58 results on '"Zhu, Huimin"'
Search Results
2. A biomimetic ion channel shortens the QT interval of type 2 long QT syndrome through efficient transmembrane transport of potassium ions.
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Sun, Shuang, Xu, Zhaocheng, Lin, Ze, Chen, Weiwei, Zhang, Yue, Yan, Mengjie, Ren, Shengnan, Liu, Qihui, Zhu, Huimin, Tian, Bin, Zhang, Jian, Zhang, Weijia, Jiang, Shan, Sheng, Chuqiao, Ge, Jingyan, Chen, Fangfang, and Dong, Zeyuan
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POTASSIUM ions ,LONG QT syndrome ,ION channels ,ION transport (Biology) ,CELL membranes - Abstract
Potassium ion transport across myocardial cell membrane is essential for type 2 long QT syndrome (LQT2). However, the dysfunction of potassium ion transport due to genetic mutations limits the therapeutic effect in treating LQT2. Biomimetic ion channels that selectively and efficiently transport potassium ions across the cellular membranes are promising for the treatment of LQT2. To corroborate this, we synthesized a series of foldamer-based ion channels with different side chains, and found a biomimetic ion channel of K
+ (BIC K) with the highest transport activity among them. The selected BIC K can restore potassium ion transport and increase transmembrane potassium ion current, thus shortening phase 3 of action potential (AP) repolarization and QT interval in LQT2. Moreover, BIC K does not affect heart rate and cardiac rhythm in treating LQT2 model induced by E4031 in isolated heart as well as in guinea pigs. By restoring ion transmembrane transport tactic, biomimetic ion channels, such as BIC K , will show great potential in treating diseases related to ion transport blockade. Type 2 long QT syndrome (LQT2) is a disease caused by K+ transport disorder, which can cause malignant arrhythmia and even death. There is currently no radical cure, so it is critical to explore ways to improve K+ transmembrane transport. In this study, we report that a small-molecule biomimetic ion channel BIC K can efficiently simulate natural K+ channel proteins on the cardiomyocyte and cure E4031-induced LQT2 in guinea pig by restoring K+ transport function for the first time. This study found that the potassium transmembrane transport by BIC K significantly reduced the QT interval, which provides a conceptually new strategy for the treatment of LQT2 disease. [Display omitted] [ABSTRACT FROM AUTHOR]- Published
- 2024
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3. Model-Free Current Predictive Control Method for Switched Reluctance Motors
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Han, Guoqiang, Zhu, Huimin, Zhang, Lin, Hong, Jingwei, and Zhu, Beibei
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It is difficult to obtain an accurate mathematical model of a switched reluctance motor (SRM). In this article, the current difference-based model-free predictive current control (CDB-MFPCC) strategy is proposed. A novel updated method of current difference is given considering the control delay. The beetle antennae search algorithm is applied to adjust the proportional and integral coefficients to increase the dynamic response. Only the phase current at two consecutive sampling points is required in this method. Moreover, the model predictive current control and the recursive least square-based model-free predictive current control strategies are investigated and compared with the CDB-MFPCC strategy. The advantages of the proposed method are validated with simulations and experiments.
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- 2024
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4. Facultative symbiont provides fitness benefits to the grain aphid, but not to parasitoid offspring
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Zhu, Huimin, Li, Delu, Desneux, Nicolas, Gatti, Jean-Luc, Hu, Zuqing, and Luo, Chen
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Symbiotic microbes have evolved to become an important source of phenotypic plasticity in host insects. In aphids, facultative endosymbionts have been found capable of influencing host phenotypes, such as against natural enemies and host fitness. However, the related evidence has been mainly gathered from a few model organisms, such as the pea aphid. Here, we explored the roles of a common facultative symbiont of the genus Rickettsia in the grain aphid pest Sitobion avenae. We first observed that Rickettsia-infected aphids (either natural or artificial status) benefit of a higher population increase rate (nearly 1.23-fold) than the Rickettsia-free aphids from the same genetic background. While Rickettsia presence did not confer resistance against the aphid parasitoid Aphidius gifuensis, emerged wasps from Rickettsia-infected aphids had a significantly reduced weight and their sex ratio was biased toward more female wasps. These results suggest that the presence of the symbiont ameliorates the fitness of its aphid host, but impacts the growth of parasitoid offspring and the parasitoid sex-ratio in a way that could be detrimental for the aphid. This demonstrates that the presence of a facultative symbiont may lead to both positive and negative trade-offs, which may ultimately not affect the fitness of the host population as they are compensatory.
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- 2024
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5. Oxidation and electrical properties of nanostructured CeO2–Ni coating on solid oxide fuel cell interconnects
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Zhu, Huimin, Zhang, Jun, and Cao, Wenbo
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A nanostructured CeO2–Ni coating is prepared on a steel substrate via two-step electrodeposition. An oxide scale with a multi-layer structure of Cr2O3–(Mn,Cr)3O4–(Ni,Mn,Cr)3O4–NiO has developed on the coated steel after 1680 h of oxidation in air at 800 °C. CeO2is uniformly distributed in the spinel and NiO layers. The synergistic effects originating from nanostructured CeO2and NiO not only reduce the growth rate of Cr2O3and suppress the outward diffusion of Cr, but also improve the electrical performance of the surface scale.
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- 2024
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6. Symbol Detection for Coarsely Quantized OTFS
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He, Junwei, Zhang, Haochuan, Dong, Chao, and Zhu, Huimin
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This letter explicitly models a coarse and noisy quantization in a communication system empowered by orthogonal time frequency space (OTFS) for cost and power efficiency. We first point out, with coarse quantization, the effective channel is imbalanced and thus no longer able to circularly shift the transmitted symbols along the delay-Doppler domain. Meanwhile, the effective channel is non-isotropic, which imposes a significant loss to symbol detection algorithms like the original approximate message passing. Although the algorithm of generalized expectation consistent for signal recovery (GEC-SR) can mitigate this loss, the complexity in computation is prohibitively high, mainly due to an dramatic increase in the matrix size of OTFS. In this context, we propose a low-complexity algorithm that embed into GEC-SR a quick inversion of the quasi-banded matrices, thus reducing the algorithm's complexity from cubic order to linear order, while keeping the performance at almost the same level.
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- 2024
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7. An Improved Virtual-Shaft Control Strategy for Speed Synchronization of Dual-SRM Drive
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Han, Guoqiang, Hong, Jingwei, Chen, Bingnan, Zhu, Huimin, Zhu, Beibei, and Yu, Dongsheng
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In order to improve the dynamic performance of the speed synchronization method for dual switched reluctance motor (SRM) drive, an improved virtual-shaft control strategy is proposed. The synchronization scheme is optimized from two aspects. First, the torque distribution and adjustment method is introduced into the overall control strategy of the dual-SRM drive. The load torque of two SRMs is observed with the sliding mode observer. Then, the feedforward reference torque of each SRM is calculated according to the reference torque and reference speed of the virtual motor. The operating states of dual-SRM are rapidly reflected in the speed synchronization method. Second, the nonsingular terminal sliding mode control method for the virtual motor and the dynamic sliding mode control method for two SRMs are designed by optimizing the sliding surface and the reaching law. The stability of the designed controllers is validated with the Lyapunov function. The effectiveness of the proposed strategy is validated with simulations and experiments.
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- 2024
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8. Knowledge, attitude, and practice regarding sarcopenia: a survey between orthopedic and geriatric professionals in China.
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Lu, Fangying, Ruan, Shengyu, Xu, Xianquan, Song, Xiaoting, Li, Zhiyan, Chen, Cunguo, Feng, Mingxuan, Zhu, Huimin, Tung, Tao-Hsin, and Hong, Dun
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Background: In elderly patients with fractures, sarcopenia impairs recovery and even increases mortality. Both orthopedic and geriatric professionals are at the forefront of treating sarcopenic patients with fractures. However, it is not clear to what extent they have knowledge and skills to diagnose and treat sarcopenia. Aims: This study aimed to analyze and compare knowledge, attitude, and practice regarding sarcopenia between orthopedic and geriatric professionals. Methods: An online cross-sectional survey was conducted in June 2022 targeting professionals in orthopedic and geriatric departments in two largest tertiary general hospitals in Taizhou, southeastern China. Results on knowledge, attitude, and practice of sarcopenia were analyzed. Variables with significance were then included in a stepwise multiple linear regression analysis. Results: A total of 220 professionals, 176 from orthopedic departments and 44 from geriatric departments, participated in this study. Orthopedic professionals scored lower than geriatrics in knowledge, attitude and practice (P < 0.001). The attitude score was high in both orthopedic and geriatric professionals. Stepwise multiple linear regression analysis showed that participants who had contact with sarcopenia patients had higher knowledge score (β = 1.941, P < 0.001); participants who had attended sarcopenia training in the past 6 months (β = 4.305, P < 0.001) had higher practice score. Discussion: Orthopedic professionals have deficiencies in the screening and diagnosis of sarcopenia. Improving the knowledge and training of professionals can strengthen practice. It is necessary to formulate diagnostic criteria and improve practice of sarcopenia through training. Conclusion: Orthopedic professionals had limited knowledge and practice regarding sarcopenia compared with geriatric professionals. To improve sarcopenia practice, the use of diagnostic tools to formally diagnose sarcopenia and regular training on sarcopenia should be encouraged. [ABSTRACT FROM AUTHOR]
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- 2023
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9. Infantile Internal and External Exposure to Neonicotinoid Insecticides: A Comparison of Levels across Various Sources.
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Zhang, Henglin, Wang, You, Zhu, Huimin, Lu, Shaoyou, Wang, Yu, Xue, Jingchuan, Zhang, Tao, Kannan, Kurunthachalam, and Sun, Hongwen
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- 2023
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10. Arctigenin derivatives improve exercise performance in mice: synthesis and biological evaluation
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Zeng, Wanbo, Wu, Xiaowen, Zhu, Huimin, Shi, Weiguo, Li, Xiang, Tan, Junjie, and Xu, Liang
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Arctigenin (ARG) has potent antifatigue activity, but its clinical application has been restricted for its poor water solubility. In this study, seven ARG derivatives containing different amino acids coupled via an ethoxy linker were synthesized, and tested for their solubility, as well as activities to improve exercise performance in mice. All of the derivatives showed improved solubility compared to that of ARG. Derivative Z-A-6 exhibited the highest activity, showing that the mice ran a 4.88-fold greater distance in the running wheel test and swam a 2.86-fold greater time in the swimming test than those in the blank control group. Z-A-6 treatment increased the plasma superoxide dismutase and catalase concentrations as well as reduced lactic acid and blood urea nitrogen accumulation during exercise. Z-A-6 treatment enhanced the phosphorylation of adenosine monophosphate-activated protein kinase, and no acute toxicity was observed. The results will contribute to the development of potential antifatigue agents.Graphical AbstractArctigenin derivatives showed better solubility and Z-A-6 showed better improvement of exercise performance compared to that of ARG.
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- 2023
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11. Infantile Internal and External Exposure to Neonicotinoid Insecticides: A Comparison of Levels across Various Sources
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Zhang, Henglin, Wang, You, Zhu, Huimin, Lu, Shaoyou, Wang, Yu, Xue, Jingchuan, Zhang, Tao, Kannan, Kurunthachalam, and Sun, Hongwen
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Little is known about exposure of infants to neonicotinoid insecticides (NEOs). In this study, concentrations of six parent NEOs (p-NEOs) and N-desmethyl-acetamiprid (N-dm-ACE) were measured in urine and whole blood samples from infants, in addition to breast milk, infant formula, and tap water collected in South China. The p-NEO with the highest median concentration in urine (0.25 ng/mL) and blood (1.30) samples was dinotefuran (DIN), while imidacloprid (IMI) was abundant in breast milk (median: 0.27 ng/mL), infant formula (0.22), and tap water (0.028). The older infants (181–360 days) might face higher NEO and N-dm-ACE exposure than younger infants (0–180 days). Blood samples contained a significantly (p< 0.01) higher median concentration of ∑6p-NEOs (2.03 ng/mL) than that of urine samples (0.41), similar to acetamiprid (ACE), IMI, thiacloprid (THD), DIN, and N-dm-ACE, suggesting that NEOs readily partition into blood. Furthermore, breast-fed infants tend to have higher exposure levels than formula-fed infants. Infant formula prepared with tap water augmented the daily intake of ∑NEOs. The external sources contributed 80% of the total dose to IMI and clothianidin (CLO) exposure, while other unknown sources contributed to ACE, THD, and DIN exposure in infants. To the best of our knowledge, this is the first study to assess levels and sources of infantile exposure to NEOs through internal and external exposure assessment.
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- 2023
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12. Mechanoactive Nanocomposite Hydrogel to Accelerate Wound Repair in Movable Parts.
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Cai, Chao, Zhu, Huimin, Chen, Yujie, Guo, Yutong, Yang, Zhi, Li, Hua, and Liu, Hezhou
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- 2022
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13. Knowledge, attitude, and practice regarding sarcopenia: a survey between orthopedic and geriatric professionals in China
- Author
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Lu, Fangying, Ruan, Shengyu, Xu, Xianquan, Song, Xiaoting, Li, Zhiyan, Chen, Cunguo, Feng, Mingxuan, Zhu, Huimin, Tung, Tao-Hsin, and Hong, Dun
- Abstract
Background: In elderly patients with fractures, sarcopenia impairs recovery and even increases mortality. Both orthopedic and geriatric professionals are at the forefront of treating sarcopenic patients with fractures. However, it is not clear to what extent they have knowledge and skills to diagnose and treat sarcopenia. Aims: This study aimed to analyze and compare knowledge, attitude, and practice regarding sarcopenia between orthopedic and geriatric professionals. Methods: An online cross-sectional survey was conducted in June 2022 targeting professionals in orthopedic and geriatric departments in two largest tertiary general hospitals in Taizhou, southeastern China. Results on knowledge, attitude, and practice of sarcopenia were analyzed. Variables with significance were then included in a stepwise multiple linear regression analysis. Results: A total of 220 professionals, 176 from orthopedic departments and 44 from geriatric departments, participated in this study. Orthopedic professionals scored lower than geriatrics in knowledge, attitude and practice (P< 0.001). The attitude score was high in both orthopedic and geriatric professionals. Stepwise multiple linear regression analysis showed that participants who had contact with sarcopenia patients had higher knowledge score (β= 1.941, P< 0.001); participants who had attended sarcopenia training in the past 6 months (β= 4.305, P< 0.001) had higher practice score. Discussion: Orthopedic professionals have deficiencies in the screening and diagnosis of sarcopenia. Improving the knowledge and training of professionals can strengthen practice. It is necessary to formulate diagnostic criteria and improve practice of sarcopenia through training. Conclusion: Orthopedic professionals had limited knowledge and practice regarding sarcopenia compared with geriatric professionals. To improve sarcopenia practice, the use of diagnostic tools to formally diagnose sarcopenia and regular training on sarcopenia should be encouraged.
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- 2023
- Full Text
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14. Speed sensorless control of a bearingless induction motor based on sliding mode observer and phase-locked loop.
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Yang, Zebin, Ding, Qifeng, Sun, Xiaodong, Lu, Chengling, and Zhu, Huimin
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INDUCTION motors ,PHASE-locked loops ,SENSORLESS control systems ,SLIDING mode control ,BOUNDARY layer (Aerodynamics) ,SPEED - Abstract
To realize the low-cost and high-performance of a bearingless induction motor (BIM), a speed sensorless control strategy combined with the improved sliding mode observer (SMO) and phase locked-loop (PLL) is proposed. Based on analyzing the principle of the traditional SMO, the improved SMO adopts a switching function that has a double boundary layer structure to reduce the high-frequency jitter. Firstly, the observation equation of the rotor flux is established where the stator current, as well as the rotor flux are two state variables, and then the system stability is discussed with the Lyapunov theory. Secondly, to reduce the rotor chatter and enhance the speed tracking performance a flux electrical angle detecting module is constructed based on the PLL structure that extracts the rotor flux electrical angle and speed from the observed flux component. Finally, the BIM speed sensorless vector control system is established and the simulation results and experimental results are respectively presented by the MATLAB/Simulink simulation platform and a laboratory prototype. Both results prove that this strategy can not only enhance the speed self-detection capability and tracking performance, but can guarantee the excellent self-suspension function as well. • The SMO of the new type induction motor BIM is designed. • The switching function with double boundary layer is introduced into the SMO. • The rotor flux electrical angle detecting module is constructed based on the PLL. [ABSTRACT FROM AUTHOR]
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- 2022
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15. Potential sources of novel proteins suitable for use as ingredients in 3D food printing, along with some of the food safety challenges
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Wu, Jinyuan, Zhu, Huimin, and Li, Changjian
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3D printing enables personalized customization and improves food production efficiency. With the increasing demand for protein, 3D printed food based on novel proteins has become a prominent research hotspot. This paper provides an overview of recent advances in novel protein research, including the categorization and examples of novel protein sources. For example, novel proteins have been derived from plants, algae, and insects. In addition, the potential of industrial microbial proteins as raw materials for 3D printing has been emphasized. Although no research has been reported on industrial microbial proteins for 3D food printing, this is expected to be an area of intense focus for the future development of 3D printed protein foods. We then discuss modification techniques for complexing novel proteins with polysaccharides, microgels, and other materials. Finally, this review explores the future challenges of combining novel proteins with 3D printing technology from food safety and regulatory perspectives. Examples include exogenous additives in novel protein products, consumer acceptance, and consumption safety, providing guidance on 3D food safety for researchers in this critical area.
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- 2024
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16. Resveratrol pretreatment protects neurons from oxygen–glucose deprivation/reoxygenation and ischemic injury through inhibiting ferroptosis
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Zhu, Huimin, Huang, Jiagui, Chen, Yue, Li, Xuemei, Wen, Jun, Tian, Mingfen, Ren, Jiangxia, Zhou, Li, and Yang, Qin
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Ferroptosis, a newly discovered iron-dependent cell death, is involved in brain ischemia–reperfusion injury. Iron scavengers or ferroptosis inhibitors could reduce infarct volume and improve neurological function in mice. Resveratrol has neuroprotective and neurorestorative effects. However, it is unclear whether resveratrol can play a neuroprotective role via inhibiting ferroptosis. Our study showed that resveratrol pretreatment had a similar effect with ferrostatin‑1, which inhibited neuronal ferroptosis-related changes, such as iron overload, damages of oxidation-reduction system, and destruction of mitochondrial structure, after oxygen–glucose deprivation/reoxygenation (OGD/R) and application of ferroptosis inducers. In addition, middle cerebral artery occlusion/reperfusion (MCAO/R) injury in vivoalso induced ferroptosis, and resveratrol pretreatment could inhibit ferroptosis and reduce degenerative neurons, cerebral ischemic damage and infarction volume. Our results are the first to indicate that resveratrol pretreatment might inhibit ferroptosis induced by OGD/R and ferroptosis inducers in neurons, and MCAO/R in rats.Graphical AbstractResveratrol pretreatment protects neurons from oxygen–glucose deprivation/reoxygenation and ferroptosis inducers in vitro, and ischemic injury in vivothrough inhibiting ferroptosis.
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- 2022
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17. The Effect of Condylar Regeneration After Different Disc Repositioning Surgeries in Adolescents with Skeletal Class II Malocclusion.
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Zhu, Huimin, He, Dongmei, Yang, Zhi, Lu, Chuan, Zhao, Jieyun, and Yang, Chi
- Abstract
Purpose: To evaluate the effect of different temporomandibular joint (TMJ) disc repositioning surgeries for the treatment of anterior disc displacement (ADD) in juvenile patients with skeletal Class II malocclusion.Patients and Methods: Patients (< 20 years, cervical vertebral maturation stage, IV-V) who had bilateral TMJ ADD with skeletal Class II malocclusion were treated by disc repositioning surgery (mini-screw anchor, [MsA]; or opening suturing, [OSu]). Magnetic resonance imaging (MRI) and lateral cephalometric films before and more than 12 months after surgery were collected from all patients. Changes of SNA, SNB, ANB, incisor overjet, pogonion position (pg'-G'), and condylar height were measured before and after surgery in different disc reposition surgeries and compared by statistical analysis.Results: Eighty-four patients with an average age of 16.44 years and follow-up time of 14.60 months (12 to 33 months) were included in the study. Among them, 16 patients had a mean follow-up of 14.8 months without treatment before disc repositioning. Their condylar height was significantly decreased (P = .004) by MRI measurement. Six patients who had cephalometric films showed significantly decreased SNB (P = .042) and increased overjet (P = .037). After disc repositioning by either OSu (54 cases) or MsA (30 cases), condylar height, SNB were significantly increased and overjet, Pg'-G', ANB were decreased in both groups (P < 0.001). There was more new bone height in OSu than MsA (P = .004), but no significant differences in SNB, ANB, overjet and Pg'-G' between the 2 groups (P > .05). The new bone height was significantly correlated with the surgical method (P = .029), age (P = .015), SNB (P = .008), overjet (P = .048) and pg'-G' (P = .001).Conclusions: Both types of disc repositioning method can effectively promote condylar regeneration and improve skeletal Class II malocclusion in adolescents with ADD. Disc repositioning by OSu obtained more new bone height than MsA. [ABSTRACT FROM AUTHOR]- Published
- 2021
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18. Preliminary Study of Standard Artificial Temporomandibular Joint Replacement With Preservation of Muscle Attachment.
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Zou, Luxiang, He, Dongmei, Yang, Chi, Lu, Chuan, Zhao, Jieyun, and Zhu, Huimin
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Purpose: To evaluate the effect of preserving the muscle attachments when performing standard artificial temporomandibular joint replacement (TJR).Patients and Methods: The clinical and radiological imaging data of patients who underwent standard artificial TJR with and without preservation of lateral pterygoid muscle (LPM) and masseter muscle attachments from January 2017 to December 2019 were collected. The maximum interincisal opening (MIO), lateral excursions and protrusion distances, visual analogue scale (VAS) scores of pain, diet, and quality of life (QoL) were recorded before the operation, and 1, 3, 6, and 12 months after the operation. The volumes of LPM and masseter muscles were measured and analyzed by computed tomography (CT) scans.Results: Twenty-seven patients with 36 joints were included in the study. Among them, 11 joints had muscle attachment preserved, and 25 had no muscle attachment preserved. After surgery, the MIO, lateral excursions, and scores of diet, pain, and QoL in the preserved muscle attachment group were significantly better than those in the unpreserved group (P < .05). The measurement volumes of LPM and masseter muscles in the preserved group were significantly larger than that in the unpreserved group (P < .05). Changes of lateral excursion from the TJR side with and without LPM preservation were statistically correlated with the LPM volume (P < .05).Conclusion: Preserving muscle attachment for the standard artificial TJR is beneficial to the recovery of postoperative mandibular function. [ABSTRACT FROM AUTHOR]- Published
- 2021
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19. The effect of TMJ disk repositioning by suturing through open incision on adolescent mandibular asymmetry with and without a functional orthodontic appliance.
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Zhu, Huimin, Yang, Zhi, He, Dongmei, Hu, Nan, and Cheng, Zheying
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Objective: The objective of this study was to evaluate the effect of combined temporomandibular joint (TMJ) disk repositioning by suturing through open incision and orthodontic functional appliance (OFA) treatment for adolescents with mandibular asymmetry.Study Design: Adolescent patients (12-20 years old) with mandibular asymmetry combined with unilateral TMJ disk displacement without reduction were treated with disk repositioning by suturing through open incision with and without postoperative OFA. Magnetic resonance imaging and posteroanterior cephalometric radiographs (PA) were used to measure and compare the changes in condylar height, joint space, and menton deviation pre- and postoperatively.Results: Twenty-six patients were included in the study. Joint space was significantly increased postoperatively and new bone mostly formed at the superior or posterior superior part of the condyle after 6 to 18 months in all surgically treated joints. Fourteen patients with OFA had a significant increase in condylar height and menton deviation compared to 12 patients without OFA (2.29 ± 0.91 mm vs 1.22 ± 0.69 mm, P = .003; 4.56 ± 1.48 mm vs 2.01 ± 0.74 mm, P = .000).Conclusions: Combined treatment with TMJ disk repositioning by suturing through open incision and OFA can promote condylar growth and correct mandibular deviation in adolescent patients. Postoperative OFA can maintain the increased joint space created by disk repositioning and promote new bone formation at the superior and posterior parts of the condyle. [ABSTRACT FROM AUTHOR]- Published
- 2021
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20. Adenosine and its derivatives improve exercise performance and exert anti-fatigue effects via AMPK/PGC-1α signaling pathway in mice.
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Zhu, Huimin, Zhao, Tangna, Zeng, Wanbo, Dong, Xiao, Luo, Yuan, Li, Xiang, Zhang, Aiping, Shi, Weiguo, and Xu, Liang
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Studies of the AMPK/PGC-1α signaling pathway and exercise-induced metabolism have facilitated the development of anti-fatigue agents and exercise mimetics. In this work, adenosine and its 22 derivatives, typical of substitutions at the hydroxyl group of the sugar moiety, were firstly evaluated as anti-fatigue agents. In the running wheel tests, adenosine and most derivatives demonstrated a significant increase in the exhaustion distance when compared to the control group. Particularly, the optimized compound 2 exhibited a 3.1-fold increase in exhaustion distance compared to the positive control group treated with AICAR, and a remarkable 9.8-fold increase compared to the blank control group. Furthermore, improved performances were observed in weight-loaded swimming, high jumping, hanging wire, and tail suspension tests. Compound 2 not only reduced levels of lactic acid (LA) and blood urea nitrogen (BUN), but also preserved hepatic and muscle glycogen content during exercise. Notably, compound 2 activated AMPK/PGC-1α pathway without stimulating the central nervous system. Moreover, compound 2 demonstrated a favorable safety in vivo at a dose of 1.96 × 10
-5 mol/kg for 21 days. This study unveils, for the first time, the ability of adenosine and its derivatives to resist exercise-induced fatigue, thereby providing promising lead compounds for the development of drugs aimed to prevent and treat fatigue-related diseases. Moreover, it sheds light on the potential therapeutic approaches utilizing endogenous substance. [ABSTRACT FROM AUTHOR]- Published
- 2024
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21. A bilayered scaffold with segregated hydrophilicity-hydrophobicity enables reconstruction of goat hierarchical temporomandibular joint condyle cartilage.
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Yu, Xi, Hu, Yihui, Zou, Luxiang, Yan, Shifeng, Zhu, Huimin, Zhang, Kunxi, Liu, Wenguang, He, Dongmei, and Yin, Jingbo
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TEMPOROMANDIBULAR joint ,CARTILAGE ,GLUTAMIC acid ,MANDIBULAR condyle ,MESENCHYMAL stem cells ,TISSUE engineering - Abstract
Temporomandibular joint (TMJ) supports chewing, talking or other daily oral activities. So far, it still remains a great challenge to treat the defected TMJ condyle cartilage through tissue engineering technology. Herein, a bilayered scaffold is designed to fully reconstruct the different cartilage matrices of TMJ condyle under same induction condition. The bilayered scaffold with segregated hydrophobicity-hydrophilicity in top and bottom layer is prepared from a low and high content of polyethylene glycol (PEG) crosslinked poly (L-glutamic acid)- g -polycaprolactone (PLGA- g -PCL). The hydrophobic aggregates in top layer support the adhesion and spread of bone mesenchymal stem cells (BMSCs), thus inducing the differentation towards fibrocartilage; while aggregates (spheroids) are formed on the hydrophlic bottom layer, showing a preferable hyaline differentiation pathway under same chondrogenic induction in vitro. After 14 d in vitro induction, the scaffold/BMSCs construct is implanted in goat TMJ condyle defects. The post-operative outcome after 2 months demonstrates that the defects are fully covered by neo-cartilage. And the regenerated hierarchical TMJ condyle cartilage perfectly consist of ordered fibrocartilage and hyaline cartilage, which is same as natural condyle cartilage. These results corroborate that this bilayered scaffold with segregated hydrophilicity-hydrophobicity carrying induced BMSCs is a promising for treatment of TMJ condyle cartilage defects. Image, graphical abstract [ABSTRACT FROM AUTHOR]
- Published
- 2021
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22. Fractional grey model based on non-singular exponential kernel and its application in the prediction of electronic waste precious metal content.
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Mao, Shuhua, Kang, Yuxiao, Zhang, Yonghong, Xiao, Xinping, and Zhu, Huimin
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METAL wastes ,PRECIOUS metals ,FORECASTING ,ELECTRONIC waste ,KERNEL functions ,ELECTRONIC waste disposal ,PRINTED circuits - Abstract
Precious metal recovery is the main economic power of electronic waste (e-waste) recovery. The prediction of e-waste and its precious metal content is of great significance to the realisation of China's circular economy. In this work, the generation mechanism of e-waste is firstly deduced to determine model characteristics suitable for its prediction. Fractional derivative grey models base on a weak singular power kernel function (PFGM(q ,1)) and a non-singular exponential kernel function (EFGM(q ,1)) are established. Compared with the PFGM(q ,1), the EFGM(q ,1) has the advantages of simpler solution, lower calculation complexity and wider scope of application. Next, some data are selected to verify the validity. The EFGM(q ,1) is used to predict mobile phone, laptop, desktop and television waste, and the weight of printed circuit boards (PCBs) in the waste and content of precious metals in these PCBs are calculated. Finally, the trend of e-waste and its precious metal contents are analysed and discussed based on the calculation results. • The kernel type of fractional derivative is considered when building model. • Two fractional derivative grey models are established. • The analytical solution of the novel models is obtained. • The EFGM(q,1) has the advantages of non-singularity, small computation. • The EFGM(q,1) can effectively predict the content of precious metals. [ABSTRACT FROM AUTHOR]
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- 2020
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23. APOE from patient-derived astrocytic extracellular vesicles alleviates neuromyelitis optica spectrum disorder in a mouse model
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Jiang, Shihe, Li, Xindi, Li, Yan, Chang, Zhilin, Yuan, Meng, Zhang, Ying, Zhu, Huimin, Xiu, Yuwen, Cong, Hengri, Yin, Linlin, Yu, Zhen-Wei, Fan, Junwan, He, Wenyan, Shi, Kaibin, Tian, De-Cai, Zhang, Jing, Verkhratsky, Alexei, Jin, Wei-Na, and Shi, Fu-Dong
- Abstract
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy of the central nervous system, mediated by antibodies against aquaporin-4 water channel protein (AQP4-Abs), resulting in damage of astrocytes with subsequent demyelination and axonal damage. Extracellular communication through astrocyte-derived extracellular vesicles (ADEVs) has received growing interest in association with astrocytopathies. However, to what extent ADEVs contribute to NMOSD pathogenesis remains unclear. Here, through proteomic screening of patient-derived ADEVs, we observed an increase in apolipoprotein E (APOE)–rich ADEVs in patients with AQP4-Abs–positive NMOSD. Intracerebral injection of the APOE-mimetic peptide APOE130–149attenuated microglial reactivity, neuroinflammation, and brain lesions in a mouse model of NMOSD. The protective effect of APOE in NMOSD pathogenesis was further established by the exacerbated lesion volume in APOE-deficient mice, which could be rescued by exogenous APOE administration. Genetic knockdown of the APOE receptor lipoprotein receptor–related protein 1 (LRP1) could block the restorative effects of APOE130–149administration. The transfusion ADEVs derived from patients with NMOSD and healthy controls also alleviated astrocyte loss, reactive microgliosis, and demyelination in NMOSD mice. The slightly larger beneficial effect of patient-derived ADEVs as compared to ADEVs from healthy controls was further augmented in APOE−/−mice. These results indicate that APOE from astrocyte-derived extracellular vesicles could mediate disease-modifying astrocyte-microglia cross-talk in NMOSD.
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- 2024
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24. A Synergistic Therapy With Antioxidant and Anti‐VEGF: Toward its Safe and Effective Elimination for Corneal Neovascularization
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Zhu, Huimin, Ye, Jinfa, Wu, Yiming, Cheng, Yuhang, Su, Min, Dai, Qixuan, Han, Yun, Pan, Jintao, Wu, Zhenyu, Chen, Chuan, Qiu, Chenyue, Li, Wei, Liu, Gang, and Chu, Chengchao
- Abstract
Corneal neovascularization (CNV) is one of the leading causes of blindness in the world. In clinical practice; however, it remains a challenge to achieve a noninvasive and safe treatment. Herein, a biocompatible shell with excellent antioxidant and antivascularity is prepared by co‐assembly of epigallocatechin gallate/gallic acid and Cu (II). After loading glucose oxidase (GOx) inside, the shell is modified with dimeric DPA‐Zn for codelivering vascular endothelial growth factor (VEGF) small interfering RNA (VEGF‐siRNA). Meanwhile, the Arg‐Gly‐Asp peptide (RGD) peptide‐engineered cell membranes coating improves angiogenesis‐targeting and is biocompatible for the multifunctional nanomedicine (CEGs/RGD). After eye drops administration, CEGs/RGD targets enrichment in neovascularization and CEGs NPs enter cells. Then, the inner GOxconsumes glucose with a decrease in local pH, which in turn leads to the release of EGCE and VEGF‐siRNA. As a result, the nanomedicines significantly reduce angiogenesis and inhibit CNV formation through synergistic effect of antioxidant and antivascular via down‐regulation of cluster of differentiation 31 and VEGF. The nanomedicine represents a safe and efficient CNV treatment through the combined effect of antioxidant/gene, which provides important theoretical and clinical significance. A kind of antioxidant and anti‐VEGF nanomaterial is prepared using epigallocatechin gallate/gallic acid, Cu(II), and glucose nanozymes. After loading with VEGF‐siRNA, the multifunctional nanomaterial is modified with neovascularization targeting cell membrane vesicles. Finally, the constructed bionic nanomedicine is applied in corneal neovascularization, achieving safe, long‐lasting, and effective treatment effect.
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- 2024
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25. A Five-in-One Novel MOF-modified Injectable Hydrogel with Thermo-sensitive and Adhesive Properties for Promoting Alveolar Bone Repair in Periodontitis: Antibacterial, Hemostasis, Immune reprogramming, Pro-osteo-/angiogenesis and Recruitment
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Yang, Shiyuan, Zhu, Yan, Ji, Chunxiao, Zhu, Huimin, Lao, An, Zhao, Ran, Hu, Yue, Zhou, Yuning, Zhou, Jia, Lin, Kaili, and Xu, Yuanjin
- Abstract
Periodontitis is a chronic inflammatory disease caused by plaque that destroys the alveolar bone tissues, resulting in tooth loss. Poor eradication of pathogenic microorganisms, persistent malignant inflammation and impaired osteo-/angiogenesis are currently the primary challenges to control disease progression and rebuild damaged alveolar bone. However, existing treatments for periodontitis fail to comprehensively address these issues. Herein, an injectable composite hydrogel (SFD/CS/ZIF-8@QCT) encapsulating quercetin-modified zeolitic imidazolate framework-8 (ZIF-8@QCT) is developed. This hydrogel possesses thermo-sensitive and adhesive properties, which can provide excellent flowability and post-injection stability, resist oral fluid washout as well as achieve effective tissue adhesion. Inspirationally, it is observed that SFD/CS/ZIF-8@QCT exhibits a rapid localized hemostatic effect following implantation, and then by virtue of the sustained release of zinc ions and quercetin exerts excellent collective functions including antibacterial, immunomodulation, pro-osteo-/angiogenesis and pro-recruitment, ultimately facilitating excellent alveolar bone regeneration. Notably, our study also demonstrates that the inhibition of osteo-/angiogenesis of PDLSCs under the periodontitis is due to the strong inhibition of energy metabolism as well as the powerful activation of oxidative stress and autophagy, whereas the synergistic effects of quercetin and zinc ions released by SFD/CS/ZIF-8@QCT are effective in reversing these biological processes. Overall, our study presents innovative insights into the advancement of biomaterials to regenerate alveolar bone in periodontitis.
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- 2024
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26. Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design
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Quinn, Taylor R., Giblin, Kathryn A., Thomson, Clare, Boerth, Jeffrey A., Bommakanti, Gayathri, Braybrooke, Erin, Chan, Christina, Chinn, Alex J., Code, Erin, Cui, Caifeng, Fan, Yukai, Grimster, Neil P., Kohara, Keishi, Lamb, Michelle L., Ma, Lina, Mfuh, Adelphe M., Robb, Graeme R., Robbins, Kevin J., Schimpl, Marianne, Tang, Haoran, Ware, Jamie, Wrigley, Gail L., Xue, Lin, Zhang, Yun, Zhu, Huimin, and Hughes, Samantha J.
- Abstract
Casitas B-lymphoma proto-oncogene-b (Cbl-b) is a RING finger E3 ligase that has an important role in effector T cell function, acting as a negative regulator of T cell, natural killer (NK) cell, and B cell activation. A discovery effort toward Cbl-b inhibitors was pursued in which a generative AI design engine, REINVENT, was combined with a medicinal chemistry structure-based design to discover novel inhibitors of Cbl-b. Key to the success of this effort was the evolution of the “Design” phase of the Design-Make-Test-Analyze cycle to involve iterative rounds of an in silico structure-based drug design, strongly guided by physics-based affinity prediction and machine learning DMPK predictive models, prior to selection for synthesis. This led to the accelerated discovery of a potent series of carbamate Cbl-b inhibitors.
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- 2024
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27. LGGA-MPP: Local Geometry-Guided Graph Attention for Molecular Property Prediction
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Song, Lei, Zhu, Huimin, Wang, Kaili, and Li, Min
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Molecular property prediction is a fundamental task of drug discovery. With the rapid development of deep learning, computational approaches for predicting molecular properties are experiencing increasing popularity. However, these existing methods often ignore the 3D information on molecules, which is critical in molecular representation learning. In the past few years, several self-supervised learning (SSL) approaches have been proposed to exploit the geometric information by using pre-training on 3D molecular graphs and fine-tuning on 2D molecular graphs. Most of these approaches are based on the global geometry of molecules, and there is still a challenge in capturing the local structure and local interpretability. To this end, we propose local geometry-guided graph attention (LGGA), which integrates local geometry into the attention mechanism and message-passing of graph neural networks (GNNs). LGGA introduces a novel method to model molecules, enhancing the model’s ability to capture intricate local structural details. Experiments on various data sets demonstrate that the integration of local geometry has a significant impact on the improved results, and our model outperforms the state-of-the-art methods for molecular property prediction, establishing its potential as a promising tool in drug discovery and related fields.
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- 2024
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28. Active Disturbance Rejection Control for Bearingless Induction Motor Based on Hyperbolic Tangent Tracking Differentiator
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Yang, Zebin, Ji, Jialei, Sun, Xiaodong, Zhu, Huimin, and Zhao, Qian
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To meet the operation requirements of a bearingless induction motor (BIM) control system, such as fast speed response, stable suspension, and high disturbance rejection ability, an active disturbance rejection control (ADRC) strategy based on hyperbolic tangent tracking differentiator (HTTD) is proposed. First, based on the air-gap magnetic field decoupling control of the BIM, the uncertainties of the system itself and the load disturbance are regarded as a total disturbance. The extended state observer (ESO) is used to observe the total disturbance in real time. The speed ADRC and suspension ADRC are designed for the torque winding and suspension winding, respectively. Second, the hyperbolic tangent function is applied to the tracking differentiator (TD) of ADRC to simplify its structure. The frequency characteristic curves are analyzed through the sweep-frequency test, and the design parameters are further determined. Finally, this strategy is analyzed with simulation in MATLAB/Simulink and verified on an experimental prototype. Both simulation and experimental results show that the strategy not only has good speed and current characteristics but also reduces the effect of load disturbance on the system and improves the suspension characteristics of the BIM.
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- 2020
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29. Cell-derived extracellular matrix-coated silk fibroin scaffold for cardiogenesis of brown adipose stem cells through modulation of TGF-β pathway.
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Liu, Wei, Sun, Yanfeng, Dong, Xiaohui, Yin, Qi, Zhu, Huimin, Li, Siwei, Zhou, Jin, and Wang, Changyong
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The cell-derived extracellular matrix (ECM)-modified scaffolds have advantages of mimic tissue specificity and been thought to better mimic the native cellular microenvironment in vitro. ECM derived from cardiac fibroblasts (CFs) are considered as key elements that provide a natural cell growth microenvironment and change the fate of cardiomyocytes (CMs). Here, a new hybrid scaffold is designed based on silk fibroin (SF) scaffold and CFs-derived ECM. CFs were seeded on the SF scaffold for 10 days culturing and decellularized to produce CFs-derived ECM-coated SF scaffold. The results showed that the cell-derived ECM-modified silk fibroin scaffold material contained collagen, laminin, fibronectin and other ECM components with myocardial-like properties. Further to explore its effects on brown adipose stem cells (BASCs) differentiation into CMs. We found that the CF-derived ECM-coated scaffold also increased the expression of CM-specific proteins (e.g. cardiac troponin T and α-actinin) of BASCs. Notably, the β1-integrin-dependent transforming growth factor-β1 signaling pathway was also involved in the regulation of CF-derived ECM by promoting the differentiation of BASCs into CMs. Overall, these findings provide insights into the bionic manufacturing of engineered cardiac tissues (ECTs) and establish a theoretical basis for the construction of ECTs.
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- 2020
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30. Hollow ferric-tannic acid nanocapsules with sustained O2and ROS induction for synergistic tumor therapyElectronic supplementary information (ESI) available. See DOI: 10.1039/d0bm00533a
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Zhu, Huimin, Cao, Guodong, Qiang, Chu, Fu, YiKe, Wu, Yulian, Li, Xiang, and Han, Gaorong
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Nanoparticles presenting promoted catalytic activity, oxygen induction and loading capability are in high demand for effective synergistic tumor therapy. Herein, ferric-tannic acid complex nanocapsules with fine hollow microstructure (HFe-TA) are synthesized and loaded with a photosensitizer (indocyanine green, ICG) for synergistic tumor therapy. In acidic environment, ICG@HFe-TA decomposes and releases Fe3+ions, TA and ICG molecules. Fe3+, with low catalytic activity, is effectively converted into highly catalytic Fe2+by the reductant TA, enabling promoted efficacy of OH induction. More importantly, the ROS (1O2) induction by ICG is significantly enhanced under 808 nm laser irradiation due to the O2byproduct of Fe3+/Fe2+conversion. In consequence, the ICG@HFe-TA nanoparticles exhibit considerable in vitroand in vivotumor inhibition owing to the combined effect of OH and 1O2induced intracellularly. This study has therefore demonstrated a potential platform enabling combined photodynamic and chemodynamic therapy with high efficacy.
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- 2020
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31. Cesium Bismuth Iodide Solar Cells from Systematic Molar Ratio Variation of CsI and BiI3.
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Johansson, Malin B., Philippe, Bertrand, Banerjee, Amitava, Phuyal, Dibya, Mukherjee, Soham, Chakraborty, Sudip, Cameau, Mathis, Zhu, Huimin, Ahuja, Rajeev, Boschloo, Gerrit, Rensmo, Håkan, and Johansson, Erik M. J.
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- 2019
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32. Bandgap Tuning of Silver Bismuth Iodide via Controllable Bromide Substitution for Improved Photovoltaic Performance.
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Hua Wu, Zhu, Huimin, Erbing, Axel, Johansson, Malin B., Mukherjee, Soham, Man, Gabriel J., Rensmo, Håkan, Odelius, Michael, and Johansson, Erik M. J.
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- 2019
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33. Modified Temporomandibular Joint Disc Repositioning With Mini-screw Anchor: Part II-Stability Evaluation by Magnetic Resonance Imaging.
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Zhou, Qin, Zhu, Huimin, He, Dongmei, Yang, Chi, Song, Xinyu, Ellis III, Edward, and Ellis, Edward 3rd
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Purpose: The purpose of this study was to evaluate the stability of disc position and condylar status by magnetic resonance imaging (MRI) after temporomandibular joint (TMJ) disc repositioning surgery with a mini-screw anchor technique.Materials and Methods: Patients diagnosed with anterior disc displacement (ADD) and operated on for disc repositioning from 2010 through 2016 were included in the study. MRI scans within 1 week after operation (T1) and during at least 1-year follow-up were used to evaluate changes in disc position and condylar bone. During follow-up, ADD without reduction was considered relapse and the bone status was classified as regeneration or degeneration.Results: One hundred seven patients with 149 joints were included in the study. Postoperative MRI scans (T1) showed that all discs were repositioned. During an average 23.40-month follow-up (range, 12 to 84 months), 95.3% of discs (142 of 149) were still in position, whereas 4.7% of discs (7 of 149) had relapsed anteriorly. New condylar bone formation was observed in 74.50% of joints (111 of 149), no bone change was observed in 23.49% of joints (35 of 149), and bone resorption was observed in 2.01% of joints (3 of 149).Conclusions: TMJ disc repositioning by a mini-screw anchor provides stability for treatment of ADD. Disc repositioning also can stimulate condylar bone regeneration. [ABSTRACT FROM AUTHOR]- Published
- 2019
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34. The effect of disc repositioning and post-operative functional splint for the treatment of anterior disc displacement in juvenile patients with Class II malocclusion.
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Zhu, Huimin, He, Dongmei, Yang, Zhi, Song, Xinyu, and Ellis III, Edward
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MANDIBULAR condyle ,MALOCCLUSION ,BONE resorption ,BONES ,RADIOGRAPHS ,TEMPOROMANDIBULAR joint ,MAGNETIC resonance imaging - Abstract
Abstract Purpose To evaluate the effect of temporomandibular joint (TMJ) disc repositioning and post-operative functional splint for the treatment of anterior disc displacement (ADD) in juvenile patients with Class II malocclusion. Materials and methods Juvenile patients (≤20 years) who had bilateral TMJ ADD with and Class II malocclusion treated by disc repositioning and functional splints were included in the study. Magnetic resonance imaging (MRI) and cephalometric radiographs before surgery (T0), immediately after surgery (T1) and more than 3 months after surgery (T3) were obtained in all patients. Cephalometric values including condylar height, overjet, SNA, SNB and pogonion position etc. were measured and compared before and after disc repositioning by statistical analysis. Fourteen patients (13 female, 1 male) were included in this study. Their average age was 16.7 years (range, 12–20 years). Results Seven patients with 14 joints had an MRI at least 6 months (6–24 months, mean 14.3) prior to disc repositioning. When compared to the MRI taken just prior to surgery, of those 14 joints, 9 condyles (64.3%) had evidence of bone resorption, 5 condyles (35.7%) had new bone formation mostly at the posterior part of the condyle (21.4%). These MRIs showed the condylar height was reduced 0.81 mm ± 0.61 (P = 0.013). Pre-operative cephalometric radiographs showed increased overjet (P = 0.039). The mean post-operative follow-up was 9.4 months (range, 4–13 months). Postoperative MRI showed the condylar height increased 1.74 ± 0.98 mm after disc repositioning (P < 0.001). Newly generated bone was observed on all condyles. 84.6% of the new bone was formed on the superior and posterior-anterior surfaces. Postoperative cephalometric radiographs showed the SNB angle increased 1.83 ± 1.56°(P < 0.001), pogonion position (pg'-G′) moved anteriorly 2.18 ± 3.13 mm (P = 0.028) and incisor overjet decreased 3.55 ± 1.86 mm (P < 0.001), whereas significant changes were not found in SNA, Sn - G Vert, Y-Axis, U1 SN, IMPA (L1-MP) and U1-L1 (P > 0.05). Conclusion Conservative treatment for ADD with Class II malocclusion in juvenile patients may cause condyle resorption and aggravate the dentofacial deformity. Disc repositioning combined with post-operative functional splints can effectively promote condylar growth and help correct the dentofacial deformity. Highlights •Disc repositioning and functional splint as a new treatment of anterior disc displacement in juvenile patients with class II malocclusion. •Through MRI and cephalometric radiograph evaluation, this therapy can stimulate condylar regeneration and alleviate facial-oral deformity to make the further treatment easy. [ABSTRACT FROM AUTHOR]
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- 2019
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35. New insights into the metabolism and toxicity of bisphenol A on marine fish under long-term exposure.
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Huang, Qiansheng, Liu, Yiyao, Chen, Yajie, Fang, Chao, Chi, Yulang, Zhu, Huimin, Lin, Yi, Ye, Guozhu, and Dong, Sijun
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BISPHENOL A ,METABOLISM ,ENVIRONMENTAL toxicology ,MARINE fishes ,GLUCURONIDES - Abstract
Bisphenol A (BPA) exposure receives great ecotoxicological concern. However, gaps in knowledge, such as metabolism of BPA and inconsistent reports on reproductive toxicity, still exist. In this study, a marine fish model ( Oryzias melastigma ) was exposed to serial concentrations of BPA throughout its whole life cycle. The level of BPA-glucuronide (BPAG) dramatically increased throughout the embryonic stage since 4 dpf. Accordingly, the mRNA level and enzymatic activity of UDP-glucuronosyltransferases (UGTs) increased across the embryonic stage. The mRNA level of UGT2 subtype rather than UGT1 or UGT5 showed a concentration dependent response to BPA exposure. BPA exposure led to the morphological disruption of the chorion and villi as shown by scanning electron microscopy; however, the hatchability was not significantly influenced after exposure. Newly hatching larvae were continuously exposed to BPA for 120 days. Lower mRNA levels of hormone metabolism-related genes, decreased ratio of E2/T, slower ovary development and decreased egg production confirmed the inhibitory effect of BPA on reproduction. Overall, our results showed the conjugation of BPA into BPAG by UGT2 at the embryonic stage and convinced the reproductive toxicity from multiple levels after whole life exposure to BPA. [ABSTRACT FROM AUTHOR]
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- 2018
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36. Platelet‐Rich Plasma Composite Organohydrogel with Water‐Locking and Anti‐Freezing to Accelerate Wound Healing
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Cai, Chao, Zhu, Huimin, Chen, Yujie, Yuan, Xiuqun, Liu, Hezhou, and Yang, Zhi
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Hydrogels have gained impressive attention in biological medicine due to their excellent biosafety, softness, and varied functional components. However, conventional hydrogels have inherent defects, such as low tensile strength, weak water‐locking, and poor anti‐freezing. In tissue engineering, once the hydrogel loses water or freezes, it will harden the interaction interfaces and destroy the nascent granulation tissue. Herein, based on the design concept of “hard frame−soft penetration”, a composite adhesive organohydrogel is fabricated by introducing bacterial cellulose and platelet‐rich plasma (PRP) into a poly‐N‐(tris[hydroxymethyl]methyl)acrylamide (THMA)/N‐acryloyl aspartic acid (AASP) hybrid gel network infiltrated with glycerol/water binary solvent. The resultant organohydrogels exhibit excellent antifreeze properties at low temperatures (−80 °C) and demonstrate stable long‐term water retention (91%) in the open environment within 12 days and can adhere firmly to the tissues by the action of “hydrogen bond clusters”. Additionally, the introduction of bacterial cellulose matrix endows the organohydrogel with high tensile strength similar to that of skin. In vivo, the PRP‐loaded organohydrogel can release a variety of growth factors to accelerate the wound healing process through collagen deposition and angiogenesis. Altogether, this strategy will extend the life of the hydrogel in some harsh medical environments. A composite adhesive organohydrogel is fabricated by introducing bacterial cellulose and platelet‐rich plasma (PRP) into a poly‐N‐(tris[hydroxymethyl]methyl)acrylamide (THMA)/N‐acryloyl aspartic acid (AASP) hybrid gel network infiltrated with glycerol/water binary solvent. The resultant organohydrogels exhibit excellent antifreeze properties and demonstrate stable long‐term water retention in the open environment. In vivo, the PRP‐loaded organohydrogel can release a variety of growth factors to accelerate wound healing.
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- 2023
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37. PCBs–high-fat diet interactions as mediators of gut microbiota dysbiosis and abdominal fat accumulation in female mice.
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Chi, Yulang, Lin, Yi, Zhu, Huimin, Huang, Qiansheng, Ye, Guozhu, and Dong, Sijun
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POLYCHLORINATED biphenyls ,HIGH-fat diet ,GUT microbiome ,ABDOMINAL adipose tissue ,BIOACCUMULATION - Abstract
Polychlorinated biphenyls (PCBs), one type of lipophilic pollutant, are ubiquitous in daily life. PCBs exposure has been implicated in the alterations of gut microbial community which is profoundly associated with diverse metabolic disorders, including obesity. High-fat diet (H) is a dietary pattern characterized by a high percentage of fat. According to the theory that similarities can be easily solvable in each other, PCBs and H exposures are inevitably and objectively coexistent in a real living environment, prompting great concerns about their individual and combined effects on hosts. However, the effects of PCBs-H interactions on gut microbiota and obesity are still incompletely understood. In the present study, the effects of PCBs and/or H on the gut microbiota alteration and obesity risk in mice were examined and the interactions between PCBs and H were investigated. Obtained results showed that PCBs and/or H exposure induced prominent variations in the gut microbiota composition and diversity. Exposure to PCBs also resulted in higher body fat percentage, greater size of abdominal subcutaneous adipocytes and increased expression of proinflammatory cytokines including TNF-α, iNOS and IL-6. Such PCBs-induced changes could be further enhanced upon the co-exposure of H, implying that obese individuals may be vulnerable to PCBs exposure. Taken together, the present study is helpful for a better understanding of the gut microbiota variation influenced by PCBs and/or H exposure, and furthermore, provides a novel insight into the mechanism of PCBs-H interactions on host adiposity. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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38. Temporomandibular Joint Disc Repositioning by Suturing Through Open Incision: A Technical Note.
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He, Dongmei, Yang, Chi, Zhu, Huimin, IIIEllis, Edward, and Ellis, Edward 3rd
- Abstract
It is technically difficult to arthroscopically reposition and suture the temporomandibular joint disc to the auricular cartilage. This article introduces a straightforward method to reposition the disc and suture it to the auricular cartilage through a small incision. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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39. Cesium Bismuth Iodide Solar Cells from Systematic Molar Ratio Variation of CsI and BiI3
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Johansson, Malin B., Philippe, Bertrand, Banerjee, Amitava, Phuyal, Dibya, Mukherjee, Soham, Chakraborty, Sudip, Cameau, Mathis, Zhu, Huimin, Ahuja, Rajeev, Boschloo, Gerrit, Rensmo, Håkan, and Johansson, Erik M. J.
- Abstract
Metal halide compounds with photovoltaic properties prepared from solution have received increased attention for utilization in solar cells. In this work, low-toxicity cesium bismuth iodides are synthesized from solution, and their photovoltaic and optical properties as well as electronic and crystal structures are investigated. The X-ray diffraction patterns reveal that a CsI/BiI3precursor ratio of 1.5:1 can convert pure rhombohedral BiI3to pure hexagonal Cs3Bi2I9, but any ratio intermediate of this stoichiometry and pure BiI3yields a mixture containing the two crystalline phases Cs3Bi2I9and BiI3, with their relative fraction depending on the CsI/BiI3ratio. Solar cells from the series of compounds are characterized, showing the highest efficiency for the compounds with a mixture of the two structures. The energies of the valence band edge were estimated using hard and soft X-ray photoelectron spectroscopy for more bulk and surface electronic properties, respectively. On the basis of these measurements, together with UV–vis–near-IR spectrophotometry, measuring the band gap, and Kelvin probe measurements for estimating the work function, an approximate energy diagram has been compiled clarifying the relationship between the positions of the valence and conduction band edges and the Fermi level.
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- 2019
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40. Atypical GATA protein TRPS1 plays indispensable roles in mouse two-cell embryo
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Liu, Yue, Xu, Songhua, Lian, Xiuli, Su, Yang, Zhong, Yuhuan, Lv, Ruimin, Mo, Kaien, Zhu, Huimin, Xiaojiang, Wang, Xu, Lixuan, and Wang, Shie
- Abstract
ABSTRACTZygotic genome activation (ZGA) is one of the most critical events at the beginning of mammalian preimplantation embryo development (PED). The mechanisms underlying mouse ZGA remain unclear although it has been widely studied. In the present study, we identified that tricho-rhino-phalangeal syndrome 1 (TRPS1), an atypical GATA family member, is an important factor for ZGA in mouse PED. We found that the Trps1mRNA level peaked at the one-cell stage while TRPS1 protein did so at the two/four-cell stage. Knockdown of Trps1by the microinjection of Trps1siRNA reduced the developmental rate of mouse preimplantation embryos by approximately 30%, and increased the expression of ZGA marker genes MuERV-Land Zscan4dvia suppressing the expression of major histone markers H3K4me3 and H3K27me3. Furthermore, Trps1knockdown decreased the expression of Sox2but increased Oct4expression. We conclude that TRPS1 may be indispensable for zygotic genome activation during mouse PED.
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- 2019
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41. Scalable calibration transfer without standards viadynamic time warping for near-infrared spectroscopyElectronic supplementary information (ESI) available. See DOI: 10.1039/c9ay01139k
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Zou, Congming, Zhu, Huimin, Shen, Junru, He, Yue, Su, Jiaen, Fan, Xiaqiong, Lu, Hongmei, Zhang, Zhimin, and Chen, Yi
- Abstract
Calibration transfer is crucial for near-infrared spectroscopy (NIR) to avoid time-consuming and labor-intensive recalibration. Classical methods require standard samples from both the master and slave spectrometers, which is the major bottleneck of large-scale NIR applications. In this study, the calibration transfer method based on variable penalty dynamic time warping (CT-VPdtw) is proposed, which can handle standard-free calibration transfer well and greatly expand the application ranges of the established model. The corn dataset with standards from Cargill and the standard-free wheat dataset from international diffuse reflectance conference (IDRC) 2016 are used to benchmark the transfer ability. When transferring from M5 to MP5 of the corn dataset, the RMSEP reduced from 0.86 to 0.152 by CT-VPdtw, 0.176 by piecewise direct standardization (PDS) and 0.207 by domain-invariant partial-least-squares (di-PLS) respectively. For the standard-free wheat dataset, CT-VPdtw has significant advantages when comparing with PDS and di-PLS. Moreover, 11 slave spectrometers can be transferred to the master spectrometer with satisfactory RMSEPs easily in the wheat dataset, which demonstrates that CT-VPdtw has potential to perform large-scale calibration transfer. With the good transfer ability, the standard-free and large-scale advantages, CT-VPdtw has the potential to be a widely used method for calibration transfer in near-infrared spectroscopy. It was implemented and is available at https://github.com/HMzhu/CTVPdtw.
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- 2019
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42. Cardiomyocyte dedifferentiation and remodeling in 3D scaffolds to generate the cellular diversity of engineering cardiac tissuesElectronic supplementary information (ESI) available: The detailed supplementary results including Fig. S1 to S6. See DOI: 10.1039/c9bm01003c
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WangThese authors contributed equally to this work., Changyong, Liu, Wei, Shen, Yuan, Chen, Jiayun, Zhu, Huimin, Yang, Xiaoning, Jiang, Xiaoxia, Wang, Yan, and Zhou, Jin
- Abstract
The use of engineered cardiac tissues (ECTs) is a new strategy for the repair and replacement of cardiac tissues in patients with myocardial infarction, particularly at late stages. However, the mechanisms underlying the development of ECTs, including cell-scaffold interactions, are not fully understood, although they are closely related to their therapeutic effect. In the present study, we aimed to determine the cellular fate of cardiomyocytes in a 3D scaffold microenvironment, as well as their role in generating the cellular diversity of ECTs by single-cell sequencing analysis. Consistent with the observed plasticity of cardiomyocytes during cardiac regeneration, cardiomyocytes in 3D scaffolds appeared to dedifferentiate, showing an initial loss of normal cytoskeleton organization in the adaptive response to the new scaffold microenvironment. Cardiomyocytes undergoing this process regained their proliferation potential and gradually developed into myocardial cells at different developmental stages, generating heterogeneous regenerative ECTs. To better characterize the remodeled ECTs, high-throughput single-cell sequencing was performed. The ECTs contained a wide diversity of cells related to endogenous classes in the heart, including myocardial cells at different developmental stages and different kinds of interstitial cells. Non-cardiac cells seemed to play important roles in cardiac reconstruction, especially Cajal-like interstitial cells and macrophages. Altogether, our results showed for the first time that cells underwent adaptive dedifferentiation for survival in a 3D scaffold microenvironment to generate heterogeneous tissues. These findings provide an important basis for an improved understanding of the development and assembly of engineered tissues.
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- 2019
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43. Ni-Mn3O4 Composite Coating by Electrophoresis/Electrodeposition for Metallic Interconnects Applications
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Zhu, Huimin, Geng, Shujiang, Chen, Gang, and Wang, Fuhui
- Abstract
The Ni-Mn3O4 composite coating has been deposited on the surface of steel interconnects by electrophoresis and electrodeposition techniques. The effect of bath temperature and bath pH on the microstructure, thickness and composition of the coating during electrodeposition process is analyzed by XRD, SEM and ICP-OES. Mn3O4 particles are uniformly distributed in Ni matrix. The optimum temperature and pH value in the electrodeposition bath are 45degC and 5, respectively. The oxide scale microstructure and electrical property of the samples are characterized after an oxidation of 100 h at 800degC in air. The results demonstrate that the area specific resistance (ASR) of the scale for the coated steel is significantly lower than that for the uncoated steel. The thermally converted (Ni,Mn,Fe)3O4/NiO layer serves as an effective obstacle against Cr outward migration.
- Published
- 2019
44. A Bayesian deep learning method based on loan default rate detection
- Author
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Subramaniam, Kannimuthu, Palanisamy Muthuramalingam, Arunkumar, Liu, ShaSha, Guan, MingXi, Ji, JinKun, Li, Yan, Wang, MengLu, and Zhu, HuiMin
- Published
- 2023
- Full Text
- View/download PDF
45. Synthesis and evaluation of 5-aminimidazole-4-carboxamide riboside derivatives as anti-fatigue agents.
- Author
-
Zhu, Huimin, Zeng, Wanbo, Zhao, Tangna, Shi, Weiguo, Dong, Xiao, Zhang, Aiping, Li, Xiang, and Xu, Liang
- Abstract
Fatigue has a negative influence on daily life and work, and serious or chronic fatigue can even cause health problems. Studies have shown that 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside (AICAR) can exert anti-fatigue effects by activating AMP-activated protein kinase (AMPK). In this study, six AICAR derivatives with substitution at the hydroxyl sites of the ribose moiety were synthesized and evaluated as anti-fatigue agents. All of the derivatives were demonstrated to effectively resist fatigue in animal models. The mice treated with the optimal compound ZHM-01 showed an 8.6-fold greater exhaustion distance in the running wheel test and a 5.1-fold greater exhaustion time in the weight-loaded swimming test than those of the blank control group. ZHM-01 treatment also reduced lactic acid (LA) and blood urea nitrogen (BUN) accumulation during exercise. In addition, ZHM-01 administration enhanced the phosphorylation of AMPK but did not excite the central nervous system. Moreover, ZHM-01 showed good biological safety in a 21-day toxicity evaluation. This study provides a new reference for the development of treatments for fatigue-related health problems. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
46. A composite arctigenin/caffeine/glucose formulation enhances anti-fatigue effect.
- Author
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Zeng, Wanbo, Sun, Le, Zhu, Huimin, Wu, Xiaowen, Xu, Lijia, and Xu, Liang
- Subjects
FATIGUE prevention ,PROTEIN kinases ,GLUCOSE ,OXIDANT status ,AMP-activated protein kinases ,LACTIC acid ,FATIGUE (Physiology) - Abstract
Fatigue is a comprehensive response to a variety of physiological and biochemical changes in the body. Combining strategies addressing relevant key factors simultaneously may enhance anti-fatigue efficiency. In this study, we aimed to develop new anti-fatigue agents with combining strategy based on bioinformatics analysis. Result indicated PI3k-Akt, cAMP, and p53 signaling pathway-related energy metabolism and antioxidant capacity were involved in exercise-induced physiological changes. A new representative complex agent (Z-005, containing arctigenin, caffeine, and glucose) addressing these key factors as well as central excitation was developed and tested. Z-005 showed a synergistic effect, greatly enhancing anti-fatigue efficiency than single components, in a mouse running wheel test. Mouse exhaustion distances were 2.40-fold greater than the control in the Z-005 group. Z-005 excited the central nervous system, increased the plasma superoxide dismutase and catalase concentrations, reduced lactic acid accumulation, maintained the glycogen content. Besides, the expression of key genes in PI3K, cAMP, and p53 pathways, as well as the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) were proved with enhancement by Z-005 administration. This composite formulation thus represents a new and practicable combined strategy for fatigue prevention, and the study findings can contribute to the development of treatments for fatigue-related sub-health. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
47. Nanoparticle-mediated corneal neovascularization treatments: Toward new generation of drug delivery systems
- Author
-
Zhu, Huimin, Yu, Jingwen, Ye, Jinfa, Wu, Yiming, Pan, Jintao, Li, Yingying, Chen, Chuan, Zheng, Li, Liu, Gang, and Chu, Chengchao
- Abstract
Corneal neovascularization (CNV) is one of the major factors for vision impairment and blindness worldwide. The current treatment for CNV focuses primarily on topical eyedrops of glucocorticoids, non-steroidal anti-inflammatory drugs, electro-coagulation and laser photo-coagulation. Unfortunately, coagulation-based treatment is restricted by corneal hemorrhage and iris atrophy. And drug treatments have limited therapeutic effects and a short duration of action. Nanoparticle-based drug delivery systems are widely applied due to their improved pharmacokinetics, optimized drug targeting and enhanced biocompatibility. In this article, we provide a comprehensive and systematic overview of the CNV nanodrug system, highlighting some of the recent advances in nanodrug design, preparation, and functional modification. Moreover, we discuss the challenges in the clinical translation and potential risks in CNV treatment. A greater effort is needed for the potential applications of nanotechnology in the field of ophthalmology.
- Published
- 2023
- Full Text
- View/download PDF
48. Bismuth Iodide Perovskite Materials for Solar Cell Applications: Electronic Structure, Optical Transitions, and Directional Charge Transport
- Author
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Pazoki, Meysam, Johansson, Malin B., Zhu, Huimin, Broqvist, Peter, Edvinsson, Tomas, Boschloo, Gerrit, and Johansson, Erik M. J.
- Abstract
Cesium and methylammonium bismuth iodides (Cs3Bi2I9and MA3Bi2I9) are new low-toxic and air stable compounds in the perovskite solar cell family with promising characteristics. Here, the electronic structure and the nature of their optical transitions, dielectric constant, and charge carrier properties are assessed for photovoltaic applications with density functional theory (DFT) calculations and experiments. The calculated direct and indirect band gap values for Cs3Bi2I9(2.17 and 2.0 eV) and MA3Bi2I9(2.17 and 1.97 eV) are found to be in good agreement with the experimental optical band gaps (2.2, 2.0 eV and 2.4, 2.1 eV for Cs3Bi2I9and MA3Bi2I9, respectively) estimated for solution-processed films. There is an error cancelation in the DFT calculated band gap similar to that for lead perovskites. However, fully relativistic DFT calculations indicate that the size of the spin orbit coupling (SOC) error cancelation for bismuth perovskite (0.5 eV) is less than for lead perovskite (1 eV), and other factors are therefore also important. Band structure calculations show high effective masses of the charge carriers along the c-axis but on the other hand lower electron effective mass in the a–bplanes, revealing the interesting possibility for a directional charge transport. Calculations of dielectric constants, absorption coefficients, carrier effective masses, and exciton binding energies emphasize the fundamental differences between the lead and bismuth iodide perovskites and clarify the reasons behind the lower power conversion efficiency of bismuth iodide perovskite solar cells. Also the calculations show that the orientational disorder of the MA dipoles in the lattice has meaningful impacts on the near valence and conduction band edge of the electronic structure.
- Published
- 2016
- Full Text
- View/download PDF
49. Reproducible One-Step Fabrication of Compact MAPbI3–xClxThinFilms Derived from Mixed-Lead-Halide Precursors.
- Author
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Wang, Dong, Liu, Zhihong, Zhou, Zhongmin, Zhu, Huimin, Zhou, Yuanyuan, Huang, Changshui, Wang, Zaiwei, Xu, Hongxia, Jin, Yizheng, Fan, Bin, Pang, Shuping, and Cui, Guanglei
- Published
- 2014
- Full Text
- View/download PDF
50. A composite arctigenin/caffeine/glucose formulation enhances anti-fatigue effect
- Author
-
Zeng, Wanbo, Sun, Le, Zhu, Huimin, Wu, Xiaowen, Xu, Lijia, and Xu, Liang
- Abstract
Fatigue is a comprehensive response to a variety of physiological and biochemical changes in the body. Combining strategies addressing relevant key factors simultaneously may enhance anti-fatigue efficiency. In this study, we aimed to develop new anti-fatigue agents with combining strategy based on bioinformatics analysis. Result indicated PI3k-Akt, cAMP, and p53 signaling pathway-related energy metabolism and antioxidant capacity were involved in exercise-induced physiological changes. A new representative complex agent (Z-005, containing arctigenin, caffeine, and glucose) addressing these key factors as well as central excitation was developed and tested. Z-005 showed a synergistic effect, greatly enhancing anti-fatigue efficiency than single components, in a mouse running wheel test. Mouse exhaustion distances were 2.40-fold greater than the control in the Z-005 group. Z-005 excited the central nervous system, increased the plasma superoxide dismutase and catalase concentrations, reduced lactic acid accumulation, maintained the glycogen content. Besides, the expression of key genes in PI3K, cAMP, and p53 pathways, as well as the phosphorylation of adenosine monophosphate-activated protein kinase (AMPK) were proved with enhancement by Z-005 administration. This composite formulation thus represents a new and practicable combined strategy for fatigue prevention, and the study findings can contribute to the development of treatments for fatigue-related sub-health.
- Published
- 2022
- Full Text
- View/download PDF
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