1. Tissue-resident memory CD8+T cells shape local and systemic secondary T cell responses
- Author
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Behr, Felix M., Parga-Vidal, Loreto, Kragten, Natasja A. M., van Dam, Teunis J. P., Wesselink, Thomas H., Sheridan, Brian S., Arens, Ramon, van Lier, Rene A. W., Stark, Regina, and van Gisbergen, Klaas P. J. M.
- Abstract
Tissue-resident memory CD8+T cells (TRMcells) are crucial in protecting against reinvading pathogens, but the impact of reinfection on their tissue confinement and contribution to recall responses is unclear. We developed a unique lineage tracer mouse model exploiting the TRM-defining transcription factor homolog of Blimp-1 in T cells (Hobit) to fate map the TRMprogeny in secondary responses. After reinfection, a sizeable fraction of secondary memory T cells in the circulation developed downstream of TRMcells. These tissue-experienced ex-TRMcells shared phenotypic properties with the effector memory T cell population but were transcriptionally and functionally distinct from other secondary effector memory T cell cells. Adoptive transfer experiments of TRMcells corroborated their potential to form circulating effector and memory cells during recall responses. Moreover, specific ablation of primary TRMcell populations substantially impaired the secondary T cell response, both locally and systemically. Thus, TRMcells retain developmental plasticity and shape both local and systemic T cell responses on reinfection.
- Published
- 2020
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