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This study is devoted to the Sunyaev-Zeldovich (S-Z) effect, and important related topics in cluster and CMB research. S-Z science is about to be significantly enhanced by unique, multi-faceted cluster and cosmological yield, at a level of precision in accord with the high standards of the current era that was heralded by spectacular achievements in cosmological CMB research. The pedagogical reviews and technical seminars included in this volume represent most of the important current topics in S-Z work and in the astrophysics of clusters. The publication touches upon all relevant aspects of the S-Z effect and its use as a precise cluster and cosmological probe. To commemorate the 40th anniversary of the detection of the CMB by Penzias and Wilson (in 1964), there is a chapter devoted to the history of this discovery. In his fascinating account of their work, he outlines also some lessons pertinent to current scientific issues. Other chapters discuss very interesting related observational work in Europe and the US.