100 results on '"Shu Peng"'
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2. EDA Complex-Enabled Annulation to Access CF2-Containing Tetralones and Quinazolinones Using Persulfates as Electron Donors
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Zhang, Shu-Peng, Guo, Da-Wei, Yang, Mei-Ling, Xia, Yun-Tao, and Yang, Wen-Chao
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A photocatalyst-free and EDA complex-enabled radical cascade cyclization reaction of inactive alkenes with bromodifluoroacetamides was reported for the divergent synthesis of fluorine-containing tetralones and quinazolinones. In this transformation, persulfates as electron donors and difluoro bromamide as electron acceptors generate the EDA complex. This is a promising photochemical method with advantages such as mild reaction conditions, simple operation, being metal-free, and excellent functional group tolerance.
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- 2024
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3. Cosmetically Approved Short-Chain Alcohol/Triethyl Citrate/Water Surfactant-Free Microemulsions and Potential Application to Transdermal Penetration of α‑Arbutin.
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Zhang, Zhiqin, Song, Qingle, Zhao, Zhen, Chang, Kuan, Shu, Peng, Wang, Jing, Yan, Hui, and Zhang, Yongmin
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- 2024
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4. Neuropilin-1-Targeted Nanomedicine for Spatiotemporal Tumor Suppression through Photodynamic Vascular Damage and Antiangiogenesis.
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Li, Xin-Yu, Yan, Ni, Wu, Ye-Yang, Kong, Ren-Jiang, Qiu, Zi-Wen, Liu, Shu-Peng, Wu, De-Hua, and Cheng, Hong
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- 2024
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5. Determination of Bovine Lactoferrin in Powdered Infant Formula and Adult Nutritionals by Heparin Affinity Extraction and Reverse-Phase High-Performance Liquid Chromatography/Ultraviolet Detection (HPLC/UV): Single-Laboratory Validation, First Action 2021.10
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Frueh, Jennifer L, Shu, Peng, Vennard, Thomas R, Gray, Michael A, and Phillips, Shay C
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- 2024
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6. Cosmetically Approved Short-Chain Alcohol/Triethyl Citrate/Water Surfactant-Free Microemulsions and Potential Application to Transdermal Penetration of α-Arbutin
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Zhang, Zhiqin, Song, Qingle, Zhao, Zhen, Chang, Kuan, Shu, Peng, Wang, Jing, Yan, Hui, and Zhang, Yongmin
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Surfactant-free microemulsions (SFMEs) exhibited remarkable advantages and potential, attributed to their similarity to traditional surfactant-based microemulsions and the absence of surfactants. Herein, a novel SFME was developed utilizing cosmetically approved materials, such as short-chain alcohol as an amphi-solvent, triethyl citrate (TEC) as the nonpolar phase, and water as the polar phase. 1,2-Pentanediol (PtDO)/TEC/water combination can form the largest monophasic zone, accounting for ∼74% of the total phase diagram area, due to an optimal hydrophilic (water)–lipophilic (TEC) balance. Comparable to surfactant-based microemulsion, PtDO/TEC/water SFME can also be categorized into three types: water-in-oil, discontinuous, and oil-in-water. As TEC or water is increased, or PtDO is decreased, the nanoaggregates in PtDO/TEC/water SFME grow from <5 nm to tens of nanometers. The addition of α-arbutin (ABN) does not disrupt PtDO/TEC/water SFME, but rather enhances its formation, resulting in a larger monophasic area and consistent size (2.8–3.8 nm) through participating in interface assembly. Furthermore, ABN-loaded PtDO/TEC/water SFME exhibits remarkable resistance to dilution, exceptional stability, and minimal irritation. Notably, PtDO/TEC/water SFME significantly boosts ABN’s solubility in water by 2 times, its percutaneous penetration rate by 3–4 times, and enables a slow-release DPPH•radical scavenging effect. This SFME serves as a safe and cosmetically suitable nanoplatform for the delivery of bioactive substances.
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- 2024
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7. Neuropilin-1-Targeted Nanomedicine for Spatiotemporal Tumor Suppression through Photodynamic Vascular Damage and Antiangiogenesis
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Li, Xin-Yu, Yan, Ni, Wu, Ye-Yang, Kong, Ren-Jiang, Qiu, Zi-Wen, Liu, Shu-Peng, Wu, De-Hua, and Cheng, Hong
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Antiangiogenic therapy is an effective way to disrupt nutrient supply and starve tumors, but it is restricted by poor efficacy and negative feedback-induced tumor relapse. In this study, a neuropilin-1 (NRP-1)-targeted nanomedicine (designated as FPPT@Axi) is reported for spatiotemporal tumor suppression by combining photodynamic therapy (PDT) with antiangiogenesis. In brief, FPPT@Axi is prepared by utilizing an NRP-1-targeting chimeric peptide (Fmoc-K(PpIX)-PEG8-TKPRR) to encapsulate the antiangiogenic drug Axitinib (Axi). Importantly, the NRP-1-mediated targeting property enables FPPT@Axi to selectively concentrate at vascular endothelial and breast cancer cells, facilitating the production of reactive oxygen species (ROS) in situfor specific vascular disruption and enhanced cell apoptosis under light stimulation. Moreover, the codelivered Axi can further inhibit vascular endothelial growth factor receptor (VEGFR) to impair the negative feedback of PDT-induced tumor neovascularization. Consequently, FPPT@Axi spatiotemporally restrains the tumor growth through blocking angiogenesis, destroying tumor vessels, and inducing tumor apoptosis. Such an NRP-1-mediated targeting codelivery system sheds light on constructing an appealing candidate with translational potential by using clinically approved PDT and chemotherapy.
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- 2024
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8. Post-marketing safety of anti-IL-5 monoclonal antibodies (mAbs): an analysis of the FDA Adverse Event Reporting System (FAERS)
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Zou, Shu-Peng, Yang, Hai-Yun, Ouyang, Mengling, Cheng, Qian, Shi, Xuan, and Sun, Ming-Hui
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ABSTRACTBackgroundAnti-IL-5 monoclonal antibodies (mAbs) targeting IL-5 or IL-5 R α (including mepolizumab, benralizumab, and reslizumab) are widely used for inflammatory diseases such as asthma, eosinophilia, and polyangiitis. However, real-world data regarding its safety in a large sample population are incomplete. So, we evaluated the safety of anti-IL-5 mAbs by pharmacovigilance analyzes based on related adverse events (AEs) from the FDA Adverse Event Reporting System (FAERS).MethodsIn disproportionality analysis, four algorithms were employed to detect the signals of anti-IL-5 mAbs from the FAERS between 2016 and 2022. In addition, we also used MYSQL 8.0, Navicat Premium 15, and Microsoft EXCEL 2019 to analyze the signals of anti-IL-5 mAbs systematically.ResultsThere are 9,476,351 reports collected from the FAERS database, of which 22,174 reports listed anti-IL-5 mAbs as the ‘primary suspected (PS)’ drug. A total of 59 (20 new signals, mepolizumab) and 62 (19 new signals, benralizumab) significant disproportionality preferred terms (PTs) conforming to the four algorithms were retained synchronously. Finally, we detected that the anti-IL-5 mAbs-induced AEs occurred in 31 organ systems (mepolizumab) and 30 organ systems (benralizumab). For mepolizumab and reslizumab, unexpected and new significant PTs of AEs were found, such as asthmatic crisis, chronic obstructive pulmonary disease (COPD), pneumonia, COVID-19, pneumothorax, adrenal insufficiency and so on. Notably, the risk signal of asthmatic crisis for mepolizumab was stronger than benralizumab (ROR 108.04 [95%CI, 96.09–121.47] vs 26.83 [95%CI, 18.91–38.06]). Comparing with mepolizumab and benralizumab, we found the proportion of serious adverse events in mepolizumab was both greater than benralizumab in each age group (≤20, 20–65, and ≥ 65). The median onset time of mepolizumab was 280 days (interquartile range [IQR] 1–367 days).ConclusionAnalysis of FAERS data identified anti-IL-5 mAbs-associated AEs, and our findings supported continuous clinical monitoring, pharmacovigilance, and further studies of anti-IL-5 mAbs. In addition, clinicians may be more aware of the limitations of use in package inserts of anti-IL-5 mAbs: Not for relief of acute bronchospasm or status asthmaticus. Because of some limitations in the FAERS such as self-reports from patients and other confounding factors, the safety of anti-IL-5 mAbs needed more studies in different dimensions, especially the risk of cancer.
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- 2024
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9. Influence of building directions on the impact properties of NiTi fabricated via laser powder bed fusion
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Zhang, Xiao-Long, Wang, Shuo, Jiang, Yue, Huang, Jie, Wang, Shu-Peng, Zhang, Qing-Quan, Li, Qiang, Guo, Yu-Qing, and Zhang, Zhi-Hui
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The Charpy impact toughness is a crucial mechanical parameter in the application of materials within the realm of engineering. This study represents the pioneering investigation into the influence of different building directions on the Charpy impact toughness of NiTi shape memory alloys (SMAs) produced via laser powder bed fusion (LPBF). Texture analysis reveals that C0 and C90 exhibit a pronounced <001>// building direction (BA), while C45 demonstrates a strong texture along <110> and <111>. The impact test results demonstrate that C0 exhibits superior impact toughness with an absorbed energy of 12.87 J. The fractured surfaces are examined using the scanning electron microscope (SEM) and transmission electron microscope (TEM). Among them, the electron backscatter diffraction (EBSD) results indicate that the samples with higher geometrically necessary dislocation (GND) and kernel average misorientation (KAM) values can effectively reflect superior impact toughness. In contrast, fewer high-angle grain boundaries (HAGBs) are preferable. Due to the adiabatic effect, the phase transformation of the samples from austenite to martensite doesn't appear under the impact loading. Additionally, this paper discusses the impact of texture orientation, defects, and the relationship between loading direction and deposited layers on the impact toughness of the samples. These findings on impact properties would provide valuable guidance for engineering applications of NiTi SMAs.
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- 2024
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10. Divergent Construction of Thiochromanes and N‑Arylbutanamides via Arylthiodifluoromethyl Radical-Triggered Cascade of Alkenes.
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Sun, Yu, Zhang, Shu-Peng, and Yang, Wen-Chao
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- 2023
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11. Sedimentary and tectonic evolution of the Banquan pull-apart basin and implications for late Cenozoic dextral strike-slip movement of the Tanlu Fault Zone
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Shu, Peng, Xu, Xiwei, Feng, Shaoying, Liu, Baojin, Li, Kang, Tapponnier, Paul, Deng, Xiaojuan, Chen, Guihua, Xia, Nuan, Xu, Hongtai, Qin, Jingjing, He, Fubing, Ma, Yan, and Zheng, Rongzhang
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The Banquan Basin is a pull-apart basin with the largest scale and the most prominent structure due to dextral slip of the Tanlu Fault Zone (TLFZ) in late Cenozoic. The depositional history of the basin records the start time and evolution of the right-lateral strike-slip movement of the TLFZ. This paper studies the sedimentary and tectonic evolution of the Banquan Basin by seismic reflection exploration, borehole detection and cosmogenic nuclide chronology. We analyze the coupling relationship between the pull-apart basin and the strike-slip fault and discuss the start time and tectonic significance of the right-lateral strike-slip of the TLFZ. Our study indicates that the Banquan Basin has undergone three evolutionary stages: weak rifting during the pre-pull-apart period, strong extension during the syn-pull-apart period and subsidence during the post-pull-apart period. This implies that the TLFZ, which controls the evolution of the basin, experienced an evolutionary process of weak activity, intensified activity and migration of activity toward the central basin. The sedimentary filling of the basin has strong response to the episodic pull-apart and extension of the basin. Lying upon the basement of the basin, a thin layer of Miocene mudstone slowly accumulated due to local rifting before the strong pull-apart event. Along with the dextral slipping and pull-apart process, the basin was filled with alluvial fan facies, fluvial facies and floodplain facies strata from bottom to top. The latest tectonic movement of the TLFZ in the North China Block in late Cenozoic was dominated by episodic dextral strike-slip motion, and this deformation pattern started at 4.01±1.27 Ma. The latest tectonic deformation in North China since late Cenozoic was governed by eastward extrusion and tectonic orogenesis of the eastern margin of the Qinghai-Xizang Plateau since late Miocene. The eastward thrusting of the Liupanshan fault zone and sinistral shearing of the Qinling fault zone led to the anticlockwise rotation and pushing of secondary blocks in North China, resulting in a planar bookshelf faulting and rotation pattern. This unique deformation pattern transferred eastwards to the North China Plain at ∼ Ma and the process continues to the present time. This planar bookshelf rotation, accompanied with regional sinistral strike-slip movement of the ∼EW-trending boundary fault zones to the north and south of the North China Block and dextral strike-slip motion of the NNE-trending boundary faults between secondary blocks, is likely to be the long-range effect of the strong extrusion of the eastern margin of the Qinghai-Xizang Plateau.
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- 2023
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12. Real-time unmanned aerial vehicle flight path prediction using a bi-directional long short-term memory network with error compensation
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Chen, Sifan, Chen, Baihe, Shu, Peng, Wang, Zhensheng, and Chen, Chengbin
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In recent years, unmanned aerial vehicle (UAV) autonomous flight technology has been applied in many fields. However, in the process of autonomous operation, the UAV may deviate from the set flight path due to various disturbance factors, which results in mission failure. In order to find the abnormal situation in time and take corresponding measures, it is necessary to monitor the operation state of the UAV. Predicting the UAV flight path is the main monitoring method at present; however, the accuracy and real-time of the existing prediction methods are limited. Therefore, this paper proposes an error compensation Bessel bidirectional long short-term memory real-time path prediction model deployed in ground stations. First, because of inconsistency of the units in all directions of the original positioning information provided by global positioning system, the Bessel geodetic coordinate transformation is introduced to unify the units of three-dimensional coordinate data, so as to improve the prediction accuracy. Second, considering the problems of poor data quality and data missing in the operation process, the least square fitting method is used to supplement and correct the positioning coordinate data to obtain more reliable and accurate path observation values as the model input. Finally, a deep learning path prediction model based on bi-directional long short-term memory (BiLSTM) network is constructed, and the appropriate network parameters are determined with the prediction accuracy and time as evaluation indicators. In order to further improve the prediction accuracy, a compensator based on proportional integral differential error control theory is designed according to the output characteristics of the BiLSTM network, which is used for providing compensation values for the prediction results of the model. The training and testing results using the actual flight data of UAV operation show that, under the experimental environment built, the model proposed in this paper can complete the UAV flight path prediction with root mean square error < 1 meter within 0.1 second, and has better performance and higher prediction accuracy than other neural network models.Graphical Abstract
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- 2023
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13. Asymmetric Divergent Synthesis of ent-Kaurane-, ent-Atisane-, ent-Beyerane-, ent-Trachylobane-, and ent-Gibberellane-type Diterpenoids
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Zhao, Xian-He, Meng, Le-Le, Liu, Xiao-Tao, Shu, Peng-Fei, Yuan, Cheng, An, Xian-Tao, Jia, Tian-Xi, Yang, Qi-Qiong, Zhen, Xiang, and Fan, Chun-An
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A unified strategy toward asymmetric divergent syntheses of nine C8-ethano-bridged diterpenoids A1–A9(candol A, powerol, sicanadiol, epi-candol A, atisirene, ent-atisan-16α-ol, 4-decarboxy-4-methyl-GA12, trachinol, and ent-beyerane) has been developed based on late-stage transformations of common synthons having ent-kaurane and ent-trachylobane cores. The expeditious assembly of crucial advanced ent-kaurane- and ent-trachylobane-type building blocks is strategically explored through a regioselective and diastereoselective Fe-mediated hydrogen atom transfer (HAT) 6-exo-trig cyclization of the alkene/enone and 3-exo-trig cyclization of the alkene/ketone, showing the multi-reactivity of densely functionalized polycyclic substrates with πC═Cand πC═Osystems in HAT-initiated reactions. Following the rapid construction of five major structural skeletons (ent-kaurane-, ent-atisane-, ent-beyerane-, ent-trachylobane-, and ent-gibberellane-type), nine C8-ethano-bridged diterpenoids A1–A9could be accessed in the longest linear 8 to 11 steps starting from readily available chiral γ-cyclogeraniol 1and known chiral γ-substituted cyclohexenone 2, in which enantioselective total syntheses of candol A (A1, 8 steps), powerol (A2, 9 steps), sicanadiol (A3, 10 steps), epi-candol A (A4, 8 steps), ent-atisan-16α-ol (A6, 11 steps), and trachinol (A8, 10 steps) are achieved for the first time.
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- 2023
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14. Influence of changes in alloying elements distribution and retained Austenite (RA) on mechanical properties of high boron alloy during quenching and partitioning(Q&P) process
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Li, Zhao, Wu, Run, Song, Shu-peng, Wang, Yu, and Wu, Teng
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The quenching and partitioning (Q&P) process has been adopted innovatively to improve the toughness and wear resistance of Fe-0.44C-1.54B-3.97Mn-0.79Al-0.95Si alloy, and the microstructure, distribution of alloying elements, mechanical properties and dry sliding wear behavior of this alloy in as-cast and heat-treated by Q&P process were systematically investigated. The results show that test alloy consists mainly of martensite, retained austenite (RA) and eutectic boride phases. After being treated by Q&P process, the distribution of alloying elements in the microstructure becomes uniform and the impact toughness increases from 4.02 J cm-2to 6.82 J cm-2, while the mass loss of the alloy is also decreased from 0.064 g to 0.051 g in dry sliding wear test. The improvement of the mechanical properties is attributed to the changes in the during Q&P process, especially the increase in the volume fraction of thin-film RA, as well as the fracture and spheroidization of part of the net-like boride.
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- 2022
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15. Development of a Nucleocapsid Protein-Based ELISA for Detection of Human IgM and IgG Antibodies to SARS-CoV‑2.
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Liu, Pan-pan, Zong, Yang, Jiang, Shu-peng, Jiao, Yong-jun, and Yu, Xue-jie
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- 2021
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16. Tandem (2 + 2) Annulation/Retro-4π Electrocyclization/Imino-Nazarov Cyclization Reaction of p-Quinone Methides with Ynamides: Expeditious Construction of Functionalized Aminoindenes
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Yu, Ke-Yin, Deng, Yu-Hua, Ge, Xiao-Min, An, Xian-Tao, Shu, Peng-Fei, Cao, Ye-Xing, Zhao, Xian-He, and Fan, Chun-An
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A new tandem annulation of p-quinone methides (p-QMs) with ynamides is described. This cascade reaction features a unique combination of (2 + 2) annulation, retro-4π electrocyclization, and imino-Nazarov cyclization, wherein vinyl p-quinone methides (p-VQMs) as one of the key intermediates have been identified chemically. Significantly, an unusual structural reconstruction of p-QMs involving the cleavage of the C5–C6 bond and the late-stage formation of the C4–C6 bond is involved, leading to a methodology development for the construction of functionalized aminoindenes.
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- 2021
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17. Yi-qi-hua-yu-jie-du decoction induces ferroptosis in cisplatin-resistant gastric cancer via the AKT/GSK3β/NRF2/GPX4 axis.
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Huang, Wenjie, Wen, Fang, Yang, Peipei, Li, Ye, Li, Qiurong, and Shu, Peng
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• The cisplatin-resistant gastric cancer was characterized with the metabolic feature of decreased GSH/GPX4 antioxidant defence system. • YJD inhibited the cisplatin drug resistance of gastric cancer through the induction of ferroptosis. • YJD induced ferroptosis in cisplatin-resistant gastric cancer via the AKT/GSK3β/NRF2/GPX4 axis. Resistance to chemotherapy in gastric cancer (GC) is a ubiquitous challenge for its treatment. Yi-qi-hua-yu-jie-du decoction (YJD), an empirical formula in Traditional Chinese Medicine (TCM), demonstrated survival-prolonging functions in patients with GC. Previous research has shown that YJD could also inhibit drug resistance in GC. However, the precise mechanisms for how YJD accomplishes this remain incompletely explained. The research aimed to identify differential metabolic characteristics in cisplatin-resistant GC and investigate whether YJD can target these differences to suppress GC drug resistance. Metabolomic analysis was conducted to identify metabolic disparities between cisplatin-resistant and parental GC cells, as well as metabolic modifications resulting from YJD intervention in cisplatin-resistant GC cells. The effect of YJD on ferroptosis stimulation was assessed by measuring the levels of reactive oxygen species (ROS), malondialdehyde (MDA), iron ions, the reduced glutathione (GSH) to oxidised glutathione (GSSG) ratio, and alterations in mitochondrial morphology. Western blotting and quantitative real-time polymerase chain reaction (Q-PCR) were employed to verity the mechanisms of YJD-triggered ferroptosis through GPX4 and NRF2 overexpression models, alongside the AKT activator SC79. In vivo validation was conducted using nude mouse xenograft models. Cisplatin-resistant GC exhibited altered GSH/GPX4 metabolism, and ferroptosis was a significantly enriched cell death pattern with YJD treatment in cisplatin-resistant GC cells. Ferroptosis biomarkers, including ROS, MDA, iron ions, the GSH/GSSG ratio, and mitochondrial morphology, were remarkably changed with the YJD intervention. Mechanistic experiments demonstrated that YJD inhibited the phosphorylation cascade activity of the AKT/GSK3β pathway, thereby reducing NRF2 expression. The level of GPX4, a crucial enzyme involved in glutathione metabolism, was attenuated, facilitating ferroptosis induction in cisplatin-resistant GC. The research reveals, for the first time, changes in GSH/GPX4 metabolism in cisplatin-resistant GC cells based on metabolomic analysis. YJD induced ferroptosis in cisplatin-resistant GC by inhibiting GPX4 through the AKT/GSK3β/NRF2 pathway, thus attenuating the cisplatin drug resistance in GC. Our findings identify metabolic changes in cisplatin-resistant GC and establish a theoretical framework for YJD on tackling drug resistance in GC through ferroptosis. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2024
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18. A damage-tolerant, self-healing and multifunctional triboelectric nanogenerator.
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Hou, Ke-Xin, Dai, Xingyi, Zhao, Shu-Peng, Huang, Long-Biao, and Li, Cheng-Hui
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Triboelectric nanogenerators (TENGs) are subjected to repeated contact and separations during operation, which inevitably cause damage from mechanical forces, leading to interface mismatch and function loss. Although self-healing property has been utilized to prolong the service life of flexible TENGs, triboelectric nanogenerators which can work stably in extreme mechanical environments have not been developed. Herein, we report a flexible single-mode triboelectric nanogenerator named V-PANI-TENG which not only have strong damage-tolerant ability including puncture-resistant ability to resist sabotage and tear-resistant ability to defend further crack propagation, but also show excellent self-healing performance upon damage based on the well-designed tribolayer PMBEug-OH-V-2–4 and electrode material PMBEug-OH-PANI-20%. Moreover, the V-PANI-TENG can also be used as an efficient self-powered sensor to monitor the movement of human body or detect the road surface roughness. Given the extraordinary durability and unprecedented applications resulting from novel material designs, this work provides an effective way to develop triboelectric nanogenerators which can work stably in extreme mechanical environments and broaden the application scenarios of triboelectric nanogenerators. [Display omitted] • A fully flexible triboelectric nanogenerator (TENG) with damage-tolerant and self-healing abilities was fabricated. • Puncture-resistant and self-healing abilities enable the TENG to work stably in extreme mechanical environments. • In spite of powering electronics and monitoring movements, the TENG is first used for detecting road surface roughness. [ABSTRACT FROM AUTHOR]
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- 2023
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19. Orbit design and mission planning for global observation of Jupiter
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Huang, An-Yi, Yan, Bing, Li, Zhen-Yu, Shu, Peng, Luo, Ya-Zhong, and Yang, Zhen
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This paper presents the method created by the National University of Defense Technology (NUDT) team in the 10th China Trajectory Optimization Competition, which entails a 3-year observation mission of 180 regions on Jupiter. The proposed method can be divided into three steps. First, a preliminary analysis and evaluation via an analytical method is undertaken to decide whether the third subtask of the mission, i.e., exploring the Galilean moons, should be ignored. Second, a near-optimal orbit for magnetic field observation is designed by solving an analytical equation. Third, a set of observation windows and their sequence are optimized using a customized genetic algorithm. The final index obtained is 354.505, ranking second out of all teams partaking in the competition.
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- 2021
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20. Design of Lead-Free and Stable Two-Dimensional Dion–Jacobson-Type Chalcogenide Perovskite A′La2B3S10(A′ = Ba/Sr/Ca; B = Hf/Zr) with Optimal Band Gap, Strong Optical Absorption, and High Efficiency for Photovoltaics
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Cen, Yu-lang, Shi, Jun-jie, Zhang, Min, Wu, Meng, Du, Juan, Guo, Wen-hui, Liu, Shi-ming, Han, Shu-peng, and Zhu, Yao-hui
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Searching for energetic photovoltaic absorbers is a favorable solution to the current energy crisis. As a star material for solar cells, MAPbI3(MA = CH3NH3) has a suitable band gap, strong optical absorption, great defect tolerance, and high certified power conversion efficiency (PCE) up to 25.2%. However, the lead toxicity and poor long-term stability limit its application in photovoltaic devices. To break through these bottlenecks, we design two-dimensional (2D) Dion–Jacobson (DJ)-type (n= 3) chalcogenide perovskites A′La2B3S10(A′ = Ba, Sr, Ca; B = Hf, Zr), with optimal band gap, strong optical absorption, high carrier mobility, and excellent optoelectronic properties, based on the powerful first-principles and advanced HSE06 calculations. Especially, we find that, superior to MAPbI3, 2D A′La2B3S10perovskites have the following several outstanding properties. (1) They are Pb-free and environmentally friendly. (2) The structural stability is better than that of MAPbI3. (3) The direct band gap (∼1.33 eV of BaLa2Hf3S10), i.e., the optimal value of the SQ limit, is more suitable than that of MAPbI3(∼1.55 eV) with a 0.22 eV energy-loss spectrum. (4) The carrier mobility (1.8–2.6 × 103cm2V–1s–1) is larger than that of MAPbI3(∼37 cm2V–1s–1). (5) The optical absorption (∼6 × 105cm–1) in the visible range is three times stronger than that of MAPbI3(∼2 × 105cm–1). (6) The estimated PCE (∼30.9% in BaLa2Hf3S10) is higher than that of MAPbI3(∼30%). These amazing characteristics indicate that 2D A′La2B3S10perovskites are promising absorbers for photovoltaics.
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- 2020
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21. Exploiting Cosegmentation and Geo-Eco Zoning for Land Cover Product Updating.
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Ling Zhu, Yang Sun, Ruoming Shi, Yixuan La, and Shu Peng
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LAND cover ,REMOTE-sensing images ,SHRUBLANDS ,ZONING - Abstract
Land cover is a commonly used index for characterizing land surface and the corresponding human or natural processes. Remote sensing-based land cover maps must be continuously updated to satisfy the requirements of their users. An incremental updating method for land cover maps based on image cosegmentation and a geo-eco zoning-rule database is presented. First, cosegmentation of multitemporal satellite images is used to extract incremental (land cover change) pixels. Then the reliability of the change-detection results is improved by using the geo-eco zoning-rule database to detect and remove spurious changes. Finally, old land cover maps are updated to create new land cover maps. A test data set of 1200×1200 pixels from GlobeLand30 2000 land cover maps are updated to GlobeLand30 2010 land cover maps with an overall accuracy of 84.6%. [ABSTRACT FROM AUTHOR]
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- 2019
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22. Reversal of carbapenem-resistance in Shewanella algae by CRISPR/Cas9 genome editing.
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Wu, Zong-Yen, Huang, Yao-Ting, Chao, Wen-Cheng, Ho, Shu-Peng, Cheng, Jan-Fang, and Liu, Po-Yu
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• Emergence of carbapenem-resistant S. algae is a severe problem. • Re-sensitization of S. algae to carbapenem by CRISPR/Cas9 genome editing. • The bla OXA-55 -like gene is essential for carbapenem resistance in S. algae. • One-plasmid genome editing system for CRISPR/Cas9 genome editing in S. algae. • CRISPR/Cas9 genome editing is a promising approach to validate the gene function. Antibiotic resistance in pathogens is a growing threat to human health. Of particular concern is resistance to carbapenem, which is an antimicrobial agent listed as critically important by the World Health Organization. With the global spread of carbapenem-resistant organisms, there is an urgent need for new treatment options. Shewanella algae is an emerging pathogen found in marine environments throughout the world that has increasing resistance to carbapenem. The organism is also a possible antibiotic resistance reservoir in humans and in its natural habitat. The development of CRISPR/Cas9-based methods has enabled precise genetic manipulation. A number of attempts have been made to knock out resistance genes in various organisms. The study used a single plasmid containing CRISPR/Cas9 and recE/recT recombinase to reverse an antibiotic-resistant phenotype in S. algae and showed bla OXA-55 -like gene is essential for the carbapenem resistance. This result demonstrates a potential validation strategy for functional genome annotation in S. algae. [ABSTRACT FROM AUTHOR]
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- 2019
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23. A Mendelian randomization study of serum uric acid with the risk of venous thromboembolism
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Ji, Lixian and Shu, Peng
- Abstract
Background: Observational studies have linked hyperuricemia with venous thromboembolism (VTE). We aimed to investigate whether there are causal relationships between uric acid levels and VTE and its subtypes, including deep venous thrombosis (DVT) of the lower extremities and pulmonary embolism (PE). Methods: We utilized Mendelian randomization (MR) analysis to estimate the causal association in European individuals. We extracted two sets of polygenic instruments strongly associated (p< 5 × 10
−8 ) with uric acid from the CKDGen consortium and UK biobank, respectively. Genetic associations with the risk of VTE, DVT, and PE were obtained from the FinnGen biobank. We used the inverse-variance weighted method as the preliminary estimate. Additionally, we employed MR-Egger, weighted median, and Mendelian randomization pleiotropy residual sum and outlier method as complementary assessments. Sensitivity analyses were performed to test for pleiotropic bias. Results: The genetically instrumented serum uric acid levels had no causal effects on VTE, DVT, and PE. Two sets of polygenic instruments used for exposure, along with three complementary MR methods, also yielded no significant association. Conclusions: Our MR analysis provided no compelling evidence for a causal relationship of serum uric acid with the risk of VTE. This suggests that uric acid-lowering therapies in patients with hyperuricemia may not be effective in reducing the likelihood of developing VTE.- Published
- 2023
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24. A damage-tolerant, self-healing and multifunctional triboelectric nanogenerator
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Hou, Ke-Xin, Dai, Xingyi, Zhao, Shu-Peng, Huang, Long-Biao, and Li, Cheng-Hui
- Abstract
Triboelectric nanogenerators (TENGs) are subjected to repeated contact and separations during operation, which inevitably cause damage from mechanical forces, leading to interface mismatch and function loss. Although self-healing property has been utilized to prolong the service life of flexible TENGs, triboelectric nanogenerators which can work stably in extreme mechanical environments have not been developed. Herein, we report a flexible single-mode triboelectric nanogenerator named V-PANI-TENG which not only have strong damage-tolerant ability including puncture-resistant ability to resist sabotage and tear-resistant ability to defend further crack propagation, but also show excellent self-healing performance upon damage based on the well-designed tribolayer PMBEug-OH-V-2–4 and electrode material PMBEug-OH-PANI-20%. Moreover, the V-PANI-TENG can also be used as an efficient self-powered sensor to monitor the movement of human body or detect the road surface roughness. Given the extraordinary durability and unprecedented applications resulting from novel material designs, this work provides an effective way to develop triboelectric nanogenerators which can work stably in extreme mechanical environments and broaden the application scenarios of triboelectric nanogenerators.
- Published
- 2023
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25. ISRIB inhibits the senescence of type II pulmonary epithelial cells to alleviate pulmonary fibrosis induced by silica in mice.
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Li, Ya-Qian, An, Xu-Liang, Jin, Fu-Yu, Bai, Yi-Fei, Li, Tian, Yang, Xin-Yu, Liu, Shu-Peng, Gao, Xue-Min, Mao, Na, Xu, Hong, Cai, Wen-Chen, and Yang, Fang
- Subjects
PULMONARY fibrosis ,EPITHELIAL cells ,CELLULAR aging ,PLASMINOGEN activator inhibitors ,WESTERN immunoblotting ,MICROFILAMENT proteins ,BONE morphogenetic protein receptors - Abstract
The role and mechanisms of integrated stress response inhibitor (ISRIB) on silicosis are still not well defined. In the present study, the effects of ISRIB on cellular senescence and pulmonary fibrosis in silicosis were evaluated by RNA sequencing, micro-computed tomography, pulmonary function assessment, histological examination, and Western blot analysis. The results showed that ISRIB significantly reduced the degree of pulmonary fibrosis in mice with silicosis and reduced the expression of type I collagen, fibronectin, α-smooth muscle actin, and transforming growth factor-β1. Both in vivo and in vitro results showed that ISRIB reversed the expression of senescence-related factors β-galactosidase, phosphor-ataxia telangiectasia mutated, phosphor-ataxia telangiectasia and Rad3-related protein, p-p53, p21, p16, and plasminogen activator inhibitor type 1. The aforementioned results were consistent with the sequencing results. These findings implied that ISRIB might reduce the degree of pulmonary fibrosis in mice with silicosis by inhibiting the cellular senescence of alveolar epithelial cell type II. • ISRIB alleviates pulmonary fibrosis induced by silica in mice. • ISRIB inhibits cellular senescence of type II pulmonary epithelial cells. • A crosstalk exists between cellular senescence and the PERK signaling pathway. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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26. Distribution of WNT10A gene rs10177996 polymorphism between Han and Uygur populations in Xinjiang area.
- Author
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LIU Jia-lin, ZHAO Chun-ping, ZHANG Jia-yu, HAN Xiang-zhen, GE Shu-peng, DU Ii-juan, and HE Hui-yu
- Published
- 2018
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27. Characteristics of Satellite Sampling Errors in Total Precipitable Water from SSMIS, HIRS, and COSMIC Observations
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Xue, Yunheng, Li, Jun, Menzel, W. Paul, Borbas, Eva, Ho, Shu‐Peng, Li, Zhenglong, and Li, Jinlong
- Abstract
This study quantifies the characteristics of different satellite sampling errors in the time series of total precipitable water (TPW) derived from Constellation System for Meteorology, Ionosphere, and Climate (COSMIC) radio occultation, Special Sensor Microwave Imager Sounder (SSMIS), and High‐resolution Infrared Radiation Sounder (HIRS) during the overlapping time period of January 2007 to December 2013. Gap‐free data from ERA5 reanalysis of the European Centre for Medium Range Weather Forecasts are used as reference values. All TPW data are first compared with microwave radiometer measurements from Atmospheric Radiation Measurement Program. In general, they are consistent, with all their regression coefficients being greater than 0.77. Discrepancies in global TPW time series can be mainly attributed to the inherent sampling errors of these three different satellite remote sensing systems. COSMIC has small sampling errors in higher latitudes. But it has scarce samples in tropical regions, which leads to a large sampling error of 3.00 mm in the estimation of global TPW. Sampling in SSMIS is more uniform with mean errors less than 0.5 mm. But the sampling is only over the ocean. Sampling errors in HIRS are larger in tropics and north subtropical areas due to clear sky biased sampling. Moreover, it is significantly correlated with the variability of TPW, whereas the sampling error in COSMIC is less influenced by TPW. Sampling errors will be reduced and more consistent global TPW time series will be derived by simply combining the multisensor samplings together. Sampling differences in COSMIC, SSMIS, and HIRS observations largely explain observed differences between associated TPW time seriesSampling in COSMIC, SSMIS, and HIRS has different characteristics; sampling errors in HIRS are significantly correlated with TPW variabilitySampling errors can be reduced by averaging multisensor sampling; more factors should be considered when merging real satellite data
- Published
- 2019
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28. Retrospectively investigating the 12-year experience of prenatal diagnosis of small supernumerary marker chromosomes through array comparative genomic hybridization
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Huang, Min-Hui, Lee, Cagge, Chang, Jia-Shyuhn, Wang, Han-Chow, Lai, Hui-Ling, Chang, Chu-Chu, Chen, Tzu-Wang, Li, Yu-Fen, Lin, Ting-Tse, Yang, Chih-Yun, and Ho, Shu-Peng
- Abstract
This study retrospectively evaluated the incidences of small supernumerary marker chromosomes (sSMCs) in prenatal diagnoses and detected with gain of pathogenic copy number variation through array comparative genomic hybridization (CGH) in a laboratory in Taiwan.
- Published
- 2019
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29. Whole-Genome Characterization of Shewanella AlgaeStrain SYT3 Isolated from Seawater Reveals Insight into Hemolysis
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Wu, Zong-Yen, Ho, Shu-Peng, Cheng, Jan-Fang, Tung, Kwong-Chung, Hong, Yu-Kai, Chen, Shi-Yu, Menzer, Alexander, Chen, Ying-Ju, Huang, Yao-Ting, and Liu, Po-Yu
- Abstract
Aim:To describe the genomic characteristics of seawater-borne hemolytic Shewanella algaeand its resistance genes. Materials & methods:Whole genome sequence of S. algaeSYT3 was determined using llumina MiSeq platform. Multiple-database-based analysis was performed to identify the genetic background of its hemolytic activity and the antibiotic resistance genes. Results:S. algaeSYT3 possesses a homolog of the hlyoperon involved in the synthesis of hemolysin. We also identified candidate genes associated with resistance to β-lactam antibiotics (blaOXA-55) and fluoroquinolone (qnrA3). Conclusion:The study provides an insight into the hemolytic activity of S. algae. Our findings also suggested S. algaeas a potential reservoir of antimicrobial resistance determinants.
- Published
- 2018
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30. Letter to the editor: “uric acid's influence on venous thromboembolism in East Asia”
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Ji, Lixian and Shu, Peng
- Published
- 2023
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31. Differences of Yield and Major Quality Characters between Four Late Double-Harvest Rice Varieties.
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CHEN Bo, LI Jun, HUA Jin, HUO Zhong-Yang, ZHANG Hong-Cheng, CHENG Fei-Hu, HUANG Da-Shan, CHEN Zhong-Ping, CHEN Heng, GUO Bao-Wei, ZHOU Nian-Bing, and SHU Peng
- Abstract
The study was conducted to clarify the discrepancy of different-types of late rice in yield and rice quality in Jiangxi province, which provides ground and reference for scientific selection of suitable late japonica rice varieties in Jiangxi. A comparative study of late rice in yield and rice quality using four kinds of rice varieties from indica-japonica hybrid rice, japonica hybrid rice, japonica conventional rice and indica hybrid rice was carried out in Shanggao (28°31'N, 115°09'E) of Jiangxi province. Compared with indica hybrid rice, indica-japonica hybrid rice, japonica hybrid rice and japonica conventional rice had improved processing and cooking/eating qualities, then appearance and nutritional qualities. The yield showed a trend of indicajaponica hybrid rice > japonica hybrid rice > japonica conventional rice > indica hybrid rice. The suitable late varieties for the project of "education of japonica rice replacing indica rice" in Shanggao should be from indica-japonica hybrid rice, japonica hybrid rice and japonica conventional rice. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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32. First Report in China on the Identification and Drug Sensitivity of Mycobacterium elephantis Isolated from the Milk of a Cow with Mastitis.
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JI, Ling Yun, XU, Dong Lei, YIN, Shu Peng, LIU, Hai Can, LI, Gui Lian, JIANG, Yi, WEI, Jian Hao, ZENG, Hao, LOU, Yong Liang, LYU, Jian Xin, and WAN, Kang Lin
- Subjects
BOVINE mastitis ,MYCOBACTERIUM ,MILK quality ,COW diseases ,POLYMERASE chain reaction ,RIBOSOMAL RNA - Abstract
Objective In this study, milk from a cow with mastitis was analyzed to determine the presence of mycobacterial infection. Milk quality and security problems pertaining to the safe consumption of dairy products were also discussed in this study. Methods Milk was preprocessed with 4% NaOH. Then, mycobacteria were isolated from the milk sample on L-J medium. The isolate was identified using multiple loci Polymerase Chain Reaction (PCR) and multi-locus sequence analysis with 16S rRNA , sodA , hsp65 , and ITS genes. The drug sensitivity of the isolate to 27 antibiotics was tested through alamar blue assay. Results Smooth, moist, pale yellow colonies appeared on the L-J medium within a week after inoculation. Based on the results of multiple loci PCR analysis, the isolate was preliminarily identified as non-tuberculous mycobacteria. The 16S rRNA , SodA , hsp65 , and ITS gene sequences of the isolate exhibited 99%, 99%, 99%, and 100% similarities, respectively, with those of the published reference strains of Mycobacterium elephantis (M. elephantis) . The drug sensitivity results showed that the strain is resistant to isoniazid, p-aminosalicylic acid, and trimesulf but is sensitive to ofloxacin, rifampicin, amikacin, capreomycin, moxifloxacin, kanamycin, levofloxacin, cycloserine, ethambutol, streptomycin, tobramycin, rifabutin, ciprofloxacin, linezolid, cefoxitin, clarithromycin, and minocycline. Conclusion To the best of our knowledge, this study is initially to report the isolation of M. elephantis from the milk of a cow with mastitis in China. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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33. Transcriptome profiling Revealed the potential mechanisms of Shen Lin Bai Zhu San n-butanol extract on DSS induced Colitis in Mice and LC-MS analysis.
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Qu, Qian, Li, Shu-Peng, Dong, Qi, Du, Hong-Liang, Wang, Zhi-Hua, Ma, Yi-Mu, Gong, Xiao-Pei, Ding, Yi-Qing, Zhou, Jing, Chen, Jia-Yan, Liu, Meng-Jie, Lv, Wei-Jie, and Guo, Shi-Ning
- Abstract
• N-butanol extract of SLBZS has a strong protective effect on DSS-induced mice. • SLBZS n-butanol extract contains high levels of ginsenoside Rg1, re and Rb1. • SLBZS n-butanol extract is also comprised of many compounds that can relieve colitis, including glycyrrhizin, indole, quercetin, L-Tryptophan, and so on. • SLBZS n-butanol extract alters the mRNA expression level of many genes in colon tissue, especially Per2, Per3, Npy and Serpina3m. Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disorder in gastrointestinal tract. Shen Ling Bai Zhu San (SLBZS), which has a long history of use in Traditional Chinese Medicine (TCM), has been widely used to treat gastrointestinal diseases. The isolated fractions of TCM have also been proved to possess an important potential for treating diseases, which are due to their effective components. In this study, we examined the possibility that SLBZS and its isolated active fractions may prevent DSS-induced colitis, and investigated the potential mechanisms by regulating genetic profile of colon. Colitis mice were induced by 2.5% DSS for 7 days, and then SLBZS and different SLBZS extracts were administrated to protect the mice for 7 days. Body weight, diarrhea, bleeding in stool, colon length, spleen weight, cytokines of serum and colon and pathology of colon were assessed. The level of Ginsenoside Rg1, Re and Rb1 in different SLBZS extracts and qualitative analysis of n- butanol extract of SLBZS (S-Nb) was performed by HPLC and LC-MS, respectively. And the effects of S-Nb on the transcriptome in colitis were investigated. Our results showed that SLBZS and S-Nb significantly regained body weight, reduced DAI, splenomegaly and the length of colon and attenuated histological damage of the colon. Meanwhile, SLBZS and S-Nb markedly reduced the levels of TNF-α, IL-1β and IL-6 and increased the level of IL-10 in serum and colon. These effects may be associated with the high levels of Ginsenoside Rg1, Re and Rb1 and rich variety of compounds in S-Nb including 6 ginsenosides, glycyrrhizin, L-tryptophan, and so on. Transcriptome analysis revealed that S-Nb selectively regulated 103 differentially expressed genes (DEGs), 36 of which were changed in DSS-induced mice. And the genes of Per2, Per3, Npy and Serpina3m were closely related to colitis and also restored by S-Nb with different extent. Remarkably, these DEGs modulated the biological functions of colitis mice, including extracellular region, response to external stimulus, MAPK signaling pathway and arginine and proline metabolism. These data indicated that SLBZS and S-Nb blunted DSS-induced colitis by modulating differentially expression gene profile and biological functions based on their ginsenosides and rich compounds. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2023
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34. 20-hydroxyecdysone reprograms amino acid metabolism to support the metamorphic development of Helicoverpa armigera
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Wang, Xiao-Pei, Sun, Shu-Peng, Li, Yan-Xue, Wang, Lin, Dong, Du-Juan, Wang, Jin-Xing, and Zhao, Xiao-Fan
- Abstract
Amino acid metabolism is regulated according to nutrient conditions; however, the mechanism is not fully understood. Using the holometabolous insect cotton bollworm (Helicoverpa armigera) as a model, we report that hemolymph metabolites are greatly changed from the feeding larvae to the wandering larvae and to pupae. Arginine, alpha-ketoglutarate (α-KG), and glutamate (Glu) are identified as marker metabolites of feeding larvae, wandering larvae, and pupae, respectively. Arginine level is decreased by 20-hydroxyecdysone (20E) regulation via repression of argininosuccinate synthetase (Ass) expression and upregulation of arginase (Arg) expression during metamorphosis. α-KG is transformed from Glu by glutamate dehydrogenase (GDH) in larval midgut, which is repressed by 20E. The α-KG is then transformed to Glu by GDH-like in pupal fat body, which is upregulated by 20E. Thus, 20E reprogrammed amino acid metabolism during metamorphosis by regulating gene expression in a stage- and tissue-specific manner to support insect metamorphic development.
- Published
- 2023
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35. Total ionizing dose effect of gamma rays on H-gate PDSOI MOS devices at different dose rates
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Wang, Qian-Qiong, Liu, Hong-Xia, Wang, Shu-Long, Fei, Chen-Xi, Zhao, Dong-Dong, Chen, Shu-Peng, and Chen, Wei
- Abstract
The total dose effect of 60Co γ-rays on 0.8-μm H-gate partially depleted-silicon-on-insulator NMOS devices was investigated at different irradiation doses. The results show that the shift in saturation current at high dose rate is greater than that at low dose rate, due to increase in interface-state density with decreasing dose rate; the scattering effect of interface state on electrons in the channel causes degradation in carrier mobility; and the body current and transconductance of the back gate enhance low-dose-rate sensitivity when the irradiation is under OFF-bias. A double transconductance peak is observed at 3 kGy(Si) under high dose rates.
- Published
- 2017
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36. Interaction of omeprazole and Helicobacter pylori-induced nuclear factor-κB activation and mediators in gastric epithelial cells.
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Peng, Yen-Chun, Huang, Lan-Ru, Shyu, Ching-Lin, Cheng, Ching-Chang, and Ho, Shu-Peng
- Subjects
OMEPRAZOLE ,HELICOBACTER pylori ,NF-kappa B ,CYTOTOXINS ,ANTIGENS ,GASTRIC mucosa ,WOUNDS & injuries - Abstract
Background Omeprazole (OMP), a proton pump inhibitor, is a highly effective drug for the management of acid-related disorders. Infections resulting from cytotoxin antigen A ( CagA ) positive Helicobacter pylori strains have been associated with higher grades of gastric mucosal inflammation. Nuclear factor (NF)-κB activation has been reported to participate in H. pylori -induced gastritis in humans. The complex interaction of OMP on the H. pylori and NF-κB related molecular mechanisms within the gastric mucosa remains unclear. In the present study, we investigated OMP, specifically its effects on NF-κB activation, and COX-2, IL-6, and IL-8 production in gastric cells (Kato-III cells) treated with CagA positive ( CagA + ) and negative ( CagA – ) H. pylori strains. Methods Kato-III cells were stimulated with H. pylori water extracts (HPE) containing ATCC 43504 ( CagA + ) and ATCC 51932 ( CagA – ) strains. NF-κB activation, inhibitory IκB expression and phosphorylation, and cyclooxygenase (COX)-2, interleukin (IL)-6, and IL-8 expression were assessed in the absence and presence of OMP. Results Both CagA + and CagA – HPE induced NF-κB activation, whereas OMP suppressed NF-κB activation in the CagA – strain. HPE demonstrated a similar effect on IκB protein expression in the absence and presence of OMP. OMP alone decreased IκB phosphorylation without promoting NF-κB and IκB expression. Additionally, both CagA + and CagA – HPE induced COX-2 expression, but no significant effect on IL-6 and IL-8. However, OMP downregulated the transcription of COX-2, IL-6, and IL-8 in CagA – HPE treated cells. Conclusion Using the Kato-III cells model, H. pylori induces NF-κB activation in a CagA- independent manner. Both CagA + HPE and CagA – HPE induced COX-2 gene expression, but not for IL-6 and IL-8 expression. However, OMP suppressed NF-κB activation via a downregulation of IκB phosphorylation in CagA – HPE treated condition. OMP also suppressed CagA – H. pylori induced-transcription of proinflammatory COX-2, IL-6, and IL-8. OMP may provide different effects on CagA + and CagA – H. pylori infection conditions. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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37. Integrating HPLC-Q-TOF-MS/MS, network pharmacology and experimental validation to decipher the chemical substances and mechanism of modified Gui-shao-liu-jun-zi decoction against gastric cancer
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Huang, Wenjie, Wen, Fang, Ruan, Shuai, Gu, Peixing, Gu, Suping, Song, Siyuan, Zhou, Jiayu, Li, Ye, Liu, Jiatong, and Shu, Peng
- Abstract
Gastric cancer (GC) is a common malignant tumor worldwide. Modified Gui-shao-liu-jun-zi decoction (mGSLJZ) is a clinically effective traditional Chinese medicine (TCM) compound in GC treatment. This study aimed to analyze main chemical substances of mGSLJZ and investigate active ingredients and molecular mechanism of mGSLJZ against GC.
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- 2023
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38. Divergent Construction of Thiochromanes and N-Arylbutanamides via Arylthiodifluoromethyl Radical-Triggered Cascade of Alkenes
- Author
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Sun, Yu, Zhang, Shu-Peng, and Yang, Wen-Chao
- Abstract
A strategy utilizing silver-catalyzed oxidative decarboxylation radical cascade cyclization of arylthiodifluoroacetic acids with alkenes for the simple and efficient preparation of difluoromethylated thiochromanes and 2,2-disubstituted-N-arylbutanamides derivatives has been developed. This approach includes good functional group tolerance, easily accessible starting materials, and operational simplicity.
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- 2023
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39. COSMIC-2 soundings impacts on a RO-based NOAA microwave satellite data quality monitoring system
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Iacovazzi, Robbie, Liu, Quanhua, Zhou, Xinjia, Kireev, Stanislav, Sun, Ninghai, and Ho, Shu-peng
- Abstract
The Constellation Observing System for Meteorology, Ionosphere and Climate-2/Formosa Satellite Mission 7 (COSMIC-2) Global Navigation Satellite System (GNSS) Radio Occultation (RO) constellation is the follow-on to the highly successful COSMIC-1 program. The GNSS RO atmospheric soundings have historically been used to generate Community Radiative Transfer Model simulated background (B) microwave (MW) brightness temperature data needed to monitor NOAA operational MW sounding instrument observed (O) antenna temperature (Ta) product quality. This study is motivated by the need to determine the impact of COSMIC-2 RO soundings on this critical long-term monitoring capability. This study is based on individual MW sensor O-B Ta bias (∆Ta) statistics and "double-difference" inter-sensor Ta bias (δTa) statistics for two time periods. Time Period 1 (TP1—May 1, 2017, to September 30, 2019) exclusively uses COSMIC-1 and Korea Multi-Purpose Satellite-5 soundings, while Time Period 2 (TP2—October 1, 2019, to December 31, 2020) expands the analysis with COSMIC-2 soundings. The TP1 and TP2 ∆Tastatistics comparisons indicate COSMIC-2 data population augmentation and latitudinal distribution impact the MW sounder performance monitoring tool transition from TP1 to TP2. COSMIC-2 competently supports long-term MW individual sensor and inter-sensor product monitoring for MW radiometer channels with weighting functions that peak between 8 and 30 km. Individual sensor ∆Tamonitoring for other microwave channels that depend on COSMIC-2 data below 8 km and from 30 km to 60 has limitations, but these limitations are shown not to inhibit critical δTamonitoring.
- Published
- 2022
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40. Effects of total dose irradiation on the threshold voltage of H-gate SOI NMOS devices
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Wang, Qian-Qiong, Liu, Hong-Xia, Chen, Shu-Peng, Wang, Shu-Long, Fei, Chen-Xi, and Zhao, Dong-Dong
- Abstract
This work researched the impact of total dose irradiation on the threshold voltage of N-type metal oxide semiconductor field effect transistors (nMOSFETs) in silicon-on-insulator (SOI) technology. Using the subthreshold separation technology, the factor causing the threshold voltage shift was divided into two parts: trapped oxide charges and interface states, the effects of which are presented under irradiation. Furthermore, by analyzing the data, the threshold voltage shows a negative shift at first and then turns to positive shift when irradiation dose is lower. Additionally, the influence of the dose rate effects on threshold voltage is discussed. The research results show that the threshold voltage shift is more significant in low dose rate conditions, even for a low dose of 100 krad(Si). The degeneration value of threshold voltage is 23.4 % and 58.0 % for the front-gate and the back-gate at the low dose rate, respectively.
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- 2016
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41. Influence of Calcium Sulfate Varieties on Properties of Calcium Aluminate Cement-Based Self-Leveling Mortars
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Dai, Hao, Zhang, Shu Peng, Ju, Cheng Lan, and Li, Dong Xu
- Abstract
The effect of calcium sulfates varieties on the properties of calcium aluminate cement-based self-leveling mortar have been investigated, and the hydration kinetics, hydrated products and microstructures are characterized by isothermal calorimeter, X-ray diffraction and mercury intrusion porosimetry, respectively. The results show that the technological properties of mortars are significantly affected by calcium sulfate varieties and content. The setting times are shortened drastically with the addition of calcium sulfates. Mortars with hemihydrate show higher early strength and less drying shrinkage. In contrast, using anhydrite in mortars cause lower strength and higher drying shrinkage at early age but larger growth of strength in the late. The increasing calcium sulfates content may result in the delay of main hydration peak in the heat evolution curve. For formulation with hemihydrate, the appearance of main hydration peaks are advanced compared with formulation without addition of calcium sulfates. Moreover, mortar microstructures are optimized by addition of β-hemihydrate, the proportion of large pores are lower than that of mortars with anhydrite.
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- 2016
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42. Drag-reduction behavior of an unusual nonionic surfactant in a circular pipe turbulent flow.
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CAI, Shu-peng and HIGUCHI, Yuta
- Abstract
The Alkyl Polyglucoside (APG) is a nonionic surfactant with no toxicity and with high biodegradability, its drag-reduction behavior in a circular pipe flow is measured, and the rheological characteristics are investigated with a rheometer with a cone-plate flow cell. From the measured results, the APG is shown to have a high drag-reduction capacity, whose shear viscosity is shear-ratedependent at high concentrations, while its solution at concentrations with drag-reduction effects is non-viscoelastic as verified by zero relaxation time in the relaxation process of the shear stress, which contradicts the general viewpoint that there is a correlation between the viscoselastic characteristics and the turbulent drag reduction for the drag-reduction surfactant. However, the APG solution is birefringent as observed through a birefringent test, which indicates that there are rod-shaped micelles in the solution under the shearing flow. The higher extensional viscosity inferred from the extensional phenomenon observed in the measurements of the shear viscosity could be responsible for the drag reduction property of this nonionic surfactant. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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43. Influence of bearing process parameters on vibration of centrifugal pump
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Sun, Tao, Shu, Peng, Yu, Qingrui, Liu, Songge, and Li, Ling
- Abstract
The safety and comfort of the ship can be affected by the vibration of pumps, which is introduced by the interaction between structure and fluid during the running of pumps. It is necessary to investigate the vibration of pumps; however, there are few existing papers regarding the effect of process parameters on the vibration characteristics of pumps. Considering bearing process parameters, a dynamic virtual prototype model is presented in this paper. The model takes the bearing clearance and preload force of deep groove ball bearings as key parameters to study the vibration of a type of centrifugal pump. It is concluded that the pump vibration does not decrease continuously with increasing bearing preload. The vibration characteristics of the pump can be effectively improved by reasonable adjustment of these two parameters. The experimental results obtained in the test rig show an agreement with model calculation. By choosing the optimal bearing clearance and preload, the peak at the shaft frequency can be reduced by 7.95 dB.
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- 2022
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44. Effect of Hydrogen on Conductivity of Metals
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Larionov, Vitalii V., Xu, Shu Peng, Shi, Kun, and Kroning, Michael X.
- Abstract
The work considers the application of a magnetic spectrometer (MS) for analyzing the hydrogenation of metals (particularly, titanium and copper). Therefore, for the sake of increasing the sensitivity of the magnetic spectrometer, the following ratios are introduced: (ΔU/U)/(Δd/d) (where ΔU/U is the relative change of the MS signal and Δd/d is the relative change in the thickness of a sample), (ΔU/U)/(Δδ/δ) (where Δδ/δ is the relative change in the depth of eddy current penetration into metal) and (ΔU/U)/(ΔS/S) (where ΔS/S is the relative change in the area of sample). These parameters allow to eliminate or reduce the error in determining the conductivity value. Parameter β that is equal to the product of the sample area and the inverse value of eddy current penetration depth into metal corresponds to the effectiveness of the current penetration into metal. The authors derived a formula that ties the electric conductivity of metal to the number of implanted hydrogen atoms, which allows determining the composition of titanium hydride at different depth of metal.
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- 2015
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45. Analysis of travelling wave vibration response for thin rotating cylindrical shell.
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SUN Shu-peng, CAO Deng-qing, and CHU Shi-ming
- Subjects
TRAVELING waves (Physics) ,BOUNDARY value problems ,DIFFERENTIAL equations ,HAMILTON'S equations ,VIBRATION (Mechanics) ,MATHEMATICAL models - Abstract
Response to travelling wave vibration of thin rotating cylindrical shells with various boundary conditions is investigated. Based on Sanders' shell theory, the differential equations of vibration of the thin rotating cylindrical shells taken into account the effects of centrifugal and Coriolis forces as well as the initial hoop tension due to rotating are established using Hamilton's principle. Beam modal function satisfying the required end-conditions at both ends has been used to express the axial modal function of the thin cylindrical shell with similar boundary conditions approximately. Then, through the process of formula derivation, the general solution of the displacement response which is caused by travelling wave vibration is derived. Finally, the general solution obtained is applied to investigate the vibration characteristics of a clamped--clamped thin rotating cylindrical shell subjected to a harmonic point load and a constant one in the transverse direction, and the results are discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2013
46. The Effect of Air Injection Method on the Airlift Pump Performance.
- Author
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Dong Hu, Chuan-Lin Tang, Shu-Peng Cai, and Feng-Hua Zhang
- Subjects
AIR injection systems (Engines) ,FLUID dynamics ,MULTIPHASE flow ,BERNOULLI effect (Fluid dynamics) ,PUMPING machinery - Abstract
With simple structure, excellent reliability, low cost, no restriction at depth of water, and easy control and operation, airlift pumps have special advantage in borehole hydraulic jet mining, river dredging and deep sea mining. To clarify the mechanism and process of action of air injection methods on air lift performance, and to enhance lifting capacity, the pump performance of a small airlift system in transporting river sands is investigated experimentally in the present study. The results are as the follows. The influences of air exit ports on water volume flow rate, mass flow rate of solids and lifting efficiency are studied and found to be very low when the number of air exit ports exceeds 3. The pump design show best pumping capability for water and solids at higher air flow rates, but the lifting efficiency is then very low. In addition, a dimensionless equation which describes the flows in the pipe is presented based on the Bernoulli equation, and compared with measurement results in the dimensionless form, which are nearly in good agreement with each other for all the arrangements of air exit ports and are basically contained within ±18% of the theoretical curve. The results are important for understanding the mechanism of airlift pumps and enriching multiphase flow theory. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
47. Automatic Measurement of Central Cornea Thickness of Eye Anterior Segment Optical Coherence Tomography Image.
- Author
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SHU Peng, SUN Yan-kui, and TIAN Xiao-lin
- Published
- 2012
- Full Text
- View/download PDF
48. Drag Reduction of a Cationic Surfactant Solution and Its Shear Stress Relaxation.
- Author
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Cai, Shu-peng
- Abstract
In order to study the mechanisms of the turbulent frictional drag reduction by surfactant additives, the drag reduction, the shear viscosity and the shear stress relaxation were measured for solutions of a cationic surfactant cetyltrimethyl ammonium bromide (CTAB) with the same molar sodium salicylate as a counter-ion. It is found that the first step relaxation time decreases with increasing concentration and, thus, with the maximum drag-reducing rates, which indicates that the stiffness of the micellar structures with the first relaxation time, increases with the increase of the concentration of CTAB. Furthermore, for this surfactant, a viscoelastic property is necessary for reducing drag, while a stronger viscoelasticity characterized by a tail relaxation time does not necessarily mean a higher drag-reducing rate. [ABSTRACT FROM AUTHOR]
- Published
- 2012
- Full Text
- View/download PDF
49. Design Considerations of Step-Down Switching Converters.
- Author
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Jian, Xue, Xiao-Qing, Zhang, Xin, Liu, and Shu-Peng, Li
- Abstract
Abstract: To obtain the design method of inductance and capacitance of a step-down switching converter, its Output Voltage Ripple (OVR) in CCM and DCM is analyzed. The Maximum OVR(MOVR) in each operating region is obtained, respectively. It is pointed out that the minimum inductance to guarantee the lowest OVR is the critical inductance of CCM and DCM under the highest input voltage and heaviest load. The design method of inductance and capacitance is proposed according to the desired OVR level within the total operating range. The analysis and feasibility of the proposed method are verified by the experiment results. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
50. Effects of high-and low temperature stress on the leaf PSII functions and physiological characteristics of tree peony (Paeonia suffruticosa cv. 'Roufurong'.
- Author
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Iu Chun-Ying, Chen Da-Yin, Gai Shu-Peng, Zhang Yu-Xi, and Zheng Guo-sheng
- Abstract
Taking the detached leaves of tree peony (Paeonia suffruticosa cv. 'Roufurong') as test materials, this paper studied the effects of high temperature (40 °C) and low temperature (15 °C) stresses on the PS II functions and physiological characteristics of peony leaves under strong light in tensity (1400 μmol·m
-2 ·s-1 ), with 25 °C as the control. With the increasing time of highand low temperature stress, the maximal photochemical efficiency (Fv / Fm ), actual quantum yield of photosystem II(ΦPS II ), and efficiency of excitation capture of open PS II center (Fv ′/ Fm ′) all decreased continuously. After recovered in the dark for 4 hours, the Fv / Fm in treatments 15 °C and 25 °C quickly recovered, but that in treatment 40 °C only recovered to 75. 5% of nontreatment, even if the leaves were treated in the dark for 15 hours. At 40 °C, the balance of excited energy be tween PS I and PS II under strong light intensity was perturbed seriously. Treatment 40 °C inhibited the superoxide dismutase (SOD) activity, enhanced the production of O2 - . -, H2 O2 , and MDA, and reduced the contents of chlorophyll and soluble protein. This study revealed that strong light combined with high temperature impaired the photosynthetic apparatus of the tree peony irreversibly, whereas strong light plus low temperature had weaker impact. [ABSTRACT FROM AUTHOR]- Published
- 2012
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