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The study employs the initial outward foreign direct investment (OFDI) of 2875 listed firms in Shanghai and Shenzhen A-shares in China from 2006 to 2019 as a quasi-natural experiment to construct a multiplicative difference model, with the objective of investigating the impact of OFDI by Chinese enterprises on the domestic enterprises green technological innovation (GTI) and the underlying mechanisms. The study found that Chinese enterprises' OFDI significantly enhances both the quantity and quality of domestic GTI. The placebo and PSM-DID tests confirm the robustness of this conclusion. The heterogeneity analysis suggests that Chinese enterprises' direct investment in countries that have rigorous environmental regulations and high technological levels can promote both the quantity and quality of domestic GTI. Mechanism analysis indicates that enterprises influenced by high environmental compliance pressure can effectively increase both the quantity and quality of GTI through OFDI; however, enterprises under strong environmental media supervision through OFDI can significantly enrich the quantity of GTI but not the quality. Enterprises' OFDI enhances the quality of domestic GTI by increasing research and development funding and the number of research personnel. Furthermore, this study reveals that Chinese enterprises' OFDI significantly promotes the quantity of green process innovation and the quality of green product innovation. However, the effect on the quality of green process innovation and the quantity of green product innovation is not statistically significant. Moreover, particularly in reducing the quality of green process utility innovation, Chinese enterprises' OFDI significantly improves the quality of green product utility innovation. These findings provide valuable insights for China to advance high levels of OFDI and promote sustainable green development. [Display omitted] • Outward foreign direct investment promotes the green innovation quantity/quality. • Environmental law enforcement/public social supervision have moderating effects. • Research and development investment has the effect of mediating variables. • Outward foreign investment enhances the green process innovation quantity. • Green product innovation quality rises by dropping the process innovation quality. [ABSTRACT FROM AUTHOR]

Exosomes from adipose-derived stem cells (ADSCs) have been demonstrated to benefit angiogenesis, wound healing, and fat grafting. Small noncoding RNAs such as microRNA (miRNA) and circular RNA play critical roles in mediating the function of ADSCs-derived exosomes. However, the underlying mechanisms have not been fully elucidated. In this study, we investigated the function and mechanism of human ADSCs-derived exosomes (hADSCs-Exo) in promoting fat graft angiogenesis and adipogenic differentiation. hADSCs-Exo were isolated and identified, and treatment with hADSCs-Exo enhanced fat graft angiogenesis and adipogenic differentiation in a mouse fat graft implantation model. We found that hADSCs-Exo overexpressed miR-671–3p and promoted human umbilical vein endothelial cell (HUVEC) proliferation, migration, and invasion. Bioinformatics analysis and luciferase reporter assay validated that TMEM127 is a direct target of miR-671–3p. Rescue experiments demonstrated that TMEM127 overexpression partially antagonized the function of hADSCs-Exo in vitro , such as suppressing HUVEC cell proliferation, migration, and invasion. Moreover, TMEM127 overexpression abrogated the function of hADSCs-Exo on fat graft angiogenesis and adipogenic differentiation. Taken together, our findings demonstrate that miR-671–3p-overexpressing exosomes from ADSC promote fat graft angiogenesis and adipogenic differentiation, which highlights the potential of targeting the ADSC-Exosomes-miR-671–3p/TMEM127 axis to improve outcome of fat graft and tissue engineering regenerative medicine. • ADSC-derived exosomes promote fat graft angiogenesis and adipogenic differentiation of ADSC. • Exosomes from ADSCs overexpressing miR-671–3p promote HUVEC proliferation, migration and invasion. • TMEM127 is a direct target of miR-671–3p. • TMEM127 overexpression abrogates the role of ADSC-derived exosomes in fat graft angiogenesis and adipogenic differentiation. [ABSTRACT FROM AUTHOR]