1. Vitamin E containing polymer micelles for reducing normal cell cytotoxicity and enhancing chemotherapy efficacy.
- Author
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Lee, Kuan-Yi, Chiang, Yi-Ting, Hsu, Ning-Yu, Yang, Chieh-Yu, Lo, Chun-Liang, and Ku, Chen-An
- Subjects
CANCER chemotherapy ,VITAMIN E ,MICELLES ,CELL-mediated cytotoxicity ,DIBLOCK copolymers ,DOXORUBICIN - Abstract
An α-tocopheryl succinate (α-TOS) containing diblock copolymer micellar system was used to deliver doxorubicin (Dox), an anticancer drug, for HCT116 colon cancer therapy. The α-TOS containing diblock copolymers were synthesized by conjugation of α-TOS molecules and a mPEG- b -PHEMA hydrophilic diblock copolymer by ester bonds. The Dox-loaded polymeric micelles were then obtained by solvent exchange process. In acidic surroundings such as endosomes or secondary lysosomes, the structures of the Dox-loaded polymeric micelles deformed and released the drug loads. Additionally, Dox-loaded polymeric micelles enhanced the cytotoxicity of Dox and α-TOS to cancer cells in vitro . Dox-loaded polymeric micelles also showed an exceptional tumor inhibiting effect in vivo. This study indicates that the α-TOS containing polymeric micelle system can be used as a drug carrier for cancer therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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