89 results on '"White, Julia"'
Search Results
2. Printed Low-Cost PEDOT:PSS/PVA Polymer Composite for Radiation Sterilization Monitoring.
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Heredia Rivera, Ulisses, Kadian, Sachin, Nejati, Sina, White, Julia, Sedaghat, Sotoudeh, Mutlu, Zeynep, and Rahimi, Rahim
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- 2022
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3. Randomized Phase III Trial Evaluating Radiation Following Surgical Excision for Good-Risk Ductal Carcinoma In Situ: Long-Term Report From NRG Oncology/RTOG 9804.
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McCormick, Beryl, Winter, Kathryn A, Woodward, Wendy, Kuerer, Henry M, Sneige, Nour, Rakovitch, Eileen, Smith, Barbara L, Germain, Isabelle, Hartford, Alan C, O'Rourke, Mark A, Walker, Eleanor M, Strom, Eric A, Hopkins, Judith O, Pierce, Lori J, Pu, Anthony T, Sumida, Kenneth N M, Vesprini, Danny, Moughan, Jennifer, and White, Julia R
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- 2021
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4. Updated Standardized Definitions for Efficacy End Points (STEEP) in Adjuvant Breast Cancer Clinical Trials: STEEP Version 2.0.
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Tolaney, Sara M, Garrett-Mayer, Elizabeth, White, Julia, Blinder, Victoria S, Foster, Jared C, Amiri-Kordestani, Laleh, Hwang, E Shelley, Bliss, Judith M, Rakovitch, Eileen, Perlmutter, Jane, Spears, Patricia A, Frank, Elizabeth, Tung, Nadine M, Elias, Anthony D, Cameron, David, Denduluri, Neelima, Best, Ana F, DiLeo, Angelo, Baizer, Lawrence, and Butler, Lynn Pearson
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- 2021
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5. Catchment‐scale urbanization diminishes effects of habitat complexity on instream macroinvertebrate assemblages.
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White, Julia Y. and Walsh, Christopher J.
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URBAN runoff ,WATERSHEDS ,SPECIES pools ,HABITATS ,URBANIZATION - Abstract
While provision of in‐stream habitat complexity remains common practice in efforts to restore streams, the evidence of positive effects on in‐stream communities is inconsistent. In streams of urban catchments, where both reach‐scale habitat manipulation and catchment‐scale actions to ameliorate the disturbance regime of urban stormwater runoff are common management responses, clearer understanding of the effects of habitat complexity under different degrees of urban impact are needed. We experimentally assessed the effect of increased surface complexity in wood, the dominant hard substrate in our 18 study reaches on 14 small streams, on in‐stream macroinvertebrate assemblages across a range of urban impact. Increased surface complexity increased abundance of most taxa, but this effect was less pronounced in urban streams, partly because of the reduced species pool tolerant of urban stormwater impacts, and partly because of a lesser response of some species to increased complexity in more urban streams. Collectively these taxon‐specific effects resulted in small, uncertain increases in taxon richness with increased complexity in rural streams, and no change in richness of the less diverse assemblages of urban streams. Increased abundances suggest increased availability of refugia or resources with increased surface complexity, while the reduced effect of complexity in urban streams suggests that any refuge or resource provided by greater surface complexity is less effective in more disturbed environments receiving urban stormwater runoff. The reduced abundance of sensitive taxa in more urban streams, and the resultant reduced richness, confirms that urban stormwater runoff acts as a strong environmental filter, limiting the species pool available for community assembly. Restoration of habitat complexity in streams without catchment‐scale drivers of degradation is likely to have positive benefits to in‐stream biotic assemblages, but the efficacy of such approaches in catchments subject to urban stormwater runoff will be greatly diminished. In such cases, restoration activities should first be aimed at controlling the larger‐scale problem. [ABSTRACT FROM AUTHOR]
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- 2020
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6. Evaluation of Safety of Stereotactic Body Radiotherapy for the Treatment of Patients With Multiple Metastases: Findings From the NRG-BR001 Phase 1 Trial
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Chmura, Steve, Winter, Kathryn A., Robinson, Clifford, Pisansky, Thomas M., Borges, Virginia, Al-Hallaq, Hania, Matuszak, Martha, Park, Sean S., Yi, Sun, Hasan, Yasmin, Bazan, Jose, Wong, Philip, Yoon, Harold A., Horton, Janet, Gan, Gregory, Milano, Michael T., Sigurdson, Elin Ruth, Moughan, Jennifer, Salama, Joseph K., and White, Julia
- Abstract
IMPORTANCE: Stereotactic body radiotherapy (SBRT) for oligometastases is hypothesized to improve survival and is increasingly used. Little evidence supports its safe use to treat patients with multiple metastases. OBJECTIVE: To establish safety of SBRT dose schedules in patients with 3 to 4 metastases or 2 metastases in close proximity to each other. DESIGN, SETTING, AND PARTICIPANTS: This phase 1 trial opened on August 4, 2014, and closed to accrual on March 20, 2018. Metastases to 7 anatomic locations were included: bone/osseous (BO), spinal/paraspinal (SP), peripheral lung (PL), central lung (CL), abdominal-pelvic (AP), mediastinal/cervical lymph node (MC), and liver (L). Six patients could be enrolled per anatomic site. The setting was a consortium of North American academic and community practice cancer centers participating in NRG Oncology trials. Patients with breast, prostate, or non–small cell lung cancer with 3 to 4 metastases or 2 metastases in close proximity (≤5 cm) amenable to SBRT were eligible for this phase 1 study. Statistical analyses were performed from December 31, 2017, to September 19, 2019. INTERVENTIONS: The starting dose was 50 Gy in 5 fractions (CL, MC), 45 Gy in 3 fractions (PL, AP, L), and 30 Gy in 3 fractions (BO, SP). MAIN OUTCOMES AND MEASURES: The primary end point was dose-limiting toxicity (DLT) defined by the Common Terminology Criteria for Adverse Events, version 4.0, as specific adverse events (AEs) of grades 3 to 5 (definite or probable per the protocol DLT definition) related to SBRT within 180 days of treatment. Dose levels were considered safe if DLTs were observed in no more than 1 of 6 patients per location; otherwise, the dose at that location would be de-escalated. RESULTS: A total of 42 patients enrolled, 39 were eligible, and 35 (mean [SD] age, 63.1 [14.2] years; 20 men [57.1%]; 30 White patients [85.7%]) were evaluable for DLT. Twelve patients (34.3%) had breast cancer, 10 (28.6%) had non–small cell lung cancer, and 13 (37.1%) had prostate cancer; there was a median of 3 metastases treated per patient. Median survival was not reached. No protocol-defined DLTs were observed. When examining all AEs, 8 instances of grade 3 AEs, most likely related to protocol therapy, occurred approximately 125 to 556 days from SBRT initiation in 7 patients. CONCLUSIONS AND RELEVANCE: This phase 1 trial demonstrated the safety of SBRT for patients with 3 to 4 metastases or 2 metastases in close proximity. There were no treatment-related deaths. Late grade 3 AEs demonstrate the need for extended follow-up in long-surviving patients with oligometastatic disease. Treatment with SBRT for multiple metastases has been expanded into multiple ongoing randomized phase 2/3 National Cancer Institute–sponsored trials (NRG-BR002, NRG-LU002). TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02206334
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- 2021
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7. Accelerated Partial Breast Irradiation and Intraoperative Partial Breast Irradiation: Reducing the Burden of Effective Breast Conservation.
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White, Julia, Thompson, Alastair, and Whelan, Timothy
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- 2020
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8. Patterns of Failure Observed in the 2-Step Institution Credentialing Process for NRG Oncology/Radiation Therapy Oncology Group 1005 (NCT01349322) and Lessons Learned.
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Li, X. Allen, Moughan, Jennifer, White, Julia R., Freedman, Gary M., Arthur, Douglas W., Galvin, James, Xiao, Ying, McNulty, Susan, Lyons, Janice A., Kavadi, Vivek S., Fields, Marc T., Mitchell, Melissa P., Anderson, Bethany M., Lock, Michael I., Kokeny, Kristine E., Bazan, Jose G., Currey, Adam D., Hijal, Tarek, Cheston, Sally B., and Vicini, Frank A.
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To investigate patterns of failure in institutional credentialing submissions to NRG/RTOG 1005 with the aim of improving the quality and consistency for future breast cancer protocols. NRG/RTOG 1005 allowed the submission of 3-dimensional conformal radiation therapy (3DCRT), intensity-modulated radiation therapy (IMRT), and simultaneous integrated boost (SIB) breast plans. Credentialing required institutions to pass a 2-step quality assurance (QA) process: (1) benchmark, requiring institutions to create a plan with no unacceptable deviations and ≤1 acceptable variation among the dose volume (DV) criteria, and (2) rapid review, requiring each institution's first protocol submission to have no unacceptable deviations among the DV criteria or contours. Overall rates, number of resubmissions, and reasons for resubmission were analyzed for each QA step. In total, 352 institutions participated in benchmark QA and 280 patients enrolled had rapid review QA. Benchmark initial failure rates were similar for 3DCRT (18%), IMRT (17%), and SIB (18%) plans. For 3DCRT and IMRT benchmark plans, ipsilateral lung most frequently failed the DV criteria, and SIB DV failures were seen most frequently for the heart. Rapid review contour initial failures (35%) were due to target rather than organs at risk. For 29% of the rapid review initial failures, the planning target volume boost eval volume was deemed an unacceptable deviation. The review of the benchmark and rapid review QA submissions indicates that acceptable variations or unacceptable deviations for the ipsilateral lung and heart dose constraints were the most commonly observed cause of benchmark QA failure, and unacceptable deviations in target contouring, rather than normal structure contouring, were the most common cause of rapid review QA failure. These findings suggest that a rigorous QA process is necessary for high quality and homogeneity in radiation therapy in multi-institutional trials of breast cancer to ensure that the benefits of radiation therapy far outweigh the risks. [ABSTRACT FROM AUTHOR]
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- 2020
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9. Reply to J. Widder.
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Chmura, Steven J., Woodward, Wendy A., and White, Julia R.
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- 2023
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10. Use of perioperative neonatology consultation with periviable cervical cerclage placement: a survey of providers nationwide.
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Milone, Gina F., Chang, Jenny, White, Julia Bregand, and Steller, Jonathan
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CERVICAL cerclage ,NEONATOLOGY ,OPERATING room nursing - Published
- 2023
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11. Scheduling Delayed Treatment and Surgeries Post-Pandemic: A Stakeholder Analysis
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Patterson, Emily S., Papautsky, Elizabeth Lerner, Krok-Schoen, Jessica L., Lee, Clara, Park, Ko Un, White, Julia R., Moffatt-Bruce, Susan, Chirumamilla, Varshita, and Lustberg, Maryam
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Many are interested in how to safely ramp up elective surgeries after national, state, and voluntary shutdowns of operating rooms to minimize the spread of COVID-19 infections to patients and providers. We conducted an analysis of diverse perspectives from stakeholders regarding how to trade off risks and benefits to patients, healthcare providers, and the local community. Our findings indicate that there are a large number of different categories of stakeholders impacted by the post-pandemic decisions to reschedule delayed treatments and surgeries. For a delayed surgery, the primary stakeholders are the surgeon with expertise about the clinical benefits of undergoing an operation and the patient’s willingness to tolerate uncertainty and the increased risk of infection. For decisions about how much capacity in the operating rooms and in the inpatient setting after the surgery, the primary considerations are minimizing staff infections, preventing patients from getting COVID-19 during operations and during post-surgical recovery at the hospital, conserving critical resources such as PPE, and meeting the needs of hospital staff for quality of life, such as child care needs and avoiding infecting members of their household. The timing and selection of elective surgery cases has an impact on the ability of hospitals to steward finances, which in turns affects decisions about maintaining employment of staff when operating rooms and inpatient rooms are not being used.
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- 2020
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12. Enclaves of Privilege: Access and Opportunity for Students with Disabilities in Urban K-8 Schools
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Ellis, Jason, Rousmaniere, Kate, Ashby, Christine, White, Julia M, Ferri, Beth, Li, Siqi, and Ashby, Lauren
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Middle grades education has been the object of efforts to remediate US education to address an array of social problems. Districts have sought out K-8 models to create smaller learning communities, require fewer school transitions, and allow sustained student connections. This paper offers a historical analysis of K-8 schools, drawing on statistical and spatial methods and a DisCrit intersectional lens to illustrate how creating K-8 schools produced enclaves of privilege in one urban school district. K-8 schools in our target district became whiter and wealthier than district averages. Students with disabilities attending K-8 schools tended to be placed in more inclusive classrooms, where they were more likely to be integrated alongside nondisabled peers than counterparts attending traditional middle schools. We consider how the configuration of K-8 schools, which could be considered an administrative decision to better serve students, has obscured interworkings of power and privilege.
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- 2020
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13. Prospective Association of Serum Opioid Levels and Clinical Outcomes in Patients With Cancer Pain Treated With Intrathecal Opioid Therapy
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Brogan, Shane E., Sindt, Jill E., Jackman, Carina M., White, Julia, Wilding, Victoria, and Okifuji, Akiko
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- 2020
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14. Effectiveness of Breast-Conserving Surgery and 3-Dimensional Conformal Partial Breast Reirradiation for Recurrence of Breast Cancer in the Ipsilateral Breast: The NRG Oncology/RTOG 1014 Phase 2 Clinical Trial
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Arthur, Douglas W., Winter, Kathryn A., Kuerer, Henry M., Haffty, Bruce, Cuttino, Laurie, Todor, Dorin A., Anne, Pramila Rani, Anderson, Penny, Woodward, Wendy A., McCormick, Beryl, Cheston, Sally, Sahijdak, Walter M., Canaday, Daniel, Brown, Doris R., Currey, Adam, Fisher, Christine M., Jagsi, Reshma, Moughan, Jennifer, and White, Julia R.
- Abstract
IMPORTANCE: Mastectomy is standard for recurrence of breast cancer after breast conservation therapy with whole breast irradiation. The emergence of partial breast irradiation led to consideration of its application for reirradiation after a second lumpectomy for treatment of recurrence of breast cancer in the ipsilateral breast. OBJECTIVES: To assess the effectiveness and adverse effects of partial breast reirradiation after a second lumpectomy and whether the treatment is an acceptable alternative to mastectomy. DESIGN, SETTING, AND PARTICIPANTS: The NRG Oncology/Radiation Therapy Oncology Group 1014 trial is a phase 2, single-arm, prospective clinical trial of 3-dimensional, conformal, external beam partial breast reirradiation after a second lumpectomy for recurrence of breast cancer in the ipsilateral breast after previous whole breast irradiation. The study opened on June 4, 2010, and closed June 18, 2013. Median follow-up was 5.5 years. This analysis used all data received at NRG Oncology through November 18, 2018. Eligible patients experienced a recurrence of breast tumor that was less than 3 cm and unifocal in the ipsilateral breast more than 1 year after breast-conserving therapy with whole breast irradiation and who had undergone excision with negative margins. INTERVENTIONS: Adjuvant partial breast reirradiation, 1.5 Gy twice daily for 30 treatments during 15 days (45 Gy), using a 3-dimensional conformal technique. MAIN OUTCOMES AND MEASURES: The main outcomes of the present study were the predefined secondary study objectives of recurrence of breast cancer in the ipsilateral breast, late adverse events (>1 year after treatment), mastectomy incidence, distant metastasis–free survival, overall survival, and circulating tumor cell incidence. RESULTS: A total of 65 women were enrolled, with 58 evaluable for analysis (mean [SD] age, 65.12 [9.95] years; 48 [83%] white). Of the recurrences of breast cancer in the ipsilateral breast, 23 (40%) were noninvasive and 35 (60%) were invasive. In all 58 patients, 53 (91%) had tumors 2 cm or smaller. All tumors were clinically node negative. A total of 44 patients (76%) tested positive for estrogen receptor, 33 (57%) for progesterone receptor, and 10 (17%) for ERBB2 (formerly HER2 or HER2/neu) overexpression. Four patients had breast cancer recurrence, with a 5-year cumulative incidence of 5% (95% CI, 1%-13%). Seven patients underwent ipsilateral mastectomies for a 5-year cumulative incidence of 10% (95% CI, 4%-20%). Both distant metastasis–free survival and overall survival rates were 95% (95% CI, 85%-98%). Four patients (7%) had grade 3 and none had grade 4 or higher late treatment adverse events. CONCLUSIONS AND RELEVANCE: For patients experiencing recurrence of breast cancer in the ipsilateral breast after lumpectomy and whole breast irradiation, a second breast conservation was achievable in 90%, with a low risk of re-recurrence of cancer in the ipsilateral breast using adjuvant partial breast reirradiation. This finding suggests that this treatment approach is an effective alternative to mastectomy.
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- 2020
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15. Long-term primary results of accelerated partial breast irradiation after breast-conserving surgery for early-stage breast cancer: a randomised, phase 3, equivalence trial
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Vicini, Frank A, Cecchini, Reena S, White, Julia R, Arthur, Douglas W, Julian, Thomas B, Rabinovitch, Rachel A, Kuske, Robert R, Ganz, Patricia A, Parda, David S, Scheier, Michael F, Winter, Kathryn A, Paik, Soonmyung, Kuerer, Henry M, Vallow, Laura A, Pierce, Lori J, Mamounas, Eleftherios P, McCormick, Beryl, Costantino, Joseph P, Bear, Harry D, Germain, Isabelle, Gustafson, Gregory, Grossheim, Linda, Petersen, Ivy A, Hudes, Richard S, Curran, Walter J, Bryant, John L, and Wolmark, Norman
- Abstract
Whole-breast irradiation after breast-conserving surgery for patients with early-stage breast cancer decreases ipsilateral breast-tumour recurrence (IBTR), yielding comparable results to mastectomy. It is unknown whether accelerated partial breast irradiation (APBI) to only the tumour-bearing quadrant, which shortens treatment duration, is equally effective. In our trial, we investigated whether APBI provides equivalent local tumour control after lumpectomy compared with whole-breast irradiation.
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- 2019
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16. Lessons Learned From Hurricane Maria in Puerto Rico: Practical Measures to Mitigate the Impact of a Catastrophic Natural Disaster on Radiation Oncology Patients.
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Gay, Hiram A., Santiago, Roberto, Gil, Betty, Remedios, Carlos, Montes, Pedro J., López-Araujo, Javier, Chévere, Carlos M., Imbert, Winston S., White, Julia, Arthur, Douglas W., Horton, Janet K., Jagsi, Reshma, Rabinovich, Rachel, Beriwal, Sushil, Viswanathan, Akila, Erickson, Beth A., Rengan, Ramesh, Palma, David, Loo, Billy W., and Kavanaugh, James A.
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- 2019
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17. The Fundamental Characteristics of a Translational Scientist.
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Gilliland, C. Taylor, White, Julia, Gee, Barry, Kreeftmeijer-Vegter, Rosan, Bietrix, Florence, Ussi, Anton E., Hajduch, Marian, Kocis, Petr, Nobuyoshi Chiba, Ryutaro Hirasawa, Makoto Suematsu, Bryans, Justin, Newman, Stuart, Hall, Matthew D., and Austin, Christopher P.
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- 2019
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18. Association of antepartum blood pressure levels and angiogenic profile among women with chronic hypertension.
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Minhas, Ruby, Young, Danielle, Naseem, Rabab, Mueller, Ariel, Chinthala, Sireesha, Perdigao, Joana Lopes, Yeo, Kiang-Teck J., Chan, Siaw Li, Tung, Avery, White, Julia Bregand, Shahul, Sajid, and Rana, Sarosh
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BLOOD pressure ,CELL receptors ,ETHNIC groups ,HYPERTENSION ,LONGITUDINAL method ,EVALUATION of medical care ,PREECLAMPSIA ,PREGNANCY ,PILOT projects ,RETROSPECTIVE studies ,CASE-control method ,BLOOD - Abstract
Background: Angiogenic factors have been implicated in the pathogenesis of preeclampsia. This pilot study explored the association between antenatal blood pressure levels and angiogenic biomarkers (sFlt1 and PlGF) among women with chronic hypertension (cHTN).Methods: Blood samples were collected from women with cHTN (with/without superimposed preeclampsia) within 96 h prior to delivery. Subjects were stratified by mean outpatient BP as controlled (cBP < 140/90) or uncontrolled (uBP ≥ 140/90). Descriptive statistics were generated and assessed as appropriate. Logistic regression was employed to assess for adverse pregnancy outcomes between groups.Results: Data from seventy-eight women were analyzed, of which 58 (74.4%) were African American. Fifty-six (71.8%) had cBP and 22 (28.2%) had uBP. Use of antepartum outpatient antihypertensive medications was more frequent in patients with uBP (46.4% vs. 13.6%, p = 0.01). Compared to women with cBP, women with uBP had higher levels of pre-delivery sFlt1 and sFlt1/PlGF ratio (sFlt: 4218.5 vs. 3056.0 pg/ml, p = 0.046; sFlt/PlGF: 62.5 vs. 25.0, p = 0.04). Additionally, more uBP patients had superimposed preeclampsia with severe features (54.6% vs. 25.0%; p = 0.01) and preterm delivery (defined as a gestational age <35 weeks (40.9% vs. 10.7%; p = 0.002)) than cBP patients. In the multivariable model, women with uBP had greater odds of preterm delivery (OR 6.78; p = 0.01), superimposed preeclampsia (OR 3.20; p = 0.03) and preeclampsia with severe features (OR 3.27; p = 0.04) than women with cBP.Conclusion: In women with cHTN, elevated antepartum BP is associated with worsened outcomes and may be associated with abnormal angiogenic profile at delivery. Larger studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]- Published
- 2018
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19. Triboluminescence from Pharmaceutical Formulations.
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Smith, Casey J., Griffin, Scott R., Eakins, Gregory S., Fengyuan Deng, White, Julia K., Thirunahari, Satyanarayana, Ramakrishnan, Srividya, Sangupta, Atanu, Siwei Zhang, Novak, Julie, Zhen Liu, Rhodes, Timothy, and Simpson, Garth J.
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- 2018
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20. Examining the Variability in General Education Placements for Students With Intellectual Disability.
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Cosier, Meghan, White, Julia M., and Wang, Qiu
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INTELLECTUAL disabilities ,EDUCATION of people with intellectual disabilities ,STUDENTS with disabilities ,GENERAL education ,ABILITY grouping (Education) ,INCLUSIVE education - Abstract
Despite the overwhelming body of research suggesting that students with intellectual disability benefit from access to general education placements, students with intellectual disability continue to be educated primarily in segregated settings. Furthermore, the percentage of students with intellectual disability included in general education classrooms varies greatly among and within states across the United States. In an effort to explore such variability in New York State, we examined trends in general education placement rates of students with intellectual disability across districts and possible predictors of placement in regular classes. Results suggest that although descriptive patterns of placement exist, a more definitive explanation of variability requires a deeper analysis of policy and procedure at the district level. [ABSTRACT FROM AUTHOR]
- Published
- 2018
21. Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.
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Luke, Jason J., Lemons, Jeffrey M., Karrison, Theodore G., Pitroda, Sean P., Melotek, James M., Zha, Yuanyuan, Al-Hallaq, Hania A., Arina, Ainhoa, Khodarev, Nikolai N., Janisch, Linda, Chang, Paul, Patel, Jyoti D., Fleming, Gini F., Moroney, John, Sharma, Manish R., White, Julia R., Ratain, Mark J., Gajewski, Thomas F., Weichselbaum, Ralph R., and Chmura, Steven J.
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- 2018
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22. Modernizing Clinical Trial Eligibility Criteria: Recommendations of the American Society of Clinical Oncology-Friends of Cancer Research Brain Metastases Working Group.
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Lin, Nancy U., Prowell, Tatiana, Tan, Antoinette R., Kozak, Marina, Rosen, Oliver, Amiri-Kordestani, Laleh, White, Julia, Joohee Sul, Perkins, Louise, Beal, Katherine, Gaynor, Richard, Kim, Edward S., and Sul, Joohee
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- 2017
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23. Hypertension and patterns of induced labor at term.
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Bregand-White, Julia M., Kominiarek, Michelle A., and Hibbard, Judith U.
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DATABASES ,LABOR (Obstetrics) ,INDUCED labor (Obstetrics) ,LONGITUDINAL method ,PREECLAMPSIA ,DURATION of pregnancy ,RESEARCH funding ,TIME ,RETROSPECTIVE studies - Abstract
Objective: To study patterns of induced labor at term in hypertensive women.Study Design: We performed a retrospective cohort study using the Consortium on Safe Labor database; a multicenter study of labor and delivery practices from electronic medical records in 19 hospitals. 55,572 women were studied: 28,254 nulliparas and 27,318 multiparas, undergoing induction of labor at term without a prior cesarean with a singleton vertex live born fetus. Four hypertensive groups were defined: chronic hypertension (n=1164), gestational hypertension (n=1861), preeclampsia (n=1513) and superimposed preeclampsia (n=655), compared to controls (no hypertension, n=50,379). Labor characteristics and patterns were compared among the groups, stratified by parity.Main Outcome Measures: Interval-censored regression analysis estimated median and 95th% duration of labor, stratified by centimeter-by-centimeter dilation. Repeated-measures analysis established mean labor curves.Results: Time to progress from 4 to 10 cm was 7.5, 6.4, 4.9 and 4.6h in nulliparous women with superimposed preeclampsia, chronic hypertension, preeclampsia and gestational hypertension respectively, which differed from controls (4.9h; p<0.05 for chronic hypertension and superimposed preeclampsia). Multiparous women required 3.8, 3.9, 3.2 and 3.3h, respectively, compared to controls (3.2h, p<0.05 except preeclampsia p=0.1) to progress from 4 to 10cm. Second stage of labor without epidural was longer for all nulliparous groups compared to controls except for women with chronic hypertension, but second stage did not differ in multiparas.Conclusion: Regardless of parity, women with chronic disease, chronic hypertension and superimposed preeclampsia, labor longer whereas those with relatively acute disease, gestational hypertension and preeclampsia, progress more rapidly. [ABSTRACT FROM AUTHOR]- Published
- 2017
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24. Current Landscape of Immunotherapy in Breast Cancer: A Review
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Adams, Sylvia, Gatti-Mays, Margaret E., Kalinsky, Kevin, Korde, Larissa A., Sharon, Elad, Amiri-Kordestani, Laleh, Bear, Harry, McArthur, Heather L., Frank, Elizabeth, Perlmutter, Jane, Page, David B., Vincent, Benjamin, Hayes, Jennifer F., Gulley, James L., Litton, Jennifer K., Hortobagyi, Gabriel N., Chia, Stephen, Krop, Ian, White, Julia, Sparano, Joseph, Disis, Mary L., and Mittendorf, Elizabeth A.
- Abstract
IMPORTANCE: There is tremendous interest in using immunotherapy to treat breast cancer, as evidenced by the more than 290 clinical trials ongoing at the time of this narrative review. The objective of this review is to describe the current status of immunotherapy in breast cancer, highlighting its potential in both early-stage and metastatic disease. OBSERVATIONS: After searching ClinicalTrials.gov on April 24, 2018, and PubMed up to June 30, 2018, to identify breast cancer immunotherapy trials, we found that immune checkpoint blockade (ICB) is the most investigated form of immunotherapy in breast cancer. Use of ICB as monotherapy has achieved objective responses in patients with breast cancer, with higher rates seen when administered in earlier lines of therapy. For responding patients, those responses are durable. More recent data suggest clinical efficacy when ICB is given in combination with chemotherapy. Ongoing studies are evaluating combination strategies pairing ICB with additional chemotherapeutic agents, targeted therapy, vaccines, and local ablative therapies to enhance response. To date, robust predictive biomarkers for response to ICB have not been established. CONCLUSIONS AND RELEVANCE: It is anticipated that combination therapy strategies will be the way forward for immunotherapy in breast cancer, with an improved understanding of tumor, microenvironment, and host factors informing treatment combination decisions. Thoughtful study design incorporating appropriate end points and correlative studies will be critical in identifying optimal strategies for enhancing the immune response against breast tumors.
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- 2019
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25. Iterative Non-Negative Matrix Factorization Filter for Blind Deconvolution in Photon/Ion Counting
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Griffin, Scott R., Biechele-Speziale, John A., Smith, Casey J., You-Dow, Ximeng, White, Julia K., Zhang, Si-Wei, Novak, Julie, Liu, Zhen, and Simpson, Garth J.
- Abstract
A digital filter based on non-negative matrix factorization (NMF) enables blind deconvolution of temporal information from large data sets, simultaneously recovering both photon arrival times and the instrument impulse response function (IRF). In general, the measured digital signals produced by modern analytical instrumentation are convolved by the corresponding IRFs, which can complicate quantitative analyses. Common examples include photon counting (PC), chromatography, super resolution imaging, fluorescence imaging, and mass spectrometry. Scintillation counting, in particular, provides a signal-to-noise advantage in measurements of low intensity signals, but has a limited dynamic range due to pulse overlap. This limitation can complicate the interpretation of data by masking temporal and amplitude information on the underlying detected signal. Typical methods for deconvolution of the photon events require advanced knowledge of the IRF, which is not generally trivial to obtain. In this work, a sliding window approach was developed to perform NMF one pixel at a time on short segments of large (e.g., 25 million point) data sets. Using random initial guesses for the IRF, the NMF filter simultaneously recovered both the deconvolved photon arrival times and the IRF. Applying the NMF filter to the analysis of triboluminescence (TL) data traces of active pharmaceutical ingredients enabled discrimination between different hypothesized physical origins of the signal.
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- 2019
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26. NRG-BR007: A phase III trial evaluating de-escalation of breast radiation (DEBRA) following breast-conserving surgery (BCS) of stage 1, HR+, HER2-, RS ≤18 breast cancer.
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White, Julia R., Cecchini, Reena S., Harris, Eleanor Elizabeth, Mamounas, Eleftherios P., Stover, Daniel G., Ganz, Patricia A., Jagsi, Reshma, Anderson, Stewart J., Bergom, Carmen, Theberge, Valerie, El-Tamer, Mahmoud, Zellars, Richard C., Shumway, Dean Alden, Chen, Guang-Pei, Julian, Thomas B., Wolmark, Norman, and Goodwin, Annabel
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- 2023
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27. Effect of a telephone-based weight loss intervention (WLI) on weight at 12-months in women with early breast cancer: Results from the Breast Cancer Weight Loss (BWEL) trial.
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Ligibel, Jennifer A., Ballman, Karla V., McCall, Linda Mackie, Goodwin, Pamela Jean, Weiss, Anna, Delahanty, Linda, Alfano, Catherine M., Crane, Tracy E, Neuhouser, Marian L., Spears, Patricia, Hershman, Dawn L., Paskett, Electra D., Hopkins, Judith O., Bernstein, Vanessa, Stearns, Vered, White, Julia R., Wadden, Thomas, Winer, Eric P., Partridge, Ann H., and Carey, Lisa A.
- Published
- 2023
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28. Likelihood of unacceptable normal tissue doses in breast cancer patients undergoing regional nodal irradiation in routine clinical practice.
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Bazan, Jose, DiCostanzo, Dominic, Kuhn, Karla, Majithia, Lonika, Quick, Allison, Gupta, Nilendu, and White, Julia
- Abstract
Purpose As indications for regional nodal irradiation (RNI) for breast cancer have expanded, so too has scrutiny over potential late toxicity from radiotherapy. This emphasizes the need for careful radiation treatment planning to maximize the therapeutic ratio. We sought to evaluate how often unacceptable doses (UDs) to organs at risk (OARs) occur and the associated factors for patients receiving RNI in daily practice. Methods and materials Treatment records of patients who received RNI from February 2012 to May 2015 were studied. The NSABP B51/RTOG 1304 clinical dose-volume constraints for targets/OARs receiving RNI were used as the benchmark. Dose-volume histograms were analyzed for the rate of ≥1 UD delivered to the following organs: heart, mean >5 Gy; ipsilateral lung, V20 >35%, V10 >60%, V5 >70%; contralateral lung (CL), V5 >15%; and contralateral breast, V4.1 >5%. Logistic regression was used to test the association between UDs to OAR and key variables. Results Two hundred three consecutive cases received RNI (105 left, 98 right), to the chest wall in 171 (84%) and to the internal mammary nodes in 170 (84%); 77.4% of cases met all OAR constraints. The most common OAR UDs were delivered to the contralateral breast (n = 32, 15.7%) and ipsilateral lung V5 (n = 22, 10.8%). On multivariate analysis, use of intensity modulated radiation therapy (odds ratio [OR], 64.7; 95% confidence interval, 20.8-201.5; P < .001) and use of nodal boost (OR, 5.5; 95% confidence interval, 1.1-27.1; P = .04), but not internal mammary node irradiation (OR, 2.7; P = .35) or reconstruction (OR, 0.62; P = .33), were independently associated with higher OAR UD rate. For 3-dimensional conformal radiation therapy plans, 7.9% had OAR UDs. Conclusion The OAR UD rate with 3-dimensional conformal radiation therapy ± deep inspiration breath-hold in routine clinical practice is low and not independently associated with internal mammary node irradiation or reconstruction presence. Women treated with intensity modulated radiation therapy had a significantly higher overall OAR UD rate, and clinicians should be aware of this as they initiate RNI treatment planning. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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29. Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement.
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Correa, Candace, Harris, Eleanor E., Leonardi, Maria Cristina, Smith, Benjamin D., Taghian, Alphonse G., Thompson, Alastair M., White, Julia, and Harris, Jay R.
- Abstract
Purpose To update the accelerated partial breast irradiation Consensus Statement published in 2009 and provide guidance on use of intraoperative radiation therapy (IORT) for partial breast irradiation in early-stage breast cancer, based on published evidence complemented by expert opinion. Methods and materials A systematic PubMed search using the same terms as the original Consensus Statement yielded 419 articles; 44 articles were selected. The authors synthesized the published evidence and, through a series of conference calls and e-mails, reached consensus regarding the recommendations. Results The new recommendations include lowering the age in the “suitability group” from 60 to 50 years and in the “cautionary group” to 40 years for patients who meet all other elements of suitability (Table 1). Patients with low-risk ductal carcinoma in situ, as per Radiation Therapy Oncology Group 9804 criteria, were categorized in the “suitable” group. The task force agreed to maintain the current criteria based on margin status. Recommendations for the use of IORT for breast cancer patients include: counseling patients regarding the higher risk of ipsilateral breast tumor recurrence with IORT compared with whole breast irradiation; the need for prospective monitoring of long-term local control and toxicity with low-energy radiograph IORT given limited follow-up; and restriction of IORT to women with invasive cancer considered “suitable.” Conclusion These recommendations will provide updated clinical guidance regarding use of accelerated partial breast irradiation for radiation oncologists and other specialists participating in the care of breast cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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30. The Role of Postmastectomy Radiation Therapy in Patients With Breast Cancer Responding to Neoadjuvant Chemotherapy.
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Bazan, Jose G. and White, Julia R.
- Abstract
When surgery is the first line of breast cancer treatment, numerous randomized clinical trials and meta-analyses have demonstrated that postmastectomy radiation therapy (PMRT) improves locoregional control and survival for many women with axillary lymph node–positive disease. In contrast, there are no randomized data regarding the use of PMRT in women who receive neoadjuvant chemotherapy (NAC) first followed by mastectomy. This has led to controversy regarding which patient with breast cancer will benefit from PMRT after NAC, particularly in women with clinically node-positive axillary disease that responds well and is down staged to pathologically negative disease at surgery (ypN0). We review the current evidence on this topic, which forms the underlying basis for the ongoing phase III clinical trial—National Surgical Adjuvant Breast and Bowel Project (NSABP) B51/RTOG 1304—that is examining the role of regional nodal irradiation in patients with clinical N1 disease that responds to NAC and becomes ypN0 at surgery. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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31. A fully automatic framework for evaluating cosmetic results of breast conserving therapy
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Guo, Chenqi, Smith, Tamara L., Feng, Qianli, Benitez-Quiroz, Fabian, Vicini, Frank, Arthur, Douglas, White, Julia, and Martinez, Aleix
- Abstract
The breast cosmetic outcome after breast conserving therapy is essential for evaluating breast treatment and determining patient’s remedy selection. This prompts the need of objective and efficient methods for breast cosmesis evaluations. However, current evaluation methods rely on ratings from a small group of physicians or semi-automated pipelines, making the processes time-consuming and their results inconsistent. To solve the problem, in this study, we proposed: 1. a fully-automaticMachine Learning Breast Cosmetic evaluation algorithm leveraging the state-of-the-art Deep Learning algorithms for breast detection and contour annotation, 2. a novel set of Breast Cosmesis features, 3. a new Breast Cosmetic dataset consisting 3k+ images from three clinical trials with human annotations on both breast components and their cosmesis scores. We show our fully-automatic framework can achieve comparable performance to state-of-the-art without the need of human inputs, leading to a more objective, low-cost and scalable solution for breast cosmetic evaluation in breast cancer treatment.
- Published
- 2022
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32. Inclusive Education National Research Advocacy Agenda: A Call to Action
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Morningstar, Mary E., Allcock, Heather C., White, Julia M., Taub, Deborah, Kurth, Jennifer A., Gonsier-Gerdin, Jean, Ryndak, Diane L., Sauer, Janet, and Jorgensen, Cheryl M.
- Abstract
The TASH Inclusive Education National Committee responded to Horner and Dunlap’s call to ensure that future research integrates inclusive values with strong science by developing an inclusive education national research advocacy agenda. Qualitative methods were implemented to answer three questions: (a) What is the state of inclusive education research? (b) What research still must be done?and (c) What are recommendations for a national inclusive education research advocacy agenda? The findings include 15 areas organized within three domains advocating for continued research across systems-level capacity building, building and classroom capacity, and student learning and development. Implications for research and policy reform are discussed.
- Published
- 2016
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33. Standardization of pathologic evaluation and reporting of postneoadjuvant specimens in clinical trials of breast cancer: recommendations from an international working group
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Provenzano, Elena, Bossuyt, Veerle, Viale, Giuseppe, Cameron, David, Badve, Sunil, Denkert, Carsten, MacGrogan, Gaëtan, Penault-Llorca, Frédérique, Boughey, Judy, Curigliano, Giuseppe, Dixon, J Michael, Esserman, Laura, Fastner, Gerd, Kuehn, Thorsten, Peintinger, Florentia, von Minckwitz, Gunter, White, Julia, Yang, Wei, and Symmans, W Fraser
- Abstract
Neoadjuvant systemic therapy is being used increasingly in the treatment of early-stage breast cancer. Response, in the form of pathological complete response, is a validated and evaluable surrogate end point of survival after neoadjuvant therapy. Thus, pathological complete response has become a primary end point for clinical trials. However, there is a current lack of uniformity in the definition of pathological complete response. A review of standard operating procedures used by 28 major neoadjuvant breast cancer trials and/or 25 sites involved in such trials identified marked variability in specimen handling and histologic reporting. An international working group was convened to develop practical recommendations for the pathologic assessment of residual disease in neoadjuvant clinical trials of breast cancer and information expected from pathology reports. Systematic sampling of areas identified by informed mapping of the specimen and close correlation with radiological findings is preferable to overly exhaustive sampling, and permits taking tissue samples for translational research. Controversial areas are discussed, including measurement of lesion size, reporting of lymphovascular space invasion and the presence of isolated tumor cells in lymph nodes after neoadjuvant therapy, and retesting of markers after treatment. If there has been a pathological complete response, this must be clearly stated, and the presence/absence of residual ductal carcinoma in situmust be described. When there is residual invasive carcinoma, a comment must be made as to the presence/absence of chemotherapy effect in the breast and lymph nodes. The Residual Cancer Burden is the preferred method for quantifying residual disease in neoadjuvant clinical trials in breast cancer; other methods can be included per trial protocols and regional preference. Posttreatment tumor staging using the Tumor–Node–Metastasis system should be included. These recommendations for standardized pathological evaluation and reporting of neoadjuvant breast cancer specimens should improve prognostication for individual patients and allow comparison of treatment outcomes within and across clinical trials.
- Published
- 2015
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34. Standardization of pathologic evaluation and reporting of postneoadjuvant specimens in clinical trials of breast cancer: recommendations from an international working group
- Author
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Provenzano, Elena, Bossuyt, Veerle, Viale, Giuseppe, Cameron, David, Badve, Sunil, Denkert, Carsten, MacGrogan, Gaëtan, Penault-Llorca, Frédérique, Boughey, Judy, Curigliano, Giuseppe, Dixon, J Michael, Esserman, Laura, Fastner, Gerd, Kuehn, Thorsten, Peintinger, Florentia, von Minckwitz, Gunter, White, Julia, Yang, Wei, and Symmans, W Fraser
- Abstract
Neoadjuvant systemic therapy is being used increasingly in the treatment of early-stage breast cancer. Response, in the form of pathological complete response, is a validated and evaluable surrogate end point of survival after neoadjuvant therapy. Thus, pathological complete response has become a primary end point for clinical trials. However, there is a current lack of uniformity in the definition of pathological complete response. A review of standard operating procedures used by 28 major neoadjuvant breast cancer trials and/or 25 sites involved in such trials identified marked variability in specimen handling and histologic reporting. An international working group was convened to develop practical recommendations for the pathologic assessment of residual disease in neoadjuvant clinical trials of breast cancer and information expected from pathology reports. Systematic sampling of areas identified by informed mapping of the specimen and close correlation with radiological findings is preferable to overly exhaustive sampling, and permits taking tissue samples for translational research. Controversial areas are discussed, including measurement of lesion size, reporting of lymphovascular space invasion and the presence of isolated tumor cells in lymph nodes after neoadjuvant therapy, and retesting of markers after treatment. If there has been a pathological complete response, this must be clearly stated, and the presence/absence of residual ductal carcinoma in situ must be described. When there is residual invasive carcinoma, a comment must be made as to the presence/absence of chemotherapy effect in the breast and lymph nodes. The Residual Cancer Burden is the preferred method for quantifying residual disease in neoadjuvant clinical trials in breast cancer; other methods can be included per trial protocols and regional preference. Posttreatment tumor staging using the Tumor–Node–Metastasis system should be included. These recommendations for standardized pathological evaluation and reporting of neoadjuvant breast cancer specimens should improve prognostication for individual patients and allow comparison of treatment outcomes within and across clinical trials.
- Published
- 2015
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35. Promising Practices for Professional Development and School Reform Affecting Students With Complex Instructional Needs: Perceptions of an Expert Panel
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Taub, Deborah A., White, Julia M., and Ryndak, Diane L.
- Abstract
AbstractFederal laws mandate students with disabilities, including students with complex instructional needs (SWCIN), be involved and progress in the general education curriculum and that schools be accountable for continuous and substantial improvement of academic achievement for all students. The limited research on teaching academic content to SWCIN indicates that they achieve more positive outcomes when standards aligned instruction occurs within general education contexts. However, long-term change for instruction in general education contexts typically seems to be personality dependent rather than embedded within a sustainable system. We present content analysis findings of an expert panel concerning one state's initiative to address these issues, organized around four themes: (a) defining inclusive practices, (b) rethinking instruction for SWCIN, (c) rethinking the individualized education program (IEP), and (d) building sustainable inclusive practices across a system. Finally, we extend the panelists' conclusions to provide implications for professional development, practice, policy and administrative procedures, monitoring the quality of services, and research.
- Published
- 2014
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36. Current clinical coverage of Radiation Therapy Oncology Group-defined target volumes for postmastectomy radiation therapy.
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Fontanilla, Hiral P., Woodward, Wendy A., Lindberg, Mary E., Kanke, James E., Arora, Gurpreet, Durbin, Rosalind R., Yu, Tse-Kuan, Zhang, Lifei, Sharp, Hadley J., Strom, Eric A., Salehpour, Mohammad, White, Julia, Buchholz, Thomas A., and Dong, Lei
- Subjects
BREAST cancer treatment ,BREAST surgery ,MASTECTOMY ,RADIOTHERAPY ,DOSAGE forms of drugs - Abstract
Abstract: Purpose: The Radiation Therapy Oncology Group (RTOG) has published consensus guidelines for contouring relevant anatomy for postmastectomy radiation therapy (RT). How these contours relate to current treatment practices is unknown. We analyzed the dose-volume histograms (DVHs) for these contours using current clinical practice at University of Texas MD Anderson Cancer Center and compared them with the proposed treatment plans to treat RTOG-defined targets to full dose. Methods and Materials: We retrospectively analyzed treatment plans for 20 consecutive women treated with postmastectomy RT for which the treatment targets were the chest wall (CW), level III axilla (Ax3), supraclavicular (SCV), and internal mammary (IM) nodes. The RTOG consensus definitions were used to contour the following anatomic structures: CW; level I, II, and III axillary nodes (Ax1, Ax2, Ax3); SCV; IM; and heart (H). DVHs for these contours and the ipsilateral lung were generated from clinically designed treatment that had actually been delivered to each patient. For comparison regarding dose to normal tissue, new treatment plans were generated with the goal of covering 95% of the anatomic contours to 45 Gy. Results: The prescribed dose was 50 Gy in each case. The mean percent of volumes that received 45 Gy (V
45 ) for the RTOG guideline-based contours were CW 74%, Ax1 84%, Ax2 88%, Ax3 96%, SCV 84%, and IM 80%. Mean heart V10 values were 11% for treatment of left-sided tumors and 6% for right-sided tumors. Mean ipsilateral lung V20 values were 28% for left-sided tumors and 34% for right-sided tumors. For the contour-based plans, mean V45 values were CW 94%, Ax1 95%, Ax2 97%, Ax3 98%, SCV 98%, and IM 85%. Mean heart V10 values were 14% for treatment of left-sided tumors and 12% for right-sided tumors. Mean ipsilateral lung V20 values were 32% for left-sided tumors and 45% for right-sided tumors. Conclusions: Clinically derived treatment plans, which have proven efficacy and are the current standard, cover 74% to 96% of the anatomy-based RTOG consensus volumes to the prescription dose. This discrepancy should be considered if treatment planning protocol guidelines are designed to incorporate these new definitions. [Copyright &y& Elsevier]- Published
- 2012
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37. Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains.
- Author
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Chung, Chun-wa, Coste, Hervé, White, Julia H., Mirguet, Olivier, Wilde, Jonathan, Gosmini, Romain L., Delves, Chris, Magny, Sylvie M., Woodward, Robert, Hughes, Stephen A., Boursier, Eric V., Flynn, Helen, Bouillot, Anne M., Bamborough, Paul, Brusq, Jean-Marie G., Gellibert, Françoise J., Jones, Emma J., Riou, Alizon M., Homes, Paul, and Martin, Sandrine L.
- Published
- 2011
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38. Using Disability Studies Theory to Change Disability Services: A Case Study in Student Activism.
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Cory, Rebecca C., White, Julia M., and Stuckey, Zosha
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DISABILITY studies ,SERVICES for people with disabilities ,STUDENT activism - Abstract
In 2001, a group of student activists at Syracuse University started an organization called the Beyond Compliance Coordinating Committee (BCCC). The BCCC activists used disability studies theory to engage the campus in conversations about disability and inform significant change in the way Syracuse administration think about disability. This paper explores what makes Syracuse unique and what happened between 2001 and the present day. It concludes with recommendations for disability services providers on how they can use the experience at Syracuse to inform their thinking about campus culture and services. [ABSTRACT FROM AUTHOR]
- Published
- 2010
39. Using QRRO™ Survey Data to Assess Compliance With Quality Indicators for Breast and Prostate Cancer.
- Author
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Owen, Jean B., White, Julia R., Zelefsky, Michael J., and Wilson, J. Frank
- Abstract
Purpose: Quality Research in Radiation Oncology
™ (QRRO™ ) has embarked on a new national process survey to provide benchmark data that will allow radiation oncologists to assess the quality of care in their own practices by measuring quality indicators (QIs) and comparing individual with national practice. Methods: Investigators at QRRO developed QIs on the basis of nationally recognized, evidence-based guidelines such as those of the National Comprehensive Cancer Network, as well as additional emerging QIs for processes involving rapidly emerging technology. They specifically defined the QIs as clinical performance measures. Published results of the national survey database for patients treated in 1998 and 1999 were reviewed and additional analyses conducted to assess data adequacy to measure compliance with these clinical performance measures. Results: Examples of workup QIs for breast cancer patients showed that 97% underwent diagnostic bilateral mammography, 96% underwent pathology reviews, 83% underwent the determination of estrogen receptor status, 81% underwent the determination of progesterone receptor status, and 31% underwent the determination of human epidermal growth factor receptor 2 status. Compliance with treatment QIs for field recommendations on the basis of nodal findings can be measured. Of patients with prostate cancer, 90% underwent digital rectal examinations, 99% underwent prostate-specific antigen tests, and 99% had their Gleason scores determined. Compliance with QIs on the basis of prognostic group can also be measured. Conclusions: Benchmarking utilization patterns provides a foundation for assessing the appropriateness of cancer care in the future. The QRRO database is a rich data source, and the new survey will provide contemporary benchmark data for these measures. [Copyright &y& Elsevier]- Published
- 2009
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40. American College of Radiology Appropriateness Criteria® on Conservative Surgery and Radiation: Stages I and II Breast Carcinoma.
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White, Julia R., Halberg, Francine E., Rabinovitch, Rachel, Green, Sheryl, Haffty, Bruce G., Solin, Lawrence J., Strom, Eric A., Taylor, Marie E., and Edge, Stephen B.
- Abstract
Background: During the past 2 decades, breast conservation therapy (BCT) has become firmly established as a standard therapeutic approach for eligible women with early-stage breast cancer. Breast radiation after conservative surgery is an integral component of BCT, resulting in comparable local control and equivalent survival to mastectomy. Successful breast conservation relies on understanding key elements for patient selection, evaluation, treatment contraindications, radiation therapy methods, and integration with systemic therapy. Methods: The Appropriateness Criteria Committee of the American College of Radiology convened an expert panel to examine BCT for early-stage breast cancer. By using a modified Delphi technique to generate consensus, the expert panel responded to questionnaires on 9 clinical cases that address various key elements of breast conservation. A literature review on BCT led to the generation of an evidence table to support the consensus and overview. Results: Consensus for appropriateness criteria for BCT was produced for various clinical scenarios commonly encountered in practice. These topics include radiation oncology management issues related to young patient age, sentinel node biopsy, elderly patients, other histology, positive margins, extensive intraductal component, node-positive breast cancer, genetic breast cancer, partial breast irradiation, and systemic therapy. Radiation methods for BCT are reviewed. Conclusion: The Breast Cancer Panel has generated a consensus of up-to-date guidelines for the appropriate use of radiation for BCT by using a modified Delphi process for the American College of Radiology Appropriateness Criteria. [Copyright &y& Elsevier]
- Published
- 2008
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41. Internal Mammary Nodal Irradiation Debate for Node-Positive Breast Cancer—Has the Needle Moved?
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Bazan, Jose G. and White, Julia R.
- Published
- 2022
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42. The Iceman Cometh as Infertility Myth.
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White, Julia
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STORY plots ,DRAMATIC structure ,THEMES in literature ,MYTHOLOGY ,LITERARY characters ,LITERATURE & myth - Abstract
The article discusses the relevance of the theme of the play "The Iceman Cometh," by Eugene O'Neill on the concept of archetype criticism and infertility myth in the U.S. According to the author, archetypal myth is carried out in accordance to god which requires the different rituals to be done in a repeated process to attain transfiguration and life renewal to help dissimilate real life lessons. In addition, the author notes that the play of O'Neill depicts mythodological content which provides a fair distribution of humanity to attain a full understanding on ancient world and religious symbolism. It also offers information on the different symbolism and implications used in the plot of the play as well as it characteristics.
- Published
- 2000
43. Formation and biochemical characterization of tube/pelle death domain complexes: Critical....
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Schiffmann, David A. and White, Julia H.M.
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- 1999
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44. The Prevention of Depression in 8- to 9-Year-Old Children: A Pilot Study
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Rooney, Rosanna, Roberts, Clare, Kane, Robert, Pike, Lisbeth, Winsor, Amber, White, Julia, and Brown, Annette
- Abstract
AbstractThe outcomes of a new universal program aimed at preventing depressive symptoms and disorders in 8- to 9-year-old children are presented. The Positive Thinking Program is a mental health promotion program based on cognitive and behavioural strategies. It is designed to meet the developmental needs of children in the middle primary school Years 4 and 5. Four state primary schools were randomly assigned to receive the program implemented by psychologists or to a control condition involving their regular Health Education curriculum. Seventy-two children participated in the intervention condition and 48 children in the control condition. Children completed measures of depressive and anxiety symptomatology, depressive disorders, and attribution style. The intervention was associated with reductions in depressive symptoms and more positive attributions at post-intervention. Compared to the control group, there was a lower prevalence of depressive disorders at posttest and fewer intervention group children developed a depressive disorder at a 9-month follow-up.
- Published
- 2006
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45. The Prevention of Depression in 8- to 9-Year-Old Children: A Pilot Study
- Author
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Rooney, Rosanna, Roberts, Clare, Kane, Robert, Pike, Lisbeth, Winsor, Amber, White, Julia, and Brown, Annette
- Abstract
The outcomes of a new universal program aimed at preventing depressive symptoms and disorders in 8- to 9-year-old children are presented. The Positive Thinking Program is a mental health promotion program based on cognitive and behavioural strategies. It is designed to meet the developmental needs of children in the middle primary school Years 4 and 5. Four state primary schools were randomly assigned to receive the program implemented by psychologists or to a control condition involving their regular Health Education curriculum. Seventy-two children participated in the intervention condition and 48 children in the control condition. Children completed measures of depressive and anxiety symptomatology, depressive disorders, and attribution style. The intervention was associated with reductions in depressive symptoms and more positive attributions at post-intervention. Compared to the control group, there was a lower prevalence of depressive disorders at posttest and fewer intervention group children developed a depressive disorder at a 9-month follow-up.
- Published
- 2006
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46. New Directions in Radiation for Breast Conserving Therapy in Early Stage Breast Cancer
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White, Julia
- Abstract
Breast conservation therapy is fully accepted as a recommended treatment instead of mastectomy for suitable early stage breast cancer patients. Long term results from the initial randomized trial comparing BCT to mastectomy have demonstrated comparable local control and equivalent survival. The diagnosis and treatment of breast cancer has evolved over the past 2 decades since the randomized trials were initiated. For example, there is now widespread mammography screening, better understanding of breast cancer pathology, and emergence of numerous effective systemic therapy agents. This makes it timely to review the current methods for BCT. This review will focus on the radiation component of BCT, its impact on local cancer control, and how newer radiation technologies may help preserve local control while reducing toxicity and burden of care.
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- 2006
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47. Compliance with breast-conservation standards for patients with early-stage breast carcinoma<FNR HREF="fn1"></FNR><FN ID="fn1">This work was a collaborative effort of the American College of Surgeons Commission on Cancer (Monica Morrow, M.D.,; Susan DesHarnais, Ph.D.; and David P. Winchester, M.D.) and the American College of Radiology Patterns of Care Study (Julia White, M.D.; Jennifer Moughan, M.S.; Jean Owen, Ph.D.; Thomas Pajak, Ph.D.; and J. Frank Wilson, M.D.).</FN>
- Author
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White, Julia, Morrow, Monica, Moughan, Jennifer, Owen, Jean, Pajak, Thomas, DesHarnais, Susan, Winchester, David P., and Wilson, J. Frank
- Abstract
Multiple treatment guidelines and practice standards have been developed regarding the management of patients with breast carcinoma. Few evaluations of the penetration and utility of these practice standards have been performed. In 1992, the American College of Surgeons (ACOS), the American College of Radiology, the College of American Pathologists, and the Society of Surgical Oncology collaborated in establishing standards for breast-conservation treatment (BCT). The authors sought to determine whether practice patterns for patients with breast carcinoma who underwent BCT were consistent with these standards 2 years after their dissemination and to establish whether compliance varied by the same patient and hospital variables that predicted for the amount of BCT performed. A study specific questionnaire was circulated to cancer registrars through the Commission on Cancer of the ACOS asking them to submit reports on patients with Stage I and II breast carcinoma who were diagnosed in 1994. Eight hundred forty-two predominantly community hospitals throughout the United States responded, yielding a total of 16,643 analyzable patients. The frequency of compliance to the 1992 published practice standards for 7097 patients who received BCT was determined. The variation in compliance rates by patient age, race, and insurance status and the treating hospital's geographic locations and cancer programs were evaluated. Of the 22 standards that were evaluated in the areas of preoperative mammography (2 standards), labeling of the surgical specimen (3 standards), pathology report content (10 standards), radiation after lumpectomy (6 standards), and systemic therapy for patients with positive lymph nodes (1 standard), treatment adherence was ≥ 80% for 16 standards (73%). Poor compliance was demonstrated for six standards: the documentation of an abnormality's size in the mammogram report, labeling the lumpectomy specimen with the affected quadrant of the breast, spatial orientation of the lumpectomy specimen and inclusion of lymphatic/vascular invasion, ductal carcinoma in situ, and macroscopic margin assessment in the pathology report. Variation in compliance to a standard occurred frequently across the type of hospital cancer program and geographic region (77% for both), and variation occurred less across the patient variables of age (32%), race (41%), and payer (23%). There was not a pattern of more frequent compliance among variables associated with more BCT use. Large-scale evaluation of the penetration of treatment standards is feasible. For patients who underwent lumpectomy, practice appeared to be consistent (≥ 80% compliance), with 73% of 22 treatment standards evaluated. The standards with poor compliance represent areas for targeted physician education and reevaluation. Significant differences in adherence to a standard were seen frequently based on a hospital's geographic location and type of cancer program. This emphasizes the importance of adequate dissemination of treatment standards to ensure penetration into medical practices of all types.Cancer 2003;97:893904. © 2003 American Cancer Society. DOI 10.1002/cncr.11141
- Published
- 2003
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48. HIV testing in antenatal care: a cross-sectional study
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Low, Nicola, Lambe, Cheryl, Welch, Jan, Kennedy, Jane, Stallard, Andrew, Clements, Vanessa, and White, Julia
- Abstract
Midwives' attitudes and practices regarding antenatal HIV testing, including integration of testing into routine antenatal care, were analysed using a self-administered structured questionnaire. This was completed by hospital and community-based midwives in an area of high HIV prevalence. In total, 162 responses were received. Most midwives (71%) agreed that HIV testing is an integral part of antenatal care but 61% also believed that only individuals with a counselling qualification should offer tests. Fifty seven per cent had attended a recent course about the management of HIV infection in pregnancy. Midwives who had attended a course were more likely to agree with integrated testing (odds ratio 5.2, 95% confidence interval 2.0–13.5). Midwives qualified between 5 and 9years ago were less likely than more recently qualified or more experienced midwives to offer tests, and this was not explained by differences in access to educational courses. Midwives' attitudes towards antenatal HIV testing are generally favourable. Despite an observed increase in uptake rates, many midwives continue to believe that only qualified counsellors should offer tests. All midwives should receive ongoing education that emphasizes the changing management of HIV infection in pregnancy and encourages testing.
- Published
- 2001
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49. Functional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein α-subunit chimeras
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Brown, Andrew J., Dyos, Susan L., Whiteway, Malcolm S., White, Julia H. M., Watson, Marie-Ange E. A., Marzioch, Martina, Clare, Jeff J., Cousens, Diane J., Paddon, Chris, Plumpton, Chris, Romanos, Mike A., and Dowell, Simon J.
- Abstract
The expression of mammalian G protein coupled receptors (GPCRs) in S. cerevisiae provides a powerful assay system for functional analysis, ligand identification and pharmaceutical screening. However, relatively few receptors have been coupled to the pheromone response pathway via the yeast G
α , Gpa1p, or chimeric yeast/mammalian Gα subunits containing long C-terminal regions of mammalian Gα proteins. We tested an extended range of seven such chimeras for Gα sub-types of three major classes (Gαi/o , Gαs and Gαq ), against eight human GPCRs (SST2 , SST5 , 5-HT1A , 5-HT1Dα , ML1B , P2Y1 and P2Y2 ). Although the Gαi/o chimeras increased the range of receptors that coupled efficiently, the Gαs and Gαq chimeras were inactive when expressed using the GPA1 promoter. We describe 10 novel Gpa1p chimeras, designated transplants, in which the C-terminal five amino acids of Gpa1p were exchanged with mammalian residues. Coupling efficiency and ligand sensitivity improved significantly using the transplants. For the P2Y purinergic receptors, coupling could only be detected with the transplants; this is the first report of Gq specificity coupling in yeast. Thus, the transplants offer major advantages over previously described approaches, in terms of both the range of receptors coupled and the efficiency of coupling. Copyright © 2000 John Wiley & Sons, Ltd.- Published
- 2000
50. Functional coupling of mammalian receptors to the yeast mating pathway using novel yeast/mammalian G protein α‐subunit chimeras
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Brown, Andrew J., Dyos, Susan L., Whiteway, Malcolm S., White, Julia H. M., Watson, Marie‐Ange E. A., Marzioch, Martina, Clare, Jeff J., Cousens, Diane J., Paddon, Chris, Plumpton, Chris, Romanos, Mike A., and Dowell, Simon J.
- Abstract
The expression of mammalian G protein coupled receptors (GPCRs) in S. cerevisiaeprovides a powerful assay system for functional analysis, ligand identification and pharmaceutical screening. However, relatively few receptors have been coupled to the pheromone response pathway via the yeast Gα, Gpa1p, or chimeric yeast/mammalian Gαsubunits containing long C‐terminal regions of mammalian Gαproteins. We tested an extended range of seven such chimeras for Gαsub‐types of three major classes (Gαi/o, Gαsand Gαq), against eight human GPCRs (SST2, SST5, 5‐HT1A, 5‐HT1Dα, ML1B, P2Y1and P2Y2). Although the Gαi/ochimeras increased the range of receptors that coupled efficiently, the Gαsand Gαqchimeras were inactive when expressed using the GPA1promoter. We describe 10 novel Gpa1p chimeras, designated ‘transplants’, in which the C‐terminal five amino acids of Gpa1p were exchanged with mammalian residues. Coupling efficiency and ligand sensitivity improved significantly using the transplants. For the P2Y purinergic receptors, coupling could only be detected with the transplants; this is the first report of Gqspecificity coupling in yeast. Thus, the transplants offer major advantages over previously described approaches, in terms of both the range of receptors coupled and the efficiency of coupling. Copyright © 2000 John Wiley & Sons, Ltd.
- Published
- 2000
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