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In this brief, a high-efficiency optimization design method is proposed for a two-stage Miller-compensated operational amplifier (TSMCOA). In the proposed method, the parameters and performance metrics of TSMCOA are simulated by Cadence software. Then, the neural network (NN) models are utilized to describe the relationship between its parameters and performance metrics, which can greatly improve simulation efficiency. Based on the performance metrics of TSMCOA, a multi-objective function is established. Then, according to the NN models and multi-objective function, the parameters of TSMCOA are optimized by particle swarm optimization algorithm with linearly decreasing inertia weight (PSO-LDIW). The optimized area is $0.1371 \mu $ m2 $72.09 \mu $ 20803

This paper presents a 50-Gb/s optical receiver (ORX) chipset, consisting of a transimpedance amplifier (TIA) and a clock and data recovery (CDR) circuit in a 45-nm silicon-on-insulator CMOS. The proposed inverter-based TIA employs hybrid shunt-series peaking inductors to extend the bandwidth (BW). A baud-rate CDR is proposed to reduce the sampling phases and clocking power by half. To optimise the ORX for in- package integration, a compact-size digital loop is adopted in each channel, and the clock is recovered by phase interpolation from a shared reference. A complete optical-to-electrical (OE) link is built by integrating the proposed ORX with a high-speed Silicon Photonics (SiP) photodetector (PD). Measurements show that the proposed TIA has a transimpedance gain of 53 dB $\Omega $ and a BW of 27 GHz. By integrating it with the SiP PD, the OE front-end (PD+TIA) achieves an input sensitivity of −7.7 dBm at 50 Gb/s and BER $ < 10^{-12}$ . It features a power efficiency of 1.61 pJ/bit at a data rate of 64 Gb/s. The complete 50 Gb/s ORX achieves data recovery at a quarter rate of 12.5 Gb/s with an output jitter of 1.6 psrms, and has a 3.125 GHz clock with phase noise of −115.22 dBc/Hz at an offset frequency of 1 MHz.

Black phosphorus is well known for its excellent electromechanical properties. Although it has previously been used for therapeutic drug delivery in cancer, it has never been applied as an electroactive polymer for post-trauma tissue regeneration (e.g., in cardiac muscles and neurons). The major concern currently preventing such applications is its controversial biosafety profile in vivo. Here, we demonstrate the production of a concentrically integrative layer-by-layer bioassembled black phosphorus nanoscaffold. This scaffold has remarkable electrical conductivity, permitting smooth release into the surrounding microenvironment. We confirmed that, under mild oxidative stress, our black phosphorus nanoscaffold induced angiogenesis and neurogenesis and stimulated calcium-dependent axon regrowth and remyelination. Long-term in vivo implantation of this nanoscaffold during severe neurological defect regeneration induced negligible toxicity levels. These results provide new insight into the regenerative capability of manufactured 3D scaffolds using neuroengineered 2D black phosphorus nanomaterials.

The aim of this study was to describe the clinical impact of commercial laboratories issuing conflicting classifications of genetic variants.

We report a targeted prodrug delivery platform that can deliver a cytostatic nucleobase analog with high drug loading. We chose fluorouracil (5FU), a drug used to treat various cancers, whose active metabolite 5-fluorodeoxyuridine monophosphate (5-FdUMP) is the antineoplastic agent. We use terminal deoxynucleotidyl transferase (TdT) to polymerize 5-fluorodeoxyuridine triphosphate (5-FdUTP) onto the 3′-end of an aptamer. We find that (i) addition of hydrophobic, unnatural nucleotides at the 3′-end of the 5-FdU polynucleotide by TdT leads to their spontaneous self-assembly into nuclease resistant micelles, (ii) aptamers presented on the micelle corona retain specificity for their cognate receptor on tumor cells, and (iii) the micelles deliver 5FU to tumor cells and exhibit greater cytotoxicity than the free drug. The modular design of our platform, consisting of a targeting moiety, a polynucleotide drug, and a self-assembly domain, can be adapted to encompass a range of polymerizable therapeutic nucleotides and targeting units.

Peripheral nerve injury (PNI) caused by injury may influence the patients' lifelong mobility unless there is an appropriate treatment. Tissue engineering has become a hot field to replace traditional autologous nerve transplantation due to its low surgical damage and easy-to-industrial advantages. Graphene (GR) is a kind of carbon nanomaterial with good electrical and mechanical properties that satisfy the demand for a good tissue scaffold for nerve regeneration. Herein, a novel and biosafe hydrogel is fabricated by using graphene and sodium alginate (GR-SA) together. This hydrogel not only can mimic the nerve growth microenvironment but also can promote the expression of neurotrophic substances and growth factors. Additionally, GR-SA hydrogel can significantly reduce inflammatory factors. Moreover, the results of both in vitro and in vivo tests demonstrate that GR-SA hydrogel has a promising prospect in PNI regeneration.

Escin is a triterpenoid saponin extracted from the fruit of Aesculus wilsoniiRehd. and Aesculus hippocastanum(Hippocastanaceae). Clinically, it is widely used in the treatment of edema induced by either trauma or surgery, as well as treating chronic venous insufficiency. The anti-inflammatory and antiedema effects of escin have been extensively investigated. This article systematically reviews the effects of escin on inflammation and gastrointestinal diseases, including its role in inflammation, as an antioxidant, and in inhibiting gastric acid secretion and promoting gastrointestinal movement, especially, the molecular mechanism. The advantages and potential uses of escin have also been discussed.