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Lung cancer is the leading cause of cancer death worldwide as well as in China. For many years, conventional oncologic treatments such as surgery, chemotherapy, and radiotherapy (RT) have dominated the field of non-small cell lung cancer (NSCLC). The recent introduction of immunotherapy in clinical practice, led to a paradigm shift in lung cancer as in many other solid tumors. Recent pre-clinical and clinical data have shown RT may also modify antitumor immune responses through induction of immunogenic cell death and reprogramming of the tumor microenvironment. This has led many to reexamine RT as a partner therapy to immuno-oncology treatments and investigate their potential synergy in an exponentially growing number of clinical trials. Clinical trials combining radiotherapy and immunotherapy are attracting major attention, experts were invited to discuss frontier and controversial academic topics: (1) Recent developments of clinical synergy between radiation and immune checkpoint inhibitors (ICIs) in the treatment of NSCLC; (2) Will immunotherapy and radiotherapy increase the toxicity risk for cancer patients; (3) How to cope the mixed responses/disassociated responses phenomenon in checkpoint inhibition therapy to NSCLC with local ablative therapy; (4) Combining radiotherapy and immunotherapy in the treatment of NSCLC brain metastases. [ABSTRACT FROM AUTHOR]

The progress of false information diffusion in the public crisis is harmful to the society. When the public crisis occurs, the public respond in different ways and the public also want to tell others what they think right. But what they think is right is not recognized by the government. Thus the false information forms and it begins to diffuse. As the false information spreads, the harm to society magnifies gradually. Particularly in network society, false information diffusion can easily cause secondary hazards and accelerate public crises to a devastating degree. Thus intervening and controlling the false information diffusion is an important aspect of the public crisis management. From the perspective of the social network theory, this study analyzes the progress of false information diffusion in terms of different public crisis management strategies and presents the result of false information diffusion through simulation on cellular automaton of different public crisis management strategies. In simulations on cellular automaton, interventions are also carried to control false information diffusion and alternatives are proposed to help reduce public crises. This study also extends the theory of false information management, which is significant for the government to improve the ability to evaluate the false information and carry out interventions effectively to control the false information when it begins to diffuse. [ABSTRACT FROM AUTHOR]

Background and objective Epidemiology of lung cancer will be changed along with time and region. The aim of this study is to acknowledge the tendency of primary lung cancer in hunan province in recent years by comparing and analyzing the distribution of gender, age, area, smoking and pathology of patients who were initial diagnosed lung cancer and ancestral or permanent residence of hunan province in 1997 and 2007. Methods Clinical data of 908 patients with primary lung cancer hospitalized in Xiangya hospital were collected and evaluated. Results Compared patients in 2007 with those in 1997, ratio between male and female dropped from 3.8:1 to 2.98:1, while the proportion of young patients who were under 40 years old raised from 4.4% to 8.6% (χ2=4.465, P=0.035), patients living in the county raised from 19.9% to 40.1% (χ2=30.670, P<0.001), smoking rate of patients from county raised from 16.9% to 39.9% (χ2= 24.939, P<0.01). In addition, the proportion of rare histological types of lung cancer were also increased from 1.3% to 4.5% (χ2= 5.142, P=0.023). Conclusion Female patients, young patients, rural patients and rare histological types of lung cancer may have a tendency of increase in hunan province in recent years, whereas smoking cessation education should be strengthened. [ABSTRACT FROM AUTHOR]