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This Thesis in biological physics has two components, describing the use of X-ray scattering techniques to study the structure of two different stacked lipid membrane systems.The first part focuses on the interaction between a short 11-mer peptide, Tat, which is part of the Tat protein in the HIV-1 virus. Although highly positively charged, the Tat protein has been shown to translocate through hydrocarbon lipid bilayers easily, without requiring the cell's energy, which is counter to its Born self-energy. In this work Tat's location in the headgroup region was demonstrated using a combined X-ray scattering and molecular dynamics approach. Bilayer thinning was observed as well as softening of different membrane mimics due to Tat. It was concluded that Tat's headgroup location, which increases the area/lipid, and its bilayer softening likely reduce the energy barrier for passive translocation.The second part is a rigorous investigation of an enigmatic phase in the phase diagram of the lipid dimyristoylphosphatidylcholine (DMPC). The ripple phase has fascinated many researchers in condensed matter physics and physical chemistry as an example of periodically modulated phases, with many theoretical and simulation papers published. Despite systematic studies over the past three decades, molecular details of the structure were still lacking. By obtaining the highest resolution X-ray data so far, this work revealed the complex nature of the chain packing, as well as confirming that the major side is thicker than the minor side of the saw-tooth ripple structure. The new model shows that the chains in the major arm are tilted with respect to the bilayer normal and that the chains in the minor arm are slightly more disordered than all-trans gel-phase chains, i.e., the chains in the minor arm are more fluid-like. This work provides the highest resolution X-ray structure of the ripple phase to-date.

HIV Essentials incorporates the latest clinical guidelines into a step-by-step guide to the diagnosis, evaluation, management, and prevention of HIV infection and its complications. Topics include opportunistic infections and other HIV complications, treatment of HIV and pregnancy, antiretroviral drug summaries, post-exposure and pre-exposure prophylaxis, as well as commercially available dosage forms for all ARVs. The Tenth Edition was revised and updated to focus on treatment and prevention and has removed HCV content.

The essential textbook for HIV care providers and pharmacists—updated for 2023! Fundamentals of HIV Medicine has served as a key resource for clinicians preventing and treating HIV for over a decade. An end-to-end clinical resource for the treatment of individuals with HIV/AIDS, Fundamentals of HIV Medicine 2023 offers practitioners immediate, indexed access to the most recent science, research, and guidelines related to all aspects of HIV care and prevention. Now updated to reflect the convergent knowledge at the intersection of two global pandemics, HIV and COVID-19, Fundamentals of HIV Medicine 2023 offers state-of-the-art continuing education for physicians, pharmacists, nurse practitioners, PAs, nurses, and other professionals working in the care of people with HIV. This revised edition features key clinical updates across classic domains of HIV medicine along with new understandings of injectable antiretroviral treatment and explorations into concepts of HIV latency for long-term viral remission. Embodying the American Academy of HIV Medicine's commitment to excellence in the care of seropositive patients, Fundamentals of HIV Medicine 2023 is a must-have for health professionals across HIV care, treatment, and prevention.

Four decades after And the Band Played On created an image of the AIDS epidemic that has survived in the public consciousness to this very day, mathematician Rebecca Culshaw is sounding the alarm that everything that iconic book told us about AIDS is demonstrably wrong. And that mistaken understanding of AIDS and its cause has the potential to affect all of us, not just certain so-called risk groups. In The Real AIDS Epidemic, Rebecca Culshaw describes her slow uncovering of these reasons over her years researching HIV for her work constructing mathematical models of its interaction with the immune system. It is rare that a researcher, having studied HIV, ever expresses any doubt in the paradigm, and an even rarer event still when she abandons the field altogether. Culshaw's book, updated from its original edition, which was titled Science Sold Out, is one of the great insider-turned-whistleblower stories of our time. The Real AIDS Epidemic focuses on the politics of the changing definition of AIDS and the flaws in all HIV testing. In a much broader sense, it explains how the current, government-based structure of scientific research has corrupted science as the search for truth. It offers not only scientific reasons for HIV/AIDS being untenable, but also sociological explanations as to how the theory was accepted by the media and the world so quickly. In particular, this book offers a scathing criticism of the outrageous discriminatory measures that have been leveled at HIV-positives from the inception. She also warns that the toxic drugs being foisted on the Black and gay communities constitute one of the worst medical violations of human rights since the Tuskegee Syphilis Experiment. The compelling case she makes that the AIDS establishment has led us into a biomedical disaster through incompetence, fraud, and deceit will have many readers throwing their hands up and feeling helpless and hopeless. But she does something no other book that is critical about HIV and AIDS has done. She suggests a series of strategic actions the scientific community, Congress, the media, and the public can take to undo the damage that the powerful AIDS establishment has done since the epidemic began in 1981.

HIV/AIDS is holding firm as one of the worst diseases in history and the leading cause of death in sub-Saharan Africa. This collection of essays shares various case studies from sub-Saharan Africa and one from the African Diaspora that demonstrate how multi-faceted women's lives, and thus their HIV risk, are. Notwithstanding women's marginalization, the essays in this volume maintain that women in Africa are not merely puppets of globalization, cultural norms, or biological imperatives, but rather agents in their own livelihoods. In each case we see women presented with many challenges that they must navigate in order to mitigate their HIV risk. Some of the most trying challenges are based on economic and political structures that occur at various scales, from the global to the household. While structural factors are indeed important, the authors in this volume also show that traditional norms, cultural beliefs, and gender roles are equally necessary to consider when planning HIV prevention programs. Gender disempowerment is of particular importance, as it is seen in all of these case studies. In order for the HIV epidemic to dissipate in sub-Saharan Africa, prevention programs that truly understand the local circumstances and strive for gender equality must be instituted immediately and broadly.The book is divided into three parts, each concentrating on a different aspect of women and HIV/AIDS in sub-Saharan Africa. The first part provides case studies of the social, political, economic, cultural, and geographic dynamics that play into women's and girls'risk for the virus. The second part transitions into case studies of prevention, concentrating on condom use. The chapters in the final section expand on Part II by highlighting other ways of promoting HIV/AIDS awareness and prevention across the region. In short, the papers in this volume highlight the complicated decision making processes that women in countries of sub-Saharan Africa must make when it comes to HIV risk. In many cases, women find themselves in economically dependent relationships with men whereby they must stay in sexually risky situations to be able to feed themselves and, very often, their children.

Completely revised and updated, HIV Essentials incorporates the latest clinical guidelines into a step-by-step guide to the diagnosis, evaluation, management, and prevention of HIV infection and its complications. Topics include: opportunistic infections and other HIV complications, treatment of HIV and pregnancy, antiretroviral drug summaries, post-exposure prophylaxis, as well as commercially available dosage forms for all ARVs.

Frontiers in Clinical Drug Research – HIV is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other disorders associated with human immunodeficiency virus (HIV) infection. The scope of the book series covers a range of topics including the medicinal chemistry and pharmacology of natural and synthetic drugs employed in the treatment of AIDS (including HAART) and resulting complications, and the virology and immunological study of HIV and related viruses. Frontiers in Clinical Drug Research – HIV is a valuable resource for pharmaceutical scientists, clinicians and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in HIV/AIDS research.The fifth volume of this series features 5 chapters that cover these topics:- Clinical Eradication of Latent HIV Reservoirs: Where Are We Now?- HIV-1 Genotypic Drug Resistance Testing and Next-Generation Sequencing- Current and Promising Multiclass Drug Regimens and Long-Acting Formulation Drugs in HIV Therapy- Role of Nanotechnology in HIV Diagnosis and Prognosis- Preventive and Therapeutic Features of Combination Therapy for HIV

The essential work in HIV for providers and pharmacists--updated with everything they need to know in 2021! An end-to-end clinical resource for the treatment of individuals with HIV/AIDS, Fundamentals of HIV Medicine has served as a key resource for clinicians preventing and treating HIV for over a decade. Now updated for 2021, Fundamentals of HIV Medicine 2021 offers state-of-the-art continuing education for physicians, pharmacists, nurse practitioners, nurses, and other professionals working in the care of HIV patients. With this volume, practitioners will have immediate, indexed access to the most updated science, research, and guidelines related to all aspects of HIV care and prevention. This revised edition features key clinical updates across classic domains of HIV medicine along with recent research in HIV medicine including HIV workforce strains and PrEP, newly emerging antiretroviral treatment options, and the evolving effects of COVID-19 on HIV care. Embodying the American Academy of HIV Medicine's commitment to excellence in the care of seropositive patients, Fundamentals of HIV Medicine 2021 is a must-have for health professionals across HIV care, treatment, and prevention.

This book serves as a reference work on pediatric HIV infection and covers the full bandwidth of topics from an introduction to pathogenesis and epidemiology, over the transmission of the HI virus, to clinical manifestations, treatment, and prevention strategies. Diseases and disorders occurring in HIV infected persons are discussed in detail. The book covers special populations, such as neonates born to an HIV positive mother and adolescents and examines the specific ways of managing HIV disease in these patient groups. This is the first book to cover palliative care as well as ethical, legal and social issues of HIV infection.

In 1992, Dr. Ross A. Slotten signed more death certificates in Chicago—and, by inference, the state of Illinois—than anyone else. As a family physician, he was trained to care for patients from birth to death, but when he completed his residency in 1984, he had no idea that many of his future patients would be cut down in the prime of their lives. Among those patients were friends, colleagues, and lovers, shunned by most of the medical community because they were gay and HIV positive. Slotten wasn't an infectious disease specialist, but because of his unique position as both a gay man and a young physician, he became an unlikely pioneer, swept up in one of the worst epidemics in modern history. Plague Years is an unprecedented first-person account of that epidemic, spanning not just the city of Chicago but four continents as well. Slotten provides an intimate yet comprehensive view of the disease's spread alongside heartfelt portraits of his patients and his own conflicted feelings as a medical professional, drawn from more than thirty years of personal notebooks. In telling the story of someone who was as much a potential patient as a doctor, Plague Years sheds light on the darkest hours in the history of the LGBT community in ways that no previous medical memoir has.

In Rethinking Diabetes, Emily Mendenhall investigates how global and local factors transform how diabetes is perceived, experienced, and embodied from place to place. Mendenhall argues that the link between sugar and diabetes overshadows the ways in which underlying biological processes linking hunger, oppression, trauma, unbridled stress, and chronic mental distress produce diabetes. The life history narratives in the book show how deeply embedded these factors are in the ways diabetes is experienced and (re)produced among poor communities around the world.Rethinking Diabetes focuses on the stories of women living with diabetes near or below the poverty line in urban settings in the United States, India, South Africa, and Kenya. Mendenhall shows how women's experiences of living with diabetes cannot be dissociated from their social responsibilities of caregiving, demanding family roles, expectations, and gendered experiences of violence that often displace their ability to care for themselves first. These case studies reveal the ways in which a global story of diabetes overlooks the unique social, political, and cultural factors that produce syndemic diabetes differently across contexts.From the case studies, Rethinking Diabetes clearly provides some important parallels for scholars to consider: significant social and economic inequalities, health systems that are a mix of public and private (with substandard provisions for low-income patients), and rising diabetes incidence and prevalence. At the same time, Mendenhall asks us to unpack how social, cultural, and epidemiological factors shape people's experiences and why we need to take these differences seriously when we think about what drives diabetes and how it affects the lives of the poor.

This book deals with Tuberculosis in exhaustive detail. It incorporates the most recent research on the disease, and is divided into different sections highlighting the chronological history of its development, global spread, the current scenario in India with regards to the disease, seasonality, co-infection with HIV-AIDS, and the novel combinatorial-therapy with special reference to underprivileged and tribal populations.Avoiding lengthy and irrelevant descriptions, it will help the reader, particularly students, to grasp the facts. The book is supplemented with figures and ray diagrams to allow full visualisation of the concepts discussed.

The Face of AIDS film archive at Karolinska Institutet, Sweden, consists of more than 700 hours of unedited and edited footage, shot over a period of more than thirty years and all over the world by filmmaker and journalist Staffan Hildebrand. The material documents the HIV/AIDS pandemic and includes scenes from conferences and rallies, and interviews with activists, physicians, people with the infection, and researchers. It represents a global historical development from the early years of the AIDS crisis to a situation in which it is possible to live a normal life with the HIV virus. This volume brings together a range of academic perspectives – from media and film studies, medical history, gender studies, history, and cultural studies – to bear on the archive, shedding light on memories, discourses, trauma, and activism. Using a medical humanities framework, the editors explore the influence of historical representations of HIV/AIDS and stigma in a world where antiretroviral treatment has fundamentally altered the conditions under which many people diagnosed with HIV live. Organized into four sections, this book begins by introducing the archive and its role, setting it in a global context. The first part looks at methodological, legal and ethical issues around archiving memories of the present which are then used to construct histories of the past; something that can be particularly controversial when dealing with a socially stigmatized epidemic such as HIV/AIDS. The second section is devoted to analyses of particular films from the archive, looking at the portrayal of people living with HIV/AIDS, the narrative of HIV as a chronic illness and the contemporary context of particular films. The third section looks at how stigma and trauma are negotiated in the material in the Face of AIDS film archive, discussing ideas about suffering and culpability. The final section contributes perspectives on and by the filmmaker as activist and auteur. This interdisciplinary collection is placed at the intersection of medical humanities, sexuality studies and film and media studies, continuing a tradition of studies on the cultural and social understandings of HIV/AIDS.

Over the past few years, ever since the advent of HIV and AIDS, there has been increasing discussion of the concept of sexual health. This upsurge is especially noticeable not only in the field of health education and promotion but also in academic sources. The recent discourse on sexual health is paralleled by an upsurge in the debate on sexual rights. This book examines the social construction of sexual health in India through an analysis of HIV and AIDS messages. The broad objective of the chapters is to trace the growth and evolution of the concept of sexual health from a health communication perspective and to understand the role of the state in determining its form and structure. The methodology used includes comparative analysis of HIV and AIDS policies, document analysis on HIV and AIDS, poster and short films analysis, in depth and open-ended Interviews and case studies. The book shows that Sexual Health is constructed in various modes in India. The models that are elaborated are the Medical model that constructs HIV scientifically and in terms of a compromised immune system; the Epidemic model that identifies risk behaviours and transmission routes and the Moralistic model. Social constructions of AIDS as plague or punishment against society are advanced by moralists who equate HIV with taboo social and sexual behaviour and the political constructions highlights public health in the face of obstacles to treatment and the delivery of services to people living with HIV.Bringing together current research and discussions on the three areas of policy, practices and theoretical perspectives related to the use and social construction of sexual health through HIV and AIDS communication approaches with specific reference to India, this book will be of interest to academics in the field of health communication, HIV and AIDS, and South Asian Studies.

In recent years, Europe and Central Asia has experienced the world's fastest growing HIV/AIDS epidemic. Yet, in the Western Balkan countries the HIV prevalence rate is under 0.1 percent, which ranks among the lowest. This may be due to a low level of infection among the population--or partly due to inadequate surveillance systems. All major contributing factors for the breakout of an HIV/AIDS epidemic are present in the Western Balkans. HIV/AIDS disproportionably affects youth (80 percent of HIV-infected people are 30 years old or younger). Most of the Western Balkan countries have very young p.

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

Approximately 70% of the global total of people living with HIV/AIDS in 2016 were in sub-Saharan Africa. After delayed governmental responses, the media has been consistently deployed as an essential tool for prevention. But HIV prevention campaigns reflect multiple conflicting and shifting agendas that encompass far more than the imparting of information about how to limit the spread of the virus. In Prevention: Gender, Sexuality, HIV, and the Media in Côte d'Ivoire, Christine Cynn draws from postcolonial, queer, and feminist film and media studies to critique global HIV prevention efforts and how they attempt to reshape gendered sexualities and notions of family in line with the rationality of neoliberalism. More specifically, Cynn argues that through the bolstering of normative conceptions of gendered sexualities and families, HIV prevention media campaigns seek to actively create proper subjects, a goal corresponding with nation-building projects and reproducing their terms of belonging. During periods of increasingly virulent political and economic struggles in Côte d'Ivoire, such HIV prevention messages have lent support to lender- and state-mandated structural adjustment policies and to the exclusionary logic that casts some—such as those suffering from AIDS-related illnesses, those labeled as “homosexual,” sex workers, intravenous drug users, and the HIV-positive child—as implicitly unassimilable to the community and nation. Deeply interdisciplinary, Prevention brings to light new forms of exclusion and expands scholarship on gender and sexual normativities as it intersects with that on public health, neoliberalism, and film and media.

This book is the first full-length study of HIV/AIDS work in relation to government and NGOs. In the early 2000s, Pakistan's response to HIV/AIDS was scaled-up and declared an area of urgent intervention. This response was funded by international donors requiring prevention, care and support services to be contracted out to NGOs - a global policy considered particularly important in Pakistan where the high risk populations are criminalized by the state. Based on unparalleled ethnographic access to government bureaucracies and their dealings with NGOs, Qureshi examines how global policies were translated by local actors and how they responded to the evolving HIV/AIDS crisis. The book encourages readers to reconsider the orthodoxy of policies regarding public-private partnership by critiquing the resulting changes in the bureaucracy, civil society and public goods. It is a must-read for students, scholars and practitioners concernedwith neoliberal agendas in global health and development.

This book addresses the ongoing problem of HIV in black South African women as a health inequity. Importantly, it argues that this urgent problem of justice is changeable. Sprague uses the capabilities approach to bring a theory of health justice, together with multiple sources of evidence, to investigate the complex problem of HIV and accompanying poor health outcomes in black South African women. Motivated by a concern for application of knowledge, this work discusses how to better conceptualise what health justice demands of state and society, and how to mobilise available evidence on health inequities in ways that compel greater state action to address problems of gender and health. HIV in women, and possible responses, are investigated on four distinct levels: conceptual, social structure, health systems, and law. The analysis demonstrates that this problem is indeed modifiable with long-term interventions and an enhanced state response targeted at multiple levels. This book will be of interest to academics and students in the social health sciences, gender and development studies, and global health, as well as HIV/health activists, government officials, policy makers, HIV clinicians and health providers interested in HIV.

This report examines how the evolution of the HIV epidemic and the scale-up of anti-retroviral therapy (ART) have impacted on the global labour force, and what its effects will be in the future. Bringing together health data, in particular HIV prevalence data, with labour force, economic and demographic data, estimates are provided for workers affected by HIV and AIDS. The report sets out social and economic impacts on workers and their households for 2005, 2010, 2015, and projections for 2020.

Dr. Phillips has assembled well-published authors on optimizing patient outcomes in those living with HIV and AIDS. The clinical reviews in this issue will provide nurses with the current clinical information they need to incorporate best practices into their patient care and manageement. Articles are devoted to the following topics: Exercise and Positive Living in HIV/AIDS; Managing Other Chronic Illnesses in PLWHAl; Nutritional Issues and Positive Living in HIV/AIDS; Spiritual Dimensions/Resilience; Positive Thinking in HIV/AIDS; Health Promotion in HIV/AIDS; Mental Health in HIV/AIDS; Promoting Cardiovascular Health in PLWHA; Pharmacological Considerations in HIV/AIDS; and Sleep Disturbances Associated with HIV/AIDS.

This book examines the structural dynamics of HIV among populations at heightened vulnerability to infection as the result of stigma, discrimination and marginalization. It first examines how the socio-structural context shapes HIV risk and how affected populations and national governments and programs have responded to these structural constraints. Chapters focus on structural determinants of HIV risk among transgender women in Guatemala, migrant workers in Mexico, Nigeria and Vietnam, and people who inject drugs in Tanzania. Next, the book examines resilience and community empowerment and mobilization among key populations such as female sex workers in the Dominican Republic and India, and young women and girls in Botswana, Malawi and Mozambique. A third set of chapters explores how national responses to HIV have addressed the role of structural factors in diverse political, geographic and epidemic settings including: Brazil, South Africa, Ukraine and the USA. Ultimately, effectiveand sustainable responses to HIV among marginalized groups must be grounded in an in-depth understanding of the factors that create vulnerability and risk and impede access to services. Throughout, this book brings together a rigorous social science research perspective with a strong rights-based approach to inform improvements in HIV programs and policies. It offers new insights into how to better address HIV and the health and human rights of historically excluded communities and groups.

The occurrence of HIV/AIDS has dramatically affected every aspect of justice systems worldwide. Legal, law enforcement and custody issues abound. This volume provides a comprehensive overview of these issues as well as strategies and solutions.

Pharmacists now have a new resource to help expand their HIV knowledge, guide their treatment, and provide comprehensive care. HIV Pharmacotherapy: The Pharmacist's Role in in Care and Treatment by Jason J. Schafer, with Jennifer Cocohoba, Elizabeth Sherman, and Alice Tseng, is the first of its kind to provide pharmacists with a consolidated resource for offering care to patients with HIV infection, including diagnosis, primary care, pharmacological management of co-infections, and more. This resource will help prepare pharmacists to take a lead role in the care and treatment of patients with HIV, and will be a valuable guide for students, residents, and clinical pharmacists to build expertise in tailoring antiretroviral regimens to maximize effectiveness and adherence and reduce drug interactions and side effects. The role of the pharmacist on the HIV health care team is evolving to meet the changing needs of HIV patients. Learn about the latest key concepts, expertise and best practices for clinical decision making.

This book analyses the impact of HIV and AIDS on performance in the twenty-first century from an international perspective. It marks a necessary reaffirmation of the productive power of performance to respond to a public and political health crisis and act as a mode of resistance to cultural amnesia, discrimination and stigmatisation. It sets out a number of challenges and contexts for HIV and AIDS performance in the twenty-first century, including: the financial interests of the pharmaceutical industry; the unequal access to treatment and prevention technologies in the Global North and Global South; the problematic division between dominant (white, gay, urban, cis-male) and marginalised narratives of HIV; the tension between a damaging cultural amnesia and a potentially equally damaging partner ‘AIDS nostalgia'; the criminalisation of HIV non-disclosure; and, sustaining and sustained by all of these, the ongoing stigmatisation of people living with HIV.This collection presents work from a vast range of contexts, grouped around four main areas: women's voices and experiences; generations, memories and temporalities; inter/national narratives; and artistic and personal reflections and interventions.

The HIV epidemic in Bolivia has received little attention on a global scale in light of the country's low HIV prevalence rate. However, by profiling the largest city in this land-locked Latin American country, Carina Heckert shows how global health-funded HIV care programs at times clash with local realities, which can have catastrophic effects for people living with HIV who must rely on global health resources to survive. These ethnographic insights, as a result, can be applied to AIDS programs across the globe. In Fault Lines of Care, Heckert provides a detailed examination of the effects of global health and governmental policy decisions on the everyday lives of people living with HIV in Santa Cruz. She focuses on the gendered dynamics that play a role in the development and implementation of HIV care programs and shows how decisions made from above impact what happens on the ground.

Winner of the 2018 Association for Africanist Anthropology Elliott P. Skinner Book Award In Zambia, due to the rise of tuberculosis and the closely connected HIV epidemic, a large number of children have experienced the illness or death of at least one parent. Children as Caregivers examines how well intentioned practitioners fail to realize that children take on active caregiving roles when their guardians become seriously ill and demonstrates why understanding children's care is crucial for global health policy. Using ethnographic methods, and listening to the voices of the young as well as adults, Jean Hunleth makes the caregiving work of children visible. She shows how children actively seek to “get closer” to ill guardians by providing good care. Both children and ill adults define good care as attentiveness of the young to adults'physical needs, the ability to carry out treatment and medication programs in the home, and above all, the need to maintain physical closeness and proximity. Children understand that losing their guardians will not only be emotionally devastating, but that such loss is likely to set them adrift in Zambian society, where education and advancement depend on maintaining familial, reciprocal relationships. View a gallery of images from the book (https://www.flickr.com/photos/childrenascaregivers) Download the open access ebook.

This book examines the impact of pediatric HIV on children, adolescents, and their families. Beginning with an overview of pediatric HIV epidemiology, it traces the medical, psychological, and social dimensions of HIV through the trajectory of childhood and youth. It examines the latest research on a wide range of topics, including treatment adherence, cultural, legal, and ethical issues, and HIV stigma and its reduction. Chapters offer expert recommendations for clinicians working with children with HIV as well as researchers studying pediatric HIV. In addition, the book also discusses daily concerns associated with pediatric HIV, such as disease management, coping, access to services, risk prevention, and health promotion. Topics featured in this book include: The impact of pediatric HIV on families. Psychosocial considerations for children and adolescents with HIV.HIV prevention and intervention in the school setting.HIV disclosure in pediatric populations.How to design effective evidence-based HIV risk-reduction programs for adolescents.A Clinical Guide to Pediatric HIV is a must-have resource for researchers, clinicians, and graduate students in child and school psychology, social work, and public health as well as pediatric medicine, nursing, epidemiology, anthropology, and other related disciplines.

In its updated and expanded second edition, this helpful guide offers a wealth of information for people living with HIV and for people caring for HIV-positive loved ones. All aspects of HIV/AIDS are discussed, including opportunistic and associated infections, dental care, exercise and nutrition, substance use and abuse and emotional treatment. New information will help the newly diagnosed adjust to their illness and long-term survivors to improve their quality of life. Up-to-date discussion of the latest medications covers the growing practice of using HIV drugs as preventatives. Essential Internet resources are provided that help patients live a longer, healthier life.

As global health institutions and aid donors expanded HIV treatment throughout Africa, they rapidly'scaled up'programs, projects, and organizations meant to address HIV and AIDS. Yet these efforts did not simply have biological effects: in addition to extending lives and preventing further infections, treatment scale-up initiated remarkable political and social shifts. In Lesotho, which has the world's second highest HIV prevalence, HIV treatment has had unintentional but pervasive political costs, distancing citizens from the government, fostering distrust of health programs, and disrupting the social contract. Based on ethnographic observation between 2008 and 2014, this book chillingly anticipates the political violence and instability that swept through Lesotho in 2014.This book is a recipient of the Norman L. and Roselea J. Goldberg Prize from Vanderbilt University Press for the best book in the area of medicine.

The Guide to AIDS is succinct review of HIV/AIDS from a human-interest perspective. Chapters focus on some of the common patterns and prevention of HIV transmission and debunks misconceptions about HIV and AIDS. Brief descriptions the human immune system and epidemiology of HIV are included. The cultural component of disease, treatment and living with AIDS is central to much of this guide intended to synthesize, explain and de-mystify HIV and AIDS.

This wide-ranging volume reviews the experience and treatment of HIV/AIDS in rural America at the clinical, care system, community, and individual levels. Rural HIV-related phenomena are explored within healthcare contexts (physician shortages, treatment disparities) and the social environment (stigma, the opioid epidemic), and contrasted with urban frames of reference. Contributors present latest findings on HIV medications, best practices, and innovative opportunities for improving care and care settings, plus invaluable first-person perspective on the intersectionality of patient subpopulations. These chapters offer both seasoned and training practitioners a thorough grounding in the unique challenges of providing appropriate and effective services in the region. Featured topics include: Case study: Georgia's rural vs. non-rural populations HIV medications: how they work and why they fail Pediatric/adolescent HIV: legal and ethical issues Our experience: HIV-positive African-American women in the Deep South Learning to age successfully with HIV Bringing important detail to an often-marginalized population, HIV/AIDS in Rural Communities will interest and inspire healthcare practitioners including physicians, nurse practitioners, physician assistants, pharmacists, case managers, psychologists, social workers, counselors, and family therapists, as well as educators, students, persons living with HIV, advocates, community leaders, and policymakers.

Completely revised and updated, HIV Essentials 2017 incorporates the latest clinical guidelines into a step-by-step guide to the diagnosis, evaluation, management, and prevention of HIV infection and its complications. Topics include: opportunistic infections and other HIV complications, treatment of HIV and pregnancy, antiretroviral drug summaries, post-exposure prophylaxis, as well as commercially available dosage forms for all ARVs.

This edited volume presents a detailed portrait of couples living with mixed HIV status, where one partner is HIV-positive and the other negative. Readers will come to understand the various and complex ways in which these mixed-status, or serodiscordant couples build a life together within the shadow of HIV-related stigma. Spanning the globe, coverage explores serodiscordance as a negotiated practice and process, inseparable from the social context in which it is situated. The book shows how couples draw on diverse and sometimes contradictory cultural discourses of medicine, romance, and “normality” to make sense of and manage their mixed HIV status and any perceived risks, not uncommonly in ways that depart from prevailing HIV prevention messages. Throughout, compelling personal stories accompany the empirical research, sharing the firsthand experiences of men and women in serodiscordant relationships. Bringing together research from diverse disciplines and geographical regions, this book contributes important insights for future HIV health promotion as well as offers new knowledge to scholarship on the cultural intersections of illness and intimacy. It will appeal to a broad audience working across the fields of HIV, health, gender, sexuality, development, and human rights.

Although morbidity among HIV/AIDS victims has decreased, the rate of new infections has remained steady for several years, substantially increasing the likelihood that this epidemic will continue and expand as a concern for social workers and their clientele, both of whom will need to be kept informed of the complex laws governing the milieu and the consequences of the disease. This is certainly the case with its spread throughout Asia and Africa. In this new work, the author draws upon statutes and court decisions from across the United States to provide a comprehensive and current picture of the many facets of HIV/AIDS law, including health policy; confidentiality; privacy; bioethics; the workplace; and criminal law and corrections. The volume of legal, medical, social science, and popular literature pertaining to HIV/AIDS that has been published over the past two decades is staggering. Hence, any addition to this collection needs some justification. What Dickson offers is different from what has preceded. Rather than one more contribution to the extensive legal or social science literature, this book attempts to integrate the perspectives from two fields: law and social work. The hope is that this will give social workers, practitioners, and teachers a better understanding of one of the major issues that may face them in their work with patients and clients every day.To date, although there is extensive HIV and AIDS-related literature in social work and the social sciences, it is primarily focused on social work practice issues. Where law has been introduced in these works, it often is narrow in focus and, given the rapid changes in the field, no longer up to date. This book does not purport to discuss all legal issues in all jurisdictions relating to HIV/AIDS, but rather to choose selectively those that have particular relevance for social work and social policy. The author has placed reliance on those published medical works cited with approval in the legal and

This book presents the history of HIV/AIDS in China, which over the last three decades has been a gripping tale of exclusion and fear, and then, by turns, of involuntary tragedy, cautious experimentation and finally vigorous response. It discusses the occurrence, development and epidemic studies and also introduces China's policies and measures to conquer this epidemic, offering readers valuable insights into China's approach to prevention in this field.

This book offers a critical inquiry into the framing of health and disease as a security issue. In particular, the book examines what happens in the United Nations when the ostensibly ‘low'politics of global health meet the ‘high'politics of security, and when the logic of security comes to shape global health initiatives. It offers a critical re-assessment of efforts in the United Nations system to position HIV as a security threat with the hope that this would attract greater attention and resources for the global HIV response. The book advances securitization theory by presenting a new framework for studying HIV as a policy process, uniting several theoretical strands into a single, powerful model for empirical application. It uses this model to draw attention to important, understudied aspects of HIV securitization, including the role played by discourses about Africa, and the evolution of ideas about HIV and security as actors learned over time. On the basis of this empirically grounded assessment of how securitization works as a theory and a political strategy, the book suggests that securitization is inherently limited, and perhaps dangerous, as a strategy for ‘securing'social change. This book will be of much interest to students of critical security studies, global health, development studies, and IR in general.

Whether you're a newly diagnosed patient or a friend or relative of someone suffering from HIV or Aids, this book can help. Offering both doctor and patient perspectives, 100 Questions & Answers About HIV and Aids, Third Edition provides authoritative and practical answers to the most commonly asked questions by patients and their loved ones. What is the difference between HIV and Aids? How can HIV infection be prevented? How do I find the right medical care?Along with the answers to these and other questions, this book provides information on diagnosis, treatment, living with HIV and more. Written by experts in the field 100 Questions & Answers About HIV and Aids, Third Edition is an invaluable resource for anyone coping with the physical and emotional uncertainty of this disease.

This book focuses on the issues encountered by children and young people who are living with HIV/AIDS. It examines their lived experiences associated with HIV/AIDS, and studies groups of children and youngsters from around the globe. Connecting empirical information with real-life situations, the book brings together results from empirical research that relates to these children and young people. Its chapters can be used as evidence for health care providers to implement socially and culturally appropriate services to assist individuals and groups of children and young people who are living with HIV/AIDS in many societies. Many of these young people are from the most marginalized and vulnerable groups; and many have been orphaned by the death of their HIV-positive parents. Marginalized young people such as refugees, migrants and street children are most at risk due to the use of illicit drugs, their exposure to unprotected sex (in exchange for food, money and protection), and stigma associated with their marginalized lives. The impact that HIV/AIDS has on the opportunities for these young people to be able to lead healthy adult lives is considerable. This book gives a voice to these children and young people and advances our understanding of their lived experiences and needs.

Patients suffering from HIV/AIDS often experience chronic pain due to the many diseases and infections they pick up as a result of a weakened immune system. It interferes with their quality of life and physical functioning, impacts adherence to antiretroviral therapy and HIV primary care, and is associated with significant psychological/social distress and substance use disorders. Chronic Pain and HIV addresses all these complex issues that can influence pain care that can influence pain care for the patient with HIV and acts both as a primer and a comprehensive review to define the field of chronic pain management. Using a clear, clinical approach, key topics include the following: Musculoskeletal pain in individuals in HIV Headache in individuals with HIV Psychiatric comorbidities among individuals with HIV and chronic pain Potential benefit and harm of prescription opioids in HIV Pain at the end of life in individuals with AIDS Treatment of chronic pain syndromes in the HIV-infected person. Edited by an outstanding team with extensive experience in HIV/AIDS and pain/palliative care, every chapter is written by a world-famous expert in their field who provides a thorough review of the relevant literature, including the very latest in management guidelines from the leading international societies. Perfect for all those in primary care, as well as infectious disease specialists managing patients with HIV/AIDS, Chronic Pain and HIV provides sensible, straightforward clinical advice to ensure the best possible patient management.

AIDS epidemics continue to threaten the livelihoods of millions of people in sub-Saharan Africa. Three decades after the disease was first recognized, the annual death toll from AIDS exceeds that from wars, famine and floods combined. Yet despite millions of dollars of aid and research, there has previously been little detailed on-the-ground analysis of the multifaceted impacts on rural people. Filling that gap, this book brings together recent evidence of AIDS impacts on rural households, livelihoods, and agricultural practice in sub-Saharan Africa. There is particular emphasis on the role of women in affected households, and on the situation of children. The book is unique in presenting micro-level information collected by original empirical research in a range of African countries, and showing how well-grounded conclusions on trends, impacts and local responses can be applied to the design of HIV-responsive policies and programmes. AIDS impacts are more diverse than we previously thought, and local responses more varied - sometimes innovative, sometimes desperate. The book represents a major contribution to our understanding of the impacts of AIDS in the epidemic's heartland, and how these can be managed at different levels.

Frontiers in Clinical Drug Research – HIV is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other

The 1992 creation of the National HIV/AIDS Program was a fundamental step for Argentina to reach the second lowest burden of HIV/AIDS in South America. From 2000 to 2010, Argentina further reduced the already low HIV/AIDS incidence of 15.9 per 100,000 by 25 percent and reduced the burden by 21 percent. This study analyzes the national and inter-provincial burden of disease, the demographics of new HIV cases, the demand and supply-sides of service delivery, and conducts a cost-benefit analysis of the National HIV/AIDS Program over the last decade. Though the National HIV/AIDS Program was an instrumental step towards these achievements, this book also examines other key programmatic innovations that have been essential to the country's success in the fight against HIV/AIDS, including the introduction of universal free antiretroviral treatment; a comprehensive legal framework for sexual and reproductive rights; the introduction of incentives and results-based financing in the HIV/AIDS program; electronic monitoring of supplies and medicines; and implementation of an electronic clinical governance system for improving the quality of care and patient follow-up, among others. Despite high costs of the Program, this study found the Argentine National HIV/AIDS Program is cost-beneficial. From 2000 to 2010, 4,379 potential lives were saved. Nonetheless, the fight against this epidemic poses continuous challenges, including a stubbornly high number of new infections among young men who have sex with men, inequalities in HIV/AIDS rates between provinces, insufficient coverage of HIV diagnostic testing, insufficient HIV testing of tuberculosis patients, low expenditure on HIV prevention, high comparative cost of antiretroviral treatment, and questions regarding the long-term financial sustainability of the AIDS program, considering the increasing number of patients in treatment.'Thirty Years of the HIV/AIDS Epidemic in Argentina: An Assessment of the National Health Response'delves into the combination of factors that make Argentina a success story in combating HIV/AIDS.

Frontiers in Clinical Drug Research – HIV is an eBook series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of acquired immune deficiency syndrome (AIDS) and other

Although adopting global norms often improves domestic systems of governance, domestic obstacles to norm diffusion are frequent. States that decide to reinvent their political authority simultaneously evaluate which current global norms are desirable and to what extent. In this study, Vlad Kravtsov argues that recent debates about the nature of authority in Putin's Russia and Mbeki's South Africa have resulted in a set of unique ideas on the cardinal goals of the state. This is the first book to explore how these consensual ideas have shaped health governance and impinged on norm diffusion processes.Detailed comparisons of HIV/AIDS governance systems in Russia and South Africa illustrate the argument. The Kremlin's dislike of international recommendations stemmed from the rapidly maturing statism and great power syndrome. Pretoria's responses to global AIDS norms were consistent with the ideas of the African Renaissance, which highlighted indigenousness, market-based empowerment, and moral leadership in global affairs. This book explains how and why the governments under investigation framed the nature of the epidemic, provided evidence-based prevention services, increased universal access to proven lifesaving medicines, and interacted with other participants in social practice.

The history of the CCR5 gene as a lens through which to view such issues as intellectual property, Big Pharma, personalized medicine, and race and genomics.In The Genealogy of a Gene, Myles Jackson uses the story of the CCR5 gene to investigate the interrelationships among science, technology, and society. Mapping the varied “genealogy” of CCR5—intellectual property, natural selection, Big and Small Pharma, human diversity studies, personalized medicine, ancestry studies, and race and genomics—Jackson links a myriad of diverse topics. The history of CCR5 from the 1990s to the present offers a vivid illustration of how intellectual property law has changed the conduct and content of scientific knowledge, and the social, political, and ethical implications of such a transformation.The CCR5 gene began as a small sequence of DNA, became a patented product of a corporation, and then, when it was found to be an AIDS virus co-receptor with a key role in the immune system, it became part of the biomedical research world—and a potential moneymaker for the pharmaceutical industry. When it was further discovered that a mutation of the gene found in certain populations conferred near-immunity to the AIDS virus, questions about race and genetics arose. Jackson describes these developments in the context of larger issues, including the rise of “biocapitalism,” the patentability of products of nature, the difference between U.S. and European patenting approaches, and the relevance of race and ethnicity to medical research.

Drawing on ten years of ethnographic research, two hundred fifty interviews, and over three hundred youth love letters, author Shanti Parikh uses lively vignettes to provide a rare window into young people's heterosexual desires and practices in Uganda. In chapters entitled'Unbreak my heart,''I miss you like a desert missing rain,'and'You're just playing with my head,'she invites readers into the world of secret longings, disappointments, and anxieties of young Ugandans as they grapple with everyday difficulties while creatively imagining romantic futures and possibilities. Parikh also examines the unintended consequences of Uganda's aggressive HIV campaigns that thrust sexuality and anxieties about it into the public sphere. In a context of economic precarity and generational tension that constantly complicates young people's notions of consumption-based romance, communities experience the dilemmas of protecting and policing young people from reputational and health dangers of sexual activity.'They arrested me for loving a school girl'is the title of a chapter on controlling delinquent daughters and punishing defiant boyfriends for attempting to undermine patriarchal authority by asserting their adolescent romantic agency. Sex education programs struggle between risk and pleasure amidst morally charged debates among international donors and community elders, transforming the youthful female body into a platform for public critique and concern. The many sides of this research constitute an eloquently executed critical anthropology of intervention.

A comprehensive health care system consists of services that are coordinated and integrated along the full continuum of care. For HIV patients, this includes physical health care, infectious disease management, crisis care, mental health care, substance abuse counseling, and social support services including housing, transportation, subsistence, and supports for dealing with multiple sources of stigma. This book highlights the dilemmas faced in providing comprehensive, integrated care to individuals living with HIV, providing both an understanding of existing efforts to integrate diverse systems of care, as well as insight into ways in which systems of care must be challenged in order to meet the needs of people living with HIV. Comprehensive Care for HIV/AIDS is the result of collaborative work with the county Health Department, numerous community-based organizations, and several planning boards in a metropolitan area, which have sought to provide integrated care to people living with HIV. It will be a valuable resource to the diverse community of HIV researchers, advocates and providers.