88 results on '"Spring, David R."'
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2. Identification of macrocyclic peptides which activate bacterial cylindrical proteasesElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00136a
3. Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5–6-mer) Peptides.
4. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of actionElectronic supplementary information (ESI) available: All data supporting this study are included in the paper and provided as ESI accompanying this paper at the journal's website. See DOI: https://doi.org/10.1039/d2md00161f
5. Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5–6-mer) Peptides
6. Selective Aurora A-TPX2 Interaction Inhibitors Have In VivoEfficacy as Targeted Antimitotic Agents
7. Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules
8. Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells.
9. Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells
10. Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design
11. Strategies for the Diversity-Oriented Synthesis of Macrocycles.
12. Spirocycles as Rigidified sp3‑Rich Scaffolds for a Fragment Collection.
13. Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.
14. Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1'-Biphenyl-2,2',6,6'-tetrol.
15. Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa.
16. Spirocycles as Rigidified sp3-Rich Scaffolds for a Fragment Collection
17. Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides
18. Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.
19. Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone
20. Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa
21. Multiple‐parameter Optimization in Drug Discovery: Example of the 5‐HT1B GPCR
22. Bioinspired Total Synthesis of Bussealin E.
23. Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut-Currier Reaction.
24. The Useof Chlorobenzene as a Probe Molecule in MolecularDynamics Simulations.
25. How DiverseAre Diversity Assessment Methods? A ComparativeAnalysis and Benchmarking of Molecular Descriptor Space.
26. Concise Copper-Catalyzed Synthesis of Tricyclic Biaryl Ether-Linked Aza-Heterocyclic Ring Systems.
27. The Application of Ligand-Mapping Molecular Dynamics Simulations to the Rational Design of Peptidic Modulators of Protein–Protein Interactions
28. Ligand Binding Kinetics of the Quorum Sensing Regulator PqsR.
29. A Lysosome-Targetable Fluorescent Probe for Imaging Hydrogen Sulfide in Living Cells.
30. Quorum Sensing in Gram-Negative Bacteria: Small-Molecule Modulation of AHL and AI-2 Quorum Sensing Pathways.
31. Microwave-assisted preparation of the quorum-sensing molecule 2-heptyl-3-hydroxy-4(1H)-quinolone and structurally related analogs
32. A Concise Total Synthesis of Deoxyschizandrin and Exploration of Its Antiproliferative Effects and those of Structurally Related Derivatives
33. Aryl–Aryl Bond Formation by the Fluoride‐Free Cross‐Coupling of Aryldisiloxanes with Aryl Bromides
34. Fluorescent Sensing and Discrimination of ATP and ADP Based on a Unique Sandwich Assembly of Pyrene-Adenine-Pyrene
35. Rational Methods for the Selection of Diverse Screening Compounds
36. Novel and Efficient Copper‐Catalysed Synthesis of Nitrogen‐Linked Medium‐Ring Biaryls
37. Induction‐Driven Stabilization of the Anion–π Interaction in Electron‐Rich Aromatics as the Key to Fluoride Inclusion in Imidazolium‐Cage Receptors
38. Is synthesis the main hurdle for the generation of diversity in compound libraries for screening?
39. Variations on a Theme: Diverse N-Acyl Homoserine Lactone-Mediated Quorum Sensing Mechanisms in Gram-Negative Bacteria
40. The oxidation of organocuprates—an offbeat strategy for synthesis
41. Synthesis of Medium-Ring and Iodinated Biaryl Compounds by Organocuprate Oxidation
42. Synthesis of Medium-Ring and Iodinated Biaryl Compounds by Organocuprate OxidationWe gratefully acknowledge financial support from the EPSRC and GSK (D.S.S.), Cambridge Trusts (X.S.), Pfizer UK (V.F.), and the BBSRC. We would also like to acknowledge the EPSRC National Mass Spectrometry Service Centre, Swansea, UK, for providing mass-spectrometric analysis.
43. Chemical genetics to chemical genomics: small molecules offer big insights
44. Studies on the Biomimetic Synthesis of the Manzamine Alkaloids
45. A novel Diels-Alder approach to hydroisoquinolines
46. Discrimination of Linguistic Stress in Early Infancy
47. Erzeugung einer Molekülbibliothek mit außergewöhnlicher Gerüstdiversität
48. Synthesis of Unprecedented Scaffold Diversity
49. Copper catalyzed oxidation of organozinc halidesElectronic supplementary information (ESI) available: Full experimental details, characterization and spectra of key compounds. See DOI: 10.1039/b610218b
50. Skeletal diversity construction viaa branching synthetic strategyElectronic supplementary information (ESI) available: Full experimental details, characterization and spectra of key compounds. See DOI: 10.1039/b607710bThe HTML version of this article has been enhanced with colour images.
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