89 results on '"Poli, Giulio"'
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2. An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent
3. A comprehensive review of synthetic strategies and SAR studies for the discovery of PfDHODH inhibitors as antimalarial agents. Part 1: triazolopyrimidine, isoxazolopyrimidine and pyrrole-based (DSM) compounds
4. An update on antibacterial AlkylGuanidino ureas: Design of new derivatives, synergism with colistin and data analysis of the whole library
5. Identification of Novel Non-Nucleoside Inhibitors of Zika Virus NS5 Protein Targeting MTase Activity
6. Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors
7. Sirtuin 1-activating derivatives belonging to the anilinopyridine class displaying in vivo cardioprotective activities
8. Carbonic Anhydrase Inhibitors: Identifying Therapeutic Cancer Agents Through Virtual Screening
9. Identification of New GSK3β Inhibitors through a Consensus Machine Learning-Based Virtual Screening
10. A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration
11. VenomPred 2.0: A Novel In Silico Platform for an Extended and Human Interpretable Toxicological Profiling of Small Molecules
12. MolBook UNIPI─Create, Manage, Analyze, and Share Your Chemical Data for Free
13. New Insights into Bitopic Orthosteric/Allosteric Ligands of Cannabinoid Receptor Type 2
14. An in silico toolbox for the prediction of the potential pathogenic effects of missense mutations in the dimeric region of hRPE65
15. miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4
16. Resveratrol Analogues as Dual Inhibitors of Monoamine Oxidase B and Carbonic Anhydrase VII: A New Multi-Target Combination for Neurodegenerative Diseases?
17. Sirtuin 1-Activating Compounds: Discovery of a Class of Thiazole-Based Derivatives
18. Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Aryloxyaryl Moiety
19. Machine Learning-Based Virtual Screening for the Identification of Cdk5 Inhibitors
20. Dissecting the Activity of Catechins as Incomplete Aldose Reductase Differential Inhibitors through Kinetic and Computational Approaches
21. Predicting potentially pathogenic effects of hRPE65 missense mutations: a computational strategy based on molecular dynamics simulations
22. Novel Potent and Selective Agonists of the GPR55 Receptor Based on the 3-Benzylquinolin-2(1H)-One Scaffold
23. Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study
24. Reversible Monoacylglycerol Lipase Inhibitors: Discovery of a New Class of Benzylpiperidine Derivatives
25. Virtual screening and crystallographic studies reveal an unexpected γ-lactone derivative active against MptpB as a potential antitubercular agent
26. New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds
27. Antibacterial alkylguanidino ureas: Molecular simplification approach, searching for membrane-based MoA
28. VenomPred: A Machine Learning Based Platform for Molecular Toxicity Predictions
29. From Anti-infective Agents to Cancer Therapy: A Drug Repositioning Study Revealed a New Use for Nitrofuran Derivatives
30. Co-Inhibition of P-gp and Hsp90 by an Isatin-Derived Compound Contributes to the Increase of the Chemosensitivity of MCF7/ADR-Resistant Cells to Doxorubicin
31. New PIN1 inhibitors identified through a pharmacophore-driven, hierarchical consensus docking strategy
32. Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold
33. Mealworm (Tenebrio molitor): Potential and Challenges to Promote Circular Economy
34. Recent Advances in In Silico Target Fishing
35. Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors
36. Discovery of Monoacylglycerol Lipase (MAGL) Inhibitors Based on a Pharmacophore-Guided Virtual Screening Study
37. The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis
38. An updated patent review of monoacylglycerol lipase (MAGL) inhibitors (2018-present)
39. Three-Dimensional Interactions Analysis of the Anticancer Target c-Src Kinase with Its Inhibitors
40. Aldose Reductase Differential Inhibitors in Green Tea
41. N-aryl-N′-ureido-O-sulfamates as potent and selective inhibitors of hCA VB over hCA VA: Deciphering the binding mode of new potential agents in mitochondrial dysfunctions
42. Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design
43. Consensus Docking in Drug Discovery
44. Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study
45. Application of MM-PBSA Methods in Virtual Screening
46. Antibacterial and ATP Synthesis Modulating Compounds from Salvia tingitana
47. 1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors
48. Modification on the 1,2-dihydro-2-oxo-pyridine-3-carboxamide core to obtain multi-target modulators of endocannabinoid system
49. Development of a cheminformatics platform for selectivity analyses of carbonic anhydrase inhibitors
50. The Extra-Virgin Olive Oil Polyphenols Oleocanthal and Oleacein Counteract Inflammation-Related Gene and miRNA Expression in Adipocytes by Attenuating NF-κB Activation
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