1. ICPBCZin: A red emitting ratiometric fluorescent indicator with nanomolar affinity for Zn2+ ions.
- Author
-
Roussakis, Emmanuel, Voutsadaki, Styliani, Pinakoulaki, Eftychia, Sideris, Dionisia P., Tokatlidis, Kostas, and Katerinopoulos, Haralambos E.
- Subjects
FLUORESCENCE spectroscopy ,ZINC compounds ,BENZIMIDAZOLES ,FLUORIMETRY ,WAVELENGTHS ,CHARGE exchange - Abstract
Summary: A new fluorescent Zn
2+ indicator, namely, ICPBCZin was synthesized and the spectral profile of its free and Zn2+ bound forms was studied. The newly synthesized zinc indicator incorporates as chromophore the chromeno [3′,2′:3,4]pyrido[1,2a] [1,3]benzimidazole moiety and belongs to the dicarboxylate-type of zinc probes. The compound is excited with visible light, exhibits high selectivity for zinc in the presence of calcium and other common biological ions, and its Zn2+ dissociation constant is 4.0nM. Fluorescence spectra studies of ICPBCZin indicated a clear shift in its emission wavelength maxima upon Zn2+ binding, as it belongs to the class of Photoinduced Charge Transfer (PCT) indicators, along with changes in fluorescence intensity that enable the compound to be used as a ratiometric, visible-excitable Zn2+ probe. [Copyright &y& Elsevier]- Published
- 2008
- Full Text
- View/download PDF