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Biotransformation of betulonic acid (1) by Rhizopus arrhizusCGMCC 3.868 resulted in the production of 16 new (3, 5, 6, and 9–21) and five known compounds. Structures of the new compounds were established by analysis of spectroscopic data. Hydroxylation, acetylation, oxygenation, glycosylation, and addition reactions involved the C-20–C-29 double bond. Antineuroinflammatory activities of the obtained compounds in NO production were tested in lipopolysaccharides-induced BV-2 cells. Compared with the substrate betulonic acid, biotransformation products 3, 8, 9, 14, and 21exhibited an improved inhibitory effect, with IC50values of 10.26, 11.09, 5.38, 1.55, and 4.69 μM, lower than that of the positive control, NG-monomethyl-l-arginine.

A temperature sensor based on polarization non–reciprocity(PNR)in fiber-optic Sagnac interferometer(PSI)can measure the temperature of one point in high precision. The phasic subtraction of two light beams was shifted while temperature field around the probe changed. Analyzing the temperature measuring theory of Sagnac fiber optic temperature sensor, a linear output model Was established. The all digital signal detection was based onsquare–wave modulation and demodulation. An all digital signal detecting system using C8051 F060 as its COre Was completed. The experimental data achieved by temperature experiments agree with theory well. The input and output of system achieve a linearity of 10°C. Discussion shows that this kind of temperature sensor can reach high precision.