350 results on '"Cabrales, Pedro"'
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2. Metformin as an alternative therapeutic intervention in hemorrhagic shock
3. Microcirculatory Evaluation of Crystalloids, Fresh Frozen Plasma, Hemoglobin Based Oxygen Carriers, and Pack Red Blood Cells in Trauma Hemorrhagic Shock
4. A Hypovolemic Infusion of Human Methemoglobin in Golden Syrian Hamsters Provides Insight on its effect on the Microcirculation
5. Toxic side-effects of diaspirin cross-linked human hemoglobin are attenuated by the apohemoglobin-haptoglobin complex
6. High molecular weight linear polymers improve microvascular perfusion after extracorporeal circulation.
7. Changes in oxygen delivery during experimental models of cerebral malaria
8. The Molecular Size of Bioengineered Oxygen Carriers Determines Tissue Oxygenation in a Hypercholesterolemia Guinea Pig Model of Hemorrhagic Shock and Resuscitation
9. Polymerized human hemoglobin with low and high oxygen affinity in trauma models
10. Data Management 101 for drug developers: A peek behind the curtain
11. The Double-Edged Sword of Erythrocytes in Health and Disease via Their Adhesiveness
12. BIO18: Hemoglobin and Heme Scavenger Proteins Reduce Free Hemoglobin During Venovenous Extracorporeal Circulation and Preserves Microvascular Function.
13. RRx-001: a chimeric triple action NLRP3 inhibitor, Nrf2 inducer, and nitric oxide superagonist
14. Phase 3 Anticancer Agent, RRx-001, Ameliorates Hypoxia-Induced Pulmonary Hypertension
15. Evaluation of hemorrhagic shock and traumatic brain injury effects on hemodynamics and metabolomics
16. Prony Analysis of Left Ventricle Pressure and Volume
17. Microvascular changes in young hamsters after single heterochronic blood transfusion of one unit of blood
18. Acellular hemoglobin impairs calcium release and contractility in cardiomyocytes from healthy animals
19. Cardioprotection from Acute Myocardial Infarction with RRx-001, an NLRP3 Inflammasome Inhibitor, in Phase 3 for the Treatment of Cancer
20. The Use of Priming Solutions to Scavenge Free Hb and Free Hb Catabolism Byproducts Reduces Hemolysis-Induced Hypertension in Venovenous Extracorporeal Circulation
21. PEGylation of Apohemoglobin Haptoglobin Complex reduces Associated Free Stroma Hemoglobin Toxicities
22. A Review of RRx-001: A Late-Stage Multi-Indication Inhibitor of NLRP3 Activation and Chronic Inflammation
23. Phase 1 pilot study of RRx-001 + nivolumab in patients with advanced metastatic cancer (PRIMETIME)
24. Effect of RRx-001 on nephrotoxicity of cisplatin/etoposide in patients with solid tumors.
25. Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues
26. The direct NLRP3 inhibitor and Phase 3 small molecule anticancer agent, RRx‐001, protects aged triple transgenic Alzheimer’s disease model mice from CNS degeneration and cognitive decline
27. Apohemoglobin-haptoglobin complex alleviates iron toxicity in mice with β-thalassemia via scavenging of cell-free hemoglobin and heme
28. Safety and efficacy of human polymerized hemoglobin on guinea pig resuscitation from hemorrhagic shock
29. Apohemoglobin-Haptoglobin Complex Prevents Microvascular Dysfunction in Sickle Cell Mice: Potential Therapeutic Approach for Vaso-Occlusive Crisis
30. Increased Hemoglobin Affinity for Oxygen with GBT021601 Reduces Pulmonary Hypertension and Lung Vascular Inflammation in a Murine Model of Sickle Cell Disease
31. GBT021601 Prevents Microvascular Dysfunction and Improves Hypoxia-Reoxygenation-Induced Vaso-Occlusion in a Murine Model of Sickle Cell Disease
32. Implications of microvascular dysfunction and nitric oxide mediated inflammation in severe COVID-19 infection
33. Changes in Oxygen Delivery during experimental models of Cerebral Malaria
34. Hyperspectral wide-field-of-view imaging to study dynamic microcirculatory changes during hypoxia
35. The NLRP3 inhibitor and Nrf2 Agonist, RRx-001, Ameliorates Non-alcoholic Fatty Liver Disease in Rats
36. Contributors
37. RRx-001 Reset: Chemoresensitization via NO-Mediated M1 Macrophage Repolarization
38. Phase 2 pilot trial of RRx-001 as an anti-mucositis agent in patients with head and neck cancer treated with chemoradiation (PREVLAR).
39. Safety profile and efficacy of low and high oxygen affinity polymerized human hemoglobin in trauma model
40. Drag Reducing Polymers Improves Microvascular Perfusion After Extracorporeal Circulation
41. Apohemoglobin‐haptoglobin (Apohb‐Hp) Complex as a Vasculo‐protective Agent in Hypoxia Induced Vaso‐occlusion in Sickle Cell Disease
42. Nitric oxide releasing nanoparticles reduce inflammation in a small animal model of ARDS
43. Extracorporeal circulation impairs microcirculation perfusion and organ function
44. The Disconnect Between Extracorporeal Circulation and the Microcirculation: A Review
45. Attenuating Ischemia and Reperfusion Injury with Polymerized Albumin
46. Heme Scavenging with Apohemoglobin-Haptoglobin Complex in Beta Thalassemia Intermedia Improves Anemia and Iron Indices: A Novel Therapeutic Approach
47. The RBC’s road to ghost and removal: splenic clearance
48. Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice
49. Discovery of RRx-001, a Myc and CD47 Downregulating Small Molecule with Tumor Targeted Cytotoxicity and Healthy Tissue Cytoprotective Properties in Clinical Development
50. Red Blood Cells: Tethering, Vesiculation, and Disease in Micro-Vascular Flow
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