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Providing effective Through Train Services (TTSs) faces challenges due to complex infrastructure conditions, train performances and passenger demands. To enhance TTSs between two different classes of urban rail transit lines with variations in train speed and capacity, we propose a multi-objective Integer Non-Linear Programming (INLP) model. This model maximizes passenger travel time savings and average train load utilization, and develops an integrated approach to simultaneously optimize the frequencies of through express trains and local trains, as well as the operation zones, stopping patterns and type selection of through trains. Additionally, a Non-Dominated Sorting Genetic Algorithm II is designed to solve the INLP model based on a simple test network and a real-world case from the Nanjing Subway. The unique benefits of our proposed method are demonstrated by a comprehensive compared with the Single Line Operation Mode and the all-stop plans under Through Operation Mode. [ABSTRACT FROM AUTHOR]

• Our findings added to the evidence of balance control, position sense, and force sense deficits in athletes with chronic ankle instability (CAI). • Athletes with CAI showed diminished ankle proprioception, including joint position sense and force sense, and demonstrated impaired balance control. • Deficit in force sense was deemed as a moderate predictor of one-leg standing balance control deficits in athletes with dominant-side injury CAI. To compare balance control and ankle proprioception between athletes with and without chronic ankle instability (CAI). A further objective was to explore the relationship between balance control performance and ankle proprioception in athletes with CAI. Cross-sectional study. Sports Rehabilitation Laboratory. Eighty-eight recreational athletes (47 CAI and 41 healthy control) were recruited. No applicable. Balance control performance was assessed using the sway velocity of the center of the pressure during the one-leg standing tasks. Ankle proprioception, including joint position sense and force sense, were tested using absolute error (AE) associated with joint position reproduction and force reproduction tasks in 4 directions, that is, plantarflexion, dorsiflexion, inversion, and eversion. Athletes with CAI performed significantly worse than those without CAI in balance control tasks. In addition, CAI athletes showed significantly worse joint position sense and force sense in all 3 movement directions tested (plantarflexion, inversion, and eversion). Correlation analysis showed that the AE of the plantarflexion force sense was significantly moderately correlated with medial-lateral sway velocity in the one-leg standing with eyes open and closed conditions (r =.372-.403, P =.006-.012), and the AE of inversion force sense was significantly moderately correlated with medial-lateral sway velocity in the one-leg standing with eyes open (r =.345, P =.018) in athletes with CAI, but the joint position sense measures were not (all P >0.05). Athletes with CAI showed significantly impaired balance control performance and diminished ankle proprioception. Deficit in force sense was deemed as a moderate predictor of one-leg standing balance control deficits in athletes with dominant-side injury CAI, whereas ankle position sense may be a small predictor. [ABSTRACT FROM AUTHOR]

Due to the typically high flow rate of nozzles on large sprinkler machines, direct use for pesticide application can lead to pesticide waste and non-point source pollution. To fulfill the multifunctional needs of large sprinkler machines for irrigation, fertilization, and pesticide application, this study installed atomizing micro-sprinklers on the machines to enable their pesticide application capabilities. Based on the spraying patterns of the atomizing micro-sprinklers, three types were selected for this study: hollow cone, solid cone, and fan-shaped micro-sprinklers. Three working pressure levels were set at 0.2 MPa, 0.3 MPa, and 0.5 MPa, with the height of the micro-sprinklers above the ground set at three levels: 0.8 m, 1.2 m, and 1.5 m. A completely randomized design was used for the experiment, which included hydraulic performance tests and software simulation. The results indicated that the spray volume of the hollow cone, solid cone, and fan-shaped atomizing micro-sprinklers approximately presented a hollow conical, solid conical, and normal distribution, respectively. The spray intensity (average and maximum values) of the atomizing micro-sprinklers increased with the increase in pressure, while the median showed an initial increase followed by a decrease as pressure increased. Under the same pressure conditions, the spray intensity of the different atomizing micro-sprinklers decreased with the increase in height above the ground, while the spray width increased with height. By comparing the spraying characteristics of micro-sprinklers with various patterns, large sprinkler machines can select atomizing micro-sprinklers in different spraying statuses according to actual conditions and determine the optimal height of the atomizing micro-sprinklers above the ground to achieve efficient and uniform pesticide application effects. This reduces the evaporation and drift loss of liquid medicine. The research findings provide a scientific basis for achieving the pesticide application function of large sprinkler machines and expanding their usage capabilities. [ABSTRACT FROM AUTHOR]

We investigate the predictive value of a comprehensive model based on preoperative ultrasound radiomics, deep learning, and clinical features for pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) for the breast cancer. We enrolled 155 patients with pathologically confirmed breast cancer who underwent NAC. The patients were randomly divided into the training set and the validation set in the ratio of 7:3. The deep learning and radiomics features of pre-treatment ultrasound images were extracted, and the random forest recursive elimination algorithm and the least absolute shrinkage and selection operator were used for feature screening and DL-Score and Rad-Score construction. According to multifactorial logistic regression, independent clinical predictors, DL-Score, and Rad-Score were selected to construct the comprehensive prediction model DLRC. The performance of the model was evaluated in terms of its predictive effect, and clinical practicability. Compared to the clinical, radiomics (Rad-Score), and deep learning (DL-Score) models, the DLRC accurately predicted the pCR status, with an area under the curve (AUC) of 0.937 (95%CI: 0.895–0.970) in the training set and 0.914 (95%CI: 0.838–0.973) in the validation set. Moreover, decision curve analysis confirmed that the DLRC had the highest clinical value among all models. The comprehensive model DLRC based on ultrasound radiomics, deep learning, and clinical features can effectively and accurately predict the pCR status of breast cancer after NAC, which is conducive to assisting clinical personalized diagnosis and treatment plan. [ABSTRACT FROM AUTHOR]

[Display omitted] • Sodium citrate induces apoptosis and ferroptosis of ovarian cancer cells. • Sodium citrate chelates intracellular Ca2+ and inhibits the CAMKK2/AKT/mTOR/HIF1α-dependent glycolysis pathway, thereby inducing cell apoptosis. • Sodium citrate inhibits activation of CAMKK2/AMPK pathway and increases NCOA4-mediated ferritinophagy. • Inactivation of CAMKK2/AMPK pathway reduces Ca2+ level in the mitochondria by inhibiting the activity of the MCU, resulting in excessive ROS production. • Sodium citrate increases the sensitivity of ovarian cancer cells to chemo-drugs. Ovarian cancer (OC) is known for its high mortality rate. Although sodium citrate has anti-tumor effects in various cancers, its effect and mechanism in OC remain unclear. To analyze the inhibitory effect of sodium citrate on ovarian cancer cells and the underlying mechanism. Cell apoptosis was examined by TUNEL staining, flow cytometry, and ferroptosis was examined intracellular Fe2+, MDA, LPO assays, respectively. Cell metabolism was examined by OCR and ECAR measurements. Immunoblotting and immunoprecipitation were used to elucidate the mechanism. This study suggested that sodium citrate not only promoted ovarian cancer cell apoptosis but also triggered ferroptosis, manifested as elevated levels of Fe2+, LPO, MDA and lipid ROS production. On one hand, sodium citrate treatment led to a decrease of Ca2+ content in the cytosol by chelating Ca2+, which further inhibited the Ca2+/CAMKK2/AKT/mTOR signaling, thereby suppressing HIF1α-dependent glycolysis pathway and inducing cell apoptosis. On the other hand, the chelation of Ca2+ by sodium citrate resulted in inactivation of CAMKK2 and AMPK, leading to increase of NCOA4-mediated ferritinophagy, causing increased intracellular Fe2+ levels. More importantly, the inhibition of Ca2+/CAMKK2/AMPK signaling pathway reduced the activity of the MCU and Ca2+ concentration within the mitochondria, resulting in an increase in mitochondrial ROS. Additionally, metabolomic analysis indicated that sodium citrate treatment significantly increased de novo lipid synthesis. Altogether, these factors contributed to ferroptosis. As expected, Ca2+ supplementation successfully reversed the cell death and decreased tumor growth induced by sodium citrate. Inspiringly, it was found that coadministration of sodium citrate increased the sensitivity of OC cells to chemo-drugs. These results revealed that the sodium citrate exerted its anti-cancer activity by inhibiting Ca2+/CAMKK2-dependent cell apoptosis and ferroptosis. Sodium citrate will hopefully serve as a prospective compound for OC treatment and for improving the efficacy of chemo-drugs. [ABSTRACT FROM AUTHOR]

Clavicle fractures are one of the most common fractures and usually occur in the medial third of the clavicle. The study explored the efficacy of three internal fixation methods to treat Edinburgh IB fractures of the proximal clavicle. 68 patients with Edinburgh IB fractures of the proximal clavicle were divided into T-shaped plate group, double-miniature steel plate group and memory alloy embracing device group. Postoperative complications, return time to work, and fracture healing time were recorded. The clinical efficacy was evaluated by Constant-Murley score of shoulder joint, Visual Analogue Scale (VAS) score of pain, and arm-shoulder-hand dysfunction score. The operative time of the memory alloy embracing device group was significantly better than T-shaped plate group and double-miniature steel plate group. The length of surgical incision in the double-miniature steel plate group was significantly shorter than that in the T-shaped plate group and the memory alloy embracing device group. The hospitalization cost and recovery time of the double-plate and memory alloy hug groups were lower than those of the T-plate group. The double-miniature steel plate group and the memory alloy embracing device group were significantly better than the T-shaped plate group at two weeks after operation. Satisfactory clinical results can be obtained by using T-shaped plate, double-miniature steel plate and memory alloy embracing device in the treatment of Edinburgh IB fracture of proximal clavicle. However, the double-miniature steel plate group has the advantages of small incision, low cost, and quick postoperative recovery, and has more early advantages. [ABSTRACT FROM AUTHOR]

This study was designed to investigate the application value of shape memory alloy embracing fixator in the treatment of proximal clavicle fracture. From April 2018 to October 2020, the fracture data of patients with proximal clavicle fractures treated with shape memory alloy embracing fixator were retrospectively analyzed, including 12 males and 8 females. The age of patients ranged from 34 to 66 years (mean, 43.4 years). According to Craig's classification, the patients were divided into the following groups: type CII (eight cases), type CIII (five cases), type CⅤ (seven cases), all of which were closed fractures without nerve or vascular injury. The fracture healing time and postoperative complications were observed, and the shoulder joint function was evaluated by Constant score. All patients were followed up for 13–19 months (average 15.6 months). The clavicle radiographs showed that all the 20 patients had bone union, and the fracture union time was 6–10 months (average 7.2 months). There were no complications such as internal fixation fracture and displacement. According to the Constant criterion, 13 cases were excellent and 5 cases were fair and 1 case was good. The treatment of proximal clavicle fracture with shape memory alloy embracing fixator is an effective treatment method with simple operation with satisfactory fixation effect and low complication rate, which is worthy of being widely used in clinical practice. [ABSTRACT FROM AUTHOR]

The article was designed to explore the clinical efficacy of 'Fast-track Management' guided by ERAS concept under the multidisciplinary collaboration model for early operation of femoral intertrochanteric fracture in the elderly. The clinical data of 198 intertrochanteric fracture in the elderly were retrospectively analyzed. According to the diagnosis and treatment mode, they were divided into cooperative group and routine group. The preoperative waiting time, preoperative deep venous thrombosis, operation time, intraoperative bleeding, hospitalization time, Harris score, VAS score, intervention effect of eras concept, complication occurrence, and 1-year mortality were made a comparison. There were notable differences in the preoperative waiting time, the number of cases of preoperative deep vein thrombosis and the length of hospital stay between the cooperative group and routine group. The incidence of complications in the cooperative group was 9.38%, which was significantly lower than that in the conventional group, 54.90%. The 1-year mortality rate was clearly lower in the cooperative group than in the routine group. At 1 and 2 weeks after operation, VAS, HAMA and PSQI of the cooperative group were lower, but Harris and Barthel were higher than the routine group. At 1 month after operation, there was no clear difference in VAS and Harris between the cooperative group and routine group. The establishment of 'Fast-track Management' based on ERAS concept in the multidisciplinary collaboration model can effectively alleviate the pain of femoral intertrochanteric fracture in the elderly, shorten the hospital stay, reduce the occurrence of postoperative complications and the mortality within 1 year. [ABSTRACT FROM AUTHOR]

Skeletal tissue development and regeneration in mammals are intricate, multistep, and highly regulated processes. Various signaling pathways have been implicated in the regulation of these processes, including redox. Redox signaling is the signal transduction by electron transfer reactions involving free radicals or related species. Redox homeostasis is essential to cell metabolic states, as the ROS not only regulates cell biological processes but also mediates physiological processes. Following a bone fracture, redox signaling is also triggered to regulate bone healing and regeneration by targeting resident stromal cells, osteoblasts, osteoclasts and endothelial cells. This review will focus on how the redox signaling impact the bone development and bone regeneration. [ABSTRACT FROM AUTHOR]

Large-artery atherosclerosis type of ischemic stroke happens when a blood clot forms in a major artery that carries blood to the brain. This causes a blockage and a decrease in blood flow to the brain tissue making up approximately 15–20% of all cases. This type of stroke is more prevalent in older adults and those with risk factors such as high blood pressure, high cholesterol, diabetes, smoking, and a family history of stroke. To investigate the correlation and predictive value of platelet-related biological indicators with recurrence of large-artery atherosclerosis type of ischemic stroke (LAA-IS)2. The patients were divided into a relapse group (R, n = 40) and non-relapse group (NR, n = 45). Platelet-related biological indicators were collected from both groups to analyze their correlation with neurological impairment score (NIHSS score). Risk factors were analyzed using binary logistic regression and a survival curve (ROC) was drawn to evaluate the predictive effect of clinical platelet-related biological indicators on LAA-IS recurrence. This study confirmed that PAg-ADP, PAg-COL, and FIB are closely related to the formation of LAA-IS due to carotid atherosclerosis, and the combined PAg-ADP, PAg-COL, and FIB index levels are the most promising for assessing the prognostic development of recurrence in patients with LAA-IS. Combined monitoring of platelet aggregation rate and FIB index is of important evaluation value in judging the recurrence prognosis of LAA-IS patients. [ABSTRACT FROM AUTHOR]

• Declare the detail relationship between perioperative fluid management and early AKI incidence after lung transplantation; • Confirm the protective effect of restrict fluid strategy on the short-term renal outcomes of lung transplant recipients; • Reveal the predictive value of positive fluid balance in short-term outcomes after lung transplantation. Postoperative acute kidney injury (AKI) after lung transplantation (LTx) is an important factor affecting the short-term outcomes. The focus item of transplantation centers is how to improve the incidence of AKI through optimal management during the perioperative period. The purpose of the study is to investigate the influence of perioperative volume in the development of early AKI following LTx. The study involved patients who had undergone LTx between October 2018 to December 2021 at China-Japan Friendship Hospital in Beijing. The patients were monitored for AKI occurring within 72 hours after LTx, as well as the renal outcomes within 30 days. The perioperative volumes were compared and analyzed to determine the impact on various clinical outcomes. 248 patients were enrolled in the study ultimately, with almost half of them (49.6 %) experiencing AKI. 48.8 % of AKI patients received continuous renal replacement therapy (CRRT), with 57.7 % recovered by the end of the 30-day follow-up period. A J-shaped relationship was demonstrated between perioperative volume and AKI incidence. Moreover, maintaining a positive fluid balance would increase the 30-day mortality and lead to poor renal outcomes. Perioperative volume is an independent risk factor of early AKI after LTx. Positive fluid balance increases the risk of AKI, 30-day mortality, and adverse renal prognosis. The LTx recipients may benefit from a relatively restrict fluid strategy during and after the lung transplantation. [ABSTRACT FROM AUTHOR]

Leveler is one of the most important organic additives in copper electroplating for microvia filling. To enhance the microvia filling efficiency and reduce the bath control difficulty, novel levelers with high filling performance and wide application concentration range has long been pursued. Herein, a novel leveler named L1 with four pyrrolidine rings linked by a pentaerythritol backbone is designed and synthesized. Compared with the previously reported leveler TPM-1, L1 shares the same nitrogen-containing group but has an additional pyrrolidine ring. The structure-property relationship of L1 is thoroughly characterized by electrochemical measurements, theoretical calculations, and electroplating experiments. Results show that with one more positively charged ammonium groups, L1 exhibits stronger interactions with Cl− and the accelerator SPS compared to TPM-1. However, due to the variation of the connecting group, its interaction with the suppressor PEG is much weaker. With L1 as the leveler, both good microvia filling performance and high-quality copper deposition was obtained within a wide concentration range. The findings indicate that L1 is a very promising leveler for microvia filling copper electroplating, and both nitrogen-containing groups and linking groups in a leveler significantly influence its properties and performances. [ABSTRACT FROM AUTHOR]

Black carbon (BC), primarily originating from fossil fuel and biomass combustion, holds significance for global carbon cycling, climate change, and human health. Despite a lake's role as a carbon sink, detailed information about BC sedimentary burial flux and sink in its sediment remains insufficiently explored. The current study investigates the distribution, sources, and burial flux of BC and its subtypes (char and soot) in the surface sediment of Daye Lake, the largest lake in Huangshi City, central China. BC concentrations in the sediment ranged from 0.10 to 3.60 mg/g, corresponding to 0.40%–17.02% of organic carbon (OC). Higher values of BC and BC/OC observed in the western region suggest direct terrestrial input via river discharge and surface runoff, influenced by anthropogenic activities. In contrast, variations in char/soot ratios reflect diverse combustion sources and hydrological dynamics in different regions. The indications from BC/OC and char/soot ratios imply that fossil fuel combustion is the predominant sources. The weak correlations between BC and OC suggest that they may come from different sources or undergo different processes that affect their distribution in the lake sediment. However, a stronger correlation was observed between BC and soot, as well as between char and soot, indicating potential similarities in their input pathways. The BC burial flux displays notable variations across the lake, ranging from 0.69 to 24.07 g/m2/yr, with elevated values observed in the western region. The BC sink in the sediments of Daye Lake was estimated to be 0.635 Gg/yr. Though locally small, it significantly contributes to the broader picture of BC burial in Chinese lakes and the global distribution of BC in lake ecosystems. [ABSTRACT FROM AUTHOR]