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Background: Pancreatic cancer (PC) continues to rank as one of the deadliest forms of cancer, with the majority of patients being diagnosed with unresectable disease. The implementation of cryoablation-based comprehensive treatment is expected to lead to a reduction in tumour size and potentially achieve complete resection. However, the availability of systematic and evidence-based treatment guidelines for cryoablation in pancreatic cancer is currently limited Materials and methods: A computerized search was conducted in the Medline, Embase, Cochrane Library databases, and Clinicaltrials to retrieve studies published from August 1987 to June 2023. The perioperative outcomes and long-term survival of patients with locally advanced pancreatic cancer (LAPC) or metastatic pancreatic cancer (mPC) who underwent cryosurgery were systematically collected. Heterogeneity was assessed using Cochran's Q test, and a funnel plot was implemented to evaluate publication bias. Data were pooled and analyzed using Stata 14.0 software. The Newcastle-Ottawa Quality Assessment Form tool was employed for quality evaluation. Results: Nine studies, including 368 patients, were identified. The pooled overall incidence rate was 4% (95% CI: 0-14%; I²=54.06%) for acute pancreatitis, 0% (95% CI: 0-0%; I²= 0.0%) for delayed gastric emptying, 0% (95% CI: 0-1%; I²=0.0%) for postoperative pancreatic fistula (POPF) or bile leakage, 2% (95% CI: 0-5%; I²= 0.0%) for bleeding, and 4% (95% CI: 0-12%; I²=70.46%) for fever. The subgroup analysis revealed that the percutaneous treatment group had a lower incidence of complications compared to laparotomy but had higher incidences of POPF, bleeding, and pancreatitis than the intraoperative group. Median overall survival (OS) varied from 5 to 16.2 months. The median survival rates at 6, 12, 24, and 36 months for patients who underwent cryosurgery were as follows: 94.9%, 64.8% (range: 4.8-63.1%), 22.80%, and 9.5%, respectively. Conclusion: With the advancements in cryoablation and anti-tumour therapy, cryoablation has emerged as a promising treatment modality for patients with unresectable pancreatic cancer. According to existing literature, the combination of cryoablation with radioactive particle implantation or immunotherapy has demonstrated considerable efficacy and safety. However, while the majority of included data is derived from retrospective studies, it is imperative to conduct larger sample sizes or prospective trials for further validation. [ABSTRACT FROM AUTHOR]

Objective: Multiple chronic physical conditions (physical multimorbidity) are common in people with depression. This study investigated the association between elevated depressive symptoms and the development and progression of physical multimorbidity in middle-aged women. Methods: A total of 7,407 women aged 45-50 years were followed up from 1996 to 2016. These women were free from diagnosed depression or chronic physical conditions at baseline. Data on depressive symptoms and chronic physical conditions were updated every 3 years, with depressive symptoms assessed using the Center for Epidemiological Studies-Depression scale. A 1-to-1 matched cohort analysis was conducted to compare the cumulative incidence and odds of physical multimorbidity between women with (depressed cohort) and women without (nondepressed cohort) elevated depressive symptoms, adjusted for sociodemographic and health behavioral factors. Results: Over 20 years of follow-up, 3,199 women (43.2%) reported elevated depressive symptoms. Of these, 2,035 (63.6%) developed physical multimorbidity. After the onset of elevated depressive symptoms, women had a more than 4-fold increase in cumulative incidence of multimorbidity. Compared with the nondepressed cohort, the odds of the depressed cohort developing multimorbidity before the onset of depressive symptoms was 1.81 (95% confidence interval = 1.49, 2.20). After the onset of depressive symptoms, the odds ratio was 2.38 (95% confidence interval = 2.20, 2.57). Conclusions: Elevated depressive symptoms were common in women's midlife. Women with elevated depressive symptoms had increased odds of physical multimorbidity both before and after the onset of depressive symptoms. These findings support the emerging integrated management and prevention of mental and physical multimorbidity. [ABSTRACT FROM AUTHOR]

In order to solve the suspension overshoot phenomenon existing in the static regulation process of the electric vehicle with electric controlled air suspension, firstly, the relevant factors of air spring are analyzed and the characteristics of the gasbag are simulated and verified in AMESim. Secondly, the model of the electric vehicle body is analyzed according to the law of dynamics and the fuzzy control theory is used to set up the electric vehicle body model in Simulink. In the case of unbalanced load, the effectiveness of the fuzzy controller is used to simulate the phenomenon of “overshoot” in the system. [ABSTRACT FROM AUTHOR]

Herein we report that the neat polyacrylonitrile (PAN) nanofibers and PAN/FeCl3 composite nanofibers were prepared by the materials-processing technique of electrospinning. The effect of FeCl3 amount on the morphology and wetting behavior of the resulting composite nanofibers were studied by scanning electron microscopy (SEM) and drop shape analysis (DSA), respectively. The SEM images indicated that the diameters of composite nanofibers decreased with increase of FeCl3 amount, and this was probably due to the conductivity increase of spinning solutions. The results acquired from DSA measurement showed that the addition of FeCl3 increased the surface contact angle of water deposited on composite nanofibers, suggesting the higher hydrophobicity and the lower wetting behavior. Additionally, the effect of FeCl3 on stabilization and carbonization of the PAN composite nanofibers were investigated. The structural and morphological evolutions of the stabilized and carbonized nanofibers were studied by Fourier transfer infrared (FTIR) spectra and SEM. The FTIR spectra showed that the presence of FeCl3 in composite nanofibers considerably varied the mechanisms of thermo-chemical reactions during the heat treatments. The SEM images revealed that there were conglutinations of nanofibers after carbonization, while the degree of conglutination for the carbonized PAN composite nanofibers with FeCl3 was higher than that for the carbonized neat PAN nanofibers. [ABSTRACT FROM AUTHOR]

Abstract: China''s primary energy consumption structure is primarily dominated by coal, and due to the excessive dependence on coal, China is facing enormous pressure in improving the power generation structure and enhancing clean energy utilization. There is growing recognition that, as the efficient clean energy, the higher proportion of natural gas plays an important role in improving the energy structure and carbon mitigation. This paper briefly introduces the current situation of carbon trade in power sector, and proposes an analytical model of gas power generation projects considering the carbon emission reduction value. For the integrated analysis presented in this article, we used the software of RETScreen to evaluate the economic benefit of the projects’ carbon emission reduction and conduct the cost-benefit analysis in the whole life cycle. The sensitivity analysis and Monte Carlo risk assessment are performed on the net present value (NPV) of the project. Through the algorithm analysis, the economic efficiency of gas powergeneration projects is significantly influenced by the natural gas price and on-grid price. Moreover, the impact of government policy on projects is also demonstrated and some feasible policy suggestions are proposed. [Copyright &y& Elsevier]