Search

Because of the multi-pathway antibacterial mechanisms of nanomaterials, they have received widespread attention in wound therapy. However, owing to the complexities of bacterial responses toward nanomaterials, antibacterial molecular mechanisms remain unclear, making it difficult to rationally design highly efficient antibacterial nanomaterials. Fortunately, molecular dynamics simulations and omics techniques have been used as effective methods to further investigate the action targets of nanomaterials. Therefore, the review comprehensively analyzes the antibacterial mechanisms of nanomaterials from the morphology-dependent antibacterial activity and physicochemical/optical properties-dependent antibacterial activity, which provided guidance for constructing excellently efficient and broad-spectrum antibacterial nanomaterials for wound therapy. More importantly, the main molecular action targets of nanomaterials from the membranes, DNA, energy metabolism pathways, oxidative stress defense systems, ribosomes, and biofilms are elaborated in detail. Furthermore, nanomaterials used in wound therapy are reviewed and discussed. Finally, future directions of nanomaterials from mechanisms to nanomedicine are further proposed.

To leverage the exceptional biomedical properties of Prussian blue (PB), we synthesized Mn2+-doped hollow mesoporous Prussian blue nanocubes (Mn-HMPB) via a straightforward ion-exchange method to enhance the photothermal/chemo synergistic therapeutic efficiency. The precise modulate of nanostructures of Mn-HMPB with notable photothermal conversion efficiencies and quercetin (QUE) loading capacities. Introducing Mn2+doping in Mn-HMPB enables pH-responsive drug release under different physiological conditions. The systematic in vitro experiments have verified that the drug release and NIR irradiation mediated by Mn-HMPB@QUE nanocubes significantly inhibit the proliferation of Hela cells, resulting in an exceptional synergistic therapeutic outcome compared to single Mn-HMPB nanocubes or free QUE. Moreover, Mn-HMPB nanocubes exhibits outstanding biocompatibility and stability in psychological environment, positioning it as a reliable nanomedicine candidate. In conclusion, this study findings demonstrate the effective inhibition of growth and metastasis of Hela cells by Mn-HMPB@QUE nanocubes, exhibiting their potential as a versatile nanoplatform for tumor therapy.