19 results on '"Xu, Yubing"'
Search Results
2. A composite hydrogel containing resveratrol-laden nanoparticles and platelet-derived extracellular vesicles promotes wound healing in diabetic mice.
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Zhu, Weidong, Dong, Yunqing, Xu, Pengcheng, Pan, Qiao, Jia, Keyao, Jin, Panshi, Zhou, Mou, Xu, Yubing, Guo, Rui, and Cheng, Biao
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EXTRACELLULAR vesicles ,RESVERATROL ,HEALING ,GLYCIDYL methacrylate ,HYDROGELS ,BIOPHARMACEUTICS ,PURINERGIC receptors - Abstract
Diabetic wounds are difficult to heal because of persistent inflammation and limited angiogenesis. Resveratrol (RES) is an anti-inflammatory and antioxidant agent. Platelet-derived extracellular vesicles (PDEVs) are rich in growth factors and cytokines, which promote proliferation and angiogenesis. However, single drug treatment has limited efficacy and delivery efficiency. Bioengineering can improve the limited effect of single drugs by combining drugs and materials to obtain complementary or cooperative bioengineered drugs. In this study, gelatin methacrylate (GelMA) and silk fibroin glycidyl methacrylate (SFMA) were used to synthesize GelMA/SFMA composite hydrogels with suitable mechanical properties, swelling ratio and biodegradability. The composite hydrogel was used as a wound dressing for sustained drug release. RES was loaded into mesoporous silica nanoparticles (MSNs) to synthesize MSN-RES to enhance the release dynamic, and MSN-RES and PDEVs were combined with the composite hydrogels to form GelMA/SFMA/MSN-RES/PDEVs hydrogels. The GelMA/SFMA/MSN-RES/PDEVs had low cytotoxicity and good biocompatibility, inhibited macrophage iNOS expression, and promoted the tube formation by human umbilical vein endothelial cells (HUVECs) in vitro. In a diabetic mouse wound model, the GelMA/SFMA/MSN-RES/PDEVs hydrogels decreased the expression of pro-inflammatory factors TNF-α and iNOS, increased the expression of anti-inflammatory factors TGF-β1 and Arg-1, promoted angiogenesis, and accelerated wound healing. Interestingly, the GelMA/SFMA/MSN-RES/PDEVs hydrogels promoted the expression of extracellular purinergic signaling pathway-related CD73 and adenosine 2A receptor (A2A-R). Therefore, the GelMA/SFMA/MSN-RES/PDEVs hydrogels could be used as wound dressings to regulate the inflammation and angiogenesis of diabetic wounds and accelerate wound healing. Drugs often fail to function because of a continuous oxidative stress microenvironment and inflammation. Here, a GelMA/SFMA hydrogel, with enhanced mechanical properties and liquid absorption ability, is proposed for sustained release of drugs. In addition to carrying platelet-derived extracellular vesicles (PDEVs) with pro-angiogenic effects, the hydrogels were also loaded with nanoparticle-encapsulated resveratrol with anti-inflammatory activities, aiming to reduce inflammation and oxidative stress in the wound microenvironment, such that the wound could receive proliferative repair signals to achieve sequential treatment and heal quickly. We also experimentally predicted that the regulatory mechanism of the GelMA/SFMA/MSN-RES/PDEVs in wound healing might be related to the extracellular purinergic signaling pathway. [Display omitted] [ABSTRACT FROM AUTHOR]
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- 2022
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3. Epitaxial Perovskite Single-Crystalline Heterojunctions for Filter-Free Ultra-Narrowband Detection with Tunable Spectral Responses.
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Pan, Yuzhu, Wang, Xin, Liao, Yuhan, Xu, Yubing, Li, Yuwei, Li, Qing, Zhang, Xiaobing, Chen, Jing, Zhu, Zhuoya, Zhao, Zhiwei, Elemike, Elias Emeka, Furuta, Mamoru, and Lei, Wei
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- 2022
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4. Electrically Modulated Near-Infrared/Visible Light Dual-Mode Perovskite Photodetectors.
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Zhao, Jingda, Wang, Xin, Xu, Yubing, Pan, Yuzhu, Li, Yuwei, Chen, Jing, Li, Qing, Zhang, Xiaobing, Zhu, Zhuoya, Zhao, Zhiwei, Elemike, Elias Emeka, Onwudiwe, Damian C., Bae, Byung Seong, Shafie, Suhaidi Bin, and Lei, Wei
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- 2022
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5. Analysis of Export Diversification and Impact of Globalisation on Income Inequality: Evidence from Asian Countries
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Li, Dan, Wang, Xinyao, Xu, Yubing, and Ren, Yutian
- Abstract
ABSTRACTDue to the importance of product and geographical diversification of exports, the gravity equation was used to predict export diversification for 19 Asian countries from 2004 to 2017 and the System Generalised Method of Moments was used to analyse the dynamic impact of globalisation at the disaggregated level of the diversification of sectoral exports and the goods specialisation on income inequalities. The results show that sectoral diversification of exports is the driving force of inequality. Furthermore, increased diversification of exports in the highly-income countries of Asia increases inequality and has little impact on low-income countries in Asia.
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- 2022
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6. Electrically Modulated Near-Infrared/Visible Light Dual-Mode Perovskite Photodetectors
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Zhao, Jingda, Wang, Xin, Xu, Yubing, Pan, Yuzhu, Li, Yuwei, Chen, Jing, Li, Qing, Zhang, Xiaobing, Zhu, Zhuoya, Zhao, Zhiwei, Elemike, Elias Emeka, Onwudiwe, Damian C., Bae, Byung Seong, Shafie, Suhaidi Bin, and Lei, Wei
- Abstract
Dual-mode photodetectors (PDs) have attracted increasing interest owing to their potential optoelectrical applications. However, the widespread use of PDs is still limited by the high cost of epitaxial semiconductors. In contrast, the solution processability and wide spectral tunability of perovskites have led to the development of various inexpensive and high-performance optoelectronic devices. In this study, we develop a high-performance electronically modulated dual-mode PD with near-infrared (NIR) narrowband and visible light broadband detection based on organic–inorganic hybrid methylammonium lead halide perovskite (MAPbX3; MA = CH3NH3and X = Cl, Br, and I) single crystals with a pnp configuration. The operating mode of the dual-mode PD can be switched according to voltage bias polarity because the photon absorption region and carrier transport performance are tuned at different bias voltages. The dual-mode PD exhibits a NIR light responsivity of 0.244 A/W and a narrow full width at half-maximum of ∼12 nm at 820 nm at positive voltages and an average visible light responsivity of ∼0.13 A/W at negative voltages. The detectivities of both modes are high (∼1012Jones), and the linear dynamic range is wide (>100 dB). Our study provides a new method for fabricating multifunctional PDs and can expand their application in integrated imaging systems.
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- 2022
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7. Parameter Estimation of a Valve-Controlled Cylinder System Model Based on Bench Test and Operating Data Fusion
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Su, Deying, Wang, Shaojie, Lin, Haojing, Xia, Xiaosong, Xu, Yubing, and Hou, Liang
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The accurate estimation of parameters is the premise for establishing a high-fidelity simulation model of a valve-controlled cylinder system. Bench test data are easily obtained, but it is challenging to emulate actual loads in the research on parameter estimation of valve-controlled cylinder system. Despite the actual load information contained in the operating data of the control valve, its acquisition remains challenging. This paper proposes a method that fuses bench test and operating data for parameter estimation to address the aforementioned problems. The proposed method is based on Bayesian theory, and its core is a pool fusion of prior information from bench test and operating data. Firstly, a system model is established, and the parameters in the model are analysed. Secondly, the bench and operating data of the system are collected. Then, the model parameters and weight coefficients are estimated using the data fusion method. Finally, the estimated effects of the data fusion method, Bayesian method, and particle swarm optimisation (PSO) algorithm on system model parameters are compared. The research shows that the weight coefficient represents the contribution of different prior information to the parameter estimation result. The effect of parameter estimation based on the data fusion method is better than that of the Bayesian method and the PSO algorithm. Increasing load complexity leads to a decrease in model accuracy, highlighting the crucial role of the data fusion method in parameter estimation studies.
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- 2024
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8. Using N–I–N Photodiodes Made of Perovskite Single Crystals for Low Noise Gamma-Ray Spectroscopy
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Wang, Xin, Xu, Yubing, Pan, Yuzhu, Chai, Shunjie, Wu, Jie, Zhao, Jingda, Li, Yuwei, Zhao, Zhiwei, Li, Qing, Wu, Jun, Chen, Jing, Bae, Byung Seong, Zhou, Jianming, Zhu, Ying, Lei, Wei, and Xu, Xiaobao
- Abstract
Solution-processed lead halide perovskite single crystals (LHPSCs) are believed to have great potential in gamma-ray spectroscopy. However, obtaining low-defect LHPSCs from a solution at low temperatures is difficult compared to obtaining Bridgman single crystals such as CdTe and Si. Herein, noise from the intrinsic defects of LHPSCs is considered as the main problem hindering their gamma-ray detection performance. By isolating the defect-induced holes in LHPSCs via energy barriers, we show that NIN photodiodes based on three types of LHPSCs, i.e., MAPbBr3(MA = CH3NH3), MAPbBr2.5Cl0.5, and cascade LHPSCs, have demonstrated good energy resolution in the range of 6.7–10.3% for 662 keV 137Cs gamma-ray photons. The noise for >10 mm3devices is low, in the order of 340–860 electrons, and the electron collection efficiency reaches 23–43%. These results pave the way for obtaining low-cost, large, high energy-resolution gamma-ray detectors at room temperature (300 K).
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- 2024
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9. Solution-Processed Halide Perovskite Single Crystals with Intrinsic Compositional Gradients for X-ray Detection
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Wang, Xin, Li, Yuwei, Xu, Yubing, Pan, Yuzhu, Zhu, Chongyang, Zhu, Dianjia, Wu, Yao, Li, Guanwen, Zhang, Qi, Li, Qing, Zhang, Xiaobing, Wu, Jun, Chen, Jing, and Lei, Wei
- Abstract
Although epitaxial growth is the fundamental method to realize lattice matched heterojunctions in electronics manufacturing, large-scale epitaxial single crystal layers based on solution-processing have rarely been reported. Here, cascade organic–inorganic hybrid perovskite single crystals with purity quotient over 99.9% consisting of chlorine, bromine, and iodine are fabricated by solution-processed epitaxial growth, in which the mismatch rate between adjacent layers is less than 1%. The area of solution-processed epitaxial growth is proved up to 4 cm2, and the speed reaches nearly 100 nm s–1. The resulting high-quality interface effectively improves bonding between adjacent layers, and the average mobility is calculated to be over 200 cm2V–1s–1in samples with different structures. Based on a specific structure with n-type, p-type, and intrinsic layers, a 7.55 mm-thickness X-ray photodiode with sensitivity 1.58 μC mGy–1cm–2is fabricated. This work provides a different method for fabricating solution-processed based electronic devices and makes stable perovskite-based devices more accessible.
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- 2020
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10. Impact of Age, Gender, and Body Composition on Bone Quality in an Adult Population From the Middle Areas of China.
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Ding, Zenghui, Chen, Yanyan, Xu, Yang, Zhou, Xu, Xu, Yubing, Ma, Zuchang, and Sun, Yining
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Identifying modifiable factors that influence bone status during adulthood to maximize bone quality is a potential primary strategy in the prevention of osteoporosis in later life. We investigated the impact of body height, body weight, body mass index, and body composition on calcaneal bone characteristics as measured with quantitative ultrasound in 441 Chinese adults (238 women) aged 20–55 yr from the middle areas of China. Body composition, including fat-free mass (FFM), muscle mass, and fat mass were obtained by bioelectrical impedance analysis. Bivariate correlation analysis demonstrated a significant negative correlation between age and broadband ultrasound attenuation (BUA), speed of sound (SOS), and stiffness index (SI) both in men (r = −0.177, p < 0.05; r = −0.499, p < 0.001; r = −0.530, p < 0.001, respectively) and women (r = −0.344, p < 0.001; r = −0.336, p < 0.001; r = −0.369, p < 0.001, respectively). Body height, body weight, FFM, and muscle mass had positive correlations with BUA, SOS, and SI in both genders, with FFM having the strongest correlation with BUA, SOS, and SI in men (r = 0.351, p < 0.001; r = 0.391, p < 0.001; r = 0.406, p < 0.001, respectively) and women (r = 0.331, p < 0.001; r = 0.288, p < 0.001; r = 0.324, p < 0.001, respectively). Fat mass had a positive correlation with BUA (r = 0.331, p < 0.001), SOS (r = 0.288, p < 0.001), and SI (r = 0.324, p < 0.001) in women, which was not found in men. Multivariate regression analysis revealed that, in both genders, FFM was a positive predictor for all 3 quantitative ultrasound variables. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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11. Digitalization, income inequality, and public health: Evidence from developing countries.
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Wang, Jing and Xu, Yubing
- Subjects
DEVELOPING countries ,MIDDLE-income countries ,INCOME inequality ,DIGITAL technology ,PUBLIC health ,PANEL analysis ,COVID-19 pandemic - Abstract
The COVID-19 pandemic has amplified the awareness and demand of public health worldwide. Based on the panel data of 81 developing countries from 2002 to 2019, this study probes into the effect of digitalization on public health and explores the mechanism through which digitalization affects public health from the perspective of income inequality. The results show that digitalization significantly enhances public health in developing countries, and this conclusion still holds after the robustness test. The heterogeneity analysis based on geographic location and income level indicates that the enhancing effect of digitalization on public health is most evident in Africa and middle-income countries. A further mechanism analysis suggests that digitalization can positively impact public health through the intermediary channel of suppressing income inequality. This study enriches the research on digitalization and public health and provides insights for comprehending public health needs and the powerful empowering effects of digitalization. • Digitalization significantly enhances public health in developing countries. • The enhancing effect of digitalization on public health is most evident in Africa and middle-income countries. • Digitalization can exert a positive impact on public health through the intermediary channel of suppressing income inequality. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Fast Response, High Spectral Rejection Ratio, Self-Filtered Ultranarrowband Photodetectors Based on Perovskite Single-Crystal Heterojunctions
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Xue, Lu, Wang, Xin, Pan, Yu-Zhu, Luo, Manman, Xu, YuBing, Li, Yu-Wei, Zhao, Jing-Da, Zhao, Zhiwei, Li, Qing, Bae, Byung-Seong, Fayemi, Omolola Esther, Zhou, Jianming, Zhu, Ying, Lei, Wei, and Zhang, Xiaobing
- Abstract
Narrowband photodetectors have wide application potential in high-resolution imaging and encrypted communication, due to their high-precision spectral resolution capability. In this work, we report a fast response, high spectral rejection ratio, and self-filtered ultranarrowband photodetector with a new mechanism, which introduces bulk recombination by doping Bi3+and cooperates with surface recombination for further quenching photogenerated charges generated by short-wavelength-light excitation in perovskite single-crystal. A perovskite film focused on collecting charges is fabricated on the single crystal by a lattice-matched solution-processed epitaxial growth method. Due to the formation of PN heterojunctions, a narrowband photodetector in this mechanism has remarkable spectral selectivity and detection performance with an ultranarrow full width at half-maximum (FWHM) of 7.7 nm and a high spectral rejection ratio of 790, as well as a high specific detectivity up to 1.5 × 1010Jones, a fast response speed with a rise time and fall time of ∼8 and 137 μs. The ultrafast and ultranarrow spectra response of self-filtered narrowband photodetector provides a new strategy in high-precision and high-resolution photoelectric detection.
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- 2023
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13. Sensitive Thermography via Sensing Visible Photons Detected from the Manipulation of the Trap State in MAPbX3
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Xu, Yubing, Wang, Xin, Liu, Shilin, Pan, Yuzhu, Perveen, Abida, Onwudiwe, Damian Chinedu, Fayemi, Omolola Esther, Elemike, Elias Emeka, Bae, Byung Seong, Zhu, Ying, Talaighil, Razika Zair, Zhang, Xiaobing, Chen, Jing, Zhao, Zhiwei, Li, Qing, Lei, Wei, and Xu, Xiaobao
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Sensitive thermometry or thermography by responding to blackbody radiation is urgently desired in the intelligent information life, including scientific research, medical diagnosis, remote sensing, defense, etc. Even though thermography techniques based on infrared sensing have undergone unprecedented development, the poor compatibility with common optical components and the high diffraction limit impose an impediment to their integration into the established photonic integrated circuit or the realization of high-spatial-resolution and high-thermal-resolution imaging. In this work, we present a sensitive temperature-dependent visible photon detection in Bi-doped MAPbX3(X = Cl, Br, and I) and employ it for uncooled thermography. Systematic measurements reveal that the Bi dopant introduces trap states in MAPbX3, thermal energy facilitates the carriers jumping from trap states to the conduction band, while the vacancies of trap states ensure the sequential absorption of visible photons with energy less than the band gap. Subsequently, the change of response toward the visible photon is applied to construct the thermograph, and it possesses a specific sensitivity of 2.11% K–1along temperature variation. As a result, our thermograph presents a temperature resolution of 0.21 nA K–1, a high responsivity of 2.06 mA W–1, and a high detectivity of 2.08 × 109Jones at room temperature. Furthermore, remote thermal imaging is successfully achieved with our thermograph.
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- 2023
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14. Detection of bone density with ultrasound.
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Chen, Yanyan, Xu, Yubing, Ma, Zuchang, and Sun, Yining
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Abstract: The broadband ultrasound attenuation (BUA) and the speed of sound (SOS) are usually measured to evaluate the bone density. However, as previous studies showed that the BUA is sensitive to repositioning and soft tissue, the reproducibility of measurement will be difficult to achieve. In our system, we used Net Delay Time (NDT) value, pressure detection and several signal-processing techniques to obtain the reproducibility. Through in-vivo examinations, the root-mean square coefficient of variation (CVRMS%) did not significantly change for SOS(about 0.4),BUA (about 2.2).Comparing with the results of other research, we found that the reproducibility of our system was better. [Copyright &y& Elsevier]
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- 2010
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15. Low-noise X-ray PIN photodiodes made of perovskite single crystals by solution-processed dopant incorporated epitaxial growth.
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Wang, Xin, Xu, Yubing, Pan, Yuzhu, Li, Yuwei, Xu, Ji, Chen, Jing, Wu, Jun, Li, Qing, Zhang, Xiaobing, Zhao, Zhiwei, Li, Chi, Elemike, Elias E., Onwudiwe, Damian C., Akram, Javed, and Lei, Wei
- Abstract
X-ray photodiodes made of metal halide perovskites (MHPs) which directly convert X-ray photons into electron-hole pairs have shown advantages in low-cost and high X-ray detection sensitivity. However, lattice-mismatched blocking layers deposited by spin-coating or evaporation cannot fully limit the dark current and noise current under large reverse bias. In this work, Solution-processed dopant incorporated epitaxial growth is employed to form sufficient blocking barriers through epitaxially growing lattice-matched n-type MHPs (bismuth-doped) and p-type MHPs (silver-doped) on opposite faces of intrinsic CH 3 NH 3 PbBr 2.5 Cl 0.5 MHP single crystals. Through energy structure design, electron/hole blocking layers can form sufficient charges barriers, the X-ray PDs exhibit a low leakage dark current density of ~ 11 nA cm
−2 under large reverse electrical field (over 500 V cm−1 ) and noise current of 47 fAHz−0.5 (1 mm2 , over 500 V cm−1 ). The large external electrical field enables a state-of-art response speed (fall) of 750 ns, large X-ray detection sensitivity of 36.0 μ C mGy − 1 c m − 2 and the lowest detectable dose rate of 16 nGys−1 (40 kVp). This work will motivate new strategies to fabricate high-performance devices based on perovskites using solution-processed methods. These founding also explore a new generation of low dose and high dynamic X-ray detectors based on MHPs. X-ray PIN photodiode with epitaxially n-type and p-type layers show extremely low dark current under large reverse bias. [Display omitted] • We provide a solution-processed method to epitaxially grow dopant-incorporated perovskite layer. • With lattice-matched epitaxial growth, the defects near the interfaces and inside the epitaxial layers are suppressed. • The X-ray PIN photodiode reported in this work shows remarkable low dark current and noise current. [ABSTRACT FROM AUTHOR]- Published
- 2021
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16. Epitaxial Perovskite Single-Crystalline Heterojunctions for Filter-Free Ultra-Narrowband Detection with Tunable Spectral Responses
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Pan, Yuzhu, Wang, Xin, Liao, Yuhan, Xu, Yubing, Li, Yuwei, Li, Qing, Zhang, Xiaobing, Chen, Jing, Zhu, Zhuoya, Zhao, Zhiwei, Elemike, Elias Emeka, Furuta, Mamoru, and Lei, Wei
- Abstract
Narrowband photodetectors (NPDs) with the capability of detecting light within a selective wavelength range are in high demand for numerous emerging applications such as imaging systems, machine vision, and optical communication. Halide perovskite materials have been developed for eliminating the current complex filtering systems in NPDs due to their beneficial properties, while currently NPDs using perovskite materials are limited by hardly fully eliminated short wavelength response, low charge collection efficiency (CCE), complex fabrication process, and so forth. Herein, a series of perovskite single-crystalline heterojunctions (PSCHs) with a structure of Bi-MAPbX3/MAPbY3are fabricated by liquid phase epitaxy for filter-free narrowband detection. By varying the halide component in the PSCH, the PSCH-based NPDs can realize continuously tunable spectral response range from blue to NIR regions and ultra-narrow full width at half-maximum (FWHM) of <20 nm. Specifically, the PSCH-based NPD with a high CCE under a large electric filed shows a high spectra rejection ratio of >1000, a fast response speed with rise/fall time of ∼160/∼225 μs, and long-term stability more than 3 months in ambient air. This work provides a simple strategy for designing low-cost and high-performance filter-free NPDs with a tunable spectral response.
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- 2022
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17. Low-noise X-ray PIN photodiodes made of perovskite single crystals by solution-processed dopant incorporated epitaxial growth
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Wang, Xin, Xu, Yubing, Pan, Yuzhu, Li, Yuwei, Xu, Ji, Chen, Jing, Wu, Jun, Li, Qing, Zhang, Xiaobing, Zhao, Zhiwei, Li, Chi, Elemike, Elias E., Onwudiwe, Damian C., Akram, Javed, and Lei, Wei
- Abstract
X-ray photodiodes made of metal halide perovskites (MHPs) which directly convert X-ray photons into electron-hole pairs have shown advantages in low-cost and high X-ray detection sensitivity. However, lattice-mismatched blocking layers deposited by spin-coating or evaporation cannot fully limit the dark current and noise current under large reverse bias. In this work, Solution-processed dopant incorporated epitaxial growth is employed to form sufficient blocking barriers through epitaxially growing lattice-matched n-type MHPs (bismuth-doped) and p-type MHPs (silver-doped) on opposite faces of intrinsic CH3NH3PbBr2.5Cl0.5MHP single crystals. Through energy structure design, electron/hole blocking layers can form sufficient charges barriers, the X-ray PDs exhibit a low leakage dark current density of ~ 11 nA cm−2under large reverse electrical field (over 500 V cm−1) and noise current of 47 fAHz−0.5(1 mm2, over 500 V cm−1). The large external electrical field enables a state-of-art response speed (fall) of 750 ns, large X-ray detection sensitivity of 36.0μCmGy−1cm−2and the lowest detectable dose rate of 16 nGys−1(40 kVp). This work will motivate new strategies to fabricate high-performance devices based on perovskites using solution-processed methods. These founding also explore a new generation of low dose and high dynamic X-ray detectors based on MHPs.
- Published
- 2021
- Full Text
- View/download PDF
18. Comprehensive Genomic Profiling of Chinese Acute Myeloid Leukemia (AML) with FLT3 ITD Using Ultra Deep Sequencing
- Author
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Kang, Hui, Lijuan, Chen, Xu, Yubing, Zeng, Fanxiang, Tong, Huan, Sun, Lihua, Hu, Jinwei, Yue, Yongqi, Chirn, Gung-wei, and Wang, Kai
- Abstract
No relevant conflicts of interest to declare.
- Published
- 2018
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19. Comprehensive Genomic Profiling of Chinese Acute Myeloid Leukemia (AML) with FLT3 ITD Using Ultra Deep Sequencing
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Kang, Hui, Lijuan, Chen, Xu, Yubing, Zeng, Fanxiang, Tong, Huan, Sun, Lihua, Hu, Jinwei, Yue, Yongqi, Chirn, Gung-wei, and Wang, Kai
- Abstract
Introduction: The FMS-like tyrosine (FLT3) gene encodes a class III receptor tyrosine kinase, belonging family members, including c-kit, c-FMS, FLT1, and PDGF-ΒR. FLT3 plays a key role in the hematopoiesis. It was discovered that in acute myeloid leukemia (AML) FLT3 is frequently mutated. Furthermore, constitutive activation of FLT3 by internal tandem duplication (ITD) mutation is one of the most common molecular variants in AML, occurring in approximately 20% to 30% of AML patients who have a comparatively poor clinical outcome and increased relapse rate. In the last years, next generation sequencing technology has allowed a high- throughput, comprehensive profiling of cancer genomes that can aid in making clinical decisions in the process of diagnosis and treatment. A few reports included somatic genomic profiling in AML with FLT3-ITD. However, none comprehensive genomic profiling data shows in chinese population. In this study, we sequenced 26 FLT3-ITD AML samples to show genomic profiling with multiple mutations types and discover the mutations associated with FLT3-ITD based on in-house bioinformatics mutation calling pipelines.
- Published
- 2018
- Full Text
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