scale for Dying Patients and Their Families (NDD). Of the 497 questionnaires sent to nurses, 401 responses (80%) were analyzed. Factor analyses revealed that the NCD and NDD consisted of 12 items with 4 subscales: “symptom management,” “reassessment of current treatment and nursing care,” “explanation to family,” and “respect for the patient and family’s dignity before and after death.” These scales had sufficient convergent and discriminative validity, sufficient internal consistency (αof subscales: NCD, 0.71-0.87; NDD, 0.74-0.93), and sufficient test-retest reliability (intraclass correlation coefficient of subscales: NCD, 0.59-0.81; NDD, 0.67-0.82) to be used as self-assessments and evaluation tools in education programs to improve the quality of nursing care for the dying patients and their families.
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- 2019
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34. Normal value and range of the humerus–elbow–wrist angle in a sample of healthy children with even distributions of age, sex, and laterality
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Inaba, Naoto, Suzuki, Taku, Iwamoto, Takuji, Matsumura, Noboru, Oki, Satoshi, Nishiwaki, Masao, Nakamura, Masaya, Matsumoto, Morio, and Sato, Kazuki
- Abstract
This study was performed to evaluate the normal value of the humerus–elbow–wrist angle (HEWA) in a sample of healthy children with even distributions of age, sex, and laterality. A total of 168 radiographs of the elbows of healthy children with even distributions of age, sex, and laterality were reviewed. The mean HEWA was 12.1° (range: 5°–20°). The value of HEWA was significantly associated with increasing age. Neither sex nor side showed significant differences for the HEWA. The data should be useful for postoperative radiographic assessment of cubitus varus or valgus deformities.
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- 2019
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35. Efficient production of bispecific antibody by FAST-IgTMand its application to NXT007 for the treatment of hemophilia A
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Koga, Hikaru, Yamano, Takashi, Betancur, Juan, Nagatomo, Satoko, Ikeda, Yousuke, Yamaguchi, Kazuki, Nabuchi, Yoshiaki, Sato, Kazuki, Teranishi-Ikawa, Yuri, Sato, Motohiko, Hirayama, Hiroyuki, Hayasaka, Akira, Torizawa, Takuya, Haraya, Kenta, Sampei, Zenjiro, Shiraiwa, Hirotake, Kitazawa, Takehisa, Igawa, Tomoyuki, and Kuramochi, Taichi
- Abstract
ABSTRACTEfficient production of bispecific antibodies (BsAbs) in single mammalian cells is essential for basic research and industrial manufacturing. However, preventing unwanted pairing of heavy chains (HCs) and light chains (LCs) is a challenging task. To address this, we created an engineering technology for preferential cognate HC/LC and HC/HC paring called FAST-Ig (Four-chain Assembly by electrostatic Steering Technology – Immunoglobulin), and applied it to NXT007, a BsAb for the treatment of hemophilia A. We introduced charged amino-acid substitutions at the HC/LC interface to facilitate the proper assembly for manufacturing a standard IgG-type BsAb. We generated CH1/CL interface-engineered antibody variants that achieved > 95% correct HC/LC pairing efficiency with favorable pharmacological properties and developability. Among these, we selected a design (C3) that allowed us to separate the mis-paired species with an unintended pharmacological profile using ion-exchange chromatography. Crystal structure analysis demonstrated that the C3 design did not affect the overall structure of both Fabs. To determine the final design for HCs-heterodimerization, we compared the stability of charge-based and knobs into hole-based Fc formats in acidic conditions and selected the more stable charge-based format. FAST-Ig was also applicable to stable CHO cell lines for industrial production and demonstrated robust chain pairing with different subclasses of parent BsAbs. Thus, it can be applied to a wide variety of BsAbs both preclinically and clinically.
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- 2023
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36. Lateral Para-Olecranon Approach for the Treatment of Distal Humeral Fracture.
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Iwamoto, Takuji, Suzuki, Taku, Matsumura, Noboru, Nakamura, Masaya, Matsumoto, Morio, and Sato, Kazuki
- Abstract
Purpose To assess the outcomes of the lateral para-olecranon triceps-splitting approach for the treatment of distal humeral fracture. Methods Ten patients (3 males, 7 females) with a mean age of 59 years were retrospectively reviewed. There were 2 A2, 3 C1, and 5 C2 fractures according to the AO/ASIF classification. Types B3 and C3 fractures were excluded from this study because the olecranon osteotomy approach was indicated to visualize the anterior fragment. The triceps was split at the midline, and the anconeus muscle was incised from the proximal ulna. The lateral half of the triceps along with anconeus was retracted laterally as a single unit. The distal part of the humerus could be visualized from medial and lateral windows by retracting the medial half of the triceps. The articular fragment was anatomically reduced and fixed temporarily with a Kirschner wire, and the reconstructed distal articular block was then fixed to the humeral shaft with double locking plates. Results After surgery, average elbow flexion was 127° (range, 110°–145°), and extension was –10° (range, –20°–0°) at the average follow-up time of 12.4 months (range, 8‒20 months). Seven patients had normal muscle strength against full resistance (manual muscle testing grade 5), and the other 3 patients had slightly reduced muscle strength (grade 4). No articular stepoffs of more than 1 mm were seen on postoperative radiographs. There were no cases of triceps insufficiency and nonunion. The average (± SD) Mayo Elbow Score was 93.5 ± 5.8 points at the final follow-up. Conclusions The lateral para-olecranon approach is useful for the management of selected fractures of the distal humerus, preserving extension strength and providing satisfactory clinical outcomes, with no risk of olecranon osteotomy-related complications. Type of study/level of evidence Therapeutic V. [ABSTRACT FROM AUTHOR]
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- 2017
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37. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry
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Sawhney, Jitendra PS., Kothiwale, Veerappa A., Bisne, Vikas, Durgaprasad, Rajashekhar, Jadhav, Praveen, Chopda, Manoj, Vanajakshamma, Velam, Meena, Ramdhan, Vijayaraghavan, Govindan, Chawla, Kamaldeep, Allu, Jagan, Pieper, Karen S., John Camm, A., Kakkar, Ajay K., Kakkar, Ajay K., Bassand, Jean-Pierre, John Camm, A., Fitzmaurice, David A., Goldhaber, Samuel Z., Goto, Shinya, Haas, Sylvia, Hacke, Werner, Mantovani, Lorenzo G., Misselwitz, Frank, Pieper, Karen S., Turpie, Alexander G.G., van Eickels, Martin, Verheugt, Freek W.A., John Camm, A., Bassand, Jean-Pierre, Goldhaber, Samuel Z., Haas, Sylvia, Kayani, Gloria, Mantovani, Lorenzo G., Fox, Keith A.A., Gersh, Bernard J., Luciardi, Hector Lucas, Gibbs, Harry, Brodmann, Marianne, Cools, Frank, Barretto, Antonio Carlos Pereira, Connolly, Stuart J., Spyropoulos, Alex, Eikelboom, John, Corbalan, Ramon, Hu, Dayi, Jansky, Petr, Nielsen, Jørn Dalsgaard, Ragy, Hany, Raatikainen, Pekka, Le Heuzey, Jean-Yves, Darius, Harald, Keltai, Matyas, Kakkar, Sanjay, Sawhney, Jitendra Pal Singh, Agnelli, Giancarlo, Ambrosio, Giuseppe, Koretsune, Yukihiro, Sánchez Díaz, Carlos Jerjes, Ten Cate, Hugo, Atar, Dan, Stepinska, Janina, Panchenko, Elizaveta, Lim, Toon Wei, Jacobson, Barry, Oh, Seil, Viñolas, Xavier, Rosenqvist, Marten, Steffel, Jan, Angchaisuksiri, Pantep, Oto, Ali, Parkhomenko, Alex, Al Mahmeed, Wael, Fitzmaurice, David, Goldhaber, Samuel Z., Hu, D.Y., Chen, K.N., Zhao, Y.S., Zhang, H.Q., Chen, J.Z., Cao, S.P., Wang, D.W., Yang, Y.J., Li, W.H., Yin, Y.H., Tao, G.Z., Yang, P., Chen, Y.M., He, S.H., Wang, Ying, Wang, Yong, Fu, G.S., Li, X., Wu, T.G., Cheng, X.S., Yan, X.W., Zhao, R.P., Chen, M.S., Xiong, L.G., Chen, P., Jiao, Y., Guo, Y., Xue, L., Wang, F.Z., Li, H., Yang, Z.M., Bai, C.L., Chen, J., Chen, J.Y., Chen, X., Feng, S., Fu, Q.H., Gao, X.J., Guo, W.N., He, R.H., He, X.A., Hu, X.S., Huang, X.F., Li, B., Li, J., Li, L., Li, Y.H., Liu, T.T., Liu, W.L., Liu, Y.Y., Lu, Z.C., Luo, X.L., Ma, T.Y., Peng, J.Q., Sheng, X., Shi, X.J., Sun, Y.H., Tian, G., Wang, K., Wang, L., Wu, R.N., Xie, Q., Xu, R.Y., Yang, J.S., Yang, L.L., Yang, Q., Yang, Y.J., Ye, Y., Yu, H.Y., Yu, J.H., Yu, T., Zhai, H., Zhan, Q., Zhang, G.S., Zhang, Q., Zhang, R., Zhang, Y., Zheng, W.Y., Zhou, B., Zhou, Z.H., Zhu, X.Y., Kakkar, S., Sawhney, J.P.S., Jadhav, P., Durgaprasad, R., Ravi Shankar, A.G., Rajput, R.K., Bhargava, K., Sarma, R., Srinivas, A., Roy, D., Nagamalesh, U.M., Chopda, M., Kishore, R., Kulkarni, G., Chandwani, P., Pothiwala, R.A., Padinhare Purayil, M., Shah, S., Chawla, K., Kothiwale, V.A., Raghuraman, B., Vijayaraghavan, G., Vijan, V.M., Bantwal, G., Bisne, V., Khan, A., Gupta, J.B., Kumar, S., Jain, D., Abraham, S., Adak, D., Barai, A., Begum, H., Bhattacharjee, P., Dargude, M., Davies, D., Deshpande, B., Dhakrao, P., Dhyani, V., Duhan, S., Earath, M., Ganatra, A., Giradkar, S., Jain, V., Karthikeyan, R., Kasala, L., Kaur, S., Krishnappa, S., Lawande, A., Lokesh, B., Madarkar, N., Meena, R., More, P., Naik, D., Prashanth, K., Rao, M., Rao, N.M., Sadhu, N., Shah, D., Sharma, M., Shiva, P., Singhal, S., Suresh, S., Vanajakshamma, V., Panse, S.G., Koretsune, Y., Kanamori, S., Yamamoto, K., Kumagai, K., Katsuda, Y., Sadamatsu, K., Toyota, F., Mizuno, Y., Misumi, I., Noguchi, H., Ando, S., Suetsugu, T., Minamoto, M., Oda, Hiroshi, Shiraishi, K., Adachi, S., Chiba, K., Norita, H., Tsuruta, M., Koyanagi, T., Yamamoto, K., Ando, H., Higashi, T., Okada, K., Azakami, S., Komaki, S., Kumeda, K., Murayama, T., Matsumura, J., Oba, Y., Sonoda, R., Goto, K., Minoda, K., Haraguchi, Y., Suefuji, H., Miyagi, H., Kato, H., Nakamura, Tadashi, Nakamura, Tsugihiro, Nandate, H., Zaitsu, R., Fujiura, Yoshihisa, Yoshimura, A., Numata, H., Ogawa, J., Tatematsu, H., Kamogawa, Y., Murakami, K., Wakasa, Y., Yamasawa, M., Maekawa, H., Abe, S., Kihara, H., Tsunoda, S., Saito, Katsumi, Saito, Kazuyuki, Fudo, T., Obunai, K., Tachibana, H., Oba, I., Kuwahata, T., Higa, S., Gushiken, M., Eto, T., Yoshida, H., Ikeda, D., Fujiura, Yoshitake, Ishizawa, M., Nakatsuka, M., Murata, K., Ogurusu, C., Shimoyama, M., Akutsu, M., Takamura, I., Hoshino, F., Yokota, N., Iwao, T., Tsuchida, K., Takeuchi, M., Hatori, Y., Kitami, Y., Nakamura, Yoichi, Oyama, R., Ageta, M., Oda, Hiroyuki, Go, Y., Mishima, K., Unoki, T., Morii, S., Shiga, Yuhei, Sumi, H., Nagatomo, T., Sanno, K., Fujisawa, K., Atsuchi, Y., Nagoshi, T., Seto, T., Tabuchi, T., Kameko, M., Nii, K., Oshiro, K., Takezawa, H., Nagano, S., Miyamoto, N., Iwaki, M., Nakamura, Yuichiro, Fujii, M., Okawa, M., Abe, Masahiko, Abe, Masatake, Abe, Mitsunori, Saito, T., Mito, T., Nagao, K., Minami, J., Mita, T., Sakuma, I., Taguchi, T., Marusaki, S., Doi, H., Tanaka, M., Fujito, T., Matsuta, M., Kusumoto, T., Kakinoki, S., Ashida, K., Yoshizawa, N., Agata, J., Arasaki, O., Manita, M., Ikemura, M., Fukuoka, S., Murakami, H., Matsukawa, S., Hata, Y., Taniguchi, T., Ko, T., Kubo, H., Imamaki, M., Akiyama, M., Inagaki, M., Odakura, H., Ueda, T., Katsube, Y., Nakata, A., Watanabe, H., Techigawara, M., Igarashi, M., Taga, K., Kimura, T., Tomimoto, S., Shibuya, M., Nakano, M., Ito, K., Seo, T., Hiramitsu, S., Hosokawa, H., Hoshiai, M., Hibino, M., Miyagawa, K., Horie, Hajime, Sugishita, N., Shiga, Yukio, Soma, A., Neya, K., Yoshida, Tetsuro, Yoshida, Tomoki, Mizuguchi, M., Ishiguro, M., Minagawa, T., Wada, M., Mukawa, H., Okuda, F., Nagasaka, S., Abe, Y., Adachi, Sen, Adachi, Susumu, Adachi, T., Akahane, K., Amano, T., Aoki, K., Aoyama, T., Arai, H., Arima, S., Arino, T., Asano, H., Asano, T., Azuma, J., Baba, T., Betsuyaku, T., Chibana, H., Date, H., Doiuchi, J., Emura, Y., Endo, M., Fujii, Y., Fujiki, R., Fujisawa, A., Fujisawa, Y., Fukuda, T., Fukui, T., Furukawa, N., Furukawa, T., Furumoto, W., Goto, T., Hamaoka, M., Hanazono, N., Hasegawa, K., Hatsuno, T., Hayashi, Y., Higuchi, K., Hirasawa, K., Hirayama, H., Hirose, M., Hirota, S., Honda, M., Horie, Hideki, Ido, T., Iiji, O., Ikeda, H., Ikeda, K., Ikeoka, K., Imaizumi, M., Inaba, H., Inoue, T., 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Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
- Abstract
The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry.
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- 2018
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38. A New Baseline Subtraction Method for Di-hadron Correlations in High-multiplicity Small System Collisions
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Han, Seyoung, Esumi, ShinIchi, Sato, Kazuki, Nakagawa, Itaru, and Todoroki, Takahito
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Azimuthal anisotropy in high-multiplicity small system collisions is often quantified by the harmonic modulations cn= ‹cos (nΔφ)› in di-hadron azimuthal correlations, with a non-flow baseline subtraction using correlation functions in low-multiplicity events. We present mathematical evaluations for three different baseline subtraction methods; i) the template fit method, ii) the reference fit method, and iii) the c1scaling method. We describe conceptual differences among the three methods. These methods are compared and examined using a toy Monte Carlo model with various realistic cnvalues implemented in high-multiplicity events. Our results show the reference fit method is more stable than the template fit method because the reference fit does not estimate the flow yield. On the other hand, the template fit method can evaluate the flow effect reasonably, for the case where the flow does not contain c1factor.
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- 2018
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39. Early control treatment with montelukast in preschool children with asthma: A randomized controlled trial
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Nagao, Mizuho, Ikeda, Masanori, Fukuda, Norimasa, Habukawa, Chizu, Kitamura, Tetsuro, Katsunuma, Toshio, Fujisawa, Takao, Tokuyama, Kennichi, Terada, Akihiko, Sato, Kazuki, Miura, Katsushi, Arakawa, Hirokazu, Zaitsu, Masafumi, Sakamoto, Tastuo, Takamasu, Tetsuya, Shimojo, Naoki, Kameda, Makoto, Mochizuki, Hiroyuki, Tachimoto, Hiroshi, Yamaguchi, Koichi, Masuda, Kei, Adachi, Yuichi, Oshima, Yusei, Yoshihara, Shigemi, Tanaka, Noriko, Ohta, Kunitaka, Morita, Masao, Tokuda, Reiko, Kitou, Yoshihiko, Araki, Hayao, Yamaoka, Akiko, and Nakamura, Akio
- Abstract
While Japanese guideline recommends initial control treatment for preschool children with asthma symptoms more than once a month, Western guidelines do not. To determine whether control treatment with montelukast was more effective than as-needed β2-agonists in this population, we conducted a randomized controlled trial.
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- 2018
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40. Three-dimensional anthropometric analysis of the glenohumeral joint in a normal Japanese population.
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Matsumura, Noboru, Oki, Satoshi, Ogawa, Kiyohisa, Iwamoto, Takuji, Ochi, Kensuke, Sato, Kazuki, and Nagura, Takeo
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Background An understanding of normal glenohumeral geometry is important for anatomical reconstruction in shoulder arthroplasty. Unfortunately, the details of the glenohumeral joint in Asian populations have not been sufficiently evaluated. The purpose of this study was to evaluate the 3-dimensional geometry of the glenohumeral joint in the normal Japanese population and to clarify its morphologic features. Methods Anthropometric analysis of the glenohumeral joint was performed using computed tomography scans of 160 normal shoulders from healthy Japanese volunteers. The glenohumeral dimensions and orientation were analyzed 3-dimensionally. Sex differences and correlations between sides and among the respective parameters in the glenohumeral dimensions were evaluated. Results The normal Japanese humeral head has an average width of 41.4 mm, thickness of 13.2 mm, diameter of 42.9 mm, retroversion of 32°, and inclination of 135°. The glenoid has an average height of 31.5 mm, width of 23.1 mm, diameter of 62.0 mm, retroversion of 0°, and inferior inclination of 2°. The values of the glenohumeral dimensions were uniform in men and women, and the humeral head and glenoid were larger in men than in women. The glenohumeral size was well correlated between the 2 sides, and there were direct correlations among the heights, humeral length, humeral head size, and glenoid size. Conclusions The present study revealed the glenohumeral geometry in the normal Japanese population. The present results would be useful to determine the size of implants and to improve the design of shoulder prostheses that reflect the normal anatomy of the Asian glenohumeral joint. [ABSTRACT FROM AUTHOR]
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- 2016
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41. Number of papers published in English from the nursing departments of 42 national universities in Japan in the past ten years.
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Kameoka, Junichi, Iwazaki, Junya, Takahashi, Fumie, Sato, Fumiko, Sato, Kazuki, Taguchi, Atsuko, Nakamura, Yasuka, Ishii, Seiichi, and Kagaya, Yutaka
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Summary Background In Japan, the departments of nursing were established by 2004, and graduate school programs for master's degree were established by 2008, in 42 national universities. With these changes, a more academic mission has been pursued, and the need for writing papers in English has increased. Aim To investigate the numbers of papers published in English from the nursing departments of national universities in Japan over the past ten years. Methods The lists of teachers who have nursing licenses in the departments of nursing in the 42 national universities (n = 2292) were obtained from the Japan Association of Nursing Programs in Universities. The number of papers published in English by these teachers from 2004 to 2013 was counted using the SCOPUS database. Results The average number of total papers, in which at least one of the authors was a nursing teacher, and first-authored papers, in which the first author was a nursing teacher, were 211.4 and 69.9 per year, respectively; both increased approximately two-fold during the past ten years. The means and standard deviations of the number of total papers and first-authored papers were 50.3 ± 63.8 (range: 1–382) and 18.3 ± 23.4 (range: 0–147) according to universities, and 1.39 ± 5.84 (range: 0–140) and 0.33 ± 1.28 (range: 0–21) according to teachers, respectively. When journals with the highest number of papers were analyzed, 12 of the top 20 (total papers) and 12 of the top 16 (first-authored papers) were in journals whose editorial offices are in Japan. Conclusion The number of papers published in English has increased over the past ten years, varied markedly depending on the universities and teachers, and many papers were published in Japanese journals. To our knowledge, this is the first report anywhere to determine the average number of nursing papers “per teacher” in a specific population. [ABSTRACT FROM AUTHOR]
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- 2016
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42. Three-Dimensional Deformities of Nonoperative Midshaft Clavicle Fractures: A Surface Matching Analysis
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Oki, Satoshi, Matsumura, Noboru, Kiriyama, Yoshimori, Iwamoto, Takuji, Sato, Kazuki, and Nagura, Takeo
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- 2017
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43. LC–MS/MS Based Quantitation of ABC and SLC Transporter Proteins in Plasma Membranes of Cultured Primary Human Retinal Pigment Epithelium Cells and Immortalized ARPE19 Cell Line
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Pelkonen, Laura, Sato, Kazuki, Reinisalo, Mika, Kidron, Heidi, Tachikawa, Masanori, Watanabe, Michitoshi, Uchida, Yasuo, Urtti, Arto, and Terasaki, Tetsuya
- Abstract
The retinal pigment epithelium (RPE) forms the outer blood–retinal barrier between neural retina and choroid. The RPE has several important vision supporting functions, such as transport mechanisms that may also modify pharmacokinetics in the posterior eye segment. Expression of plasma membrane transporters in the RPE cells has not been quantitated. The aim of this study was to characterize and compare transporter protein expression in the ARPE19 cell line and hfRPE (human fetal RPE) cells by using quantitative targeted absolute proteomics (QTAP). Among 41 studied transporters, 16 proteins were expressed in hfRPE and 13 in ARPE19 cells. MRP1, MRP5, GLUT1, 4F2hc, TAUT, CAT1, LAT1, and MATE1 proteins were detected in both cell lines within 4-fold differences. MPR7, OAT2 and RFC1 were detected in the hfRPE cells, but their expression levels were below the limit of quantification in ARPE19 cells. PCFT was detected in both studied cell lines, but the expression was over 4-fold higher in hfRPE cells. MCT1, MCT4, MRP4, and Na+/K+ATPase were upregulated in the ARPE19 cell line showing over 4-fold differences in the quantitative expression values. Expression levels of 25 transporters were below the limit of quantification in both cell models. In conclusion, we present the first systematic and quantitative study on transporter protein expression in the plasma membranes of ARPE19 and hfRPE cells. Overall, transporter expression in the ARPE19 and hfRPE cells correlated well and the absolute expression levels were similar, but not identical. The presented quantitative expression levels could be a useful basis for further studies on drug permeation in the outer blood–retinal barrier.
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- 2017
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44. Total Finger Arthroplasty Using Costal Osteochondral Autograft for Finger Joint Ankylosis: Mid- to Long-Term Clinical Outcomes Up to 11 Years of Follow-Up: Level 4 Evidence.
- Author
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Sato, Kazuki, Iwamoto, Takuji, Matsumura, Noboru, Suzuki, Taku, and Oki, Satoshi
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- 2018
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45. Shoulder position increases ulnar nerve strain at the elbow of patients with cubital tunnel syndrome.
- Author
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Ochi, Kensuke, Horiuchi, Yukio, Horiuchi, Koichi, Iwamoto, Takuji, Morisawa, Yasushi, and Sato, Kazuki
- Abstract
Background Previous studies have shown that the shoulder internal rotation elbow flexion (SIREF) test, which is a modified elbow flexion (EF) test, has significantly higher sensitivity than the EF test in patients with cubital tunnel syndrome (CubTS). Here, we hypothesized that this increase in sensitivity was due to increase in the ulnar nerve strain around the elbow introduced by the additional shoulder position. Methods Ulnar nerve strain at the elbow was intraoperatively measured at both the EF test and SIREF test positions in 20 patients with CubTS before simple decompression. Statistical analysis was performed with the Wilcoxon signed rank test at a confidence level of 99% ( P < .001). Results Mean ulnar nerve strain in the EF test position was 18.9% ± 12.1%, whereas that in the SIREF test position was 24.7% ± 14.0%. Ulnar nerve strain was higher in the SIREF than in the EF test position in all cases, and the difference was significant (mean, 5.8% ± 0.9%; 95% confidence interval, 3.90%-7.73%). Conclusion This study indicated that increased sensitivity in the SIREF test compared with the EF test was due to the increase in ulnar nerve strain around the elbow. To the best of our knowledge, this is the first study showing that shoulder position changes the ulnar nerve strain around the elbow in living patients with CubTS. [ABSTRACT FROM AUTHOR]
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- 2015
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46. AQUACEL® Ag Advantage reduces the stress of postoperative packing removal after endoscopic sinus surgery
- Author
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Hosoya, Kei, Maeda, Yohei, Komachi, Taro, Sato, Kazuki, and Okubo, Kimihiro
- Abstract
•Packing removal after endoscopic nasal sinus surgery causes stress to the physician.•Physician stress in packing removal is lower with AQUACEL® Ag Advantage than control.•AQUACEL® Ag Advantage is useful for packing after endoscopic nasal sinus surgery.
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- 2023
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47. Recent advances in unlinked total elbow arthroplasty in Japan
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Iwamoto, Takuji, Ikegami, Hiroyasu, Tanji, Atsushi, Kiyota, Yasuhiro, Suzuki, Taku, Matsumura, Noboru, and Sato, Kazuki
- Abstract
Total elbow arthroplasty (TEA) is a valuable therapeutic approach for improving function and relieving pain in severely deformed elbow joints. However, TEA is associated with a high incidence of complications. In Japan, the use of unlinked TEA has a long history, with the development of the Kudo prosthesis marking a significant milestone. Subsequently, various unlinked implant designs have been developed. Although favorable long-term clinical results have been reported, complications remain a concern. To further improve the outcome of unlinked TEA, attempts have been made in recent years to develop various surgical approaches and intraoperative support devices. This review focuses on the clinical outcomes and recent advances in unlinked TEA in Japan.
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- 2023
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48. Solid-Phase Synthesis of Glycosyl Phosphate Repeating Units via Glycosyl Boranophosphates as Stable Intermediates
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Sato, Kazuki, Muramoto, Kazumasa, Hagio, Tomoya, I. Hara, Rintaro, and Wada, Takeshi
- Abstract
Solid-phase synthesis of glycosyl phosphate repeating units was investigated using glycosyl boranophosphates as stable precursors. The stable nature of glycosyl boranophosphate enables the elongation of a saccharide chain without remarkable decomposition. After deprotection of the boranophosphotriester linkages to boranophosphodiesters, the intersugar linkages were converted to the phosphate counterparts quantitatively using an oxaziridine derivative. This method significantly improves the synthesis of oligosaccharides containing glycosyl phosphate units.
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- 2023
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49. Electrodeposition of Al-W Alloys in AlCl3-NaCl-KCl Molten Salt Containing WCl4
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Sato, Kazuki, Matsushima, Hisayoshi, and Ueda, Mikito
- Abstract
To form Al-W alloys for high temperature oxidation resistance components, molten salt electrolysis was carried out in an AlCl3-NaCl-KCl melt containing WCl4 at 423 K. The voltammogram showed two cathodic waves at 1.1 V and 0.5 V vs. Al/Al(III), which may correspond to the reduction from W(IV) to W(III) and from W(III) to tungsten metal, respectively. Electrodeposits of Al and W were obtained in the range from -0.05 to 0.4 V and the highest concentration of W in the electrodeposit was 95 at% at 0.4 V. With increasing W content in the alloy, the morphology of the electrodeposits became more powdery and the particle size smaller.
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- 2016
50. Active Sites of Spinoxin, a Potassium Channel Scorpion Toxin, Elucidated by Systematic Alanine Scanning
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Peigneur, Steve, Yamaguchi, Yoko, Kawano, Chihiro, Nose, Takeru, Nirthanan, Selvanayagam, Gopalakrishnakone, Ponnampalam, Tytgat, Jan, and Sato, Kazuki
- Abstract
Peptide toxins from scorpion venoms constitute the largest group of toxins that target the voltage-gated potassium channel (Kv). Spinoxin (SPX) isolated from the venom of scorpion Heterometrus spiniferis a 34-residue peptide neurotoxin cross-linked by four disulfide bridges. SPX is a potent inhibitor of Kv1.3 potassium channels (IC50= 63 nM), which are considered to be valid molecular targets in the diagnostics and therapy of various autoimmune disorders and cancers. Here we synthesized 25 analogues of SPX and analyzed the role of each amino acid in SPX using alanine scanning to study its structure–function relationships. All synthetic analogues showed similar disulfide bond pairings and secondary structures as native SPX. Alanine replacements at Lys23, Asn26, and Lys30resulted in loss of activity against Kv1.3 potassium channels, whereas replacements at Arg7, Met14, Lys27, and Tyr32also largely reduced inhibitory activity. These results suggest that the side chains of these amino acids in SPX play an important role in its interaction with Kv1.3 channels. In particular, Lys23appears to be a key residue that underpins Kv1.3 channel inhibition. Of these seven amino acid residues, four are basic amino acids, suggesting that the positive electrostatic potential on the surface of SPX is likely required for high affinity interaction with Kv1.3 channels. This study provides insight into the structure–function relationships of SPX with implications for the rational design of new lead compounds targeting potassium channels with high potency.
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- 2016
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