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Climate effects of land use change in China as simulated by a regional climate model (RegCM2) are investigated. The model is nested in one-way mode within a global coupled atmosphere-ocean model (CSIRO R21L9 AOGCM). Two multi-year simulations, one with current land use and the other with potential vegetation cover, are conducted. Statistically significant changes of precipitation, surface air temperature, and daily maximum and daily minimum temperature are analyzed based on the difference between the two simulations. The simulated effects of land use change over China include a decrease of mean annual precipitation over Northwest China, a region with a prevalence of arid and semi-arid areas; an increase of mean annual surface air temperature over some areas; and a decrease of temperature along coastal areas. Summer mean daily maximum temperature increases in many locations, while winter mean daily minimum temperature decreases in East China and increases in Northwest China. The upper soil moisture decreases significantly across China. The results indicate that the same land use change may cause different climate effects in different regions depending on the surrounding environment and climate characteristics.