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Wetenschappelijk onderzoek laat zien dat omstandigheden rondom de conceptie, zwangerschap en de eerste levensjaren van invloed kunnen zijn op de gezondheid op korte en lange termijn. Metabole programmering is beschreven als een van de processen die hieraan ten grondslag zou kunnen liggen. Dit heeft geleid tot de hypothese dat de periode van conceptie tot ongeveer het tweede levensjaar een kritieke periode is, die mede bepaalt of een kind gezond oud zal worden. Deze cruciale periode van 1000 dagen kan worden gezien als een window of opportunityvoor preventie en gezondheidsbevordering, met een blijvende positieve invloed op de latere gezondheid. In dit referaat worden onderzoeken besproken waaruit het belang van het proces van metabole programmering blijkt. Dit proces start mogelijk al tijdens de conceptie en wellicht zelfs eerder.

Objective In 1995, the requirement to visit the dentist for a check-up every six months in The Netherlands was replaced by the obligation to get a routine examination no more than once a year. The aim of this study was to determine patients' opinions about this change in policy, and to assess their preferences regarding frequency and content of regular dental check-up visits. Possible associations between patients' preferences for regular dental check-ups and a number of antecedent variables, such as dental attitudes, were examined as well. Basic research design Patients' preferences for regular dental check-ups were assessed by means of a questionnaire, containing a 19-item Likert-type scale, twelve visual analogue scales and seven forced choice items. Items assessing various background variables and a selection of items of the Dental Attitude Questionnaire were also added. This questionnaire was administered to patients of seven dental practices. A total of 428 patients completed the questionnaire. Results Results indicated that patients prefer to have regular dental check-ups. Patients' evaluation of six-monthly dental check-up visits was significantly more positive than their evaluation of flexible, individualized, check-up frequencies. Factors positively associated with a higher preference for regular dental check-up visits were female gender, being more satisfied with one's teeth, less cynicism toward dental health care professionals and more intrinsic motivation to maintain one's oral health. Conclusions Patients seem to prefer to attend their dentist regularly, at fixed intervals of about six months. This fact should be taken into account when deciding about the most appropriate interval between dental examinations. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To compare the outcome of abdominal infection in patients with or without previous systemic glucocorticoid therapy and to determine the effect of steroid administration on the relationship between APACHE II (Acute Physiology and Chronic Health Evaluation) scores and mortality. HYPOTHESIS: Steroid therapy leads to greater mortality and relatively lower APACHE II scores. DESIGN: Prospective cohort study. SETTING: University hospital. PATIENTS: Two hundred ninety-seven consecutive adult patients with abdominal infection treated by surgical or percutaneous drainage. Treatment was at the clinician's discretion. Seventy-one patients received systemic steroid therapy. OUTCOME MEASURES: APACHE II score, clinical course, and death in hospital; relationship between APACHE II score and mortality in the steroid and no steroid groups. RESULTS: Thirty-three patients receiving steroid therapy (46%) died vs 55 (24%) of 226 patients not receiving steroid therapy. The APACHE II score (P<.0001) and steroid administration (P=.04) were each independently associated with death. Steroid-treated patients had the same probability of dying as "nonsteroid" patients with an APACHE II score a mean of 3.7 points higher (95% confidence limits, 0.03 and 7.7). The confidence that 2, 3, or 4 extra APACHE II points is the appropriate correction for steroid-treated patients is 80%, 60%, or 40%, respectively. CONCLUSIONS: Patients receiving steroid therapy appear to be at higher risk of dying of abdominal infection than predicted by APACHE 11 scores. The number of patients receiving cancer chemotherapy was too small to determine whether this was an additional risk factor. In the design of clinical trials stratified by APACHE II scores, steroid-treated patients should either be excluded or assigned two extra APACHE II points.(Arch Surg. 1994;129:33-38)

• Nosocomial pneumonia (NP) is associated with a significant mortality, 66% in a previous retrospective study of NP complicating intra-abdominal sepsis (IAS). We prospectively compared the outcome of NP complicating IAS with that of recurrent IAS (R-IAS) in the absence of NP. Data were collected prospectively on 300 patients with IAS; 34 patients who presented with pneumonia were excluded from the analysis (44% mortality). One hundred seventy-one patients with no NP and no R-IAS (group 1) had a hospital mortality of 20% (34 patients); 36 without NP in whom R-IAS developed (group 2) had a 17% mortality (six patients); and 47 with NP but no R-IAS (group 3) had a 53% mortality (25 patients). Finally, 12 patients who had both NP and R-IAS suffered a 75% mortality (nine patients). We examined the relationships among the following putative risk factors and mortality: APACHE (acute physiology and chronic health evaluation) II score (at initial presentation with IAS), the need for mechanical ventilatory assistance following initial treatment for peritonitis, steroid requirement, generalized peritonitis vs abscess, and the need for surgical as opposed to percutaneous treatment. Using mortality as the dependent variable, group 2 vs 3 as the explanatory variable, and the risk factors as confounders, logistic regression analysis indicated that the group difference was significant after controlling for confounders. We conclude that NP complicating IAS is an independent risk factor associated with a significant mortality compared with R-IAS. These data challenge the notion that death in IAS is usually due to recurrent or persistent intra-abdominal infection.(Arch Surg. 1991;126:170-175)

To compare the profiles of those patients selected by general practitioners for measurement of serum cholesterol with the recommended profiles for opportunistic cholesterol testing described in the national practice guidelines published by the Dutch College of General Practitioners.

• Therapeutic trials for intra-abdominal sepsis require pretreatment stratification; physiologic scoring has been recently proposed for this purpose. We have prospectively tested the validity of one such scoring system, namely, the Acute Physiology and Chronic Health Evaluation (APACHE II). As part of a larger database, we correlated APACHE II scores with mortality in 100 patients hospitalized for generalized peritonitis or abdominal abscess. Use of steroids was recorded because of our suspicion that steroids increase mortality but blunt the physiologic response to sepsis. Thirty-one patients died, including 12 of 19 patients receiving steroids. Stepwise discriminant analysis revealed that the APACHE II score and steroid use were each independently associated with the rate of mortality. We report a prospective validation of pretreatment APACHE II scoring in abdominal sepsis. Steroid use is an independent risk factor.(Arch Surg 1988;123:225-229)

Multiple organ system failure may result from tissue damage caused by activated neutrophils or endotoxin. A significant part of this tissue damage is due to peroxidation induced by oxygen-free radicals and requires iron as a co-factor. Iron chelation has been shown to prevent tissue damage in some models. This experiment was carried out to determine whether iron chelation with deferoxamine (DFO) would prevent lung damage in a swine model of Gram-negative septicemia. Fifteen animals were randomized to control, Pseudomonas aeruginosainfusion at a rate of 2 ± 107colony forming units/20 kg/min (septic group), or Pseudomonasinfusion combined with DFO pretreatment at a dose of 80 mg/kg/h (septic-treated group). Three of six septic-treated animals became severely hypotensive and died during the course of the experiment as opposed to none of six septic animals. Surviving septic-treated animals were significantly hypotensive (60 ± 24 mmHg mean arterial pressure) compared to septic (122 ± 9 mmHg) and control (109 ± 8 mmHg) animals. DFO did not improve respiratory function (e.g., pO2) or morphology in septic animals. We conclude that iron-chelation therapy with DFO at the above dosage results in a significant deterioration in cardiovascular function in septic swine. Lung damage was not prevented.

The trend toward outpatient surgery led to this study to determine the safety of elective outpatient laparoscopic surgery for the higher risk patient. One hundred consecutive higher risk patients from all patients scheduled for elective outpatient laparoscopic surgery were studied prospectively in a 256-bed community hospital. Seventeen percent of patients required admission. In each instance the need was readily evident in the perioperative observation period. Eighty-three percent of patients were stable and were successfully treated as outpatients. No patient who remained stable decompensated later, and none required readmission to treat complications resulting from outpatient status. The 2 % readmission rate (for unrelated reasons) was comparable to the 2 % readmission rate for low-risk patients. It was concluded that routine outpatient laparoscopic surgery is safe for elective higher risk patients. Problems requiring admission are readily evident during the period of observation and no patient who remains stable decompensates later.