62 results on '"Cheng, Yi-Qiang"'
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2. Overexpression of somatostatin receptor type 2 in neuroendocrine tumors for improved Ga68-DOTATATE imaging and treatment
3. Polyketide Biosynthesis beyond the Type I, II, and III Polyketide Synthase Paradigms: A Progress Report
4. Hybrid Peptide-Polyketide Natural Products: Biosynthesis and Prospects Towards Engineering Novel Molecules
5. Enzymology, Molecular Genetics, and Regulation of Biosynthesis of the Host-Selective Toxin HC-Toxin
6. Origin and bioactivities of thiosulfinated FK228
7. Genomics-guided discovery of a new and significantly better source of anticancer natural drug FK228
8. Engineer Novel Anticancer Bioagents
9. Abstract A090: Targeting androgen receptor (AR) variants in castration-resistant prostate cancer (CRPC) with a cancer-specific theranostic agent
10. Mechanistic studies of DepR in regulating FK228 biosynthesis in Chromobacterium violaceum no. 968
11. Chromobacterium spp. mediate their anti-Plasmodium activity through secretion of the histone deacetylase inhibitor romidepsin
12. Histone deacetylase inhibitor thailandepsin-A activates Notch signaling and suppresses neuroendocrine cancer cell growthin vivo
13. Developing new targeting strategy for androgen receptor variants in castration resistant prostate cancer
14. HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFβ2 in the Trabecular Meshwork
15. Improved production of cytotoxic thailanstatins A and D through metabolic engineering of Burkholderia thailandensis MSMB43 and pilot scale fermentation
16. Target engagement and drug residence time can be observed in living cells with BRET
17. Disulfide cross-linked micelles of novel HDAC inhibitor thailandepsin A for the treatment of breast cancer
18. Minimum Information about a Biosynthetic Gene cluster
19. Determination of thailandepsin B in rat plasma with a LC–MS/MS method
20. Identification and characterization of the spiruchostatin biosynthetic gene cluster enable yield improvement by overexpressing a transcriptional activator
21. The novel histone deacetylase inhibitor thailandepsin A inhibits anaplastic thyroid cancer growth
22. The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis
23. Genome-guided discovery of diverse natural products from Burkholderia sp.
24. Activation of ClpP Protease by ADEP Antibiotics: Insights from Hydrogen Exchange Mass Spectrometry
25. Structural determinants stabilizing the axial channel of ClpP for substrate translocation
26. Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663
27. Effects of Thailanstatins on Glucocorticoid Response in Trabecular Meshwork and Steroid-Induced Glaucoma
28. Abstract 2257: Thailanstatins: New pre-mRNA splicing inhibitors and potent antiproliferative agents discovered from Burkholderia Thailandensis MSMB43.
29. Abstract 1014: Thailandepsin A, a new HDAC inhibitor, reduces cellular proliferation and activates the Notch pathway in human carcinoids cancer cells.
30. Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensis MSMB43
31. Cyclo(-L-prolyl-L-valinyl-) fromBurkholderia thailandensisMSMB43
32. FK228 fromBurkholderia thailandensisMSMB43
33. Extractive fermentation for enhanced production of thailandepsin A from Burkholderia thailandensis E264 using polyaromatic adsorbent resin Diaion HP-20
34. Thailandepsins are new small molecule class I HDAC inhibitors with potent cytotoxic activity in ovarian cancer cells: a preclinical study of epigenetic ovarian cancer therapy
35. Abstract 4646: Toward engineering of novel anticancer bio-agents
36. Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264
37. Thailandepsin A
38. Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease
39. Thailandepsins: Bacterial Products with Potent Histone Deacetylase Inhibitory Activities and Broad-Spectrum Antiproliferative Activities
40. Biosynthesis of Himastatin: Assembly Line and Characterization of Three Cytochrome P450 Enzymes Involved in the Post-tailoring Oxidative Steps
41. Biosynthesis of Himastatin: Assembly Line and Characterization of Three Cytochrome P450 Enzymes Involved in the Post-tailoring Oxidative Steps
42. Abstract 5418: Thailandepsins: Novel bacterial natural products with potent histone deacetylase inhibition activities and promising anticancer activities
43. New Insights into the Genetic Organization of the FK228 Biosynthetic Gene Cluster in Chromobacterium violaceum No. 968
44. Reconstitution of the FK228 Biosynthetic Pathway Reveals Cross Talk between Modular Polyketide Synthases and Fatty Acid Synthase
45. Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP
46. Yersinia ironomics: comparison of iron transporters among Yersinia pestis biotypes and its nearest neighbor, Yersinia pseudotuberculosis
47. Novel Features of the Polysaccharide-Digesting Gliding Bacterium Flavobacterium johnsoniae as Revealed by Genome Sequence Analysis
48. Valinomycin Biosynthetic Gene Cluster in Streptomyces: Conservation, Ecology and Evolution
49. Pseudomerohedrally twinned monoclinic structure of unfolded `free' nonactin: comparative analysis of its large conformational change upon encapsulation of alkali metal ions
50. An FAD-Dependent Pyridine Nucleotide-Disulfide Oxidoreductase Is Involved in Disulfide Bond Formation in FK228 Anticancer Depsipeptide
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