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2. Further delineation of Wiedemann‐Rautenstrauch syndrome linked with POLR3A

4. Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders

5. A Middle Eastern Founder Mutation Expands the Genotypic and Phenotypic Spectrum of Mitochondrial MICU1 Deficiency: A Report of 13 Patients

6. Clinical, Biochemical, and Molecular Features in 37 Saudi Patients with Very Long Chain Acyl CoA Dehydrogenase Deficiency

8. Genetic impact of non-consanguineous marriages in Saudi Arabia

9. RRM1 variants cause a mitochondrial DNA maintenance disorder via impaired de novo nucleotide synthesis

10. HMG-CoA Lyase Deficiency: A Retrospective Study of 62 Saudi Patients

11. Genetic impact of non-consanguineous marriages in Saudi Arabia.

12. Asparagine Synthetase Deficiency: New Inborn Errors of Metabolism

14. Long-term effectiveness of carglumic acid in patients with propionic acidemia (PA) and methylmalonic acidemia (MMA): a randomized clinical trial

15. Spectrum of Mutations in 60 Saudi Patients with Mut Methylmalonic Acidemia

16. Combining exome/genome sequencing with data repository analysis reveals novel gene–disease associations for a wide range of genetic disorders

17. Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy

18. Loss of C2orf69 defines a fatal autoinflammatory syndrome in humans and zebrafish that evokes a glycogen-storage-associated mitochondriopathy

19. A recurrent, homozygous EMC10 frameshift variant is associated with a syndrome of developmental delay with variable seizures and dysmorphic features

20. The Leukodystrophy Spectrum in Saudi Arabia: Epidemiological, Clinical, Radiological, and Genetic Data

21. Loss of C2orf69 defines a fatal auto-inflammatory mitochondriopathy in Humans and Zebrafish

23. Amended Informative Negative Whole Exome Sequencing Results

24. Clinical, molecular, and biochemical delineation of asparagine synthetase deficiency in Saudi cohort

25. Biallelic loss-of-function variants in NEMF cause central nervous system impairment and axonal polyneuropathy

26. Successful application of genome sequencing in a diagnostic setting: 1007 index cases from a clinically heterogeneous cohort

27. NCKAP1L defects lead to a novel syndrome combining immunodeficiency, lymphoproliferation, and hyperinflammation

28. What is the right sequencing approach? Solo VS extended family analysis in consanguineous populations

30. Front Cover

31. Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15

32. Phenotypic delineation of the retinal arterial macroaneurysms with supravalvular pulmonic stenosis syndrome

33. 6-Pyruvoyltetrahydropterin Synthase Deficiency: Review and Report of 28 Arab Subjects

34. Evaluation of long-term effectiveness of the use of carglumic acid in patients with propionic acidemia (PA) or methylmalonic acidemia (MMA): study protocol for a randomized controlled trial

35. Phenotypic and biochemical analysis of an international cohort of individuals with variants in NAA10 and NAA15

36. Clinical, biochemical, and molecular overview of transaldolase deficiency and evaluation of the endocrine function: Update of 34 patients

37. The many faces of peroxisomal disorders: Lessons from a large Arab cohort

38. Whole-genome sequencing offers additional but limited clinical utility compared with reanalysis of whole-exome sequencing

40. Molecular autopsy in maternal–fetal medicine

41. Phenotypic and Molecular Spectrum of Aicardi-Goutières Syndrome: A Study of 24 Patients

44. A multicenter clinical exome study in unselected cohorts from a consanguineous population of Saudi Arabia demonstrated a high diagnostic yield

46. Expanded Newborn Screening Program in Saudi Arabia: Incidence of screened disorders

48. Clinical exome sequencing: results from 2819 samples reflecting 1000 families

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