139 results on '"Santos, Tiago"'
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2. Avaliação de diferentes técnicas de preparação de terreno na instalação de povoamentos de eucalipto
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Oliveira, António, Mendes, Eduardo, Quintela, Ana, Fabres, Sérgio, Ventura, Pedro, Santos, Tiago, Pato, Rosinda, Silva, João, Gomes, Filomena, Oliveira, António, Mendes, Eduardo, Quintela, Ana, Fabres, Sérgio, Ventura, Pedro, Santos, Tiago, Pato, Rosinda, Silva, João, and Gomes, Filomena
- Abstract
Este trabalho foi desenvolvido no âmbito do projeto “Instalação eficiente de povoamentos de eucalipto” com o objetivo de estudar alternativas de mobilização do solo ajustadas à escala da propriedade (minifúndio dominante no Centro/Norte do país), associadas a menor intervenção e impacto ambiental. Foram consideradas para comparação algumas técnicas de mobilização utilizadas em propriedades de maior dimensão. Instalaram-se 4 ensaios na região Centro (três em Cantanhede e um em Mortágua; cada um com 65 a 270 plantas, considerando 3 repetições). A rearborização com eucalipto implicou em todos os casos destroçamento de cepos com enxó. O tratamento convencional - “Operacional” consistiu numa gradagem contínua seguida de ripagem. Em Cantanhede foram colocados dois tratamentos a teste: T1 ripagem (tri-riper) e T2 coveamento (com enxó) para plantação entre cepos. Em Mortágua, devido à dimensão das varas, diferentes opções de gestão de sobrantes foram testadas. O tratamento “Operacional”, com a incorporação de sobrantes durante a gradagem, foi comparado com os tratamentos teste “TA” e “TB”, ambos sem gradagem e, ainda, sem vs.com remoção de sobrantes, respetivamente. Nos tratamentos “TA e TB” testou-se a ripagem na linha (ripado) vs.coveamento na linha de plantação (coveado). Em Mortágua, comparou-se ainda com a construção de terraços, técnica generalizada na região, dada a orografia com declive acentuado. Ao fim de um ano, nos 4 ensaios, os tratamentos em teste não diferiram significativamente do operacional no tocante à taxa de sobrevivência. Mas, em Cantanhede (nos 3 ensaios), o tratamento operacional apresentou um acréscimo em altura significativamente superior aos tratamentos teste. O acréscimo em altura mostrou variar numa razão direta com os teores em matéria orgânica do solo e potássio. Ao fim de 3 anos, o volume médio/árvore não mostrou diferenças significativas entre os tratamentos (Operacional vs.Teste), em 2 ensaios em Cantanhede, mantendo-se significativamente superior no outro ensaio. Em Mortágua a altura média superior foi de 2,75±0,06m (1 ano) em terraços (tratamento com maior mobilização do solo), mas, sem diferenças significativas para o TA-coveado (alinhamento de resíduos na entrelinha e coveamento na linha). No âmbito do projeto tenciona-se dar continuidade à monitorização dos ensaios no sentido de corroborar os resultados do presente estudo obtidos na fase inicial do ciclo de crescimento do povoamento, altura em que as técnicas de preparação do terreno terão, previsivelmente, maior impacte.
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- 2024
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3. High-Pressure Promoted Nazarov-like Electrocyclization Enables Access to trans-4,5-Diamino-cyclopent-2-enones Bearing Electron-Poor Anilines
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Cavaca, Lídia A. S., Santos, Tiago M. P., Ravasco, Joao M. J. M., Gomes, Rafael F. A., and Afonso, Carlos A. M.
- Abstract
Unlike secondary alkyl amines and electron-rich anilines, secondary electron-poor anilines are challenging amine sources to explore the chemical space of Lewis acid-catalyzed condensation-based transformations with furfural. In this work, we report the efficient synthesis of trans-4,5-diamino cyclopentenones (DCP) using a high-pressure promoted Nazarov-like electrocyclization of Stenhouse salts arising from the Sc(III)-catalyzed condensation of furfural with secondary electron-poor anilines. The reaction enables access to otherwise difficult-to-access DCP and compatibility with a large scope of alkyl and aryl secondary amines. A 2- to 18-fold increase in yields for electron-poor anilines was highlighted using this approach in the synthesis of a pharmacologically active compound.
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- 2024
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4. A Randomized, Open-Label, Non-inferiority Clinical Trial Assessing 7 Versus 14 Days of Antimicrobial Therapy for Severe Multidrug-Resistant Gram-Negative Bacterial Infections: The OPTIMISE Trial Protocol.
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Arns, Beatriz, Horvath, Jaqueline Driemeyer C., Rech, Gabriela Soares, Sesin, Guilhermo Prates, Agani, Crepin Aziz Jose Oluwafoumi, da Rosa, Bruna Silveira, dos Santos, Tiago Marcon, Brochier, Liliane Spencer Bittencourt, Cavalcanti, Alexandre Biasi, Tomazini, Bruno Martins, Pereira, Adriano Jose, Veiga, Viviane Cordeiro, Nascimento, Giovana Marssola, Kalil, Andre C., and Zavascki, Alexandre P.
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- 2024
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5. Autonomous Driving of Trucks in Off-Road Environment.
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Caldas, Kenny A. Q., Barbosa, Filipe M., Silva, Junior A. R., Santos, Tiago C., Gomes, Iago P., Rosero, Luis A., Wolf, Denis F., and Grassi Jr., Valdir
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AUTONOMOUS vehicles ,HEAVY duty trucks ,GENERALIZED spaces ,VEHICLE models ,LABOR costs ,TRUCK driving ,DRIVERLESS cars - Abstract
Off-road driving operations can be a challenging environment for human conductors as they are subject to accidents, repetitive and tedious tasks, strong vibrations, which may affect their health in the long term. Therefore, they can benefit from a successful implementation of autonomous vehicle technology, improving safety, reducing labor costs and fuel consumption, and increasing operational efficiency. The main contribution of this paper is the experimental validation of a path tracking control strategy, composed of longitudinal and lateral controllers, on an off-road scenario with a fully loaded heavy-duty truck. The longitudinal control strategy relies on a nonlinear model predictive controller, which considers the path geometry and simplified vehicle dynamics to compute a smooth and comfortable input velocity, without violating the imposed constraints. The lateral controller is based on a robust linear quadratic regulator, which considers a vehicle model subject to parametric uncertainties to minimize its lateral displacement and heading error, as well as ensure stability. Experiments were carried out using a fully loaded vehicle on unpaved roads in an open-pit mine. The truck followed the reference path within the imposed constraints, showing robustness and driving smoothness. [ABSTRACT FROM AUTHOR]
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- 2023
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6. Microstructure characterization of the weld cladding of clad steel plate A516 GR.70 - AISI 904L by electroslag strip cladding using Inconel 625 strip.
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Picchi, Ivan Bezerra de Mello, dos Santos, Mathews Lima, de Santana, Thiago Henrique Bezerra, de Santana, Renato Alexandre Costa, Torres López, Edwar Andrés, Vicente, André de Albuquerque, and de Abreu Santos, Tiago Felipe
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- 2023
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7. Microstructure characterization of the weld cladding of clad steel plate A516 GR.70 - AISI 904L by electroslag strip cladding using Inconel 625 strip
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Picchi, Ivan Bezerra de Mello, dos Santos, Mathews Lima, de Santana, Thiago Henrique Bezerra, de Santana, Renato Alexandre Costa, Torres López, Edwar Andrés, Vicente, André de Albuquerque, and de Abreu Santos, Tiago Felipe
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This work investigates the effect of welding on microstructure and microhardness of the clad plate of ASTM A516 steel Grade 70 coated with AISI 904L steel, used in the manufacture of oil separator vessels. The plates were welded with a V-groove butt joint by gas tungsten arc welding (GTAW), gas metal arc welding (GMAW), and submerged arc welding (SAW) employing mild steel filler wires. The joint back was then cladded with electroslag strip cladding using a single pass of Inconel 625 alloy. Microstructural characterization by optical microscopy reveals predominantly dendritic microstructures and hot cracks at the A516/904L and 904L/IN625 interfaces, with sensitization occurring at the A516/904L interface. Characterization by scanning electron microscopy and X-ray energy dispersive spectroscopy indicates a strong dispersion of deleterious phases identified as laves, sigma, and the NbC in the vicinity of the partially diluted zones, harmful to properties such as toughness and corrosion resistance. The A516/904L interface presented microhardness regions with values around 400 HV in partially diluted zones, equivalent to martensitic structures, usually associated with stress concentration and reduced fracture strength of the welded joint.
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- 2023
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8. Progress in Development of Magadiite to Produce Multifunctional Lamellar Materials.
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dos Santos, Tiago G., de Assis, Geovânia C., da Silva, Antonio O. S., and Meneghetti, Simoni M. P.
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- 2023
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9. Evaluation and Qualification of the Brazing of Stainless Steel Joints Employing Silver-Based Filler Metals for Application in Aircraft Pressurized Oxygen Systems.
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Siqueira, Lucas Oliveira, de Mello Picchi, Ivan Bezerra, Simões Andrade, André Luís, Torres López, Edwar Andrés, de Lima, Nathalia Bezerra, and de Abreu Santos, Tiago Felipe
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- 2023
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10. A coupled computational fluid dynamics approach as a viable tool for thermal history assessment of UNS S32205 duplex stainless steels friction stir welded joints.
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de Sousa Figueiredo, Guilherme Gadelha, Marques, Igor Jordão, Siqueira, Lucas Oliveira, Shen, Jiajia, Oliveira, Joao Pedro, and de Abreu Santos, Tiago Felipe
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- 2023
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11. Evaluation and Qualification of the Brazing of Stainless Steel Joints Employing Silver-Based Filler Metals for Application in Aircraft Pressurized Oxygen Systems
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Siqueira, Lucas Oliveira, de Mello Picchi, Ivan Bezerra, Simões Andrade, André Luís, Torres López, Edwar Andrés, de Lima, Nathalia Bezerra, and de Abreu Santos, Tiago Felipe
- Abstract
The oxyacetylene torch brazing of stainless steel plates using silver-based filler metals (Ag–Cu–Zn–Sn) was investigated. Filler metals with silver quantities of 25%, 35%, and 45% were used to evaluate the influence of silver contents on the processing of joints. The brazed joints were evaluated in accordance with brazing qualification standards. Further, the number of pores from cross sections in different samples for each brazed joint condition was evaluated. The results revealed that the brazed joints exhibited pores, however, did not exceed the maximum percentage allowed in the same cross section. Scanning electron microscopy analysis revealed that the brazed joints are mainly composed of Ag solid solution, Cu solid solution and (Ag + Cu) eutectic microconstituent. Furthermore, the Vickers microhardness test indicated the presence of microstructural discontinuities in the joints 25 and 35 Ag. Finally, the shear strength testing revealed that the joint 45 Ag has a higher average performance.
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- 2023
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12. Evaluation of mechanical performance and microstructural aspects of AISI 304 stainless steel welded joints produced by controlled short circuit GMAW and GTAW.
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Araújo, Helen Rodrigues, Torres, Edwar Andrés, Apolinário, Luis Henrique Rodrigues, Vicente, Andre de Albuquerque, da Silva Júnior, Deusdedit Carlos, and Santos, Tiago Felipe de Abreu
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- 2022
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13. Reproductive phenology of neotropical leptodactylid frogs (genera Physalaemus and Pseudopaludicola): Integrating gametogenic cycle, sexual maturity and age.
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Brum, Amanda J.C., dos Santos, Tiago G., and Cechin, Sonia Z.
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LEPTODACTYLIDAE ,LIFE history theory ,SWAMPS ,SEXUAL cycle ,PHENOLOGY ,SKELETOCHRONOLOGY - Abstract
Ontogeny, temporal strategies and the reproductive cycle are basic aspects of a species' life history and can provide us with information about the current status and future trends of a population. Here, we present data on reproductive biology, influence of environmental factors on male and female reproductive parameters and intra- and interspecific comparisons regarding these parameters, as well as unpublished data on age at sexual maturity and longevity of the syntopic and phylogenetically close frogs Physalaemus cuvieri – dog frog –, Physalaemus riograndensis – Rio Grande frog – and Pseudopaludicola falcipes – Hensel's swamp frog –, in southern Brazil. Accordingly, we used morphoanatomical and histological analyses, whose results were associated with climatological environmental variables (temperature, rainfall, relative humidity and photoperiod). Our results indicate that although they are phylogenetically close and that they co-occur in reproductive environments, the species differ in terms of reproductive cycle and in how environmental variables affect reproductive parameters between the sexes: photoperiod was the most important environmental factor for males and females of P. falcipes , while air humidity was more important for P. cuvieri. The age aspects also varied between the species, where sexual maturity was reached later in the Physalaemus species and the greatest longevity recorded for P. cuvieri. In addition, we found that there was intersexual and interspecific variation in the patterns measured, reflecting intrinsic differences in reproductive strategies and modes. Such studies are of paramount importance, as they serve as a basis for further research, in addition to allowing comparisons and/or possible generalizations about the evolutionary meaning of reproductive strategies. [ABSTRACT FROM AUTHOR]
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- 2022
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14. A coupled computational fluid dynamics approach as a viable tool for thermal history assessment of UNS S32205 duplex stainless steels friction stir welded joints
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de Sousa Figueiredo, Guilherme Gadelha, Marques, Igor Jordão, Siqueira, Lucas Oliveira, Shen, Jiajia, Oliveira, Joao Pedro, and de Abreu Santos, Tiago Felipe
- Abstract
Friction stir welding is a manufacturing process with several positive outputs for duplex stainless steel joints, such as improved mechanical resistance and the maintenance of optimal phase fraction. Duplex steels are vastly used in naval and petrochemical operations, being commonly manufactured and joined via welding processes. Thus, there is a high demand for straightforward methods of thermal evaluation of friction stir welded joints. In this sense, numerical models are a practical tool for assessing the joints’ welding condition. However, the vast majority of works concerning numerical modeling of FSW of duplex steels are limited, by some considerations regarding the heat source modeling, by neglecting the material’s flow convective influence, and by omitting the thermomechanical properties of individual phases. This work focused on the development and application of a more complete coupled numerical model for friction stir welding of UNS S32205 plates in order to correlate processing conditions with microstructure evolution. A peak temperature of 1213 °C at the joint’s central line was observed. Distributions of temperature and material flow through the joint cross-section indicate that a more intense material flow at the retreating side favors coarser grain size. Simulation results indicated that the strain rate plays a more intense effect in microstructure development compared to the welding peak temperatures. The coupled numerical model was additionally used to obtain the temperature profile of the tool, which was thermally stable even after standing temperature values greater than 1200 °C. Even after 18 cm of welding procedure, thermal damage of the tool was not observed, leading to sound welded joints.
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- 2023
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15. A Randomized, Open-Label, Non-inferiority Clinical Trial Assessing 7 Versus 14 Days of Antimicrobial Therapy for Severe Multidrug-Resistant Gram-Negative Bacterial Infections: The OPTIMISE Trial Protocol
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Arns, Beatriz, Horvath, Jaqueline Driemeyer C., Rech, Gabriela Soares, Sesin, Guilhermo Prates, Agani, Crepin Aziz Jose Oluwafoumi, da Rosa, Bruna Silveira, dos Santos, Tiago Marcon, Brochier, Liliane Spencer Bittencourt, Cavalcanti, Alexandre Biasi, Tomazini, Bruno Martins, Pereira, Adriano Jose, Veiga, Viviane Cordeiro, Nascimento, Giovana Marssola, Kalil, Andre C., and Zavascki, Alexandre P.
- Abstract
Introduction: Shorter courses of antimicrobials have been shown to be non-inferior to longer, “traditional” duration of therapies, including for some severe healthcare-associated infections, with a few exceptions. However, evidence is lacking regarding shorter regimes against severe infections by multidrug-resistant Gram-negative bacteria (MDR-GNB), which are often caused by distinct strains and commonly treated with second-line antimicrobials. In the duratiOn of theraPy in severe infecTIons by MultIdrug-reSistant gram-nEgative bacteria (OPTIMISE) trial, we aim to assess the non-inferiority of 7-day versus 14-day antimicrobial therapy in critically ill patients with severe infections caused by MDR-GNB. Methods: This is a randomized, multicenter, open-label, parallel controlled trial to assess the non-inferiority of 7-day versus 14-day of adequate antimicrobial therapy for intensive care unit (ICU)-acquired severe infections by MDR-GNB. Adult patients with severe infections by MDR-GNB initiated after 48 h of ICU admission are screened for eligibility. Patients are eligible if they proved to be hemodynamically stable and without fever for at least 48 h on the 7th day of adequate antimicrobial therapy. After consenting, patients are 1:1 randomized to discontinue antimicrobial therapy on the 7th (± 1) day or to continue for a total of 14th (± 1) days. Planned Outcomes: The primary outcome is treatment failure, defined as death or relapse of infection within 28 days after randomization. Non-inferiority will be achieved if the upper edge of the two-tailed 95% confidence interval of the difference between the clinical failure rate in the 7-day and the 14-day group is not higher than 10%. Conclusion: The OPTIMISE trial is the first randomized controlled trial specifically designed to assess the duration of antimicrobial therapy in patients with severe infections by MDR-GNB. Trial Registration: ClinicalTrials.gov, NCT05210387. Registered on 27 January 2022. Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections (OPTIMISE).
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- 2023
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16. Autonomous Driving of Trucks in Off-Road Environment
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Caldas, Kenny A. Q., Barbosa, Filipe M., Silva, Junior A. R., Santos, Tiago C., Gomes, Iago P., Rosero, Luis A., Wolf, Denis F., and Grassi Jr., Valdir
- Abstract
Off-road driving operations can be a challenging environment for human conductors as they are subject to accidents, repetitive and tedious tasks, strong vibrations, which may affect their health in the long term. Therefore, they can benefit from a successful implementation of autonomous vehicle technology, improving safety, reducing labor costs and fuel consumption, and increasing operational efficiency. The main contribution of this paper is the experimental validation of a path tracking control strategy, composed of longitudinal and lateral controllers, on an off-road scenario with a fully loaded heavy-duty truck. The longitudinal control strategy relies on a nonlinear model predictive controller, which considers the path geometry and simplified vehicle dynamics to compute a smooth and comfortable input velocity, without violating the imposed constraints. The lateral controller is based on a robust linear quadratic regulator, which considers a vehicle model subject to parametric uncertainties to minimize its lateral displacement and heading error, as well as ensure stability. Experiments were carried out using a fully loaded vehicle on unpaved roads in an open-pit mine. The truck followed the reference path within the imposed constraints, showing robustness and driving smoothness.
- Published
- 2023
- Full Text
- View/download PDF
17. Microstructural Features of Dissimilar Thin Sheets Aging Aluminum Alloy – Low Carbon Steel Joined by Friction Stir Welding.
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Torres López, Edwar Andrés, Graciano-Uribe, Jonathan Andrés, Marques, Igor Jordão, and de Abreu Santos, Tiago Felipe
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- 2022
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18. Discontinuing vs continuing ACEIs and ARBs in hospitalized patients with COVID-19 according to disease severity: Insights from the BRACE CORONA trial.
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Macedo, Ariane Vieira Scarlatelli, de Barros e Silva, Pedro Gabriel Melo, de Paula, Thiago Ceccatto, Moll-Bernardes, Renata Junqueira, Mendonça dos Santos, Tiago, Mazza, Lilian, Feldman, Andre, Arruda, Guilherme D'Andréa Saba, de Albuquerque, Denílson Campos, de Sousa, Andrea Silvestre, de Souza, Olga Ferreira, Gibson, C. Michael, Granger, Christopher B., Alexander, John H., and Lopes, Renato D.
- Abstract
Background: We explored the effect of discontinuing versus continuing angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) on clinical outcomes in patients with COVID-19 according to baseline disease severity.Methods: We randomized 659 patients with a confirmed diagnosis of COVID-19 and classified them as having mild or moderate COVID-19 disease severity at hospital presentation using blood oxygen saturation and lung imaging. The primary outcome was the mean ratio of number of days alive and out of the hospital at 30 days according to disease severity.Results: At presentation, 376 patients (57.1%) had mild and 283 (42.9%) had moderate COVID-19. In patients with mild disease, there was no significant difference in the number of days alive and out of the hospital between ACEI/ARB discontinuation (mean 23.5 [SD 6.3] days) and continuation (mean 23.8 [SD 6.5] days), with a mean ratio of 0.98 (95% CI 0.92-1.04). However, in patients with moderate disease, there were fewer days alive and out of the hospital with ACEI/ARB discontinuation (mean 19.6 [SD 9.5] days) than continuation (mean 21.6 [SD 7.6] days), with a mean ratio of 0.90 (95% CI 0.81-1.00; P-interaction = .01). The impact of discontinuing versus continuing ACEIs/ARBs on days alive and out of hospital through 30 days differed according to baseline COVID-19 disease severity.Conclusions: Unlike patients with mild disease, patients with moderate disease who continued ACEIs/ARBs had more days alive and out of hospital through 30 days than those who discontinued ACEIs/ARBs. This suggests that ACEIs/ARBs should be continued for patients with moderate COVID-19 disease severity.Clinical Trial Registration: ClinicalTrials.gov (NCT04364893). [ABSTRACT FROM AUTHOR]- Published
- 2022
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19. 48 Use of 4,500 FTU/kg of phytase on performance and blood parameters of finishing pigs
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de Brito, Alexandre Barbosa, da Costa, Miliane Alves, Rojas, Ingrid Y Martinez, Cordero, Gustavo, Gomes, Gilson A, and Santos, Tiago
- Abstract
Phytase hyper-dosing is a recent concept in nutrition based on the use of high doses of the enzyme with growth promoting effect. Supplementary release of inosotol, rapid and strong destruction of phytic acid and other non-phosphoric effects are proposed mechanisms for the positive results found on pig growth. The hypothesis of this concept would be to accelerate this destruction of the phytate improving feed conversion ratio (FCR). A second hypothesis is that this increased destruction of the phytate may generate decreased concentrations of cortisol, because the inositol has insulin-like effects, reducing glycemy and reducing cortisol concentrations and FCR. To evaluate these hypotheses, two different studies were conducted, in Brazil and Mexico, using Quantum Blue (AB Vista) in two formulation strategies, Control Group - a dose and nutritional matrix of 750 FTU/kg; Hyper-dosing Group - a dose strategy of 4,500 FTU/kg (but with the same matrix of 750 FTU/kg). In the Brazilian evaluation (Trial 1 - RESTRICTED feed consumption trial), 364 animals/treatment were used, divided into 26 replications of 14 animals each (13 pens of males and 13 pens of females). In the Mexican evaluation (Trial 2 – NO restricted feed consumption trial), 400 animals/treatment were used, divided into 8 replications of 50 animals each, all animals used in this evaluation were males. In both studies, body weight gain, feed intake and FCR were evaluated. In the Brazilian study, in addition, the blood cortisol concentration of the animals was also evaluated. The data from each experiment were analyzed using the GLM platform (Minitab 18), and ANOVA used to assess differences on treatments (P≤ 0.05). As presented in Table 1, in Trial 1, no differences were noted (P> 0,05) with the Hyper-dosing strategy for males; however, for females, this strategy improved (P≤ 0.05) the FCR in Hyper-dosing Group versus Control Group. This difference in results between sexes can be explained by the feeding rate adopted in this experiment, which was similar for all animals (highly restrictive), what may have penalized some animals more because of the greater maintenance costs. The analysis of the blood parameters of these animals demonstrated a reduction (P≤ 0.05) in cortisol concentrations, indicating that the use of phytase Hyper-dosing can be even better in situations of thermal or environmental stress. Also presented in Table 1, in the Mexican study the results were possible to observe a statistical trend (P≤ 0.05 and > 0.10) for the use of the Hyper-dosing concept for FCR. In conclusion, the use of 4,500 FTU/kg of Quantum Blue in the last 30 d of finishing pigs helps to improve performance and reduce blood cortisol concentrations of these animals, especially in situations where the production efficiency rate is moderate.
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- 2024
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20. State-of-the-art Medical Therapy Versus Roux-en-Y Gastric Bypass Alone for Treatment of Early Diabetic Kidney Disease
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Friedman, Allon N., Petry, Tarissa B.Z., Aboud, Cristina M., Mendonca dos Santos, Tiago, Roux, Carel W. le, and Cohen, Ricardo V.
- Abstract
Type 2 diabetic kidney disease (DKD) is the most common global cause of kidney disease and failure. Obesity is a major risk factor for DKD due to its causal relationship with diabetes, hypertension, and other factors promoting kidney disease. We therefore investigated whether metabolic surgery such as Roux-en-Y gastric bypass is more effective than state-of-the-art medical therapy (i.e., renin-angiotensin-aldosterone system, sodium-glucose co-transporter 2 inhibitors, and glucagon-like peptide-1 receptor agonists) in treating DKD.
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- 2022
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21. Pediatric adrenal insufficiency: thirty years experience at a Portuguese hospital.
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Mosca, Sara M. F. S., Santos, Tiago S., Mendes, Ana C. B., Ribeiro, Luís F. M., Freitas, Joana M. C., Oliveira, Maria J. R., Rocha, Carla A., and Borges, Teresa M. S.
- Abstract
Adrenal insufficiency (AI) is a life-threatening condition caused by an impaired secretion of the adrenal glucocorticoid and mineralocorticoid hormones. It comprises a heterogeneous group of primary, secondary and acquired disorders. Presentation differs according to the child's age, but it usually presents with nonspecific and insidious symptoms and signs. The main purpose of this study was to describe and compare patients with primary or secondary AI. Retrospective analysis of all patients with adrenal insufficiency followed at the Pediatric Endocrinology Unit in a tertiary care Portuguese hospital over the last 30 years. Data on family history, age at the first manifestation and at etiological diagnosis, and clinical presentation (symptoms, signs and laboratory evaluation) was gathered for all patients. Twenty-eight patients with AI were included; 67.9% were male, with a median (25th–75th percentile, P25–P75) age of 1 (0.5–36) month at the first presentation. The principal diagnostic categories were panhypopituitarism (42.9%) and congenital adrenal hyperplasia (25%). The most frequent manifestations (75%) were vomiting and weight loss. They were followed for a median (P25–P75) period of 3.5 (0.6–15.5) years. In respect to neurodevelopmental delay and learning difficulties, they were more common in the secondary AI group. Despite medical advances, the diagnosis and management of AI remains a challenge, particularly in the pediatric population, and clinicians must have a high index of suspicion. An early identification of AI can prevent a potential lethal outcome, which may result from severe cardiovascular and hemodynamic instability. [ABSTRACT FROM AUTHOR]
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- 2022
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22. Microstructural Features of Dissimilar Thin Sheets Aging Aluminum Alloy – Low Carbon Steel Joined by Friction Stir Welding
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Torres López, Edwar Andrés, Graciano-Uribe, Jonathan Andrés, Marques, Igor Jordão, and de Abreu Santos, Tiago Felipe
- Abstract
The environmental crisis has raised serious concerns regarding fuel consumption, inciting a race to reduce vehicles’ weight. The design of structures combining different materials is a common factor in various industries, where the synergy between steel and aluminum is the starting point for many applications. Metallurgical challenges and the implementation of joining processes for thin sheets are some challenges that friction stir welding has overcome in the last two decades. In this manuscript, the methodology for joining aluminum alloy 6063-T5 and SAE 1020 steel, in thin sheets, employing friction stir welding, is presented. The research evaluated the offset in obtaining joints with complete joint penetration, heat generation, and microstructural changes. Joints with no defects were obtained, with a low thermal input, which favored the formation of tiny grain size in the stir zone, as well as an interface free of intermetallic compounds.
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- 2022
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23. Pediatric adrenal insufficiency: thirty years experience at a Portuguese hospital
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Mosca, Sara M. F. S., Santos, Tiago S., Mendes, Ana C. B., Ribeiro, Luís F. M., Freitas, Joana M. C., Oliveira, Maria J. R., Rocha, Carla A., and Borges, Teresa M. S.
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- 2022
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24. Novel management of insulin autoimmune syndrome with methylprednisolone and flash glucose monitoring
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Monteiro, Sílvia Santos, Santos, Tiago Silva, and Dores, Jorge
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- 2023
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25. Educar pela sombra: contemporâneo e educação a partir de uma pintura de Jan Lievens.
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Augsburger, Luiz Guilherme and Santos, Tiago Ribeiro
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EDUCATIONAL technology ,ARTISTS' studios ,PHILOSOPHY of education ,HUMAN beings ,GAMES - Abstract
Copyright of Educação is the property of EDIPUCRS - Editora Universitaria da PUCRS and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
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26. THE EFFECT OF THE CALCINATION TEMPERATURE ON THE PHYSICAL, CHEMICAL AND MINERALOGICAL CHARACTERISTICS OF SUGAR CANE BAGASSE ASH (SCBA) FOR USE AS POZZOLAN.
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Assunção Santos, Tiago, Arraes Argolo, Raquel, and Véras Ribeiro, Daniel
- Abstract
Statement of Novelty: This study analyzes the influence of the washing process and the calcination temperature on the morphological, physical, chemical and mineralogical characteristics of SCBA. The objective of the present study is to evaluate the morphological, physical, chemical and mineralogical characteristics of sugar cane bagasse ash (SCBA). The ashes were obtained by calcination of sugarcane bagasse (SCB), a waste product generated by the sugar and alcohol industry, at temperatures of 500°C, 600° C and 700°C, and the influence of this calcination on the pozzolanic activity of SCBA. The techniques used to characterize these ashes include helium gas picnometry, sedigraphy, scanning electron microscopy (SEM), X-ray fluorescence (XRF), X-ray diffractometry (XRD) and Fourier transform infrared spectrometry (FTIR). The evaluation of the pozzolanicity of these ashes was carried according to chemical titration method as proposed by Fratini, modified Chapelle method and finally using the pozzolanic activity index (PAI) with cement. The results showed that the SCBA presented high pozzolanicity, regardless of the calcination temperature. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
27. Patient-Derived Renal Cell Carcinoma Xenografts Capture Tumor Genetic Profiles and Aggressive Behaviors
- Author
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Beserra, Adriano O., Estevan, Ethiene C., Bezerra, Stephania M., Torrezan, Giovana T., Ikegami, Amanda, Dellê, Humberto, Cunha, Isabela W., Meira, Isabella T., Carraro, Dirce M., Lara, Primo N., Zequi, Stenio C., Martins, Vilma R., and Santos, Tiago G.
- Abstract
Patient-derived xenografts (PDX) have emerged as one of the most promising model systems to study cancer biology and to develop new antineoplastic drugs. Renal cell carcinoma (RCC) represents up to 90% of all kidney tumors, exhibits aggressive behavior, and has a propensity for metastasis. At diagnosis, 30% of patients with RCC have metastases, while up to 50% of those with localized disease treated with curative protocols experience recurrence. This study aimed to establish an RCC PDX platform to identify novel clinical and molecular biomarkers of recurrence risk in order to facilitate precision medicine. Tumor samples were obtained from surgical specimens of 87 RCC patients; fragments were implanted in immunodeficient NOD/SCID/gamma (NSG) mice. 17 Fragments were implanted subcutaneously in an initial group while a second group of 70 samples were implanted orthotopically in the subcapsular space. A total of 19 PDX developed only after orthotopic implantation, and included 15 cases of clear cell RCC subtype, 3 cases of papillary subtype, and 1 unclassifiable tumor. 1 PDX of clear cell RCC recapitulated the phenotype of vena caval tumor thrombus extension that had been diagnosed in the source patient. PDX characterization by immunohistochemistry and targeted sequencing indicated that all PDXs preserved RCC identity and major molecular alterations. Moreover, the capacity of tumor engraftment was a strong prognostic indicator for patients with locally advanced disease. Taken together, these results suggest that the orthotopic xenograft model of RCC represents a suitable tool to study RCC biology, identify biomarkers, and to test therapeutic candidates.
- Published
- 2022
- Full Text
- View/download PDF
28. On the application of the Two-Factor Theory to online employer reviews
- Author
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Koncar, Philipp, Santos, Tiago, Strohmaier, Markus, and Helic, Denis
- Abstract
Monitoring hygiene and motivation factors from Herzberg’s Two-Factor Theory is a popular way of understanding the influential aspects for employee satisfaction and motivation. The increased availability of employee feedback comprised in online employer reviews yields a promising data source to learn more about these influential factors and the theory itself. However, the application of the Two-Factor Theory to such reviews is yet missing. Thus, this article demonstrates how to apply this theory to more than 2 million online employer reviews. For that, review aspects as well as review ratings are leveraged to study factors that influence employee satisfaction with respect to the theory. Based on the gained insights, a prediction experiment is conducted to forecast employee satisfaction through the textual content of reviews. The presented approach identifies relevant aspects for satisfied and dissatisfied employees working in 43 different industries and 4 different countries. Overall, the results indicate that hygiene factors are most relevant for reviewers, while motivation factors are rather incidental. The prediction experiment achieves a mean balanced accuracy of 0.87, suggesting that review text is predictive for employee satisfaction. Further, the article adds useful input to the discussion of the Two-Factor Theory by providing comparative results across a plethora of different employers, industries and countries.
- Published
- 2022
- Full Text
- View/download PDF
29. Evaluation of mechanical performance and microstructural aspects of AISI 304 stainless steel welded joints produced by controlled short circuit GMAW and GTAW
- Author
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Araújo, Helen Rodrigues, Torres, Edwar Andrés, Apolinário, Luis Henrique Rodrigues, Vicente, Andre de Albuquerque, da Silva Júnior, Deusdedit Carlos, and Santos, Tiago Felipe de Abreu
- Abstract
Recently, developments in the technology used in gas metal arc welding (GMAW) have provided greater control over the parameters, reducing the heat generated, in addition to addressing limitations previously linked to the conventional process. In this work, in comparison to the gas tungsten arc welding (GTAW), the application of the controlled short-circuit GMAW in AISI 304 austenitic stainless steel was evaluated, with and without the use of purging gas to protect the root pass, analyzing the microstructural characteristics and the mechanical behavior, through the microscopy analysis, microhardness, bending, and tensile tests performed on the joints. The heat input associated with the controlled short circuit has shown a significant reduction concerning those produced by the GTAW, affecting the dilution. The application of different processes did not modify the microstructural characteristics due to the similarity in the composition of the filler metals used, presenting the solidification mode in the fusion zone, of the ferrite–austenite. The application of the controlled short circuit resulted in higher microhardness, with 211 HV, the highest value. From the results of the bending tests, it was possible to verify that the ductility of the material was not affected by the application of arc welding processes and was not influenced by the lack of purging protection in the root. The tensile strength limit values associated with the different applications satisfied the minimum requirements for the used materials, and the application of the controlled short circuit without purging has shown the highest value, 615 MPa.
- Published
- 2022
- Full Text
- View/download PDF
30. Microstructural Evaluation of Copper Brazed Joints Using Silver-Based Filler Metal.
- Author
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Siqueira, Lucas Oliveira, da Silva, Ana Carla Santos, Marques, Igor Jordão, Gonzalez, Cezar Henrique, and de Abreu Santos, Tiago Felipe
- Published
- 2021
- Full Text
- View/download PDF
31. EFEITO DE TRÊS SEMANAS DE TREINAMENTO DE FLEXIBILIDADE NO TORQUE E POTÊNCIA MUSCULAR DE MEMBROS INFERIORES.
- Author
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Magalhães Dias, Helton, Callegari Zanetti, Marcelo, de Amorim Santos, Tiago, Destefani Silva, Elaine Cristina, Alexandre Falconi, Carlos, Silva Serafim, Allan Igor, de Jesus Santana, Wiliam, and Figueira Júnior, Aylton José
- Abstract
Copyright of Journal of Physical Education (24482455) is the property of Universidade Estadual de Maringa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
32. ARTIFICIAL INTELLIGENCE TECHNIQUES APPLIED TO PREDICT TEAMS POSITION OF THE BRAZILIAN FOOTBALL CHAMPIONSHIP.
- Author
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Kleina, Mariana, Noronha dos Santos, Mateus, Noronha dos Santos, Tiago, Mendes Marques, Marcos Augusto, and de Assis Silva, Wiliam
- Subjects
ARTIFICIAL intelligence ,SOCCER teams ,PHYSICAL education ,SPORTS forecasting ,NATIONAL championships - Abstract
Copyright of Journal of Physical Education (24482455) is the property of Universidade Estadual de Maringa and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
- Full Text
- View/download PDF
33. Microstructural Evaluation of Copper Brazed Joints Using Silver-Based Filler Metal
- Author
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Siqueira, Lucas Oliveira, da Silva, Ana Carla Santos, Marques, Igor Jordão, Gonzalez, Cezar Henrique, and de Abreu Santos, Tiago Felipe
- Abstract
The oxy-acetylene torch brazing of copper tubes using silver-based filler metals (Ag-Cu-Zn-Cd) was investigated in this study. Filler metals containing silver content of 15% and 35%, designated by BR15 and BR35, were used to assess the influence of the silver content in the microstructure and mechanical performance of brazed joints. The brazed joints microstructure was analyzed by means of optical microscopy, scanning electron microscopy, and energy-dispersive spectroscopy. The microstructures of the BR15 and BR35 samples were composed mainly of Ag–Cd-rich phase, solid solution of Cu–Zn, and a eutectic structure of Ag and Cu. The increase in the Ag content changed the solidification mode from cellular to dendritic and caused an increase in the eutectic phase volume fraction. The tensile strength of the Ag–Cu–Zn–Cd filler and the phos–copper filler metals was compared. The tensile strength of silver-based filler metal was slightly higher than the phos–copper filler metal brazed joints.
- Published
- 2021
- Full Text
- View/download PDF
34. Focused Endocardial Septal Ablation: A New Technique to Treat Postmyectomy Recurrent Gradient.
- Author
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Valdigem, Bruno Pereira, Correia, Edileide Barros, Ribeiro Moreira, Dalmo Antonio, Costa de Souza Le Bihan, David, Pinto Filho, Ibraim Masciarelli, Paladino Filho, Antonio Tito, Cunha Abizaid, Alexandre Antonio, Zucco Viesi, Joao Henrique, Garcia dos Santos, Tiago Senra, and Chaccur, Paulo
- Abstract
This report describes the case of a 64-year-old woman with a previous diagnosis of obstructive hypertrophic cardiomyopathy who underwent surgical myectomy but who had a persistent midventricular residual gradient. The patient was symptomatic despite medical treatment and chose to undergo percutaneous radiofrequency (RF) ablation focused on the gradient. RF delivery was performed, and the gradient was reduced from the initial 105/68 mm Hg (during Valsalva maneuver/at rest before ablation) to 24/10 mm Hg. This reduction was sustained for the next 12 months. Percutaneous RF ablation may be a reasonable option for second surgical myectomy, and the protocol can be easily reproduced. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
35. Patient-derived organoids unveil sarcoma vulnerabilities
- Author
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Góss dos Santos, Tiago
- Abstract
In this Journal Club, Góss dos Santos discusses a study that successfully generated sarcoma-derived organoids and utilized them to identify a novel therapeutic target.
- Published
- 2024
- Full Text
- View/download PDF
36. MINERALOGICAL ANALYSIS OF PORTLAND CEMENT PASTES REHYDRATED.
- Author
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Assunção Santos, Tiago, de Oliveira e Silva, Guilherme Augusto, and Véras Ribeiro, Daniel
- Abstract
Hydrated products, such as (hydrated) cement pastes, decomposition through physicalchemical alterations when submitted to high temperatures. One of the main factors that lead to microstructural changes during calcination up to 800°C, is the dehydration phases of hydrated Portland cement. The present study sought to characterize crystalline phases occurring before and after calcination to the produced pastes using X-ray diffraction (XRD) analysis. Cement pastes were produced using Portland cement CP V-ARI RS, similar to type II (ASTM C150-07), with water/cement ratio 0.5. After a 28-day curing period, the pastes were calcinated at 800°C for 60 minutes with a 10°C / min heating rate. Afterwards, the newly produced hydraulic binder was cooled abruptly and reactivated through a rehydration process, and underwent analyses on the 7 and 28 day. During this study it was observed that the originally hydrated products can be rehydrated. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
37. A fisherman's tale: Activity, habitat use and the first evidence of lingual lure behavior in a South American snake.
- Author
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MARIO-DA-ROSA, CONRADO, ABEGG, ARTHUR DIESEL, MALTA-BORGES, LEANDRO, FERREIRA RIGHI, ALEXANDRE, SÉRGIO BERNARDE, PAULO, CECHIN, SONIA ZANINI, and GOMES DOS SANTOS, TIAGO
- Abstract
Literature data suggests that Thamnodynastes strigatus (Serpentes, Dipsadidae) is a snake that actively forages for anurans near waterbodies, using several microhabitats for this activity (e.g., shrubs, soil, and water). However, herein we present dissonant data previously known to the species, both concerning type of prey and foraging strategy. A total of 72 observations were performed exclusively at night, when snakes were in vegetation near streams in 93% of the cases. Among these observations, 41 were active snakes, and most of them (97%) were in an ambush position on the vegetation, peering at fishes. On two occasions, the snakes used a lingual lure behavior in order to attract fishes. This is only the sixth species in which this behavior has been observed, and the first in South America. Therefore, we provide additional data on T. strigatus habitat activity and habitat use, as well as unpublished data on ambush and lingual lure behavior for the Neotropical genus Thamnodynastes. [ABSTRACT FROM AUTHOR]
- Published
- 2020
38. Photocatalytic processes for biomass conversion
- Author
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de Assis, Geovânia C., Silva, Igor M. A., dos Santos, Tiago G., dos Santos, Thatiane V., Meneghetti, Mario R., and Meneghetti, Simoni M. P.
- Abstract
This review focuses on the photocatalytic conversion of biomass, emphasizing several types of systems, including different photocatalysts and biomass derivatives. The strengthening of the relationship between green chemistry and heterogeneous photocatalysis is highlighted, demonstrating the possibility of obtaining chemical products for several industrial sectors, using relatively mild reaction conditions.
- Published
- 2021
- Full Text
- View/download PDF
39. Parasitic encephalitis caused by Stephanurus dentatus in a pig in Brazil.
- Author
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Prado, Robert G. S., Gardiner, Chris H., Moura, Márcio A. O., Gonzalez, Gerson B. E., Duarte, Marcos D., Santos, Tiago F. S., Bezerra, Pedro S., Cerqueira, Valíria D., Amaral, Alessandra S., and Riet-Correa, Gabriela
- Subjects
ENCEPHALITIS ,MEDULLA oblongata ,SWINE ,PLASMA cells ,EOSINOPHILS - Abstract
A pig was in left lateral recumbency with limb spasticity, accentuated prostration, and strabismus, and was euthanized. During autopsy, yellowing of the leptomeninges at the ventral pons to medulla oblongata was noted. In the cerebellar peduncles, there was a focally extensive black-to-yellow area at the level of the vestibular nuclei. Histologic examination revealed a cross-section of a nematode larva, consistent with Stephanurus dentatus, bordered by edema and marked infiltration of mononuclear cells, plasma cells, and a few eosinophils. Vacuolation of the neuropil, with rare gitter cells and axonal spheroids, was also observed. We diagnosed parasitic encephalitis caused by S. dentatus migration based on the pathology findings and characterization of the parasite. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
40. Ligand screening to pre-miRNA 149 G-quadruplex investigated by molecular dynamics
- Author
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Carvalho, Josué, Santos, Tiago, Carrilho, Rui, Sousa, Fani, Salgado, Gilmar F., Queiroz, João António, and Cruz, Carla
- Abstract
AbstractUsing a molecular dynamics approach, the study of the interaction between six different known ligands and a predicted pre-miRNA 149 RNA G-quadruplex (rG4) structure is reported. The stabilization of rG4 structures formed within the pre-miRNA stem-loop regions using small ligands is an attractive anticancer strategy. Particularly, miRNA-149 is upregulated in a variety of cancers such as prostate cancer and is therefore a potential target for drug development. The results show that ligands C8and PhenDC3interact with the rG4 structure via stacking interactions with the end G-quartets. Ligands [16]phenN2, [32]phen2N4and pyridostatin on the other hand bind the loops/groove interface of the rG4 being H-bonding and electrostatic interactions the driving force of the interaction. The C8precursor, C8-NH2, emphasizes the structural nuances of the rG4 short loops as the lack of a large terminal aromatic moiety produced a mixed stacking-groove binding mode. Overall, this study may help the design of specific ligands for pre-miRNA rG4 towards anticancer therapeutics development.Communicated by Ramaswamy H. Sarma
- Published
- 2020
- Full Text
- View/download PDF
41. Negative affect and eating psychopathology: the moderator effect of gender
- Author
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Marques, Cristiana, Santos, Tiago, Martins, Maria João, Rodrigues, Inês, Pereira, Ana Telma, and Macedo, António
- Abstract
Purpose: This study examined the moderator role of gender in the relationship between negative affect and eating psychopathology as well as gender differences in these variables. Methods: A community sample of 285 students (61.8% females), aged 13–25, was recruited in middle and high schools and universities. They filled instruments that assess negative affect and eating disordered symptoms (restraint, eating concern, shape concern, weight concern, and global scale). Results: Females scored higher both in all subscales and the global scale of eating psychopathology. The restraint subscale was the only subscale showing non-significant differences between females and males. Controlling for BMI, moderation analyses revealed that gender moderated the relationship between negative affect and eating psychopathology, except for restraint behavior. Conclusions: To deal with negative affect, females engage in more cognitive symptoms associated with disordered eating than males, but both endorse equally in eating restraint. These findings suggest that interventions focused on emotion regulation could help to reduce eating disordered symptoms among females and males. Level of evidence: Level V, cross-sectional descriptive study.
- Published
- 2019
- Full Text
- View/download PDF
42. Reference Signal Injection in Induction Motors Drives to Electrical Failures Detection.
- Author
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Gongora, Wylliam Salviano, da Silva, Ivan Nunes, Goedtel, Alessandro, Castoldi, Marcelo Favoretto, and dos Santos, Tiago Henrique
- Subjects
INDUCTION machinery ,INDUCTION motors ,SUPPORT vector machines ,ELECTRIC motors ,FAULT diagnosis ,PERFORMANCE ,ELECTRIC currents - Abstract
This paper shows an alternative method to electrical fault diagnosis in three-phase induction motors using reference signal injection. The proposal is based on the insertion of search reference harmonic signals in the supply voltage by the frequency inverter module of the induction machine and the observation of the signals of the electric current of the motor, preprocessed through the FFT and machine signature component analysis. In order to obtain a greater precision of fault classification and state of degradation through intelligent systems, results are validated by different algorithms whose performance are compared in the following methods: k nearest neighbors, naive Bayes, support vector machine, multilayer perceptron and decision tree. The practical results for the tests with controlled simulation of the electrical faults of broken rotor bars and short circuit in stator windings show the capacity that this insertion technique has when it is used as a tool to diagnose three-phase induction motors. The five proposals of intelligent systems result in a classification with success rates of 93% to 100% in different classes, separated into types of faults and according to the degradation intensity. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
43. Pitfalls in the diagnosis of insulin autoimmune syndrome (Hirata's disease) in a hypoglycemic child: a case report and review of the literature.
- Author
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Dos Santos, Tiago Jeronimo, Passone, Caroline Gouvêa Buff, Ybarra, Marina, Ito, Simone Sakura, Teles, Milena Gurgel, Manna, Thais Della, and Damiani, Durval
- Abstract
Background: Insulin autoimmune syndrome (IAS) is a rare cause of hyperinsulinemic hypoglycemia (HH) not addressed as a potential differential diagnosis in current pediatric guidelines. We present a case of IAS in a child with no previous history of autoimmune disease, no previous intake of triggering medications and absence of genetic predisposition. Case presentation: A 6-year-old boy presented with recurrent HH (blood glucose of 26 mg/dL [1.4 mmol/L] and insulin of 686 μU/mL). Abdominal imaging was normal. After multiple therapeutic failures, we hypothesized misuse of exogenous insulin and factitious hypoglycemia. Council of Guardianship had the child separated from his mother, but insulin levels remained high. A chromatography test was then performed which showed high titers of endogenous insulin autoantibody (IAA) with early dissociation from the insulin molecule. The human leukocyte antigen (HLA) test showed a DRB1 *13:01/*08:02 genotype. The patient was advised to control food intake and physical activity routines. During a 5-year follow-up, hypoglycemic episodes were sparse, despite high insulin levels. Conclusions: Misdiagnosis of IAS with factitious hypoglycemia may happen if IAS is not considered as a differential diagnosis, leading to potential traumatic consequences. Further efforts should be made to increase awareness of IAS as a differential diagnosis of hypoglycemia and to include it in pediatric guidelines. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
44. Corrosion Evaluation of Duplex and Superduplex Stainless Steel Friction Stir Welds Using Potentiodynamic Measurements and Immersion Tests in Chloride Environments.
- Author
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Santa Cruz, Larissa A., Marques, Igor J., Urtiga Filho, Severino L., Hermenegildo, Tahiana F. C., and Santos, Tiago F. A.
- Published
- 2019
- Full Text
- View/download PDF
45. Tadpole of Pithecopus rusticus (Bruschi, Lucas, Garcia & Recco-Pimentel, 2014) (Anura, Phyllomedusidae): description of external morphology and natural history notes of a microendemic species.
- Author
-
De Bastiani, Veluma Ialú Molinari, Boschetti, Joana Priscilla, dos Santos, Tiago Gomes, and Lucas, Elaine Maria
- Abstract
Copyright of Biota Neotropica (Edicao em Iingles) is the property of Biota Neotropica and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2019
- Full Text
- View/download PDF
46. Bioengineering a novel 3D in vitro model of gastric mucosa for stomach permeability studies.
- Author
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Lourenço, Bianca N., dos Santos, Tiago, Oliveira, Carla, Barrias, Cristina C., and Granja, Pedro L.
- Subjects
BIOENGINEERING ,GASTRIC mucosa ,PERMEABILITY ,STOMACH ,EXTRACELLULAR matrix - Abstract
Graphical abstract Abstract The field of stomach-directed therapeutics and diagnosis is still hampered by the lack of reliable in vitro models that closely mimic the gastric mucosa where gastric cancer cells are generally confined. Here we propose a rapid, complex, and innovative 3D in vitro model of the gastric mucosa, by extending a conventional gastric monolayer model to an inner stratum of the mucosa – the lamina propria. The developed model comprises normal stomach fibroblasts embedded in a 3D RGD-modified alginate hydrogel prepared on the basolateral side of a Transwell® insert, mimicking the extracellular matrix and cellular component of the lamina propria , onto which a moderately differentiated adenocarcinoma stomach cell line (MKN74) was seeded, reproducing the physiological conditions of the gastric barrier. The integrity and functionality of the in vitro model was evaluated through permeability studies of FITC-dextran and 200 nm fluorescent polystyrene nanoparticles at gastric conditions. Nanoparticle transport was pH-dependent and strongly impacted by the biomimetic lamina propria , highlighting that a gastric extracellular matrix (ECM)-like microenvironment should be integrated in an in vitro permeability model to be adopted as a reliable evaluation tool of innovative therapeutics and diagnosis of gastric diseases. Statement of Significance Current in vitro models of the gastric mucosa are limited to simplistic 2D cell culture systems, which ignore the dimensionality of the stomach wall and make it difficult to reliably test new therapeutic approaches to gastric pathologies. By combining stomach fibroblasts embedded within a 3D RGD-modified alginate hydrogel and epithelial gastric cancer cells in a Transwell® system, we established a new biomimetic model of the stomach mucosa. Epithelial cells recreate the gastric epithelium, while the cell-laden 3D hydrogel recapitulates both the cellular composition and dimensionality of the extracellular matrix of gastric lamina propria. This cellularized 3D model stands as a promising evaluation platform to assist the development of new strategies for the treatment and diagnosis of gastric diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
47. Environmental superbugs: The case study of Pedobacter spp.
- Author
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Viana, Ana Teresa, Caetano, Tânia, Covas, Claúdia, Santos, Tiago, and Mendo, Sónia
- Subjects
DRUG resistance ,MULTIDRUG resistance in bacteria ,ANTIBIOTICS ,GENETIC code ,BETA lactam antibiotics - Abstract
The environment is one of the main reservoirs of antibiotic resistance genes (ARGs) but multidrug resistant (MDR) environmental isolates are barely characterised. As suggested by the name, Pedobacter species have been predominantly isolated from soils, but are also recovered from water (including drinking water), chilled food, fish, compost, sludge, glaciers and other extreme environments. The susceptibility phenotype of Pedobacter lusitanus NL19 (isolated from a deactivated uranium mine), its closely related species and the genus type strain were investigated. All strains are MDR bacteria, resistant to β-lactams, colistin, aminoglycosides and ciprofloxacin. Therefore, Pedobacter spp. are likely intrinsically resistant to β-lactams (including ertapenem) and to other three classes of antibiotics. 6%–8% of their total protein-encoding genes encode a diverse collection of putative ARGs, including β-lactamases. These enzymes are highly abundant in all the other Pedobacter strains with sequenced genomes, especially class C, class B3 and class A. LUS-1 and PLN-1 were further characterised in E. coli . LUS-1 is a class A β-lactamase and it conferred an increase in the MIC of cefotaxime, albeit very low. PLN-1 is a class B3 β-lactamase with carbapenemase activity, conferring resistance to ertapenem and a 66x and 16x increase in the MIC of imipenem and meropenem, respectively. PLN-1 also hydrolyses ampicillin, 1st and 3rd generation cephalosporins, and at a lower extent cephamycins and 4th generation cephalosporins. Therefore, Pedobacter spp. encode a large and diverse arsenal of resistance mechanisms that make them environmental superbugs. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
48. Accidental poisoning by castor bean (Ricinus communis) cake in horses.
- Author
-
Montão, Daniele P., Araújo, Bruna T. S., Santos, Tiago F. S., Lima, Danielli B., Gonçalves, Fábio T., Duarte, Marcos D., Riet-Correa, Gabriela, and Bezerra Júnior, Pedro S.
- Abstract
Copyright of Pesquisa Veterinaria Brasileira is the property of Colegio Brasileiro de Patologia Animal - CBPA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2018
- Full Text
- View/download PDF
49. Parasitic encephalitis caused by Stephanurus dentatusin a pig in Brazil
- Author
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Prado, Robert G. S., Gardiner, Chris H., Moura, Márcio A. O., Gonzalez, Gerson B. E., Duarte, Marcos D., Santos, Tiago F. S., Bezerra, Pedro S., Cerqueira, Valíria D., Amaral, Alessandra S., and Riet-Correa, Gabriela
- Abstract
A pig was in left lateral recumbency with limb spasticity, accentuated prostration, and strabismus, and was euthanized. During autopsy, yellowing of the leptomeninges at the ventral pons to medulla oblongata was noted. In the cerebellar peduncles, there was a focally extensive black-to-yellow area at the level of the vestibular nuclei. Histologic examination revealed a cross-section of a nematode larva, consistent with Stephanurus dentatus, bordered by edema and marked infiltration of mononuclear cells, plasma cells, and a few eosinophils. Vacuolation of the neuropil, with rare gitter cells and axonal spheroids, was also observed. We diagnosed parasitic encephalitis caused by S. dentatusmigration based on the pathology findings and characterization of the parasite.
- Published
- 2021
- Full Text
- View/download PDF
50. Secondary hypertension due to a juxtaglomerular cell tumor.
- Author
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Nunes, Igor, Santos, Tiago, Tavares, Joana, Correia, Lurdes, Coutinho, João, Nogueira, J.M. Braz, Carvalho, Leonor, and Soares, J.L. Ducla
- Abstract
Abstract Juxtaglomerular cell tumors are rare, generally benign, and they are one of the secondary surgically treatable causes of arterial hypertension. There are about 100 reported cases on literature, and the diagnosis is usually carried out based on a high clinic suspicion index, mostly in patients with hypokalemia and arterial hypertension. The diagnosis involves blood tests and imaging studies, but it is only definite with histopathological exam after surgical treatment. We present a case of a 22-year-old woman with resistant arterial hypertension and renal and cardiovascular target-organ lesions. High plasmatic renin and a nodular renal mass on magnetic resonance imaging were present. A tumorectomy was performed and the histological exam confirmed a reninoma. After surgery, blood pressure and serum renin values returned to normal without medication. This work focuses on the need to exclude rare secondary causes of hypertension in young patients with resistant forms of this disease. Highlights • Juxtaglomerular cell tumors are a rare cause of secondary hypertension. • They are a surgically treatable cause of secondary hypertension. • It is important to exclude rare causes of hypertension in young patients with resistance to the standard treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
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