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5. Intravenous thrombolysis with tenecteplase versus alteplase combined with endovascular treatment of anterior circulation tandem occlusions: A pooled analysis of ETIS and TETRIS

Author

Marnat, Gaultier, Lapergue, Bertrand, Gory, Benjamin, Kyheng, Maeva, Labreuche, Julien, Turc, Guillaume, Olindo, Stephanze, Sibon, Igor, Caroff, Jildaz, Smadja, Didier, Chausson, Nicolas, Clarençon, Frederic, Seners, Pierre, Bourcier, Romain, Pop, Raoul, Olivot, Jean-Marc, Mazighi, Mikael, Moulin, Solène, Janot, Kevin, Cognard, Christophe, Alamowitch, Sonia, and Gerschenfeld, Gaspard

Abstract

Background: Tandem occlusions are a singular large vessel occlusion entity involving specific endovascular and perioperative antithrombotic management. In this context, data on safety and efficacy of prior intravenous thrombolysis (IVT) with tenecteplase is scarce. We aimed to compare IVT with tenecteplase or alteplase in patients with acute tandem occlusions intended for endovascular treatment.Patients and methods: A retrospective pooled analysis of two large observational registries (ETIS (Endovascular Treatment of Ischemic Stroke) and TETRIS (Tenecteplase Treatment in Ischemic Stroke)) was performed on consecutive patients presenting with anterior circulation tandem occlusion treated with IVT using either alteplase (ETIS) or tenecteplase (TETRIS) followed by endovascular treatment between January 2015 and June 2022. Sensitivity analyses on atherosclerosis related tandem occlusions and on patient treated with emergent carotid stenting were conducted. Propensity score overlap weighting analyses were performed.Results: We analyzed 753 patients: 124 in the tenecteplase and 629 in the alteplase group. The overall odds of favorable outcome (3-month modified Rankin score 0–2) were comparable between both groups (49.4% vs 47.1%; OR = 1.10, 95%CI 0.85–1.41). Early recanalization, final successful recanalization and mortality favored the use of tenecteplase. The occurrence of any intracranial hemorrhage (ICH) was more frequent after tenecteplase use (OR = 2.24; 95%CI 1.75–2.86). However, risks of symptomatic ICH and parenchymal hematoma remained similar. In atherosclerotic tandems, favorable outcome, mortality, parenchymal hematoma, early recanalization, and final successful recanalization favored the tenecteplase group. In the carotid stenting subgroup, PH were less frequent in the tenecteplase group (OR = 0.18; 95%CI 0.05–0.69).Conclusion: In patients with tandem occlusions, IVT with tenecteplase seemed reasonably safe in particular with increased early recanalization rates. These findings remain preliminary and should be further confirmed in randomized trials.

Published
2024
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6. Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes

Author

Strambo, Davide, Marto, João Pedro, Ntaios, George, Nguyen, Thanh N., Michel, Patrik, Herzig, Roman, Członkowksa, Anna, Demeestere, Jelle, Yassin Mansour, Ossama, Georgiopoulos, Georgios, Nogueira, Raul G., Salerno, Alexander, Wegener, Susanne, Baumgartner, Philipp, Cereda, Carlo W., Bianco, Giovanni, Beyeler, Morin, Arnold, Marcel, Carrera, Emmanuel, Machi, Paolo, Altersberger, Valerian, Bonati, Leo, Gensicke, Henrik, Bolognese, Manuel, Peters, Nils, Wetzel, Stephan, Magriço, Marta, Nuno Ramos, João, Sargento-Freitas, João, Machado, Rita, Maia, Carolina, Machado, Egídio, Paiva-Nunes, Ana, Ferreira, Patrícia, Pinho-e-Melo, Teresa, Carvalho-Dias, Mariana, Paula, André, Alberto Correia, Manuel, Castro, Pedro, Azevedo, Elsa, Albuquerque, Luís, Nuno-Alves, José, Ferreira-Pinto, Joana, Meira, Torcato, Pereira, Liliana, Rodrigues, Miguel, Araújo, André, Rodrigues, Marta, Rocha, Mariana, Pereira-Fonseca, Ângelo, Ribeiro, Luís, Varela, Ricardo, Cappellari, Manuel, Zivelonghi, Cecilia, Sajeva, Giulia, Zini, Andrea, Gentile, Mauro, Forlivesi, Stefano, Migliaccio, Ludovica, Sessa, Maria, Pezzini, Alessandro, Sangalli, Davide, Zedde, Marialuisa, Pascarella, Rosario, Diamanti, Susanna, Beretta, Simone, Schwarz, Ghil, Frisullo, Giovanni, Marcheselli, Simona, Seners, Pierre, Sabben, Candice, Escalard, Simon, Piotin, Michel, Maier, Benjamin, Charbonnier, Guillaume, Vuillier, Fabrice, Legris, Loic, Cuisenier, Pauline, Vodret, Francesca R., Marnat, Gaultier, Liegey, Jean-Sebastien, Sibon, Igor, Flottmann, Fabian, Broocks, Gabriel, Gloyer, Nils-Ole, Bohmann, Ferdinand O., Hendrik Schaefer, Jan, Nolte, Christian H., Audebert, Heinrich, Siebert, Eberhard, Sykora, Marek, Lang, Wilfried, Ferrari, Julia, Mayer-Suess, Lukas, Knoflach, Michael, Gizewski, Elke-Ruth, Stolp, Jeffrey, Stolze, Lotte J., Coutinho, Jonathan M., Nederkoorn, Paul J., van-den-Wijngaard, Ido, de Meris, Joke, Lemmens, Robin, De Raedt, Sylvie, Vandervorst, Fenne, Pierre Rutgers, Matthieu, Guilmot, Antoine, Dusart, Anne, Bellante, Flavio, Calleja-Castaño, Patricia, Ostos, Fernando, Gonzalez-Ortega, Guillermo, Martín-Jiménez, Paloma, García-Madrona, Sebastian, Cruz-Culebras, Antonio, Vera, Rocio, Matute, Maria-Consuelo, Fuentes, Blanca, Alonso-de-Leciñana, María, Rigual, Ricardo, Díez-Tejedor, Exuperio, Pérez-Sánchez, Soledad, Montaner, Joan, Díaz-Otero, Fernando, Perez de la Ossa, Natalia, Flores-Pina, Belén, Muñoz-Narbona, Lucia, Chamorro, Angel, Rodríguez-Vázquez, Alejandro, Renú, Arturo, Ayo-Martin, Oscar, Hernandez-Fernandez, Francisco, Segura, Tomas, Tejada-Meza, Herbert, Hlaing, Thant, See, Isaiah, Simister, Robert, Werring, David J., Saxhaug Kristoffersen, Espen, Nordanstig, Annika, Jood, Katarina, Rentzos, Alexandros, Šimůnek, Libor, Krajíčková, Dagmar, Krajina, Antonín, Mikulík, Robert, Cviková, Martina, Vinklárek, Jan, Školoudík, David, Roubec, Martin, Hurtikova, Eva, Hrubý, Rostislav, Ostry, Svatopluk, Skoda, Ondrej, Pernicka, Marek, Kočí, Lubomír, Eichlová, Zuzana, Jíra, Martin, Kovář, Martin, Panský, Michal, Mencl, Pavel, Paloušková, Hana, Tomek, Aleš, Janský, Petr, Olšerová, Anna, Šrámek, Martin, Havlíček, Roman, Malý, Petr, Trakal, Lukáš, Fiksa, Jan, Slovák, Matěj, Karliński, Michał, Nowak, Maciej, Sienkiewicz-Jarosz, Halina, Bochynska, Anna, Wrona, Pawel, Homa, Tomasz, Sawczynska, Katarzyna, Slowik, Agnieszka, Wlodarczyk, Ewa, Wiącek, Marcin, Tomaszewska-Lampart, Izabella, Sieczkowski, Bartosz, Bartosik-Psujek, Halina, Bilik, Marta, Bandzarewicz, Anna, Dorobek, Malgorzata, Zielińska-Turek, Justyna, Nowakowska-Kotas, Marta, Obara, Krystian, Urbanowski, Paweł, Budrewicz, Sławomir, Guziński, Maciej, Świtońska, Milena, Rutkowska, Iwona, Sobieszak-Skura, Paulina, Łabuz-Roszak, Beata, Dębiec, Aleksander, Staszewski, Jacek, Stępień, Adam, Zwiernik, Jacek, Wasilewski, Grzegorz, Tiu, Cristina, Terecoasă, Elena-Oana, Radu, Razvan-Alexandru, Negrila, Anca, Dorobat, Bogdan, Panea, Cristina, Tiu, Vlad, Petrescu, Simona, Özcan-Özdemir, Atilla, Mahmoud, Mostafa, El-Samahy, Hussam, Abdelkhalek, Hazem, Al-Hashel, Jasem, Ibrahim Ismail, Ismail, Salmeen, Athari, Ghoreishi, Abdoreza, Sabetay, Sergiu, Gross, Hana, Klein, Piers, Abdalkader, Mohamad, Jabbour, Pascal, El Naamani, Kareem, Tjoumakaris, Stavropoula, Abbas, Rawad, Mohamed, Ghada-A., Chebl, Alex, Min, Jiangyong, Hovingh, Majesta, Tsai, Jenny, Khan, Muhib-A., Nalleballe, Krishna, Onteddu, Sanjeeva, Masoud, Hesham E., Michael, Mina, Kaur, Navreet, Maali, Laith, Abraham, Michael, Khandelwal, Priyank, Bach, Ivo, Ong, Melody, Babici, Denis, Khawaja, Ayaz-M., Hakemi, Maryam, Rajamani, Kumar, Cano-Nigenda, Vanessa, Arauz, Antonio, Amaya, Pablo, Llanos, Natalia, Arango, Akemi, Vences, Miguel A., Barrientos, José-Domingo, Caetano, Rayllene, Targa, Rodrigo, Scollo, Sergio, Yalung, Patrick, Nagendra, Shashank, Gaikwad, Abhijit, and Seo, Kwon-Duk

Published
2024
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7. Factors Associated With Fast Early Infarct Growth in Patients With Acute Ischemic Stroke With a Large Vessel Occlusion.

Author

Seners, Pierre, Yuen, Nicole, Olivot, Jean-Marc, Mlynash, Michael, Heit, Jeremy J., Christensen, Soren, Escribano-Paredes, José Bernardo, Carrera, Emmanuel, Strambo, Davide, Michel, Patrik, Salerno, Alexander, Wintermark, Max, Hui Chen, Albucher, Jean-François, Cognard, Christophe, Sibon, Igor, Obadia, Michael, Savatovsky, Julien, Lansberg, Maarten G., and Albers, Gregory W.

Published
2023
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10. Infarct Core Growth During Interhospital Transfer For Thrombectomy Is Faster At Night.

Author

Seners, Pierre, Mlynash, Michael, Sreekrishnan, Anirudh, Ter Schiphorst, Adrien, Arquizan, Caroline, Costalat, Vincent, Henon, Hilde, Bretzner, Martin, Heit, Jeremy J., Olivot, Jean-Marc, Lansberg, Maarten G., Albers, Gregory W., Schmitt, Perrine, Sablot, Denis, Lalu, Thibault, Bricout, Nicolas, Albucher, Jean-François, Cognard, Christophe, Cordonnier, Charlotte, and Christensen, Soren

Published
2023
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11. Consensus Recommendations for Standardized Data Elements, Scales, and Time Segmentations in Studies of Human Circadian/Diurnal Biology and Stroke.

Author

Saver, Jeffrey L., Klerman, Elizabeth B., Buchan, Alastair M., Calleja, Patricia, Lizasoain, Ignacio, Bahr-Hosseini, Mersedeh, Lee, Sarah, Liebeskind, David S., Mergenthaler, Philipp, Mun, Katherine T., Ning, MingMing, Pelz, David, Ray, David, Rothwell, Peter M., Seners, Pierre, Sreekrishnan, Anirudh, Sung, Eleanor Mina, Tiedt, Steffen, Webb, Alastair J.S., and Wölfer, Teresa A.

Published
2023
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12. Infarct Core Growth During Interhospital Transfer For Thrombectomy Is Faster At Night

Author

Seners, Pierre, Mlynash, Michael, Sreekrishnan, Anirudh, Ter Schiphorst, Adrien, Arquizan, Caroline, Costalat, Vincent, Henon, Hilde, Bretzner, Martin, Heit, Jeremy J., Olivot, Jean-Marc, Lansberg, Maarten G., Albers, Gregory W., Schmitt, Perrine, Sablot, Denis, Lalu, Thibault, Bricout, Nicolas, Albucher, Jean-François, Cognard, Christophe, Cordonnier, Charlotte, Christensen, Soren, and Scheldeman, Lauranne

Published
2023
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13. Role of Brain Imaging in the Prediction of Intracerebral Hemorrhage Following Endovascular Therapy for Acute Stroke

Author

Seners, Pierre, Wouters, Anke, Maïer, Benjamin, Boisseau, William, Gory, Benjamin, Heit, Jeremy J., Cognard, Christophe, Mazighi, Mikael, Gaudilliere, Brice, Lemmens, Robin, Zaharchuk, Greg, Albers, Gregory W., Leigh, Richard, and Olivot, Jean-Marc

Abstract

Currently most acute ischemic stroke patients presenting with a large vessel occlusion are treated with endovascular therapy (EVT), which results in high rates of successful recanalization. Despite this success, more than half of EVT-treated patients are significantly disabled 3 months later partly due to the occurrence of post-EVT intracerebral hemorrhage. Predicting post-EVT intracerebral hemorrhage is important for individualizing treatment strategies in clinical practice (eg, safe initiation of early antithrombotic therapies), as well as in selecting the optimal candidates for clinical trials that aim to reduce this deleterious outcome. Emerging data suggest that brain and vascular imaging biomarkers may be particularly relevant since they provide insights into the ongoing acute stroke pathophysiology. In this review/perspective, we summarize the accumulating literature on the role of cerebrovascular imaging biomarkers in predicting post-EVT–associated intracerebral hemorrhage. We focus on imaging acquired before EVT, during the EVT procedure, and in the early post-EVT time frames when new therapeutic therapies could be tested. Accounting for the complex pathophysiology of post-EVT–associated intracerebral hemorrhage, this review may provide some guidance for future prospective observational or therapeutic studies.

Published
2023
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14. Consensus Recommendations for Standardized Data Elements, Scales, and Time Segmentations in Studies of Human Circadian/Diurnal Biology and Stroke

Author

Saver, Jeffrey L., Klerman, Elizabeth B., Buchan, Alastair M., Calleja, Patricia, Lizasoain, Ignacio, Bahr-Hosseini, Mersedeh, Lee, Sarah, Liebeskind, David S., Mergenthaler, Philipp, Mun, Katherine T., Ning, MingMing, Pelz, David, Ray, David, Rothwell, Peter M., Seners, Pierre, Sreekrishnan, Anirudh, Sung, Eleanor Mina, Tiedt, Steffen, Webb, Alastair J.S., Wölfer, Teresa A., and Albers, Gregory W.

Abstract

Increasing evidence indicates that circadian and diurnal rhythms robustly influence stroke onset, mechanism, progression, recovery, and response to therapy in human patients. Pioneering initial investigations yielded important insights but were often single-center series, used basic imaging approaches, and used conflicting definitions of key data elements, including what constitutes daytime versus nighttime. Contemporary methodologic advances in human neurovascular investigation have the potential to substantially increase understanding, including the use of large multicenter and national data registries, detailed clinical trial data sets, analysis guided by individual patient chronotype, and multimodal computed tomographic and magnetic resonance imaging. To fully harness the power of these approaches to enhance pathophysiologic knowledge, an important foundational step is to develop standardized definitions and coding guides for data collection, permitting rapid aggregation of data acquired in different studies, and ensuring a common framework for analysis. To meet this need, the Leducq Consortium International pour la Recherche Circadienne sur l’AVC (CIRCA) convened a Consensus Statement Working Group of leading international researchers in cerebrovascular and circadian/diurnal biology. Using an iterative, mixed-methods process, the working group developed 79 data standards, including 48 common data elements (23 new and 25 modified/unmodified from existing common data elements), 14 intervals for time-anchored analyses of different granularity, and 7 formal, validated scales. This portfolio of standardized data structures is now available to assist researchers in the design, implementation, aggregation, and interpretation of clinical, imaging, and population research related to the influence of human circadian/diurnal biology upon ischemic and hemorrhagic stroke.

Published
2023
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16. Quantification of Penumbral Volume in Association With Time From Stroke Onset in Acute Ischemic Stroke With Large Vessel Occlusion

Author

Seners, Pierre, Yuen, Nicole, Mlynash, Michael, Snyder, Sarah J., Heit, Jeremy J., Lansberg, Maarten G., Christensen, Soren, Albucher, Jean-François, Cognard, Christophe, Sibon, Igor, Obadia, Michael, Savatovsky, Julien, Baron, Jean-Claude, Olivot, Jean-Marc, and Albers, Gregory W.

Abstract

IMPORTANCE: The benefit of reperfusion therapies for acute ischemic stroke decreases over time. This decreasing benefit is presumably due to the disappearance of salvageable ischemic brain tissue (ie, the penumbra). OBJECTIVE: To study the association between stroke onset-to-imaging time and penumbral volume in patients with acute ischemic stroke with a large vessel occlusion. DESIGN, SETTING, AND PARTICIPANTS: A retrospective, multicenter, cross-sectional study was conducted from January 1, 2015, to June 30, 2022. To limit selection bias, patients were selected from (1) the prospective registries of 2 comprehensive centers with systematic use of magnetic resonance imaging (MRI) with perfusion, including both thrombectomy-treated and untreated patients, and (2) 1 prospective thrombectomy study in which MRI with perfusion was acquired per protocol but treatment decisions were made with clinicians blinded to the results. Consecutive patients with acute stroke with intracranial internal carotid artery or first segment of middle cerebral artery occlusion and adequate quality MRI, including perfusion, performed within 24 hours from known symptoms onset were included in the analysis. EXPOSURES: Time from stroke symptom onset to baseline MRI. MAIN OUTCOMES AND MEASURES: Penumbral volume, measured using automated software, was defined as the volume of tissue with critical hypoperfusion (time to maximum >6 seconds) minus the volume of the ischemic core. Substantial penumbra was defined as greater than or equal to 15 mL and a mismatch ratio (time to maximum >6-second volume/core volume) greater than or equal to 1.8. RESULTS: Of 940 patients screened, 516 were excluded (no MRI, n = 19; no perfusion imaging, n = 59; technically inadequate perfusion imaging, n = 75; second segment of the middle cerebral artery occlusion, n = 156; unwitnessed stroke onset, n = 207). Of 424 included patients, 226 (53.3%) were men, and mean (SD) age was 68.9 (15.1) years. Median onset-to-imaging time was 3.8 (IQR, 2.4-5.5) hours. Only 16 patients were admitted beyond 10 hours from symptom onset. Median core volume was 24 (IQR, 8-76) mL and median penumbral volume was 58 (IQR, 29-91) mL. An increment in onset-to-imaging time by 1 hour resulted in a decrease of 3.1 mL of penumbral volume (β coefficient = −3.1; 95% CI, −4.6 to −1.5; P < .001) and an increase of 3.0 mL of core volume (β coefficient = 3.0; 95% CI, 1.3-4.7; P < .001) after adjustment for confounders. The presence of a substantial penumbra ranged from approximately 80% in patients imaged at 1 hour to 70% at 5 hours, 60% at 10 hours, and 40% at 15 hours. CONCLUSIONS AND RELEVANCE: Time is associated with increasing core and decreasing penumbral volumes. Despite this, a substantial percentage of patients have notable penumbra in extended time windows; the findings of this study suggest that a large proportion of patients with large vessel occlusion may benefit from therapeutic interventions.

Published
2023
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17. Endovascular Therapy or Medical Management Alone for Isolated Posterior Cerebral Artery Occlusion: A Multicenter Study

Author

Sabben, Candice, Charbonneau, Frédérique, Delvoye, François, Strambo, Davide, Heldner, Mirjam R., Ong, Elodie, Ter Schiphorst, Adrien, Henon, Hilde, Ben Hassen, Wagih, Agasse-Lafont, Thomas, Legris, Loïc, Sibon, Igor, Wolff, Valérie, Sablot, Denis, Elhorany, Mahmoud, Preterre, Cécile, Nehme, Nour, Soize, Sébastien, Weisenburger-Lile, David, Triquenot-Bagan, Aude, Mione, Gioia, Aignatoaie, Andreea, Papassin, Jérémie, Poll, Roxana, Béjot, Yannick, Carrera, Emmanuel, Garnier, Pierre, Michel, Patrik, Saliou, Guillaume, Mordasini, Pasquale, Berthezene, Yves, Costalat, Vincent, Bricout, Nicolas, Albers, Gregory W., Mazighi, Mikael, Turc, Guillaume, Seners, Pierre, Antonenko, Kateryna, Arquizan, Caroline, Benammar, Lynda, Boutet, Claire, Clarençon, Frédéric, Comby, Pierre-Olivier, Desal, Hubert, Detante, Olivier, Eugene, François, Gerardin, Emmanuel, Gory, Benjamin, Kremer, Stéphane, Ledure, Sylvain, Krug, Mathieu, Lapergue, Bertrand, Niclot, Philippe, Magni, Christophe, Obadia, Michael, Ozsancak, Canan, Pico, Fernando, Pilgram-Pastor, Sara, Pop, Raoul, Richard, Sébastien, Rosso, Charlotte, Savatovsky, Julien, Moulin, Solène, Tracol, Clément, and Zbinden, Martin

Published
2023
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19. Perfusion Imaging and Clinical Outcome in Acute Minor Stroke With Large Vessel Occlusion.

Author

Seners, Pierre, Arquizan, Caroline, Fontaine, Louis, Ben Hassen, Wagih, Heldner, Mirjam R., Strambo, Davide, Nagel, Simon, Carrera, Emmanuel, Mechtouff, Laura, McCullough-Hicks, Margy, Mohammaden, Mahmoud H., Cottier, Jean-Philippe, Henon, Hilde, Aignatoaie, Andreea, Laksiri, Nadia, Papassin, Jérémie, Lucas, Ludovic, Garnier, Pierre, Triquenot, Aude, and Mione, Gioia

Published
2022
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20. Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19

Author

Marto, João Pedro, Strambo, Davide, Ntaios, George, Nguyen, Thanh N., Herzig, Roman, Czlonkowska, Anna, Demeestere, Jelle, Mansour, Ossama Yassin, Salerno, Alexander, Wegener, Susanne, Baumgartner, Philipp, Cereda, Carlo W., Bianco, Giovanni, Beyeler, Morin, Arnold, Marcel, Carrera, Emmanuel, Machi, Paolo, Altersberger, Valerian, Bonati, Leo, Gensicke, Henrik, Bolognese, Manuel, Peters, Nils, Wetzel, Stephan, Magriço, Marta, Ramos, João Nuno, Sargento-Freitas, João, Machado, Rita, Maia, Carolina, Machado, Egídio, Nunes, Ana Paiva, Ferreira, Patricia, Pinho e Melo, Teresa, Dias, Mariana Carvalho, Paula, André, Correia, Manuel Alberto, Castro, Pedro, Azevedo, Elsa, Albuquerque, Luís, Alves, José Nuno, Ferreira-Pinto, Joana, Meira, Torcato, Pereira, Liliana, Rodrigues, Miguel, Araujo, Andre Pinho, Rodrigues, Marta, Rocha, Mariana, Pereira-Fonseca, Ângelo, Ribeiro, Luís, Varela, Ricardo, Malheiro, Sofia, Cappellari, Manuel, Zivelonghi, Cecilia, Sajeva, Giulia, Zini, Andrea, Gentile, Mauro, Forlivesi, Stefano, Migliaccio, Ludovica, Sessa, Maria, La Gioia, Sara, Pezzini, Alessandro, Sangalli, Davide, Zedde, Marialuisa, Pascarella, Rosario, Ferrarese, Carlo, Beretta, Simone, Diamanti, Susanna, Schwarz, Ghil, Frisullo, Giovanni, Marcheselli, Simona, Seners, Pierre, Sabben, Candice, Escalard, Simon, Piotin, Michel, Maïer, Benjamin, Charbonnier, Guillaume, Vuillier, Fabrice, Legris, Loïc, Cuisenier, Pauline, Vodret, Francesca R., Marnat, Gaultier, Liegey, Jean-Sebastien, Sibon, Igor, Flottmann, Fabian, Broocks, Gabriel, Gloyer, Nils-Ole, Bohmann, Ferdinand O., Schaefer, Jan Hendrik, Nolte, Christian, Audebert, Heinrich J., Siebert, Eberhard, Sykora, Marek, Lang, Wilfried, Ferrari, Julia, Mayer-Suess, Lukas, Knoflach, Michael, Gizewski, Elke Ruth, Stolp, Jeffrey, Stolze, Lotte J., Coutinho, Jonathan M., Nederkoorn, Paul, van den Wijngaard, Ido, De Meris, Joke, Lemmens, Robin, De Raedt, Sylvie, Vandervorst, Fenne, Rutgers, Matthieu Pierre, Guilmot, Antoine, Dusart, Anne, Bellante, Flavio, Calleja-Castaño, Patricia, Ostos, Fernando, González-Ortega, Guillermo, Martín-Jiménez, Paloma, García-Madrona, Sebastian, Cruz-Culebras, Antonio, Vera, Rocio, Matute, Maria Consuelo, Fuentes, Blanca, Alonso-de-Leciñana, María, Rigual, Ricardo, Díez-Tejedor, Exuperio, Perez-Sanchez, Soledad, Montaner, Joan, Díaz-Otero, Fernando, Pérez-de-la-Ossa, Natalia, Flores-Pina, Belén, Muñoz-Narbona, Lucia, Chamorro, Angel, Rodríguez-Vázquez, Alejandro, Renú, Arturo, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Segura, Tomas, Tejada-Meza, Herbert, Sagarra-Mur, Daniel, Serrano-Ponz, Marta, Hlaing, Thant, See, Isaiah, Simister, Robert, Werring, David, Kristoffersen, Espen Saxhaug, Nordanstig, Annika, Jood, Katarina, Rentzos, Alexandros, Šimůnek, Libor, Krajíčková, Dagmar, Krajina, Antonín, Mikulik, Robert, Cviková, Martina, Vinklárek, Jan, Školoudík, David, Roubec, Martin, Hurtikova, Eva, Hrubý, Rostislav, Ostry, Svatopluk, Skoda, Ondrej, Pernicka, Marek, Jurak, Lubomir, Eichlová, Zuzana, Jíra, Martin, Kovar, Martin, Panský, Michal, Mencl, Pavel, Palouskova, Hana, Tomek, Aleš, Janský, Petr, Olšerová, Anna, Sramek, Martin, Havlicek, Roman, Malý, Petr, Trakal, Lukáš, Fiksa, Jan, Slovák, Matěj, Karlinski, Michal Adam, Nowak, Maciej, Sienkiewicz-Jarosz, Halina, Bochynska, Anna, Wrona, Pawel, Homa, Tomasz, Sawczynska, Katarzyna, Slowik, Agnieszka, Wlodarczyk, Ewa, Wiacek, Marcin, Tomaszewska-Lampart, Izabella, Sieczkowski, Bartosz, Bartosik-Psujek, Halina, Bilik, Marta, Bandzarewicz, Anna, Dorobek, Malgorzata, Zielinska-Turek, Justyna, Nowakowska-Kotas, Marta, Obara, Krystian, Urbanowski, Paweł, Budrewicz, Slawomir, Guziński, Maciej, Świtońska, Milena, Rutkowska, Iwona, Sobieszak-Skura, Paulina, Labuz-Roszak, Beata M., Debiec, Aleksander, Staszewski, Jacek, Stępień, Adam, Zwiernik, Jacek, Wasilewski, Grzegorz, Tiu, Cristina, Terecoasă, Elena Oana, Radu, Razvan Alexandru, Negrila, Anca, Dorobat, Bogdan, Panea, Cristina, Tiu, Vlad, Petrescu, Simona, Ozdemir, Atilla, Mahmoud, Mostafa, El-Samahy, Hussam, Abdelkhalek, Hazem, Al-Hashel, Jasem, Ismail, Ismail Ibrahim, Salmeen, Athari, Ghoreishi, Abdoreza, Sabetay, Sergiu Ionut, Gross, Hana, Klein, Piers, Abdalkader, Mohamad, Jabbour, Pascal, El Naamani, Kareem, Tjoumakaris, Stavropoula, Abbas, Rawad, Mohamed, Ghada A., Chebl, Alex, Min, Jiangyong, Hovingh, Majesta, Tsai, Jenney P., Khan, Muhib, Nalleballe, Krishna, Onteddu, Sanjeeva, Masoud, Hesham, Michael, Mina, Kaur, Navreet, Maali, Laith, Abraham, Michael G., Khandelwal, Priyank, Bach, Ivo, Ong, Melody, Babici, Denis, Khawaja, Ayaz M., Hakemi, Maryam, Rajamani, Kumar, Cano-Nigenda, Vanessa, Arauz, Antonio, Amaya, Pablo, Llanos, Natalia, Arango, Akemi, Vences, Miguel Ángel, Barrientos Guerra, Jose Dominguo, Caetano, Rayllene, Martins, Rodrigo Targa, Scollo, Sergio Daniel, Yalung, Patrick Matic, Nagendra, Shashank, Gaikwad, Abhijit, Seo, Kwon-Duk, Georgiopoulos, Georgios, Nogueira, Raul G., and Michel, Patrik

Published
2023
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21. Successful thrombectomy is beneficial in patients with pre-stroke disability: Results from an international multicenter cohort study

Author

Ducroux, Célina, Derex, Laurent, Nourredine, Mikaïl, Haesebaert, Julie, Buisson, Marielle, Alesefir, Walid, Boisseau, William, Daneault, Nicole, Deschaintre, Yan, Diestro, Jose Danilo B., Eker, Omer, Eneling, Johanna, Gioia, Laura C., Iancu, Daniella, Jacquin, Grégory, Odier, Céline, Stapf, Christian, Raymond, Jean, Roy, Daniel, Weill, Alain, Lapergue, Bertrand, Poppe, Alexandre Y., Piotin, Michel, Blanc, Raphael, Escalard, Hocine Redjem Simon, Desilles, Jean-Philippe, Delvoye, François, Smajda, Stanislas, Maier, Benjamin, Hebert, Solène, Mazighi, Mikael, Obadia, Mikael, Sabben, Candice, Seners, Pierre, Raynouard, Igor, Corabianu, Ovide, de Broucker, Thomas, Manchon, Eric, Taylor, Guillaume, Ben Maacha, Malek, Thion, Laurie-Anne, Lecler, Augustin, Savatovsky, Julien, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Ajili, Nadia, Lapergue, Bertrand, Weisenburger-Lile, David, Gorza, Lucas, Buard, Géraldine, Coskun, Oguzhan, Consoli, Arturo, Di Maria, Federico, Rodesh, Georges, Zimatore, Sergio, Leguen, Morgan, Gratieux, Julie, Pico, Fernando, Rakotoharinandrasana, Haja, Tassan, Philippe, Poll, Roxanna, Marinier, Sylvie, Nighoghossian, Norbert, Riva, Roberto, Eker, Omer, Turjman, Francis, Derex, Laurent, Cho, Tae-Hee, Mechtouff, Laura, Lukaszewicz, Anne Claire, Philippeau, Frédéric, Cakmak, Serkan, Blanc-Lasserre, Karine, Vallet, Anne-Evelyne, Marnat, Gaultier, Gariel, Florent, Barreau, Xavier, Berge, Jérôme, Menegon, Patrice, Sibon, Igor, Lucas, Ludovic, Olindo, Stéphane, Renou, Pauline, Sagnier, Sharmila, Poli, Mathilde, Debruxelles, Sabrina, Rouanet, François, Tourdias, Thomas, Liegey, Jean-Sebastien, Briau, Pierre, Pangon, Nicolas, Bourcier, Romain, Detraz, Lili, Daumas-Duport, Benjamin, Alexandre, Pierre-Louis, Roy, Monica, Lenoble, Cédric, Desal, Hubert, Guillon, Benoît, de Gaalon, Solène, Preterre, Cécile, Gory, Benjamin, Bracard, Serge, Anxionnat, René, Braun, Marc, Derelle, Anne-Laure, Tonnelet, Romain, Liao, Liang, Zhu, François, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Humbertjean, Lisa, Mione, Gioia, Lacour, Jean-Christophe, Riou-Comte, Nolwenn, Audibert, Gérard, Voicu, Marcela, Alb, Ionel, Reitter, Marie, Brezeanu, Madalina, Masson, Agnès, Tabarna, Adriana, Podar, Iona, Macian-montoro, Francisco, Saleme, Suzanna, Mounayer, Charbel, Rouchaud, Aymeric, Costalat, Vincent, Arquizan, Caroline, Dargazanli, Cyril, Gascou, Grégory, Lefèvre, Pierre-Henri, Derraz, Imad, Riquelme, Carlos, Gaillard, Nicolas, Mourand, Isabelle, Corti, Lucas, Cagnazzo, Federico, ter Schiphorst, Adrien, Francois, Eugene, Vannier, Stéphane, Ferre, Jean-christophe, Raoult, Helene, Ronziere, Thomas, Lassale, Maria, Paya, Christophe, Gauvrit, Jean-Yves, Tracol, Clément, Langnier-Lemercier, Sophie, Samson, Yves, Rosso, Charlotte, Leger, Anne, Deltour, Sandrine, Clarencon, Frederic, Shotar, Eimad, Spelle, Laurent, Denier, Christian, Chassin, Olivier, Chalumeau, Vanessa, Caroff, Jildaz, Chassin, Olivier, Venditti, Laura, Naggara, Olivier, Hassen, Wagih Ben, Boulouis, Grégoire, Rodriguez-Régent, Christine, Trystram, Denis, Kerleroux, Basile, Turc, Guillaume, Domigo, Valérie, Lamy, Catherine, Birchenall, Julia, Isabel, Clothilde, Lun, François, Viguier, Alain, Cognard, Christophe, Januel, Anne Christine, Olivot, Jean-Marc, Raposo, Nicolas, Bonneville, Fabrice, Albucher, Jean François, Calviere, Lionel, Darcourt, Jean, Tall, Philippe, Bellanger, Guillaume, Fontaine, Louis, Touze, Emmanuel, Barbier, Charlotte, Schneckenburger, Romain, Boulanger, Marion, Cogez, Julien, Guettier, Sophie, Timsit, Serge, Gentric, Jean-christophe, Ognard, Julien, Merrien, Francois Mathias, Wermester, Ozlem Ozkul, Massardier, Evelyne, Papagiannaki, Chrysanthi, Bourdain, Frédéric, Bernady, Patricia, Lagoarde-Segot, Laurent, Cailliez, Hélène, Veunac, Louis, Higue, David, Wolff, Valérie, Pop, Raoul, Beaujeux, Rémi, Dan-Sorin, Mihoc, Manisor, Monica, Le Bras, Anthony, Evain, Sarah, Le Guen, Arnaud, Richter, Sebastian, Hubrecht, Regis, Demasles, Stéphanie, Barroso, Bruno, Sablot, Denis, Farouil, Geoffroy, Tardieu, Maxime, Smadja, Philippe, Aptel, Sabine, and Seiler, Ian

Abstract

Patients with pre-stroke disability, defined as a modified Rankin Scale (mRS) ≥3, were excluded from most trials of endovascular thrombectomy (EVT) for acute stroke. We sought to evaluate the prognostic factors associated with favorable outcome in stroke patients with known disability undergoing EVT, and the impact of successful reperfusion.

Published
2023
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22. Influence of prior intravenous thrombolysis in patients treated with mechanical thrombectomy for M2 occlusions: insight from the Endovascular Treatment in Ischemic Stroke (ETIS) registry

Author

Le Floch, Agathe, Clarencon, Frédéric, Rouchaud, Aymeric, Kyheng, Maeva, Labreuche, Julien, Sibon, Igor, Boulouis, Gregoire, Gory, Benjamin, Richard, Sébastien, Caroff, Jildaz, Blanc, Raphae¨l, Seners, Pierre, Eker, Omer F, Cho, Tae-Hee, Consoli, Arturo, Bourcier, Romain, guillon, benoit, Dargazanli, Cyril, Arquizan, Caroline, Denier, Christian, Eugene, Francois, Vannier, Stephane, Gentric, Jean-Christophe, Gauberti, Maxime, Naggara, Olivier, Rosso, Charlotte, Turc, Guillaume, Ozkul-Wermester, Ozlem, Cognard, Christophe, Albucher, Jean Francois, Timsit, Serge, Bourdain, Frederic, Le Bras, Anthony, Richter, Sebastian, Moulin, Solène, Pop, Raoul, Heck, Olivier, Moreno, Ricardo, L'Allinec, Vincent, Lapergue, Bertrand, and Marnat, Gaultier

Abstract

BackgroundIntravenous thrombolysis (IVT) for patients treated with mechanical thrombectomy (MT) for proximal occlusions has recently been questioned through randomized trials. However, few patients with M2 occlusions were included. We investigated the influence of prior IVT for patients presenting M2 occlusions treated with MT in comparison with MT alone.MethodsWe conducted a retrospective analysis of the Endovascular Treatment in Ischemic Stroke (ETIS) registry, a multicenter observational study. Data from consecutive patients treated with MT for M2 occlusions between January 2015 and January 2022 at 26 comprehensive stroke centers were analyzed. The primary endpoint was 90-day modified Rankin Scale score of 0–2. Outcomes were compared using propensity score approaches. We also performed sensitivity analysis in relevant subgroups of patients.ResultsAmong 1132 patients with M2 occlusions treated with MT, 570 received prior IVT. The two groups were comparable after propensity analysis. The rate of favorable functional outcome was significantly higher in the IVT+MT group compared with the MT alone group (59.8% vs 44.7%; adjusted OR 1.38, 95% CI 1.10 to 1.75, P=0.008). Hemorrhagic and procedural complications were similar in both groups. In sensitivity analysis excluding patients with anticoagulation treatment, favorable recanalization was more frequent in the IVT+MT group (OR 1.37, 95% CI 1.11 to 1.70, P=0.004).ConclusionsIn cases of M2 occlusions, prior IVT combined with MT resulted in better functional outcome than MT alone, without increasing the rate of hemorrhagic or procedural complications. These results suggest the benefit of IVT in patients undergoing MT for M2 occlusions.

Published
2023
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23. Thrombectomy in basilar artery occlusions: impact of number of passes and futile reperfusion

Author

de Havenon, Adam, Elhorany, Mahmoud, Boulouis, Gregoire, Naggara, Olivier, Darcourt, Jean, Clarencon, Frédéric, Richard, Sébastien, Marnat, Gaultier, Bourcier, Romain, Sibon, Igor, Arquizan, Caroline, Dargazanli, Cyril, Mai¨er, Benjamin, Seners, Pierre, Lapergue, Bertrand, Consoli, Arturo, Eugene, Francois, Vannier, Stephane, Caroff, Jildaz, Denier, Christian, Boulanger, Marion, Gauberti, Maxime, Rouchaud, Aymeric, Macian, Francisco, Rosso, Charlotte, Turc, Guillaume, Ozkul-Wermester, Ozlem, Papagiannaki, Chrisanthi, Albucher, Jean Francois, Le Bras, Anthony, Evain, Sarah, Wolff, Valerie, Pop, Raoul, Timsit, Serge, Gentric, Jean-Christophe, Bourdain, Frédéric, Veunac, Louis, Fahed, Robert, Finitsis, Stephanos Nikolaos, and Gory, Benjamin

Abstract

BackgroundThe number of mechanical thrombectomy (MT) passes is strongly associated with angiographic reperfusion as well as clinical outcomes in patients with anterior circulation ischemic stroke. However, these associations have not been analyzed in patients with basilar artery occlusion (BAO). We investigated the influence of the number of MT passes on the degree of reperfusion and clinical outcomes, and compared outcome after ≤3 passes versus >3 passes.MethodsWe used data from the prospective multicentric Endovascular Treatment in Ischemic Stroke (ETIS) Registry at 18 sites in France. Patients with BAO treated with MT were included. The primary outcome was a favorable outcome, defined as a modified Rankin Scale score of 0–3 at 90 days. We fit mixed multiple regression models, with center as a random effect.ResultsWe included 275 patients. Successful recanalization (modified Thrombolysis In Cerebral Infarction (mTICI) 2b-3) was achieved in 88.4%, and 41.8% had a favorable outcome. The odds ratio for favorable outcome with each pass above 1 was 0.41 (95% CI 0.23 to 0.73) and for recanalization (mTICI 2b-3) it was 0.70 (95% CI 0.57 to 0.87). In patients with ≤3 passes, the rate of favorable outcome in recanalized versus non-recanalized patients was 50.5% versus 10.0% (p=0.001), while in those with >3 passes it was 16.7% versus 15.2% (p=0.901).ConclusionsWe found that BAO patients had a significant relationship between the number of MT passes and both recanalization and favorable functional outcome. We further found that the benefit of recanalization in BAO patients was significant only when recanalization was achieved within three passes, encouraging at least three passes before stopping the procedure.

Published
2023
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24. Should Patients With Acute Minor Ischemic Stroke With Isolated Internal Carotid Artery Occlusion Be Thrombolysed?

Author

Boulenoir, Naouel, Turc, Guillaume, Ter Schiphorst, Adrien, Heldner, Mirjam R., Strambo, Davide, Laksiri, Nadia, Girard Buttaz, Isabelle, Papassin, Jérémie, Sibon, Igor, Chausson, Nicolas, Michel, Patrik, Rosso, Charlotte, Bourdain, Frédéric, Lamy, Chantal, Weisenburger-Lile, David, Agius, Pierre, Yger, Marion, Obadia, Michael, Sablot, Denis, Legris, Nicolas, Jung, Simon, Pilgram-Pastor, Sara, Henon, Hilde, Bernardaud, Lucy, Arquizan, Caroline, Baron, Jean-Claude, Seners, Pierre, Ben Hassen, Wagih, Lapergue, Bertrand, Lucas, Ludovic, Leys, Didier, Philippeau, Frédéric, Bennani, Omar, Mechtouff, Laura, Klapczynski, Frédéric, Detante, Olivier, Costalat, Vincent, Mione, Gioia, Gazzola, Sébastien, Debiais, Séverine, Cakmak, Serkan, Grigoras, Valer, Denier, Christian, Smadja, Didier, Mounier-Vehier, François, Peres, Roxane, Spelle, Laurent, Bricout, Nicolas, Bracard, Serge, Triquenot, Aude, Lyoubi, Aïcha, Cottier, Jean-Philippe, Duong, Duc-Long, and Ollivier, Camille

Published
2022
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25. Perfusion Imaging and Clinical Outcome in Acute Minor Stroke With Large Vessel Occlusion

Author

Seners, Pierre, Arquizan, Caroline, Fontaine, Louis, Ben Hassen, Wagih, Heldner, Mirjam R., Strambo, Davide, Nagel, Simon, Carrera, Emmanuel, Mechtouff, Laura, McCullough-Hicks, Margy, Mohammaden, Mahmoud H., Cottier, Jean-Philippe, Henon, Hilde, Aignatoaie, Andreea, Laksiri, Nadia, Papassin, Jérémie, Lucas, Ludovic, Garnier, Pierre, Triquenot, Aude, Mione, Gioia, Hajdu, Steven, Costalat, Vincent, Potreck, Arne, Detante, Olivier, Bonneville, Fabrice, Berthezene, Yves, Bracard, Serge, Sibon, Igor, Bricout, Nicolas, Boutet, Claire, Mordasini, Pasquale, Michel, Patrik, Oppenheim, Catherine, Olivot, Jean-Marc, Nogueira, Raul G., Albers, Gregory W., Baron, Jean-Claude, Turc, Guillaume, Cognard, Christophe, Marnat, Gaultier, Menegon, Patrice, Ledure, Sylvain, Dargazanli, Cyril, Cho, Tae-Hee, Nighoghossian, Norbert, Eker, Omer, Gouttard, Sylvain, Haussen, Diogo, Debiais, Séverine, Charron, Vladimir, Charron, Nicolas, Leys, Didier, Ozsancak, Canan, Delpech, Mathilde, Brunel, Hervé, Papagiannaki, Chrysanti, Girardin, Emmanuel, Richard, Sébastien, Gory, Benjamin, Zbinden, Martin, Dobrocky, Tomas, Ringelb, Peter, and Möhlenbruch, Markus

Published
2022
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26. Functional Outcome, Recanalization, and Hemorrhage Rates After Large Vessel Occlusion Stroke Treated With Tenecteplase Before Thrombectomy.

Author

Gerschenfeld, Gaspard, Smadja, Didier, Turc, Guillaume, Olindo, Stephane, Laborne, François-Xavier, Yger, Marion, Caroff, Jildaz, Gonçalves, Bruno, Seners, Pierre, Cantier, Marie, l'Hermitte, Yann, Aghasaryan, Manvel, Alecu, Cosmin, Marnat, Gaultier, Ben Hassen, Wagih, Kalsoum, Erwah, Clarençon, Frédéric, Piotin, Michel, Spelle, Laurent, and Denier, Christian

Published
2021
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27. Relevance of Brain Regions' Eloquence Assessment in Patients With a Large Ischemic Core Treated With Mechanical Thrombectomy.

Author

Kerleroux, Basile, Benzakoun, Joseph, Janot, Kévin, Dargazanli, Cyril, Eraya, Dimitri Daly, Ben Hassen, Wagih, Zhu, François, Gory, Benjamin, Hak, Jean-Francois, Perot, Charline, Detraz, Lili, Bourcier, Romain, Aymeric, Rouchaud, Forestier, Géraud, Marnat, Gaultier, Gariel, Florent, Mordasini, Pasquale, Seners, Pierre, Turc, Guillaume, and Kaesmacher, Johannes

Published
2021
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28. Impact of COVID‐19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID‐19 patients with acute ischemic stroke

Author

Desilles, Jean‐Philippe, Solo Nomenjanahary, Mialitiana, Consoli, Arturo, Ollivier, Véronique, Faille, Dorothée, Bourrienne, Marie‐Charlotte, Hamdani, Mylène, Dupont, Sébastien, Di Meglio, Lucas, Escalard, Simon, Maier, Benjamin, Blanc, Raphael, Piotin, Michel, Lapergue, Bertrand, Ajzenberg, Nadine, Vasse, Marc, Mazighi, Mikael, Ho‐Tin‐Noé, Benoît, Désilles, Jean‐Philippe, Mazighi, Mikael, Piotin, Michel, Blanc, Raphael, Redjem, Hocine, Smajda, Stanislas, Seners, Pierre, Escalard, Simon, Delvoye, Francois, Maier, Benjamin, Hebert, Solene, Ben Maacha, Malek, Hamdani, Mylene, Sabben, Candice, Obadia, Michael, Deschildre, Catherine, Lapergue, Bertrand, Consoli, Arturo, Rodesch, Georges, Maria, Federico, Coskun, Okuzan, Lopez, Delphine, Bourcier, Romain, Detraz, Lili, Desal, Hubert, Roy, Monica, Clavier, Delphine, Marnat, Gaultier, Gariel, Florent, Lucas, Ludovic, Sibon, Igor, Eugene, Francois, Vannier, Stéphane, Ferre, Jean‐Christophe, LeBras, Anthony, Raoult, Hélène, Paya, Christophe, Gauvrit, Jean‐Yves, Richard, Sébastien, Gory, Benjamin, Barbier, Charlotte, Vivien, Denis, Touze, Emmanuel, Gauberti, Maxime, Blaizot, Gaetane, Ifergan, Héloïse, Herbreteau, Denis, Bibi, Richard, Janot, Kevin, Charron, Vladimir, and Boulouis, Grégoire

Abstract

Resistance to fibrinolysis, levels of procoagulant/antifibrinolytic neutrophil extracellular traps (NETs), and the severity of acute ischemic stroke (AIS) are increased by COVID‐19. Whether NETs are components of AIS thrombi from COVID‐19 patients and whether COVID‐19 impacts the susceptibility of these thrombi to thrombolytic treatments remain unknown, however.

Published
2022
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29. Influence de la thrombolyse intraveineuse chez les patients traites par thrombectomie mecanique pour une occlusion M2: une analyse du registre etis

Author

Floch, Agathe Le, Clarencon, Frederic, Rouchaud, Aymeric, Khyeng, Maeva, Labreuche, Julien, Sibon, Igor, Boulouis, Gregoire, Gory, Benjamin, Richard, Sebastien, Caroff, Jildaz, Blanc, Raphael, Seners, Pierre, Eker, Omer, Cho, Tae-Hee, Consoli, Arturo, Bourcier, Romain, Guillon, Benoit, Dargazanli, Cyril, Arquizan, Caroline, Denier, Christian, Eugene, Francois, Vannier, Stephanie, Gentric, Jean-Christophe, Gauberti, Maxime, Nagarra, Olivier, Rosso, Charlotte, Turc, Guillaume, Ozkul-Wermester, Ozlem, Cognard, Christophe, Albucher, Jean-Francois, Timsit, Serge, Bourdain, Frederic, Bras, Anthony Le, Richter, Sebastian, Moulin, Solene, Pop, Raoul, Heck, Olivier, Moreno, Ricardo, L'Allinec, Vincent, Lapergue, Bertrand, and Marnat, Gaultier

Abstract

– Le bénéfice de la thrombolyse intraveineuse (TIV) préalable chez les patients traités par thrombectomie mécanique (TM) pour une occlusion d'un gros vaisseau a récemment été remise en question par plusieurs essais randomisés. Ces études incluaient cependant peu de patients avec des occlusions M2. Nous avons étudié l'influence de la TIV préalable chez les patients traités pas TM pour une occlusion M2, comparativement à la TM seule.

Published
2023
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30. Functional Outcome, Recanalization, and Hemorrhage Rates After Large Vessel Occlusion Stroke Treated With Tenecteplase Before Thrombectomy

Author

Gerschenfeld, Gaspard, Smadja, Didier, Turc, Guillaume, Olindo, Stephane, Laborne, François-Xavier, Yger, Marion, Caroff, Jildaz, Gonçalves, Bruno, Seners, Pierre, Cantier, Marie, l'Hermitte, Yann, Aghasaryan, Manvel, Alecu, Cosmin, Marnat, Gaultier, Ben Hassen, Wagih, Kalsoum, Erwah, Clarençon, Frédéric, Piotin, Michel, Spelle, Laurent, Denier, Christian, Sibon, Igor, Alamowitch, Sonia, Chausson, Nicolas, Degos, Vincent, Sarov, Mariana, Legris, Nicolas, Chassin, Olivier, Soumah, Djibril, Altarcha, Tony, Imbernon, Carole, Renou, Pauline, Poli, Mathilde, Debruxelles, Sabrina, Sagnier, Sharmila, Rouanet, François, Liegey, Jean-Sebastien, Calvet, David, Baron, Jean-Claude, Bottin, Laure, Delorme, Stephen, Capron, Jean, Doukhi, Diana, Ghazanfari, Sam, Weisenburger, David, Lescieux, Edwige, Gariel, Florent, Barreau, Xavier, Menegon, Patrice, Tourdias, Thomas, Oppenheim, Catherine, Naggara, Olivier, Tuilier, Titien, Sourour, Nader, Sourour, Nader, Shotar, Eimad, Lenck, Stéphanie, Premat, Kévin, Blanc, Raphaël, Escalard, Simon, Fahed, Robert, Smajda, Stanislas, and Mazighi, Mikael

Published
2021
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31. Relevance of Brain Regions' Eloquence Assessment in Patients With a Large Ischemic Core Treated With Mechanical Thrombectomy

Author

Kerleroux, Basile, Benzakoun, Joseph, Janot, Kévin, Dargazanli, Cyril, Eraya, Dimitri Daly, Ben Hassen, Wagih, Zhu, François, Gory, Benjamin, Hak, Jean-Francois, Perot, Charline, Detraz, Lili, Bourcier, Romain, Aymeric, Rouchaud, Forestier, Géraud, Marnat, Gaultier, Gariel, Florent, Mordasini, Pasquale, Seners, Pierre, Turc, Guillaume, Kaesmacher, Johannes, Oppenheim, Catherine, Naggara, Olivier, Boulouis, Gregoire, Fischer, Urs, Gralla, Jan, Mosimann, Pascal J, Arnold, Marcel, Meinel, Thomas R, Costalat, Vincent, Benali, Amel, Derraz, Imad, Lefevre, Pierre-Henri, Gascou, Grégory, Riquelme, Carlos, Bonafe, Alain, Le Bars, Emmanuelle, Moynier, Marinette, Barreau, Xavier, Berge, Jérôme, Menegon, Patrice, Tourdias, Thomas, Lucas, Ludovic, Sibon, Igor, Saleme, Suzanna, Mounayer, Charbel, Girard, Nadine, Bartoli, Jean-Michel, Brunel, Hervé, Testud, Benoit, Puech, Basile, Laksiri, Nadia, Robinet, Emmanuelle, Pelletier, Jean, Herbreteau, Denis, Bibi, Richard, Narata, Ana-Paula, Boustia, Fakhreddine, Maldonado, Igor, Cottier, Jean- Philippe, Gaudron, Marie, Annan, Mariam, Meder, Jean-François, Trystram, Denis, Rodriguez, Christine, Edjlali, Myriam, Desal, Hubert, Daumasduport, Benjamin, Lallinec, Vincent, Lenoble, Cédric, Alexandre, Pierre-Louis, Bracard, Serge, Anxionnat, René, Degrelle, Anne-Laure, Tonnelet, Romain, Lao, Liang, Richard, Sébastien, Humbertjean, Lisa, Mione, Gioia, and Labour, Jean Christophe

Published
2021
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35. Prediction of Early Neurological Deterioration in Individuals With Minor Stroke and Large Vessel Occlusion Intended for Intravenous Thrombolysis Alone

Author

Seners, Pierre, Ben Hassen, Wagih, Lapergue, Bertrand, Arquizan, Caroline, Heldner, Mirjam R., Henon, Hilde, Perrin, Claire, Strambo, Davide, Cottier, Jean-Philippe, Sablot, Denis, Girard Buttaz, Isabelle, Tamazyan, Ruben, Preterre, Cécile, Agius, Pierre, Laksiri, Nadia, Mechtouff, Laura, Béjot, Yannick, Duong, Duc-Long, Mounier-Vehier, François, Mione, Gioia, Rosso, Charlotte, Lucas, Ludovic, Papassin, Jérémie, Aignatoaie, Andreea, Triquenot, Aude, Carrera, Emmanuel, Niclot, Philippe, Obadia, Alexandre, Lyoubi, Aïcha, Garnier, Pierre, Crainic, Nicolae, Wolff, Valérie, Tracol, Clément, Philippeau, Frédéric, Lamy, Chantal, Soize, Sébastien, Baron, Jean-Claude, and Turc, Guillaume

Abstract

IMPORTANCE: The best reperfusion strategy in patients with acute minor stroke and large vessel occlusion (LVO) is unknown. Accurately predicting early neurological deterioration of presumed ischemic origin (ENDi) following intravenous thrombolysis (IVT) in this population may help to select candidates for immediate transfer for additional thrombectomy. OBJECTIVE: To develop and validate an easily applicable predictive score of ENDi following IVT in patients with minor stroke and LVO. DESIGN, SETTING, AND PARTICIPANTS: This multicentric retrospective cohort included 729 consecutive patients with minor stroke (National Institutes of Health Stroke Scale [NIHSS] score of 5 or less) and LVO (basilar artery, internal carotid artery, first [M1] or second [M2] segment of middle cerebral artery) intended for IVT alone in 45 French stroke centers, ie, including those who eventually received rescue thrombectomy because of ENDi. For external validation, another cohort of 347 patients with similar inclusion criteria was collected from 9 additional centers. Data were collected from January 2018 to September 2019. MAIN OUTCOMES AND MEASURES: ENDi, defined as 4 or more points’ deterioration on NIHSS score within the first 24 hours without parenchymal hemorrhage on follow-up imaging or another identified cause. RESULTS: Of the 729 patients in the derivation cohort, 335 (46.0%) were male, and the mean (SD) age was 70 (15) years; of the 347 patients in the validation cohort, 190 (54.8%) were male, and the mean (SD) age was 69 (15) years. In the derivation cohort, the median (interquartile range) NIHSS score was 3 (1-4), and the occlusion site was the internal carotid artery in 97 patients (13.3%), M1 in 207 (28.4%), M2 in 395 (54.2%), and basilar artery in 30 (4.1%). ENDi occurred in 88 patients (12.1%; 95% CI, 9.7-14.4) and was strongly associated with poorer 3-month outcomes, even in patients who underwent rescue thrombectomy. In multivariable analysis, a more proximal occlusion site and a longer thrombus were independently associated with ENDi. A 4-point score derived from these variables—1 point for thrombus length and 3 points for occlusion site—showed good discriminative power for ENDi (C statistic = 0.76; 95% CI, 0.70-0.82) and was successfully validated in the validation cohort (ENDi rate, 11.0% [38 of 347]; C statistic = 0.78; 95% CI, 0.70-0.86). In both cohorts, ENDi probability was approximately 3%, 7%, 20%, and 35% for scores of 0, 1, 2 and 3 to 4, respectively. CONCLUSIONS AND RELEVANCE: The substantial ENDi rates observed in these cohorts highlights the current debate regarding whether to directly transfer patients with IVT-treated minor stroke and LVO for additional thrombectomy. Based on the strong associations observed, an easily applicable score for ENDi risk prediction that may assist decision-making was derived and externally validated.

Published
2021
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36. MT-DRAGON score for outcome prediction in acute ischemic stroke treated by mechanical thrombectomy within 8 hours

Author

Ben Hassen, Wagih, Raynaud, Nicolas, Bricout, Nicolas, Boulouis, Gregoire, Legrand, Laurence, Ferrigno, Marc, Kazemi, Apolline, Bretzner, Martin, Soize, Sebastien, Farhat, Wassim, Seners, Pierre, Turc, Guillaume, Zuber, Mathieu, Oppenheim, Catherine, Cordonnier, Charlotte, Naggara, Olivier, and Henon, Hilde

Abstract

ObjectivesThe MRI-DRAGON score includes clinical and MRI parameters and demonstrates a high specificity in predicting 3 month outcome in patients with acute ischemic stroke (AIS) treated with intravenous tissue plasminogen activator (IV tPA). The aim of this study was to adapt this score to mechanical thrombectomy (MT) in a large multicenter cohort.MethodsConsecutive cases of AIS treated by MT between January 2015 and December 2017 from three stroke centers were reviewed (n=1077). We derived the MT-DRAGON score by keeping all variables of the MRI-DRAGON score (age, initial National Institutes of Health Stroke Scale score, glucose level, pre-stroke modified Rankin Scale (mRS) score, diffusion weighted imaging-Alberta Stroke Program Early CT score ≤5) and considering the following variables: time to groin puncture instead of onset to IV tPA time and occlusion site. Unfavorable 3 month outcome was defined as a mRS score >2. Score performance was evaluated by c statistics and an external validation was performed.ResultsAmong 679 included patients (derivation and validation cohorts, n=431 and 248, respectively), an unfavorable outcome was similar between the derivation (51.5%) and validation (58.1%, P=0.7) cohorts, and was significantly associated with all MT-DRAGON parameters in the multivariable analysis. The c statistics for unfavorable outcome prediction was 0.83 (95%CI 0.79 to 0.88) in the derivation and 0.8 (95%CI 0.75 to 0.86) in the validation cohort. All patients (n=55) with an MT-DRAGONscore ≥11 had an unfavorable outcome and 60/63 (95%) patients with an MT-DRAGON score ≤2 points had a favorable outcome.ConclusionThe MT-DRAGON score is a simple tool, combining admission clinical and radiological parameters that can reliably predict 3 month outcome after MT.

Published
2020
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37. White matter hyperintensity burden in patients with ischemic stroke treated with thrombectomy.

Author

Boulouis, Grégoire, Bricout, Nicolas, Benhassen, Wagih, Ferrigno, Marc, Turc, Guillaume, Bretzner, Martin, Benzakoun, Joseph, Seners, Pierre, Personnic, Thomas, Legrand, Laurence, Trystram, Denis, Rodriguez-Regent, Christine, Charidimou, Andreas, Rost, Natalia S., Bracard, Serge, Cordonnier, Charlotte, Oppenheim, Catherine, Naggara, Olivier, and Henon, Hilde

Published
2019
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38. Better Collaterals Are Independently Associated With Post-Thrombolysis Recanalization Before Thrombectomy.

Author

Seners, Pierre, Roca, Pauline, Legrand, Laurence, Turc, Guillaume, Cottier, Jean-Philippe, Cho, Tae-Hee, Arquizan, Caroline, Bracard, Serge, Ozsancak, Canan, Ben Hassen, Wagih, Naggara, Olivier, Lion, Stéphanie, Debiais, Séverine, Berthezene, Yves, Costalat, Vincent, Richard, Sébastien, Magni, Christophe, Mas, Jean-Louis, Baron, Jean-Claude, and Oppenheim, Catherine

Published
2019
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39. Thrombus Length Predicts Lack of Post-Thrombolysis Early Recanalization in Minor Stroke With Large Vessel Occlusion.

Author

Seners, Pierre, Delepierre, Julie, Turc, Guillaume, Henon, Hilde, Piotin, Michel, Arquizan, Caroline, Cho, Tae-Hee, Lapergue, Bertrand, Cottier, Jean-Philippe, Richard, Sébastien, Legrand, Laurence, Bricout, Nicolas, Mazighi, Mikaël, Dargazanli, Cyril, Nighoghossian, Norbert, Consoli, Arturo, Debiais, Séverine, Bracard, Serge, Naggara, Olivier, and Leclerc, Xavier

Published
2019
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40. Perfusion imaging for delayed cerebral ischemia detection in patients following ruptured aneurysmal subarachnoid hemorrhage: Interrater reliability assessment

Author

Bombardieri, Anna Maria, Wouters, Anke, Seners, Pierre, Zamarud, Aroosa, Mlynash, Michael, Yuen, Nicole, Albers, Greg W, Sussman, Eric S, Pulli, Benjamin, Lansberg, Maarten G, Steinberg, Gary K, and Heit, Jeremy J

Abstract

Background Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) is associated with adverse neurological outcomes. Early and accurate diagnosis of DCI is crucial to prevent cerebral infarction. This study aimed to assess the diagnostic accuracy and interrater agreement of the visual assessment of neuroimaging perfusion maps to detect DCI in patients suspected of vasospasm after aSAH.Methods In this case-control study, cases were adult aSAH patients with DCI who underwent magnetic resonance perfusion or computed tomography perfusion (CTP) imaging in the 24 h prior to digital subtraction angiography for vasospasm diagnosis. Controls were patients with dizziness and no aSAH on CTP imaging. Three independent raters, blinded to patients’ clinical information, other neuroimaging studies, and angiographic results, visually assessed anonymized perfusion color maps to classify patients as either having DCI or not. Tmax delay was classified by symmetry into no delay, unilateral, or bilateral.Results Perfusion imaging of 54 patients with aSAH and 119 control patients without aSAH was assessed. Sensitivities for DCI diagnosis ranged from 0.65 to 0.78, and specificities ranged from 0.70 to 0.87, with interrater agreement ranging from 0.60 (moderate) to 0.68 (substantial).Conclusion Visual assessment of perfusion color maps demonstrated moderate to substantial accuracy in diagnosing DCI in aSAH patients.

Published
2024
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41. Incidence and predictors of intracranial hemorrhage after intravenous thrombolysis with tenecteplase

Author

Marnat, Gaultier, Gerschenfeld, Gaspard, Olindo, Stephane, Sibon, Igor, Seners, Pierre, Clarençon, Frederic, Smadja, Didier, Chausson, Nicolas, Ben Hassen, Wagih, Piotin, Michel, Caroff, Jildaz, Alamowitch, Sonia, and Turc, Guillaume

Abstract

Background: Despite its increasing use, there are limited data on the risk of intracranial hemorrhage (ICH) after intravenous thrombolysis with tenecteplase in the setting of acute ischemic stroke. Our aim was to investigate the incidence and predictors of ICH after tenecteplase administration.Methods: We reviewed data from the prospective ongoing multicenter TETRIS (Tenecteplase Treatment in Ischemic Stroke) registry. Patients with available day-1 imaging were included in this study. Clinical, imaging and biological variables were collected. Follow-up imaging performed 24 h after IVT was locally reviewed by senior neuroradiologists and neurologists. The incidence of parenchymal hematoma (PH) and any ICH were investigated. Potential predictors of PH and any ICH were assessed in multivariable logistic regressions. Subgroup analyses focusing on patients intended for endovascular treatment were performed.Results: PH and any ICH occurred in 126/1321 (incidence rate: 9.5%, 95% CI 8.1–11.2) and 521/1321 (39.4%, 95% CI 36.8–42.1) patients, respectively. Symptomatic ICH was observed in 77/1321 (5.8%; 95% CI 4.7–7.2). PH occurrence was significantly associated with poorer functional outcomes (p< 0.0001) and death (p< 0.0001) after 3 months. Older age (aOR = 1.03; 95% CI 1.01–1.05), male gender (aOR = 2.07; 95% CI 1.28–3.36), a history of hypertension (aOR = 2.08; 95% CI 1.19–3.62), a higher baseline NIHSS (aOR = 1.07; 95% CI 1.03–1.10) and higher admission blood glucose level (aOR = 1.12; 95% CI 1.05–1.19) were independently associated with PH occurrence. Similar associations were observed in the subgroup of patients intended for endovascular treatment.Conclusion: We quantified the incidence of ICH after IVT with tenecteplase in a real-life prospective registry and determined independent predictors of ICH. These findings allow to identify patients at high risk of ICH.

Published
2024
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42. Larger ischemic cores and poor collaterals among large vessel occlusions presenting in the late evening.

Author

Sreekrishnan, Anirudh, Tiedt, Steffen, Seners, Pierre, Yuen, Nicole, Olivot, Jean-Marc, Mlynash, Michael, Lansberg, Maarten G., Heit, Jeremy J., Lee, Sarah, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Paredes, José Bernardo Escribano, Carrera, Emmanuel, and Albers, Gregory W.

Abstract

Components critical to cerebral perfusion have been noted to oscillate over a 24-h cycle. We previously reported that ischemic core volume has a diurnal relationship with stroke onset time when examined as dichotomized epochs (i.e. Day, Evening, Night) in a cohort of over 1,500 large vessel occlusion (LVO) patients. In this follow-up analysis, our goal was to explore if there is a sinusoidal relationship between ischemic core, collateral status (as measured by HIR), and stroke onset time. We retrospectively examined collection of LVO patients with baseline perfusion imaging performed within 24 h of stroke onset from four international comprehensive stroke centers. Both ischemic core volume and HIR, were utilized as the primary radiographic parameters. To evaluate for differences in these parameters over a continuous 24-h cycle, we conducted a sinusoidal regression analysis after linearly regressing out the confounders age and time to imaging. A total of 1506 LVO cases were included, with a median ischemic core volume of 13.0 cc (IQR: 0.0-42.0) and median HIR of 0.4 (IQR: 0.2-0.6). Ischemic core volume varied by stroke onset time in the unadjusted (p = 0.001) and adjusted (p = 0.003) sinusoidal regression analysis with a peak in core volume around 7:45PM. HIR similarly varied by stroke onset time in the unadjusted (p = 0.004) and adjusted (p = 0.002) models with a peak in HIR values at around 8:18PM. The results suggest that critical factors to the development of the ischemic core vary by stroke onset time and peak around 8PM. When placed in the context of prior studies, strongly suggest a diurnal component to the development of the ischemic core. [ABSTRACT FROM AUTHOR]

Published
2023
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43. Post-Thrombolysis Recanalization in Stroke Referrals for Thrombectomy: Incidence, Predictors, and Prediction Scores.

Author

Seners, Pierre, Turc, Guillaume, Naggara, Olivier, Henon, Hilde, Piotin, Michel, Arquizan, Caroline, Cho, Tae-Hee, Narata, Ana-Paula, Lapergue, Bertrand, Richard, Sébastien, Legrand, Laurence, Bricout, Nicolas, Blanc, Raphaël, Dargazanli, Cyril, Gory, Benjamin, Debiais, Séverine, Tisserand, Marie, Bracard, Serge, Leclerc, Xavier, and Obadia, Michael

Published
2018
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44. Thrombus Length Predicts Lack of Post-Thrombolysis Early Recanalization in Minor Stroke With Large Vessel Occlusion

Author

Seners, Pierre, Delepierre, Julie, Turc, Guillaume, Henon, Hilde, Piotin, Michel, Arquizan, Caroline, Cho, Tae-Hee, Lapergue, Bertrand, Cottier, Jean-Philippe, Richard, Sébastien, Legrand, Laurence, Bricout, Nicolas, Mazighi, Mikaël, Dargazanli, Cyril, Nighoghossian, Norbert, Consoli, Arturo, Debiais, Séverine, Bracard, Serge, Naggara, Olivier, Leclerc, Xavier, Obadia, Michael, Costalat, Vincent, Berthezène, Yves, Tisserand, Marie, Narata, Ana-Paula, Gory, Benjamin, Mas, Jean-Louis, Oppenheim, Catherine, and Baron, Jean-Claude

Abstract

Supplemental Digital Content is available in the text.

Published
2019
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45. Elevated Hypoperfusion Intensity Ratio (HIR) observed in patients with a large vessel occlusion (LVO) presenting in the evening.

Author

Sreekrishnan, Anirudh, Seners, Pierre, Yuen, Nicole, Olivot, Jean-Marc, Mlynash, Michael, Lansberg, Maarten G, Heit, Jeremy J, Lee, Sarah, Michel, Patrik, Strambo, Davide, Salerno, Alexander, Paredes, José Bernardo Escribano, Carrera, Emmanuel, and Albers, Gregory W

Abstract

Circadian variability has been implicated in timing of stroke onset, yet the full impact of underlying biological rhythms on acute stroke perfusion patterns is not known. We aimed to describe the relationship between time of stroke onset and perfusion profiles in patients with large vessel occlusion (LVO). A retrospective observational study was conducted using prospective registries of four stroke centers across North America and Europe with systematic use of perfusion imaging in clinical care. Included patients had stroke due to ICA, M1 or M2 occlusion and baseline perfusion imaging performed within 24h from last-seen-well (LSW). Stroke onset was divided into eight hour intervals: (1) Night: 23:00-6:59, (2) Day: 7:00-14:59, (3) Evening: 15:00-22:59. Core volume was estimated on CT perfusion (rCBF <30%) or DWI-MRI (ADC <620) and the collateral circulation was estimated with the Hypoperfusion Intensity Ratio (HIR = [Tmax>10s]/[Tmax>6s]). Non-parametric testing was conducted using SPSS to account for the non-normalized dependent variables. A total of 1506 cases were included (median age 74.9 years, IQR 63.0-84.0). Median NIHSS, core volumes, and HIR were 14.0 (IQR 8.0-20.0), 13.0mL (IQR 0.0-42.0), and 0.4 (IQR 0.2-0.6) respectively. Most strokes occurred during the Day (n = 666, 44.2%), compared to Night (n = 360, 23.9%), and Evening (n = 480, 31.9%). HIR was highest, indicating worse collaterals, in the Evening compared to the other timepoints (p = 0.006). Controlling for age and time to imaging, Evening strokes had significantly higher HIR compared to Day (p = 0.013). Our retrospective analysis suggests that HIR is significantly higher in the evening, indicating poorer collateral activation which may lead to larger core volumes in these patients. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Efficacy of Endovascular Therapy in Acute Ischemic Stroke Depends on Age and Clinical Severity

Author

Le Bouc, Raphaël, Clarençon, Frédéric, Meseguer, Elena, Lapergue, Bertrand, Consoli, Arturo, Turc, Guillaume, Naggara, Olivier, Duong, Duc Long, Servan, Jerome, Reiner, Peggy, Labeyrie, Marc Antoine, Fisselier, Mathieu, Blanc, Raphaël, Farhat, Wassim, Pires, Christine, Zuber, Mathieu, Obadia, Michael, Mazighi, Mikael, Pico, Fernando, Mas, Jean-Louis, Amarenco, Pierre, Samson, Yves, Rosso, Charlotte, Crozier, Sophie, Deltour, Sandrine, Leger, Anne, Baronnet, Flore, Frasca-Polara, Giulia, Diaz, Belen, Sourour, Nader, Di Maria, Frederico, Pistocchi, Silvia, Bartolini, Bruno, Hobeanu, Christina, Rigual, Ricardo, Guidoux, Céline, Cabrejo, Lucie, Lavallée, Philippa, Martin-Bechet, Anna, Sabben, Candice, Bourdain, Frédéric, Wang, Adrien, Evrard, Serge, Decroix, Jean-Pierre, Tchikviladze, Maya, Tisserand, Marie, Rodesch, Georges, Coskun, Oguzhan, Seners, Pierre, Isabel, Clothilde, Lamy, Catherine, Domigo, Valérie, Birchenall, Julia, Guiraud, Vincent, Bodiguel, Eric, Calvet, David, Trystram, Denis, Rodriguez-Régent, Christine, Ben Hassen, Wagih, Boulouis, Grégoire, Godon-Hardy, Sylvie, Méder, Jean-François, Oppenheim, Catherine, Zeghoudi, Anne-Cécile, Nifle, Chantal, Yeung, Jennifer, Stanciu, Daniela, Buch, Dan, Chadenat, Marie-Laure, Girbovan, Aandrei, Bayon, Laeticia, Troussiere, Anne-Cécile, Calinescu, Georgina, Rostomashvili, Sophio, SudaveschiVeronica, Maxime, Malherbe, de, Chabriat, Hugues, Jouvent, Eric, Herve, Dominique, Porcher, Frédérique, Bouquet-Castiglione, Floriane, Morvan, Typhaine, Lyoubi-Idrissi, Aïcha, Cognat, Emmanuel, Join Lambert, Claire, Tamazyan, Ruben, and Gerber, Sophie

Abstract

Supplemental Digital Content is available in the text.

Published
2018
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