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This book explores the essence of immunity. After an initial review of hypotheses, models, and theories proposed to explain immune phenomena in humans and mice, it summarizes the results from synchronic organism‑level analyses and diachronic analyses tracing phylogeny. These results suggest that immunity is coextensive with life and is equipped with functions similar to the nervous system. Philosophical reflection with reference to Spinoza and Canguilhem suggests immunity is part of the essence of life—and the essence of immunity embraces mental elements with normativity. Approaching the essence of any phenomenon in this way is called'metaphysicalization of science.'This book demonstrates the potential of this approach and contributes to a richer understanding of nature.Key Features Reviews the history of immunological theories Discusses and integrates science and philosophy Provides a biological framework for cognition and self vs. nonself Inspired by Auguste Comte's'The Law of Three Stages'

Unveils how the immune system works and explores strategies for harnessing its potential for maintaining good health.Embark on a fascinating journey into the human immune system with The Logic of Immunity. B. J. Cherayil, an accomplished immunologist and educator, demystifies the complex workings of our body's defense system. This scientifically grounded book illustrates the inner mechanisms of specialized cells and molecules that safeguard our health, shedding light on how and why our immune systems can malfunction and lead to disease. Drawing from years of experience and expertise, Dr. Cherayil skillfully guides readers through the intricacies of immune responses and offers invaluable insights into the latest research-backed strategies to harness their power for maintaining and restoring well-being. Blending scientific knowledge with historical anecdotes, this work also introduces the remarkable scientists who have shaped our understanding of immune function. Complemented by detailed illustrations and a glossary of key terms, The Logic of Immunity explains how the immune system interacts with other body systems, why some people develop autoimmune diseases while others do not, and how lifestyle factors may activate or suppress the immune system. Explore the enigmatic world of immunity, unlock its secrets, and discover the power it holds to protect our health.

The U.S. Social Security Administration (SSA) administers the Social Security Disability Insurance program and the Supplemental Security Income program. As part of their process, immune system disorders are evaluated under Listing of Impairments 14.00 for adults and 114.00 for children. At the request of the SSA, the National Academies of Sciences, Engineering, and Medicine assembled a committee to review selected conditions related to the immune system. In particular, the SSA was interested in the current status of the diagnosis, treatment, and prognosis of immune system disorders including systemic lupus erythematosus (SLE), scleroderma, polymyositis, Sjögren's syndrome/disease, and inflammatory arthritis. This report provides an overview of the current status of the diagnosis, treatment, and prognosis of these immune system disorders in the U.S. population and the relative levels of functional limitation typically associated with them, common treatments, and other considerations.

••Selected for Doody's Core Titles® 2024 in Immunology•• Introductory Immunology: Basic Concepts for Interdisciplinary Applications, 3rd Edition, is a completely updated, revised, and expanded concise, conceptual approach to understanding the immune systems as a primary defense to maintain health and homeostasis. This expanded version includes the aspects of microbiology and related immune defense mechanisms important in combating disease, as well critical components related to the field of vaccine development. Immunology as a subject is no longer confined to the realms of'immunology'or'microbiology'studies. Indeed, the subject matter has become increasingly important to understand complex mechanisms found within a wider range of biological systems. This book aims specifically at educated audiences who do not have a deep understanding of medical, biochemical, or cellular knowledge. The overall text will present concepts that portray a comprehensive picture of the natural defenses to infectious agents as well as provide an introduction to mechanisms that lead to autoimmune dysfunction. In addition, immunological diseases will be detailed, with the goal of allowing the readers to gain sufficient knowledge to make sound choices for clinical decisions to affect treatment outcomes. This new edition expands on the existing chapters, focusing on updating the previous text. It has been expanded to include knowledge on effector mechanisms addressing components inherent within cellular responses that are either newly discovered, or missing from the previous edition. It has an extra emphasis on aspects related to mechanisms important in combating microbial agents and critical sections on how vaccines protect against pathogenic invaders to limit associated pathology. The goal is that Introductory Immunology will become the preferred provider of core knowledge in immunology to build a foundation to explore components of the human immune system that work together to confer and understand dysregulation that causes clinical diseases. This book serves as a basic platform to define therapeutic interventions by:creating appreciation for components of the human immune system to work together to confer lifelong protection;providing a core knowledge in immunology to build a foundation to explore mechanisms involved in clinical disease, and defining functional aspects of immunological terms to permit the reader easy access to comprehend specific topics;presenting introduction to complex immunological concepts in a concise and easy manner that relates to clinical disease;breaking down all of immunology into manageable, logically digestible building blocks, and providing a map to explore overlapping mechanisms of immune protective responses;providing a platform to readers without medical, biochemical, or cellular expertise to understand and appreciate how immunology controls homeostasis and protects against pathogens.

•2022 Foreword INDIES Book of the Year Award Finalist for Health Learn how to take control of your health—and decrease susceptibility to infectious viral disease before it strikes. There will almost certainly be more pandemics in our future. Yet, during the coronavirus crisis, not a single major public health official took the simple step of telling Americans what we all need to hear: Robust good health—healthy immunity, low inflammation, low toxic burden, and freedom from stealth infection and chronic disease—is our best defense against infectious viral disease. Of course, it's not that simple. The way our bodies interact with infectious disease is complicated—both a function of the “germ” and the “terrain”—the virus and the host. In The Virus and the Host, Dr. Chlebowski succinctly describes emerging science on the virome and how toxic exposure, chronic inflammation, infections, and chronic diseases interact and predispose us to poor outcomes from acute viral infection. He then clearly outlines the tools needed for better health, including: How to eat like your life depends on it The best nutrients to supercharge your immunity How to harness the power of botanical medicine How to detoxify simply and safely at home Valuable information on simple treatment and recommended diagnostic tests for given conditions As we move forward from the tragedy of COVID-19, it is essential that we come together to learn from our mistakes, and work hard—and work together—to prevent a similar crisis in the future. When the next pandemic hits, we need to be better prepared. Now is the time to do something, and it is the best investment we can make so that when—not if—the next “big one” hits we can keep our loved ones and ourselves safe and healthy.'A gem of a book at a timely moment in history.'—Stephanie Seneff, author of Toxic Legacy'This book left me feeling optimistic and empowered, and gave me greater knowledge about the history of viruses, as well as their future.”—Erin Elizabeth, author; public speaker; founder, Health Nut News

Designed as an introductory textbook, Infection, Resistance and Immunity provides basic information on the workings of the immunological system and on infectious processes and their control. With sections on immunological disorders, immunization, immunodiagnosis, and epidemiology, it relates immunology to practical problems in medicine. The book includes a section on comparative immunology, introducing students to differences among immunological systems among common species of nonhuman animals. Written for the advanced undergraduate, the focus is on host-parasite interactions—distinguishing this text from other standard texts, which focus on the cellular mechanisms of the immune response.

Avian Immunology, Third Edition contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers, include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. With contributions from the foremost international experts in the field, Avian Immunology 3rd, provides the most up-to-date crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. Avian Immunology, Third Edition, is a fascinating and growing field and surely provides new and exciting insights for mainstream immunology in the future. Reflects significant advances in the field since the second edition, particularly the explosion of knowledge on genomics including work on the chicken, turkey and zebra finch genomes Provides a single source reference ranging from the basic science to cutting edge research Provides practical information for veterinarians particularly those specialised in poultry or companion bird medicine New chapters on the impact of the microbiome on the immune system, defence mechanisms in the egg and embryo and emerging transgene technologies

Drawing on indigenous and scientific knowledge of medicinal plants, Traditional Herbal Therapy for the Human Immune System presents the protective and therapeutic potential of plant-based drinks, supplements, nutraceuticals, synergy food, superfoods, and other products. Medicinal plants and their products can affect the immune system and act as immunomodulators.Medicinal plants are popularly used in folk medicine to accelerate the human immune defence and improve body reactions against infectious or exogenous injuries, as well as to suppress the abnormal immune response occurring in immune disorders. This book explains how medicinal plants can act as a source of vitamins and improve body functions such as enhanced oxygen circulation, maintained blood pressure and improved mood. It also outlines how specific properties of certain plants can help boost the immune system of humans with cancer, HIV, and COVID-19.Key features: Provides specific information on how to accelerate and or fortify the human immune system by using medicinal plants. Presents scientific understanding of herbs, shrubs, climbers and trees and their potential uses in conventional and herbal medicine systems. Discusses the specific role of herbal plants that act as antiviral and antibacterial agents and offer boosted immunity for cancer, H1N1 virus, relieving swine flu, HIV and COVID-19 patients. Part of the Exploring Medicinal Plants series, this book is useful for researchers and students, as well as policy makers and people working in industry, who have an interest in plant-derived medications.

Perfect for clinicians in both primary and secondary care settings, Allergy Essentials, 2nd Edition, covers the information you need most in your daily practice, with a strong emphasis on disease diagnosis and management. In one concise, convenient volume, it covers all common allergies in children and adults, offering authoritative content from the world's leading allergy experts in conjunction with primary care/family practitioners for a practical, balanced approach. You'll find up-to-date information on everything from basic immunology and physiology to new medications, new therapies, and individualized treatment options, allowing you to confidently integrate these changes into your practice.Offers a practical approach to evaluation, differential diagnosis, and treatment of allergic disorders, focused specifically on what the non-specialist needs to know for everyday practice. Includes new content on allergen-specific immunotherapy as well as a new chapter on precision medicine.Covers the most recent allergy tests, including blood tests, and includes current discussions of biologicals as therapeutics.Provides focused, relevant information on basic immunology and physiology, epidemiology, and allergens. Begins each chapter with a handy summary of key concepts to help you quickly identify important information. Authored by the same internationally recognized experts that produce Middleton's Allergy, the definitive text in the field.An ideal resource for primary care providers who are increasingly seeing and treating patients with allergic conditions as well as allergists who need a concise and current practice reference.Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Selling Immunity Self, Culture and Economy in Healthcare and Medicine provides a groundbreaking study of the ways in which immunity shapes life. Through its up-to-date discussion of immunity cultures, alongside detailed real-world examples, the book demonstrates how immunity is enmeshed in concepts of possessive individualism, self-defence and health consumerism. The book explores the rich metaphorical powers of immunity and the life narratives it inspires with reference to the talk of scientists, immunology texts and popular science magazines. The author provides a detailed overview of the ways in which digital media can shape the immune self with reference to cultural and social theories, providing insight into how immunitary knowledge and products are consumed and the benefits and drawbacks this has for healthcare. The book considers the significance of immunity for individuals navigating the threats to health that arise with pandemics and superbugs, with a keen look into how these ideas surface in everyday life across the globe. Finally, the book also discusses economic bases of healthcare technologies bent towards the protection and restoration of immunity. This book is essential reading for professionals within the fields of psychology, sociology, biomedical science, healthcare and other related disciplines. A broader audience will appreciate the book's attention on the ways immunity is understood to be a personal possession, an object of life craft, and the basis for healthcare consumerism.

This book updates in detail the microbial pathogenesis of various important pathogens, including HIV-1, MERS, SARS-CoV-2, Mycobacterium and Plasmodium. There is also a general discussion of the innate and adaptive immune responses against primary and opportunistic infections. The overall purpose of the book is to aid in the development of anti-viral and anti-microbial targets.

In this book, several functional foods or food ingredients, their mechanism of immune enhancing properties and use in food products have been discussed through seventeen chapters written by eminent authors. There are several medicinal plants which have significant role for immunity boosting such as Ashwagandha, Tulsi, Shatavari, Giloy, Aloe vera, Amla, Neem, licorice, garlic, ginger, turmeric, rosemary, black cumin, cinnamon, sage, thyme,fenugreek, peppermint, black pepper, clove etc. These have been discussed in detail.Note: T&F does not sell or distribute the hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

This new edition of Clinical Immunology and Allergy is a practical and clinically based guide for clinicians and laboratory staff to aid diagnosis and management of immunological and allergic disease, and provides examples of the correct selection and interpretation of immunological tests for a wide range of conditions. Fully updated from the previous edition, with the addition of new diseases recently identified from the use of genetic testing, and novel biological therapies and autoantibody tests, this title covers the entire breadth of the field, with the information at your fingertips. Split into two sections, the first covering individual diseases and allergies, with diagnosis and management strategies, and the second describing appropriate laboratory tests and their interpretation, the Oxford Handbook of Clinical Immunology and Allergy is an invaluable reference text, and works as a succinct revision guide for the FRCPath in Immunology. Filled with cross-references to create a cohesive overview of a complex subject, and presented in concise bullet-points for detailed direction to the key facts, this handbook provides everything you need to help you in clinical practice.

This book highlights information derived primarily from clinical samples, with particular reference to theoretical and scientific aspects of the human immune system. This text will focus on topics that range from host-pathogen interactions in infectious disease to host immune response in cancer, allergic diseases, neuroinflammatory diseases, and autoimmune disorders. The reader will also have a well-rounded understanding of the behavior of the immune system with particular emphasis on the role of immunoproteomics in immunotherapy, neuroprotective immunity for neurodegenerative and neuroinfectious disease, leukemia-associated dendritic cell induction of adaptive immunity dysregulation, and the role of immune checkpoint inhibitors in cancer, infection, as well as neuroinflammation. Taken together, the contents of this book are intended for both clinicians and researchers in academia and industry.

How viruses emerge to cause pandemics, how our immune system combats them, and how diagnostic tests, vaccines, and antiviral therapies work.Throughout history, humans have contended with pandemics. History is replete with references to plagues, pestilence, and contagion, but the devastation wrought by pandemics had been largely forgotten by the twenty-first century. Now, the enormous human and economic toll of the rapidly spreading COVID-19 disease offers a vivid reminder that infectious disease pandemics are one of the greatest existential threats to humanity. This book provides an accessible explanation of how viruses emerge to cause pandemics, how our immune system combats them, and how diagnostic tests, vaccines, and antiviral therapies work-- concepts that are a foundation for our public health policies.

How viruses emerge to cause pandemics, how our immune system combats them, and how diagnostic tests, vaccines, and antiviral therapies work.Throughout history, humans have contended with pandemics. History is replete with references to plagues, pestilence, and contagion, but the devastation wrought by pandemics had been largely forgotten by the twenty-first century. Now, the enormous human and economic toll of the rapidly spreading COVID-19 disease offers a vivid reminder that infectious disease pandemics are one of the greatest existential threats to humanity. This book provides an accessible explanation of how viruses emerge to cause pandemics, how our immune system combats them, and how diagnostic tests, vaccines, and antiviral therapies work—concepts that provide the foundation for our public health policies.The authors, both experts in immunology, interweave explanations of scientific principles and ongoing efforts to combat COVID-19 with stories of the people behind the science. They recount the eradication of smallpox—the greatest accomplishment of vaccines and public health; discuss microbial pathogens; and describe what we know about modern pandemics, including how they spread, how they can be contained, and how they can be treated. They do not offer prescriptions for what to do, but equip readers to be informed participants in debates about how to create a more pandemic-resilient world. We do not have to repeat the mistakes made with COVID-19.

Immunization during pregnancy with currently recommended vaccines prevents infection in the mother, the unborn fetus, and the young infant, and there is an increasing focus from different stakeholders to use this approach for other infections of importance to protect these vulnerable groups. The aim of this Maternal Immunization book is to provide a contemporary overview of vaccines used in pregnancy (and the lactation period), with emphasis on aspects of importance for the target groups, namely, rationale for the use of vaccines in pregnancy, safety, immunogenicity (immunology), timing to vaccinate, repeat doses, protective effects in the mother, fetus, and infant, and public acceptance and implementation, of existing and of future vaccines. Provides an overview of a quickly evolving topic. This will benefit the reader who wishes to rapidly become informed and up-to-date with new developments in this field Suitable to a broad audience: scientific researchers, obstetricians, gynecologists, neonatologists, vaccinators, pediatricians, students, and industry. Maternal vaccination impacts a wide range of specialists Allows health care professionals/researchers to gain insight into other aspects of vaccination in pregnancy outside of their specialism Is coauthored by specialists from multiple disciplines, providing a diverse view of the subject, increasing its interest and appeal Creates awareness of the current developments in this area of medicine and of the potential of maternal vaccination to improve the health of mothers and infants worldwide

This book fills a gap at the interface of fundamental and clinical immunology, and allergy. For many years, experts in fundamental immunology and physicians involved in clinical immunology and allergy worked separately – but the fundamental immunologists did not have medical qualifications and the physicians were not involved in the field of fundamental research. Written by a teacher and an expert in both fields, this book combines current knowledge on basic immunology and immunopathology with clinical comments that complete the whole picture.Immunology is a complex science, which requires a simplified approach in order to be taught and understood effectively. This book is based on the authors'long experience in teaching undergraduate, postgraduate students and interns both basic and clinical immunology.Reviewing a variety of important components related to the immune system, it is clearly and logically structured, and enriched by figures, tables and boxes with important immunology definitions. Each chapter has its own bibliography, and most units include links to electronic quizzes and audio files to accompany readers step by step. This easy-to-follow volume concludes with suggestions for future study. It is a valuable resource for undergraduate and postgraduate students, as well as medical practitioners.

First published in 1985: This book deals with the physiology and pathophysiology of the peripheral, i.e., prenodal, lymph.

First published in 1986, the influence of hormones secreted or regulated by the pituitary gland on the immune system is examined in detail, including discussions of adrenocorticotropic hormone, glucocorticoids, catecholamines, growth hormone, insulin, prolactin, gonadotropins, sex steroid hormones, and thyroid hormones. The relative importance of various hormones in immunoregulation is considered, and evidence for interaction between the immune and neurohormonal systems is presented. The possible effects of hormonal immunomodulation in reproduction, infections and parasitic disease, autoimmu-nity, and cancer are examined. This comprehensive reference serves both basic and clinical researchers and practitioners in immunology, microbiology, endocrinology, reproduction biology, neurology, oncology, psychology, medicine, and veterinary medicine.

“Visceral.”—Wall Street Journal “Illuminating.”—Publishers Weekly “Heroic.”—Science The immune system holds the key to human health. In The Beautiful Cure, leading immunologist Daniel M. Davis describes how the scientific quest to understand how the immune system works—and how it is affected by stress, sleep, age, and our state of mind—is now unlocking a revolutionary new approach to medicine and well-being. The body's ability to fight disease and heal itself is one of the great mysteries and marvels of nature. But in recent years, painstaking research has resulted in major advances in our grasp of this breathtakingly beautiful inner world: a vast and intricate network of specialist cells, regulatory proteins, and dedicated genes that are continually protecting our bodies. Far more powerful than any medicine ever invented, the immune system plays a crucial role in our daily lives. We have found ways to harness these natural defenses to create breakthrough drugs and so-called immunotherapies that help us fight cancer, diabetes, arthritis, and many age-related diseases, and we are starting to understand whether activities such as mindfulness might play a role in enhancing our physical resilience. Written by a researcher at the forefront of this adventure, The Beautiful Cure tells a dramatic story of scientific detective work and discovery, of puzzles solved and mysteries that linger, of lives sacrificed and saved. With expertise and eloquence, Davis introduces us to this revelatory new understanding of the human body and what it takes to be healthy.

Plasmodium falciparum malaria is responsible for the deaths of nearly 500,000 people each year. Much attention has been paid to antibody and cellular mechanisms of immunity against this pathogen. By contrast, the role that the complement system plays in immunity and pathogenesis in this infection is not very well recognized or understood. Based on the work of a number of research groups, we know that complement plays an important role in these processes. In this book, some of the leading scientists in the field discuss the mechanisms of complement activation during malaria infection as well as the role of complement in the pathogenesis of key syndromes such as severe malarial anemia, cerebral malaria, and placental malaria. In addition, they review recently-identified complement evasion strategies of P. falciparum merozoites, and how these mechanisms may translate into paradoxical enhancement of infection rather than protection. Finally, they also discuss the role of the mosquito complement system on immunity against the parasite.

Immunobiologie de Janeway est devenu un ouvrage classique en raison du caractère complet et très à jour des notions rapportées. C'est un ouvrage de référence qui convient aussi bien aux étudiants qu'aux chercheurs. Comme son titre l'indique, il s'agit d'un ouvrage consacré surtout à l'immunologie fondamentale, mais qui intègre bien les nombreuses découvertes résultant de l'étude du vaste spectre des pathologies immunitaires. S'il est richement documenté, ce livre ne tombe pas dans le travers d'un excès de détails, les matières sont ordonnées logiquement et les titres, très explicites, guident efficacement le lecteur. L'iconographie est remarquable de clarté ; elle offre l'avantage des séquences de type cinématographique, ce qui convient tout particulièrement dans la description des processus immunologiques.

This book is a sincere venture to present the new concepts in Agriculture and Veternary Science.

The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.

For decades, health care practitioners have relied on Middleton's Allergy as their go-to reference for comprehensive information on allergic disorders. Now Middleton's Allergy Essentials, by Drs. Robyn E. O'Hehir, Stephen T. Holgate, and Aziz Sheikh, offers a concise resource that's both easily accessible and highly authoritative. Perfect for clinicians in primary and secondary care settings, this practical volume covers what is most useful in your daily practice, with a strong emphasis on disease diagnosis and management. A practical approach to evaluation, differential diagnosis, and treatment of allergic disorders, focused specifically on what the non-specialist needs to know for everyday practice. Each chapter begins with a handy summary of key concepts to help you quickly identify important information. Coverage of today's hot topics includes asthma, drug allergies, food allergies and gastrointestinal disorders, anaphylaxis, atopic dermatitis, and allergic contact dermatitis. Concise sections on mechanisms are included where relevant, keeping you up to date with this rapidly evolving field. Authored by the same internationally recognized experts that produce Middleton's Allergy, the definitive text in the field. Ideal for physicians, residents, general and family practitioners, nurse practitioners, primary care doctors, hospitalists, general internists – anyone who is called upon to make effective diagnostic and treatment decisions regarding allergic disorders.

Roitt's Essential Immunology - the textbook of choice for students and instructors of immunology worldwide Roitt's Essential Immunology clearly explains the key principles needed by medical and health sciences students, from the basis of immunity to clinical applications. A brand new introduction sets the scene to section 1, Fundamentals of Immunology, introducing the microbial world and the strategies the body employs to defend itself. Each chapter then guides the reader through a different part of the immune system, and explains the role of each cell or molecule individually, and then as a whole. Section 2, Applied Immunology, discusses what happens when things go wrong, and the role the immune system plays alongside the damaging effects of a disease, including cancer, immunodeficiency, allergies and transplantation and the beneficial effects of vaccines. The 13th edition continues to be a user-friendly and engaging introduction to the workings of the immune system, whilst supporting those who require a slightly more detailed understanding of the key developments in immunology. The content has been fully updated throughout and includes: An expansion on key clinical topics, including: innate immunity, autoimmune conditions, asthma, primary immunodeficiency, and HIV/AIDS Beautifully presented with improved artwork and new illustrations A range of learning features, including introduction re-cap boxes, end of chapter and section summaries to aid revision, as well as further reading suggestions, and a glossary to explain the most important immunology terms. Roitt's Essential Immunology is also supported by a companion website at www.roitt.com including: An additional online only chapter on immunological methods and applications Further interactive multiple choice and single best answer questions for each chapter Animations and videos showing key concepts Fully downloadable figures and illustrations, further reading and useful links Updated extracts from the Encyclopaedia of Life Sciences Podcasts to reinforce the key principles explained in the text

A thrilling, fact-packed journey of discovery through the body's immune systemThe human body is like an exceedingly well-fortified castle, defended by billions of soldiers – some live for less than a day, others remember battles for decades, but all are essential in protecting us from disease. This hidden army is our immune system, and without it we could not survive the eternal war between our microscopic enemies and ourselves.Immune explores the incredible arsenal that lives within us – how it knows what to attack and what to defend, and how it kills everything from the common cold virus to plague bacteria. We see what happens when the immune system turns on us, and how life is impossible without its protection. We learn how diseases try to evade the immune system and exploit its vulnerabilities, and we discover how scientists are designing new drugs to harness the power of the system to fight disease. Do transplants ever reject their new bodies? What is pus? How can your body make more antibodies than there are stars in our galaxy? Why is cancer so hard for our immune system to fight? Why do flu outbreaks cause a spike in sleep disorders? Can we smell someone else's immune system, and does that help us subconsciously decide who we fall in love with? In this book, Catherine Carver answers all of these compelling questions, and many more besides.Drawing on everything from ancient Egyptian medical texts to cutting-edge medical science, Immune will take you on an adventure packed with weird and wonderful revelations about your own internal defensive system.

Janeway's Immunobiology is a textbook for students studying immunology at the undergraduate, graduate, and medical school levels. As an introductory text, all students will appreciate the book's clear writing and informative illustrations, and advanced students and working immunologists will appreciate its comprehensive scope and depth. Janeway's I

Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices

Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: Amphioxus as a model for understanding the evolution of vertebrates basic knowledge of immunology immune organs and cells of amphioxus a genomic and transcriptomic view of the Amphioxus immunity pattern recognition system in Amphioxus transcription factors in Amphioxus the complement system of Amphioxus the oxidative burst system in Amphioxus immune effectors in Amphioxus lipid signaling of immune response in Amphioxus apoptosis in amphioxus; primitive adaptive immune system of Amphioxus and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity. Provides new evidence on the origin of the adaptive immune system, the evolution of innate immunity, and evolution-stage specific immune defense mechanisms Not only presents the cells and molecules involved in the adaptive immune response in Amphioxus, but also characterizes the origination and evolution of the gene families and pathways involved in innate immunity Includes much pioneering work, from the molecular, genomic, and cellular to the individual level

Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March provides valuable insights on the atopic diseases, including asthma, allergic rhinitis, atopic dermatitis, and food allergies, which have developed into major health problems in most parts of the world. As the natural history of these chronic diseases has been extensively studied, including their major genetic, environmental, and lifestyle determinants and potential protective factors, the book presents tactics on how pediatric allergists can provide early intervention. In addition, the book unites key, global experts in the field who summarize their collective, and current, knowledge of the early stage of the'Atopic March', along with novel ideas for potential options of prevention. Summarizes the current knowledge of the epidemiological, genetic, and cellular basis of allergic diseases Ideal reference for the study of allergies in young children, atopic dermatitis, allergic rhinitis, childhood asthma, and food allergies Provides landmark findings in the field of immunology and allergy development Fulfills the need for a book that focuses on primary and secondary allergy prevention, especially during the first years of life Unites key, global experts in the field who summarize their collective, and current, knowledge, along with novel ideas for potential options of prevention

Several years ago, two of us published a full-length textbook entitled Nutrition and Immunology: Principles and Practice. The book was aca­ demically successful and well received by our peers. Our colleagues commented that while the book was eminently suitable for a library, there was still an intellectual need for a more concise volume on nutrition and immunology for health care providers and scientists working at the inter­ face of delivering therapeutic and/or preventive health care. We agreed and decided that a book focused on issues relevant to laboratory workers and to developing countries would be valuable. We invited well-known experts in their fields to contribute a chapter each and asked that they err on the short rather than the long side and update cited review articles rather than original papers wherever possible. The Handbook of Nutrition and Immunity is the culmination of that process. Our intention is that the book will grow over time and new editions will fill identified voids that meet the changing needs of health care providers and scientists interested in the practical aspects related to evaluating nutrition and immunology in the field. The Handbook of Nutrition and Immunity is for those people working in both adult and child nutrition throughout the world. It is also of relevance to those in the pharmaceutical and the food industry who are interested in developing ways to evaluate both the efficacy and effective­ ness of their products.

A leading figure in immunology takes readers inside the remarkably powerful human immune system.Winner of the CHOICE Outstanding Academic Title of the Choice ACRLThe immune system has incredible power to protect us from the ravages of infection. Boosted by vaccines, it can protect us from diseases such as measles. However, the power of the immune system is a double-edged sword: an overactive immune system can wreak havoc, destroying normal tissue and causing diseases such as type I diabetes, rheumatoid arthritis, and multiple sclerosis. The consequences of an impaired immune system, on the other hand, are all too evident in the agonies of AIDS.Packed with illustrations, stories from Dr. William E. Paul's distinguished career, and fascinating accounts of scientific discovery, Immunity presents the three laws of the human immune system—universality, tolerance, and appropriateness—and explains how the system both protects and harms us. From the tale of how smallpox was overcome and the lessons of the Ebola epidemic to the hope that the immune system can be used to treat or prevent cancer, Dr. Paul argues that we must take advantage of cutting-edge technologies and promising new tools in immunological research.

Microbiology For Dummies (9781119544425) was previously published as Microbiology For Dummies (9781118871188). While this version features a new Dummies cover and design, the content is the same as the prior release and should not be considered a new or updated product. Microbiology is the study of life itself, down to the smallest particle Microbiology is a fascinating field that explores life down to the tiniest level. Did you know that your body contains more bacteria cells than human cells? It's true. Microbes are essential to our everyday lives, from the food we eat to the very internal systems that keep us alive. These microbes include bacteria, algae, fungi, viruses, and nematodes. Without microbes, life on Earth would not survive. It's amazing to think that all life is so dependent on these microscopic creatures, but their impact on our future is even more astonishing. Microbes are the tools that allow us to engineer hardier crops, create better medicines, and fuel our technology in sustainable ways. Microbes may just help us save the world. Microbiology For Dummies is your guide to understanding the fundamentals of this enormously-encompassing field. Whether your career plans include microbiology or another science or health specialty, you need to understand life at the cellular level before you can understand anything on the macro scale. Explore the difference between prokaryotic and eukaryotic cells Understand the basics of cell function and metabolism Discover the differences between pathogenic and symbiotic relationships Study the mechanisms that keep different organisms active and alive You need to know how cells work, how they get nutrients, and how they die. You need to know the effects different microbes have on different systems, and how certain microbes are integral to ecosystem health. Microbes are literally the foundation of all life, and they are everywhere. Microbiology For Dummies will help you understand them, appreciate them, and use them.

Develop Effective Immunogenicity Risk Mitigation StrategiesImmunogenicity assessment is a prerequisite for the successful development of biopharmaceuticals, including safety and efficacy evaluation. Using advanced statistical methods in the study design and analysis stages is therefore essential to immunogenicity risk assessment and mitigation stra

Immunology: A Short Course, 7th Edition introduces all the critical topics of modern immunology in a clear and succinct yet comprehensive fashion. The authors offer uniquely-balanced coverage of classical and contemporary approaches and basic and clinical aspects. The strength of Immunology: A Short Course is in providing a complete review of modern immunology without the burden of excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics, illustrated by uniformly drawn, full-color illustrations and photographs.This new edition of Immunology: A Short Course: • Has been fully revised and updated, with a brand new art program to help reinforce learning• Includes a new chapter on Innate Immunity to reflect the growth in knowledge in this area • Highlights important therapeutic successes resulting from targeted antibody therapies• Includes end of chapter summaries and review questions, a companion website at www.wileyimmunology.com/coico featuring interactive flashcards, USMLE-style interactive MCQs, figures as PowerPoint slides, and case-based material to help understand clinical applications

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. Volume 5 comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy's effects in various cardiovascular, metabolic, and neurodegenerative disorders. In spite of the increasing importance of autophagy in the various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases remains poorly understood. This book is an asset to newcomers as a concise overview of the diverse disease implications of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series

Nutrition and infection are often at a crossroads, interacting with each other and influencing human health. Infection is a major health problem and nutritional deficiency plays a significant role in increasing the risk of infection. Nutrition-Infection Interactions and Impacts on Human Health presents state-of-the-art evidence on nutrition-infecti

The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors Contains a wide-ranging review of the'ecoimmunology'of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research

In this bold, fascinating book, Eula Biss addresses a chronic condition of fear – fear of the government, the medical establishment, and what may be in your children's air, food, mattresses, medicines, and vaccines. Reflecting on her own experience as a new mother, Biss investigates the metaphors and myths surrounding our conception of immunity and its implications for the individual and the social body. She extends a conversation with other mothers to meditations on Voltaire's Candide, Bram Stoker's Dracula, Rachel Carson's Silent Spring, Susan Sontag's AIDS and Its Metaphors, and beyond. On Immunity is an inoculation against our fear and a moving account of how we are all interconnected – our bodies and our fates.

Angiogenesis, the formation of new blood vessels, is fundamental for physiological processes such as embryonic and postnatal development, wound repair, and reproductive functions. Angiogenesis plays a major role in tumor growth and in several autoimmune and allergic disorders. Lymphangiogenesis, the formation of new lymphatic vessels, is also important for tumor growth, the formation of metastasis, and chronic inflammatory diseases. Judah Folkman, a pioneer in the study of angiogenesis, first proposed that macrophages and mast cells could be a relevant source of angiogenic factors. Since then, much effort has gone into the elucidation of the role of immune cells in the modulation of angiogenesis and lymphangiogenesis. There is now compelling evidence that several components of the innate and adaptive immune system are implicated in inflammatory and neoplastic angiogenesis and lymphangiogenesis. Articles in this volume deal with the emerging, intriguing possibility that immune cells are both a source and a target of angiogenic and lymphangiogenic factors. Therefore, cells of the immune system might play a role in inflammatory and neoplastic angiogenesis/lymphangiogenesis through the expression of several angiogenic factors and their receptors and co-receptors. The important new findings in this volume will be of special interest to vascular biologists, basic and clinical immunologists, oncologists and to specialists in allergic and immune disorders.

Written in the same engaging conversational style as the acclaimed first edition, Primer to The Immune Response, 2nd Edition is a fully updated and invaluable resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology. The authors bring clarity and readability to their audience, offering a complete survey of the most fundamental concepts in basic and clinical immunology while conveying the subject's fascinating appeal. The content of this new edition has been completely updated to include current information on all aspects of basic and clinical immunology. The superbly drawn figures are now in full color, complemented by full color plates throughout the book. The text is further enhanced by the inclusion of numerous tables, special topic boxes and brief notes that provide interesting insights. At the end of each chapter, a self-test quiz allows students to monitor their mastery of major concepts, while a set of conceptual questions prompts them to extrapolate further and extend their critical thinking. Moreover, as part of the Academic Cell line of textbooks, Primer to The Immune Response, 2nd Edition contains research passages that shine a spotlight on current experimental work reported in Cell Press articles. These articles also form the basis of case studies that are found in the associated online study guide and are designed to reinforce clinical connections. Complete yet concise coverage of the basic and clinical principles of immunology Engaging conversational writing style that is to the point and very readable Over 200 clear, elegant color illustrations Comprehensive glossary and list of abbreviations

This best-selling resource has a worldwide reputation as the leader in its field. Focusing on human immunology and biology, while also reporting on scientific experimentation and advancement, it provides comprehensive coverage of state-of-the-art basic science as well as authoritative guidance on the practical aspects of day-to-day diagnosis and management. This new edition includes 700 full-color illustrations and a new, more accessible format to make finding information a snap for the busy practitioner.Includes a glossary of allergy and immunology for quick and easy reference.Contains keypoints and clinical pearls highlighted to find important information quickly.links to useful online resources both for you and for your patients.Offers contributions from hundreds of international authorities for world-class expertise in overcoming any clinical challenge.Contains 400 new illustrations, 700 in all, to better illustrate complex immunology.Covers the very latest in the field, including hot topics such as food allergy and immunotherapy.Includes the latest guidelines from The National Asthma Education and Prevention Program (NAEPP).Utilizes a new, more user-friendly full-color format for easier reference.

Understand all the essential concepts in immunology with Basic Immunology: Functions and Disorders of the Immune System! This concise, focused text provides you with an up-to-date, accessible introduction to the workings of the human immune system. Efficiently master the immunology information you need through clinically focused content, logically organized by mechanism. Apply what you've learned to real-world situations by referencing the appendix of clinical cases. Enhance your learning with the help of numerous full-color illustrations and useful tables, as well as summary boxes, review questions, and a glossary of immunology terms.Study immunology anywhere! Online access to www.StudentConsult.com opens the door to an enhanced e-book and ancillary components!Visualize complex immunology concepts with a completely updated art program.Test your knowledge. New PowerPoint Review slides added to www.StudentConsult.com are ideal for study sessions.

Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. his book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic. The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair. Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics.

Immunology at a Glance provides a user-friendly overview of the body's defence mechanisms. Ideal from day one of a medical, biomedical or life science course, the text begins with a basic overview of both adaptive and innate immunity, before progressing to applied immunological concepts, which look at what happens when things go wrong, and how, in clinical medicine, each body system can be affected by immunity. Each double-page spread corresponds to a typical lecture and diagrammatically summarises core concepts in immunology, through accessible schematic diagrams on left-hand pages, with key points concisely summarised on the right-hand page. There are also self-assessment essay questions so you can test your knowledge. New for this 10th edition: Thoroughly updated and reorganised chapters offer greater clarity and easier understanding for those new to the subject New chapters on cytokine receptors and ‘Immunology in the Laboratory'A completely re-written section on autoimmunity A brand new companion website featuring self-assessment questions and PowerPoint slides of images from the book, ideal for teaching and revision at www.ataglanceseries.com/immunology Immunology at a Glance is the ideal companion for anyone about to start a new course in immunology and will appeal to medical and biomedical science students. Perfect for exam preparation, it provides the concepts and frameworks you need to succeed in your exam.

Immunology, 8th Edition makes it easy for you to learn all the basic and clinical concepts you need to know for your courses and USMLEs. This medical textbook's highly visual, carefully structured approach makes immunology simple to understand and remember. Understand the building blocks of the immune system - cells, organs and major receptor molecules - as well as initiation and actions of the immune response, especially in a clinical context. Visually grasp and retain difficult concepts easily thanks to a user-friendly color-coded format, key concept boxes, explanatory diagrams, and over 190 photos to help you visualize tissues and diseases. Put concepts into practice.'Critical Thinking Boxes'and 25 online cases encourage you to'think immunologically'while anchoring your understanding of immunology through clinical application. Gauge your mastery of the material and build confidence with high-yield style chapter-opening summaries and case-based and USMLE-style questions that provide effective chapter review and quick practice for your exams. Access the full contents online at www.studentconsult.com where you'll find the complete text and illustrations, USMLE-style questions, clinical cases, and much more! Get the depth of coverage you need in a smaller, more manageably sized book. Through meticulous editing and reorganization, primary material remains in the book while more specialized and clinical material has been moved online. Master the most cutting-edge concepts in immunology. Thorough updates throughout provide the timely knowledge you need ace your exams.

Comprendre tous les concepts essentiels de l'immunologie! Concis et accessible, ce manuel représente une parfaite introduction à l'immunologie moderne pour les élèves de tout niveau. Cette 4e édition s'enrichit des résultats des recherches les plus récentes pour offrir la meilleure compréhension possible du système immunitaire et des pathologies causant ses dérégulations. Cet ouvrage propose : - 250 illustrations et tableaux en couleur ; - Un programme entièrement mis à jour ; - Un accès rapide et clair à l'information grâce à une organisation par mécanismes ; - Des points récapitulatifs ; - Une validation immédiate des connaissances acquises par des cas cliniques réels. Un glossaire, disponible en annexe et en livret détachable, rassemble l'ensemble des termes indispensables en anglais et en français. Ce livre se révèle incontournable pour les étudiants en médecine, biologie, biochimie et pharmacie.