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Peripheral neuropathies, especially those with atypical features, remain a diagnostic challenge. In this case, a 60-year-old patient presented with acute-onset weakness starting in the right hand then sequentially involving the left leg, left hand, and right leg over 5 days. The asymmetric weakness was accompanied by persistent fever and elevated inflammatory markers. Subsequent development of rashes combined with careful review of the history led us to the final diagnosis and targeted treatment. This case highlights clinical pattern recognition with the help of electrophysiologic studies in peripheral neuropathies, which provide shortcuts to narrow the differential diagnosis. We also illustrate the important pitfalls from history taking to ancillary testing in diagnosing the rare but treatable cause of peripheral neuropathy (eFigure 1, links.lww.com/WNL/C541).

Objective To compare the staining quality between rapid hematoxylin and eosin (H&E) staining and routine H&E staining of frozen breast tissue sections.Methods In this cross-sectional observational study, 120 frozen breast tissue sections were randomly assigned to rapid or routine H&E staining (n = 60 per group). Rapid H&E staining used a 7:1 mixture of modified Gill’s hematoxylin and alcohol-soluble 1% eosin Y. The staining quality of each section was evaluated and scored. A score of >7 was considered excellent, a score of 6 to 7 good, and a score of ≤5 poor.Results The staining time for rapid staining was approximately 3 minutes, whereas that of routine staining was approximately 12 minutes. There were no significant differences in the staining quality scores or proportions of sections in each grade between the two staining methods. The proportions of sections that were classified as excellent or good were 96.7% and 98.3% for rapid and routine staining, respectively.Conclusions In frozen breast tissue sections, rapid H&E staining may provide staining quality that is comparable to that of routine staining, while markedly reducing the staining time.

This article disclosed the influence of acid-ether ratio, n(SH)/n(IPEG), and n(APS)/n(IPEG) on adsorption and fluidity performance. The optimum synthetic parameters of acid-ether ratio, n(SH)/n(IPEG) and n(APS)/n(IPEG) were 0.5, 0.35 and 0.05, respectively. The rheology fitting equation was τ= 719.55γ+ 1834.54. And the correlation coefficient was 0.9843. The cement paste conformed to the law of pseudoplastic fluid. The preferred PCE-11 had excellent performance in freshly mixed and hardened concrete.

Non-healing diabetic wounds (DW) are a serious clinical problem that remained poorly understood. We recently found that topical application of growth differentiation factor 11 (GDF11) accelerated skin wound healing in both Type 1 DM (T1DM) and genetically engineered Type 2 diabetic db/db(T2DM) mice. In the present study, we elucidated the cellular and molecular mechanisms underlying the action of GDF11 on healing of small skin wound. Single round-shape full-thickness wound of 5-mm diameter with muscle and bone exposed was made on mouse dorsum using a sterile punch biopsy 7 days following the onset of DM. Recombinant human GDF11 (rGDF11, 50 ng/mL, 10 μL) was topically applied onto the wound area twice a day until epidermal closure (maximum 14 days). Digital images of wound were obtained once a day from D0 to D14 post-wounding. We showed that topical application of GDF11 accelerated the healing of full-thickness skin wounds in both type 1 and type 2 diabetic mice, even after GDF8 (a muscle growth factor) had been silenced. At the cellular level, GDF11 significantly facilitated neovascularization to enhance regeneration of skin tissues by stimulating mobilization, migration and homing of endothelial progenitor cells (EPCs) to the wounded area. At the molecular level, GDF11 greatly increased HIF-1ɑ expression to enhance the activities of VEGF and SDF-1ɑ, thereby neovascularization. We found that endogenous GDF11 level was robustly decreased in skin tissue of diabetic wounds. The specific antibody against GDF11 or silence of GDF11 by siRNA in healthy mice mimicked the non-healing property of diabetic wound. Thus, we demonstrate that GDF11 promotes diabetic wound healing via stimulating endothelial progenitor cells mobilization and neovascularization mediated by HIF-1ɑ-VEGF/SDF-1ɑ pathway. Our results support the potential of GDF11 as a therapeutic agent for non-healing DW.

Longitudinal image analysis plays an important role in depicting the development of the brain structure, where image regression and interpolation are two commonly used techniques. In this paper, we develop an efficient model and approach based on a path regression on the image manifold instead of the geodesic regression to avoid the complexity of the geodesic computation. Concretely, first we model the deformation by diffeomorphism; then, a large deformation is represented by a path on the orbit of the diffeomorphism group action. This path is obtained by compositing several small deformations, which can be well approximated by its linearization. Second, we introduce some intermediate images as constraints to the model, which guides to form the best-fitting path. Thirdly, we propose an approximated quadratic model by local linearization method, where a closed form is deduced for the solution. It actually speeds up the algorithm. Finally, we evaluate the proposed model and algorithm on a synthetic data and a real longitudinal MRI data. The results show that our proposed method outperforms several state-of-the-art methods.

In order to research the sintering mechanism of Y2O3on CaZrO3, CaZrO3was synthesized by solid reaction using analytical ZrO2and CaCO3as raw materials and Y2O3as additive. The liner change rate, the relative density, XRD and the microstructure of the CaZrO3samples were determined, and the effect of Y2O3on sintering of CaZrO3was researched. The results show that the sintering property of CaZrO3is enhanced by adding Y2O3. When the content of Y2O3 is lower than 2 % (mass-%), the lattice volume of CaZrO3increases to 0.262 nm3, which is attributed to Zr4+being replaced by Y3+in the CaZrO3crystal. However, the content of Y2O3is up to 4 %, and the lattice volume decreases due to Ca2+being replaced by Y3+. The liner change rate of the samples increases with increasing Y2O3additive. When Y2O3is 4 %, the liner change rate of CaZrO3reaches maximum (26.9 %). The relative density of the samples increases from 63.99 to 84.45 % with increasing addition of Y2O3, and the average grain size of CaZrO3increases from 1.64 to 2.65 μm when the additive increases from 0 to 4 %.

In a fusion reactor, plasma-facing components (PFCs) will suffer severe thermal shock; behavior and performance of PFCs under high heat flux (HHF) loads are of major importance for the long-term stable operation of the reactor. This work investigates the thermo-mechanical behaviors of tungsten armor under high heat loads by the method of finite element modeling and simulating. The temperature distribution and corresponding thermal stress changing rule under different HHF are analyzed and deduced. The Manson–Coffin equation is employed to evaluate the fatigue lifetime (cyclic times of HHF loading) of W-armored first wall under cyclic HHF load. The results are useful for the formulation design and structural optimization of tungsten-armored PFCs for the future demonstration fusion reactor and China fusion experimental thermal reactor.

The detection of disease-related DNA is of great significance for early and accurate diagnosis and therapy. In this work, we successfully achieved the sensitive detection of target DNA based on a thioflavin T (ThT)-induced G-quadruplex fluorescent biosensor. ThT, a water-soluble fluorescent dye, can induce G-rich sequences to form G-quadruplexes and obtain an obviously enhanced fluorescence. In this work, it was employed to construct a biosensor for the detection of HIV. When the target HIV existed, the hairpin DNA probes would be opened in succession and release the completely exposed G-rich sequence to combine with ThT. The simple and rapid biosensor performed satisfactory selectivity; it also exhibited sensitivity with a detection limit of 2.4 nM. With good performance in human serum, we believe that this optical biosensor has the potential to be applied to the practical detection of target DNA.

Efficient method was proposed for the qualitative detection of 6 illegal sweeteners in commercial liquor and wine by laser Raman spectroscopy. The method was based on the comparative analysis of Raman spectrogram of pure sweeteners and alcohol samples. For the 6 kinds of sweeteners tested, saccharin sodium, acesulfame potassium impurity and cyclamate, were present as additives in the samples. The results showed that the proposed method was fast and simple with high repeatability and sensitivity, and needed little samples and cost less. Keywords: Sweeteners, Qualitative Analysis, Micro-Laser Raman, Liquor and Wine

With the continuous improvement in technology, campus life and learning applications are becoming increasingly modernization, and the popularity of mobile networks makes mobile terminals (especially smart phones) work as the most important information form for college students. Taking advantages of Android platform’s features to achieve efficient and intelligent campus applications, not only can implement synchronization of information dissemination, as well as in-time, learning and life convenience, but also reduce the students’ dependence on computers, which makes interpersonal communication everywhere. This paper takes the campus dining application for example, to explore campus applications based on Android, thereby promoting the construction of campus information technology, and further enrich the local campus life and learning.

The influence of performance is difference along with the change content of chloride ion through the experimental study, so it is necessary to carry on the analysis of the reaction mechanism in blend. At the base of dissemination mechanism and solidification mechanism, the thorough research can be conducted about chloride ion is cured by cement-fly-ash-flushed-by-seawater. The contrast analysis about the dissemination and solidification of chloride ion in base-materials will be researched through microscopic experimental and the analysis of solidification rate. The best chloride ion content can be discovered from the research that it can obtain the best dissemination-solidification and make the influence of performance to be smallest. The dissemination-process of chloride ion in fly-ash-flushed-by-seawater is from the surface of fly-ash-flushed-by-seawater to the interior of cement-gelatin, it is different from internal addition method, and it is proposed for the first time in this what simulate the fly-ash-flushed-by-seawater by soaking fly-ash by the solution of NaCl.

As the development of network the grid will be widely used. To choose a suitable authentication mechanism in a large grid is very important. Identity authentication is one of the important mechanisms that can achieve grid security. It is the first line in the grid applications. It is also a portal in the security system. In the light of the advantages and disadvantages of PKI and ID-PKI, this paper provides a new technology. Presently, PKI and ID-PKI authentication technology is a popular authentication technology. This technology uses the identity certification to reduce the overhead in the domain, and uses CA authentication between domains to guarantee the security of the system.

Due to the heavy traffic and channelization, vehicle often brake and park for a long time at the urban road signal intersection, especially at heavy traffic intersection, for which it is easy to present permanent deformation on asphalt pavement. It can significantly improve the technical characteristics of the road intersection with adding Dolanit fiber into asphalt concrete. Based on BISAR3.0 software of applying layered elastic system theory and combined with the surface layer analysis on indoor mechanical property test to Dolanit fiber rein-forced asphalt concrete pavement, the results show that the allowable tensile stress is 0.61MPa. Even if at the condition of overload 50% and emergency braking, there is no shear failure on the Dolanit fiber rein-forced asphalt concrete pavement.

Through analyzing the influence of different slat content on the microstructure of cement and fly-ash-flushed-by-seawater binder, the solidification mechanism of salt added cement and fly-ash-flushed-by-seawater binder is investigated. The Scanning Electron Microscope test, X-Ray diffraction and theoretical analysis method are adopted to study the performance and the microstructure of cement and fly-ash-flushed-by-seawater, and to analyze the solidification mechanism of chloride in the mixture. When content of the chloride ions is added to the cement and fly-ash-flushed-by-seawater binder, a new kind of crystal-Friedel can be generated in the age of 7d and 28d. According to the unconfined strength test on the specimens which contain 0.5% chloride ions, the strength is high in 7d, highest in 28d. The chloride ions of the fly-ash-flushed-by-seawater can be solidified in the cement and fly-ash-flushed-by-seawater binder, which can increase the strength of the binder.

In order to study on the influence of chloride ion on pavement performance of base material with fly-ash-flushed-by-seawater and the feasibility of fly-ash-flushed-by-seawater material used to road construction, the analysis and evaluation on the influence of chloride salt content on pavement performance of material base course are obtained through the laboratory test on pavement performance of base course with adding different content of chloride salt. The study shows that the chloride salt content in fly-ash-flushed-by-seawater influences slightly on the early strength of base course and even plays a function of early strength agent; the chloride salt content in fly-ash-flushed-by-seawater has an inhibiting effect on the growth of strength when it is more than 1.3%; the dry shrinkage coefficient increases with the aggrandizement of chloride salt content and the anti-erosion performance of material is sensitive to the chloride salt content, but temperature shrinkage coefficient and anti-freeze performance are slightly influenced by it. Fly-ash-flushed-by-seawater used to base course construction is feasible because the pavement performance of fly-ash-flushed-by-seawater base material satisfies the request of Specifications for Design of Highway Asphalt Pavement JTG D50-2006.

AbstractDue to its potential to greatly accelerate a wide variety of applications, reconfigurable computing has become a subject of a great deal of research. In this paper, we explore the representation models of 1D routing structure and 2D routing structure, we also focus on the task scheduling that targets these representation models. A fast navigation-placement tree algorithm is proposed to formulate the scheduling problem for guarantee-based scheduling of hardware tasks. We present two heuristics, the horizon and the vertical technique, which can be summarized on bin-packing and applied to the problem of placing tasks on guarantees. Simulation experiments evaluate the performance and runtime efficiency of the proposed algorithm.