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[Display omitted] • Two new alkaloidal flavonoids were isolated from H. littoralis. • Glycosidic narciclasine derivative was obtained from H. littoralis for the first time. • The chemical composition of H. littoralis was further understand. A chemical study focusing on the N-containing constituents of Hymenocallis littoralis was carried out, leading to the isolation of two new alkaloidal flavonoids (1 – 2) and five known alkaloids (3 - 7). Structures of the isolated compounds were established mainly by spectroscopic techniques, including NMR spectroscopy and mass spectrometry as well as the CD experiment. These compounds were subjected to the in vitro cytotoxicity assays using Hep3B cells, and among them only the known pancratistatine (3) and lycorine (5) could significantly inhibit the Hep3B cell proliferation. [ABSTRACT FROM AUTHOR]

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Coffee is the most widely consumed beverage around the world, and it contains many compounds that have beneficial effects on human health. Chlorogenic acid (CGA), the most abundant polyphenol in coffee, has been reported to inhibit cancer cell growth and has a beneficial effect on ameliorating aging-related diseases. We found that CGA decreased HIF-1α levels in human hepatoma cell line Hep3B under hypoxic conditions (O 2 = 1%) in a dose-dependent manner, thereby decreasing the expression of its downstream targets EPO and VEGF. However, similar effects were not found in the presence of 100 μM 2,2′-dipyridyl. Further studies showed that the lysosomal protease inhibitor NH 4 Cl inhibited the decrease in HIF-1α levels, whereas the proteasome inhibitor MG132 did not, indicating that CGA requires lysosomal protease to affect the hypoxia response. [ABSTRACT FROM AUTHOR]