53 results on '"Bruin, Gerard"'
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2. Secukinumab dosing every 2 weeks demonstrated superior efficacy compared with dosing every 4 weeks in patients with psoriasis weighing 90 kg or more: results of a randomized controlled trial*
3. Absorption, Distribution, Metabolism, and Excretion of Therapeutic Proteins: Current Industry Practices and Future Perspectives
4. Characterizing the pharmacokinetics and biodistribution of therapeutic proteins: an industry white paper
5. Secukinumab demonstrates efficacy, safety, and tolerability upon administration by 2 ml autoinjector in adult patients with plaque psoriasis: 52‐week results from MATURE, a randomized, placebo‐controlled trial
6. Secukinumab for the treatment of psoriasis, psoriatic arthritis, and axial spondyloarthritis: Physical and pharmacological properties underlie the observed clinical efficacy and safety
7. L’administration du sécukinumab par un auto-injecteur de 2 mL démontre une efficacité élevée avec une sécurité et une tolérance comparables chez les patients adultes atteints de psoriasis en plaques : résultats à 16 semaines de l’étude MATURE
8. 27599 Secukinumab administration by a 2 mL autoinjector demonstrates high efficacy with comparable safety and tolerability in adult patients with plaque psoriasis: 16-week results from MATURE
9. 25482 Secukinumab efficacy and safety profile in pediatric patients with severe chronic plaque psoriasis up to 1 year
10. 27519 Efficacy, pharmacokinetics, and tolerability of subcutaneous secukinumab injections with 2 mL prefilled syringes (300 mg) in adult subjects with moderate to severe plaque psoriasis
11. Efficacy, tolerability, patient usability, and satisfaction with a 2 mL pre-filled syringe containing secukinumab 300 mg in patients with moderate to severe plaque psoriasis: results from the phase 3 randomized, double-blind, placebo-controlled ALLURE study
12. In reply: Use of a second ventilatory circuit when using a double-lumen endotracheal tube
13. Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different delivery systems in healthy volunteers and in psoriasis patients
14. Advantages of a second ventilation circuit when using a double-lumen endotracheal tube
15. Analysis of Oligonucleotides and Antisense DNA Analogs
16. Secukinumab Treatment Does Not Alter the Pharmacokinetics of the Cytochrome P450 3A4 Substrate Midazolam in Patients With Moderate to Severe Psoriasis
17. Secukinumab Immunogenicity over 52 Weeks in Patients with Psoriatic Arthritis and Ankylosing Spondylitis
18. 263 Secukinumab, a fully human anti-interleukin-17A monoclonal antibody, exhibits low immunogenicity in patients with psoriatic arthritis and ankylosing spondylitis during a 52week treatment period
19. Population Pharmacokinetic Modeling of Secukinumab in Patients With Moderate to Severe Psoriasis
20. β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis
21. Interleukin-17A blockade with secukinumab results in decreased neutrophil infiltration in psoriasis: minimally-invasive measurement by tape stripping
22. Secukinumab, a novel anti-IL-17A antibody, exhibits low immunogenicity in clinical trials and human in vitro assays
23. Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated by open flow microperfusion
24. On-Line Preconcentration and Separation of Antisense Oligonucleotides by ITP-CE in Dextran-Filled Capillaries
25. Lung re-inflation after one-lung ventilation for thoracic surgery: importance of clamping the dependent lung
26. AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women
27. Nanoparticle Flotation Collectors—The Influence of Particle Softness
28. ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans
29. Pharmacokinetics, Metabolism, and Disposition of Deferasirox in β-Thalassemic Patients with Transfusion-Dependent Iron Overload Who Are at Pharmacokinetic Steady State
30. Pharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and Its Iron Complex in Rats
31. Radioactivity Detectors for High-Performance Liquid Chromatography in Drug Metabolism Studies
32. A microplate solid scintillation counter as a radioactivity detector for high performance liquid chromatography in drug metabolism: Validation and applications
33. Thoracoabdominal Aortic Aneurysm Repair: A Prospective Cohort Study of 121 Cases
34. Immunoaffinity screening with capillary electrochromatography
35. A cohort study of coagulation parameters and the use of blood products in surgery of the thoracic and thoracoabdominal aorta
36. Recent developments in electrokinetically driven analysis on microfabricated devices
37. Kommerell’s diverticulum and aneurysmal right-sided aortic arch: A case report and review of the literature
38. Use of a Microplate Scintillation Counter as a Radioactivity Detector for Miniaturized Separation Techniques in Drug Metabolism
39. Fritless capillary electrochromatography
40. Fritless capillary electrochromatography
41. Preconcentration and separation of antisense oligonucleotides by on-column isotachophoresis and capillary electrophoresis in polymer-filled capillaries
42. Reply
43. Integrated Capillary Electrophoresis on Flexible Silicone Microdevices: Analysis of DNA Restriction Fragments and Detection of Single DNA Molecules on Microchips
44. Intubating conditions and correct application of cricoid pressure during rapid sequence induction: who should hold the mask?
45. Integrated chip-based capillary electrophoresis
46. The Miller Blade and the Disappearing Light Source
47. The Miller Blade and the Disappearing Light Source
48. Stability measurements of antisense oligonucleotides by capillary gel electrophoresis
49. Hologram-based refractive index detector for capillary electrophoresis: separation of metal ions
50. Preparation of polyacrylamide gel-filled capillaries by photopolymerization for capillary electrophoresis
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