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8 results on '"Soleto, Irene"'

1. CARACTERIZACIÓN PROTEÓMICA DE LAS VESÍCULAS EXTRACELULARES SÉRICAS DE PACIENTES RECIÉN DIAGNOSTICADOS DE ENFERMEDAD INFLAMATORIA INTESTINAL

Author

Soleto, Irene, Baldan-Martín, Montse, Ramirez, Cristina, Orejudo, Macarena, García, Sara, Mercado, Jorge, Azkargorta, Mikel, Iloro, Ibon, Moreno, Lorena Ortega, Garcia, Laila Aldars, Riestra, Sabino, Rivero, Montserrat, Gutierrez, Ana, Rodríguez-Lago, Iago, Fernández, Luis, Ceballos, Daniel, Benitez, Jose Manuel, Aguas, Mariam, Rey, Iria Bastón, Bermejo, Fernando, Casanova, Maria Jose, Llorente, Rufo, Ber, Yolanda, Ginard, Daniel, Esteve, Maria, Elortza, Felix, Gisbert, Javier P, Martín-Cofreces, Noa, and Chaparro, Maria

Published
2023
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3. 66 - EL ANÁLISIS DEL TEJIDO INTESTINAL DE PACIENTES RECIÉN DIAGNOSTICADOS DE ENFERMEDAD INFLAMATORIA INTESTINAL REVELA PERFILES PROTEÓMICOS ESPECÍFICOS

Author

Baldán-Martín, Montse, Iloro, Ibon, Azkargorta, Mikel, Ramirez, Cristina, Soleto, Irene, Orejudo, Macarena, Mercado, Jorge, Gordillo, Carlos H., Riestra, Sabino, Rivero, Montserrat, Gutiérrez, Ana, Rodríguez-Lago, Iago, Fernández-Salazar, Luis, Ceballos, Daniel, Benítez, José Manuel, Aguas, Mariam, Bastón-Rey, Iria, Bermejo, Fernando, Casanova, María José, Lorente, Rufo, Ber, Yolanda, Royo, Vanesa, Esteve, María, Elortza, Félix, Gisbert, Javier P., and Chaparro, María

Published
2023
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4. 54 - CARACTERIZACIÓN DE LA MICROBIOTA FECAL EN PACIENTES CON ENFERMEDAD INFLAMATORIA INTESTINAL DE RECIENTE DIAGNÓSTICO MEDIANTE UN ABORDAJE METAGENÓMICO SHOTGUN

Author

del Río, Macarena Orejudo, Baldán-Martín, Montse, Soleto, Irene, Ramirez, Cristina, Mercado, Jorge, Riestra, Sabino, Rivero, Montserrat, Gutiérrez, Ana, Rodríguez-Lago, Iago, Fernández, Luis, Ceballos, Daniel, Benítez, José Manuel, Aguas, Mariam, Bastón-Rey, Iria, Bermejo, Fernando, Casanova, María José, Lorente, Rufo, Ber, Yolanda, Ginard, Daniel, Esteve, María, Gisbert, Javier P., and Chaparro, María

Published
2023
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5. 62 - EFECTO EX VIVODE INFLIXIMAB EN LOS NIVELES DE EXPRESIÓN DE LOS LONG NON-CODINGRNAS EN LA ENFERMEDAD DE CROHN

Author

Baldán-Martín, Montse, de Célix, Cristina Rubín, Orejudo, Macarena, Ortega, Lorena, Tomé, Samuel Fernández, Soleto, Irene, Ramirez, Cristina, Arroyo, Ricardo, Fernández, Paloma, Santander, Cecilio, Moreno-Monteagudo, José Andrés, Casanova, María José, Casals, Fernando, Casabona, Sergio, Becerro, Irene, Marigorta, Urko M., Aransay, Ana M., Bernardo, David, Chaparro, María, and Gisbert, Javier P.

Published
2023
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7. 50 - IDENTIFICACIÓN DE BIOMARCADORES DIAGNÓSTICOS DE LA ENFERMEDAD INFLAMATORIA INTESTINAL EN SUERO Y ORINA MEDIANTE UN ABORDAJE PROTEÓMICO

Author

Baldán-Martín, Montse, Azkargorta, Mikel, Iloro, Ibon, Soleto, Irene, Orejudo, Macarena, Ramirez, Cristina, Mercado, Jorge, Riestra, Sabino, Rivero, Montserrat, Gutiérrez, Ana, Rodríguez-Lago, Iago, Fernández-Salazar, Luis, Ceballos, Daniel, Benítez, José Manuel, Aguas, Mariam, Bastón-Rey, Iria, Bermejo, Fernando, Casanova, María José, Lorente, Rufo, Ber, Yolanda, Royo, Vanesa, Esteve, María, Elortza, Félix, Gisbert, Javier P., and Chaparro, María

Published
2023
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8. Teleost IgD+IgM−B Cells Mount Clonally Expanded and Mildly Mutated Intestinal IgD Responses in the Absence of Lymphoid Follicles

Author

Perdiguero, Pedro, Martín-Martín, Alba, Benedicenti, Ottavia, Díaz-Rosales, Patricia, Morel, Esther, Muñoz-Atienza, Estefanía, García-Flores, Mónica, Simón, Rocío, Soleto, Irene, Cerutti, Andrea, and Tafalla, Carolina

Abstract

Immunoglobulin D (IgD) is an ancient antibody with dual membrane-bound and fluid-phase antigen receptor functions. The biology of secreted IgD remains elusive. Here, we demonstrate that teleost IgD+IgM−plasmablasts constitute a major lymphocyte population in some mucosal surfaces, including the gut mucosa. Remarkably, secreted IgD binds to gut commensal bacteria, which in turn stimulate IgD gene transcription in gut B cells. Accordingly, secreted IgD from gut as well as gill mucosae, but not the spleen, show a V(D)J gene configuration consistent with microbiota-driven clonal expansion and diversification, including mild somatic hypermutation. By showing that secreted IgD establishes a mutualistic relationship with commensals, our findings suggest that secreted IgD may play an evolutionary conserved role in mucosal homeostasis.

Published
2019
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