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This article describes 313 healthcare providers in Colorado who were exposed to patients with monkeypox and had low rates of personal protective equipment use and postexposure prophylaxis vaccination. Despite this, through 21 days of follow-up, none of the healthcare providers had acquired monkeypox infection, suggesting the risk for acquiring monkeypox among U.S. healthcare providers is very low. This is reassuring data for organ procurement teams who are exposed to potential organ donors with possible monkeypox infection or undiagnosed skin lesions.

This article describes 313 healthcare providers in Colorado who were exposed to patients with monkeypox and had low rates of personal protective equipment use and postexposure prophylaxis vaccination. Despite this, through 21 days of follow‐up, none of the healthcare providers had acquired monkeypox infection, suggesting the risk for acquiring monkeypox among U.S. healthcare providers is very low. This is reassuring data for organ procurement teams who are exposed to potential organ donors with possible monkeypox infection or undiagnosed skin lesions.