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This study explores the protective effects of sheepskin collagen peptide (SSCP) against ultraviolet (UV) radiation-induced skin damage. Molecular docking revealed that SSCP bind to matrix metalloproteinase 1 (MMP-1), forming hydrogen bonds and salt bridges, particularly through interactions with key residues Glu219, Tyr237, Ser239, and Tyr240, thereby potentially inhibiting MMP-1's catalytic activity. In UVA-irradiated human skin fibroblasts, SSCP improved cell viability and migration, reduced matrix metalloproteinases overexpression, and decreased levels of reactive oxygen species and malondialdehyde. Additionally, SSCP suppressed mitogen-activated protein kinase pathway activation, indicated by reduced phosphorylation of JNK and p38, highlighting its role in mitigating oxidative stress and aiding cellular recovery post-UVA exposure. These findings underscore the potential of SSCP as an effective ingredient in anti-photoaging cosmetics and functional foods, offering a comprehensive strategy for preserving skin health and combating UV-induced aging. [ABSTRACT FROM AUTHOR]

In this study, we demonstrated that the fermentation of Armillaria luteo-virens with Lactobacillus delbrueckii subsp. bulgaricus has a protective effect on human skin fibroblasts (HSFs) irradiated by UVA. We studied the fermentation broth of Armillaria luteo-virens (FBA) at the structural, cellular and genetic levels, and found that the content of polysaccharides in FBA increased, and the molecular weight of polysaccharides decreased by fermentation. After FBA pretreatment, we irradiated the cells with UVA, and found that the antioxidant capacity of the cells was significantly enhanced, and the activity of mitogen activated protein kinase (MAPK) pathway induced by UVA was weakened. The secretion of tissue inhibitory metalloproteinases (TIMPs) was inhibited, which decreased the activity of matrix metalloproteinases (MMPs) and increased the content of type I collagen (COL-I). Experiments have proved that FBA can enhance the antioxidant capacity and reduce the oxidative stress caused by UVA irradiation, giving it prevention potential against the photoaging process. [Display omitted] • We used Lactobacillus delbrueckii subsp. bulgaricus to ferment Armillaria luteo-virens. • The fermentation broth of Armillaria luteo-virens (FBA) has a certain antioxidant capacity and high safety in vitro. • FBA has a good protective effect on UVA-induced HSFs and can slow down the photoaging process. [ABSTRACT FROM AUTHOR]

• The Mesenchymal stem cells (MSCs) show strong protective roles against skin photoaging. • Several approaches have been proposed by researchers to intensify the bioactivity and treatment effects of MSCs. • The specific mechanisms of MSCs in clinical treatment of skin photoaging are multifaceted and complex. Skin is a natural barrier of human body and a visual indicator of aging process. Exposure to ultraviolet (UV) radiation in the sunlight may injure the skin tissues and cause local damage. Besides, it is reported that repetitive or long-term exposure to UV radiation may reduce the collagen production, change the normal skin structure and cause premature skin aging. This is termed "photoaging". The classical symptoms of photoaging include increased roughness, wrinkle formation, mottled pigmentation or even precancerous changes. Mesenchymal stem cells (MSCs) are a kind of cells with the ability of self-renewal and multidirectional differentiation into many types of cells, like adipocytes, osteoblasts and chondrocytes. Researchers have explored diverse pharmacological actions of MSCs because of their migratory activity, paracrine actions and immunoregulation effects. In recent years, the huge potential of MSCs in preventing skin from photoaging has gained wide attention. MSCs exert their beneficial effects on skin photoaging via antioxidant effect, anti-apoptotic/anti-inflammatory effect, reduction of matrix metalloproteinases (MMPs) and activation of dermal fibroblasts proliferation. MSCs and MSC related products have demonstrated huge potential in the treatment of skin photoaging. This narrative review concisely sums up the recent research developments on the roles of MSCs in protection against photoaging and highlights the enormous potential of MSCs in skin photoaging treatment. [ABSTRACT FROM AUTHOR]

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• Orange cold-pressed oil (CPO) protects mouse skin from UVB-induced oxidative damage. • CPO helps to maintain collagen normality by regulating TIMP 1&2 and MMP 2&9. • 5-hydroxy products found as UVB degradation of topical polymethoxyflavones (PMFs). • PMFs and hydroxy-PMFs play important part in the anti-photoaging effects of CPO. The protective effects of the topical application of orange peel cold-pressed oil (CPO), a rich polymethoxyflavones (PMFs) source, on ultraviolet B (UVB)-induced skin injury were studied. Depilated KM mice were irradiated by UVB at one minimal erythemal dose every day and the treated groups were smeared with CPO before radiation. After two weeks we found that CPO helped to maintain the dermal structure and enhanced serum levels and skin tissue expression of superoxide dismutase, catalase and glutathione peroxidase. In serum CPO lowered interleukin-6/-1β and tumor necrosis factor α levels; in skin it decreased the levels of type III collagen and H 2 O 2 but increased hydroxyproline and type I collagen. Moreover, the skin expression of matrix metalloproteinases 2/9 was downregulated, whereas the expression of tissue inhibitor of metalloproteinases 1/2 was upregulated. The above effects followed a dose-dependent manner. Liquid chromatography analysis of irradiated skin tissue showed partial decomposition of PMFs into 5-hydroxy-PMFs. [ABSTRACT FROM AUTHOR]