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2. Reconstitution of the latent T-lymphocyte response to Epstein-Barr virus is coincident with long-term recovery from posttransplant lymphoma after adoptive immunotherapy

Author

Sherritt, Martina A., Bharadwaj, Mandvi, Burrows, Jacqueline M., Morrison, Leanne E., Elliott, Suzanne L., Davis, Joanne E., Kear, Laurie M., Slaughter, Richard E., Bell, Scott C., Galbraith, Andrew J., Khanna, Rajiv, and Moss, Denis J.

Abstract

Adoptive transfer of Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes (CTLs) has been used to treat EBV-induced posttransplant lymphoproliferative disease (PTLD) in solid-organ recipients. This study defines, in detail, the temporal relationship between adoptive transfer and the clinical response, EBV DNA load, and CTL response to EBV latent and lytic antigens in a patient with a subcutaneous PTLD presentation treated with adoptive transfer of autologous CTL.

Published
2003
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