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This entirely revised edition of the successful work presents the state of the art in clinics, research and practical management of atopic dermatitis - eczema. The wide variability in clinical morphology including differences between age groups and ethnicities is illustrated by color pictures including the typical minimal manifestations or “stigmata” suggestive of atopy. The dramatic rise in the prevalence of this disease over the last few decades is reflected by detailed analyses of epidemiological data from all over the world. In-depth descriptions of key pathophysiological mechanisms including epidermal barrier, molecular genetics, itch pathophysiology and modern cellular immunology offer readers a deeper understanding of the complex events leading to the often excruciating symptoms. Treatment – and management – comprises all aspects from elicitor avoidance to basic emollient skin care, immuno-modulating treatments both topical and systemic, up to the latest advances in kinase inhibitors and biologics.In turn, the book discusses the role of the microbiome and antimicrobial treatments as well as phototherapy, provides dietary recommendations for individuals with food allergies, and explores psychosocial aspects of the disease. Environmental influences are considered with regard to irritants and allergens. All recommendations are based on current national and international guidelines. The complex management strategies for this disease have led to the emergence of educational programs (Eczema Schools), which the authors have developed and promoted at the national and international level. This new revised edition of Atopic Dermatitis - Eczema will be an invaluable asset for dermatologists, allergists, pediatricians and general practitioners, but also for all related health personnel and patient organizations interested in gaining a fuller understanding of this widespread skin disease.

Hauttumoren – Übersichtliche Infos für die tägliche Praxis und das HautkrebsscreeningWarzen, Nävi, Zysten, Aktinische Keratosen, Malignes Melanom – in der täglichen Praxis begegnet der Arzt einer Vielzahl von Hauttumoren und tumorartigen Hautveränderungen. Die exakte Diagnose, die Einleitung einer passgenauen Therapie oder auch die Beruhigung eines Patienten mit einem harmlosen Befund setzten eine genaue Kenntnis der häufigsten Hauttumoren voraus. Bei malignen Erkrankungen erhöht eine frühzeitige exakte Diagnose die Chancen auf eine erfolgreiche Heilung.In der zweiten Auflage wurden alle Kapitel unter Berücksichtigung bestehender Leitlinien überarbeitet und mit neuen, aussagekräftigen Bildern unterlegt.Zusätzlich wurde ein neues Kapitel zu Sarkomen erstellt, einer seltenen aber äußerst wichtigen Differenzialdiagnose für/bei Hautveränderungen.Häufige Hauttumoren in der Praxis bietetübersichtliche Tabellen zur Schnellorientierungprägnante Darstellung des klinischen Bildes mit hervorragenden FarbfotosHinführung zur angemessenen TherapieZusätzlich zur praxisrelevanten Darstellung der Hauttumoren finden Sie hier die wesentlichen Informationen für die Durchführung des Hautkrebsscreenings.Für alle Dermatologen in der Praxis oder Weiterbildung und ebenso für Hausärzte, Internisten und Kinderärzte

This book presents the state of the art in research into atopic dermatitis, or atopic eczema, and provides numerous effective practical management recommendations that are grounded in the immense clinical experience of the author. A scientific evidence-based approach to the subject is adopted, progressing from clinical symptoms in different disease stages, molecular genetics, and pathophysiology through to treatment and prevention. All aspects of patient management are covered, including diagnostics, avoidance strategies, emollient therapy, and acute treatment of eczema and itch. Diverse special therapeutic approaches are discussed, ranging from glucocorticoids, topical calcineurin inhibitors, and antimicrobial therapy through to UV therapy, allergen-specific immunotherapy, systemic immunosuppressive therapy, and emerging options. Environmental influences are considered, and there is a focus on the whole human being, with attention to psychosocial aspects of the disease and the benefit of educational programs such as “eczema schools”. Atopic Dermatitis will be invaluable for dermatologists, allergists, pediatricians, and general practitioners and informative for other interested persons and sufferers.

Der Grundgedanke dieses Buches ist der pragmatische Umgang mit Komplikationen, also wertfreies Aufzeigen des Abweichens vom'idealen'Verlauf in der Dermatologie. Die dermatologische Diagnostik und Therapie umfassen eine Vielzahl verschiedener Verfahren, die von konservativen bis zu invasiven Techniken reichen. Eine Zusammenfassung klinisch relevanter Komplikationen, getrennt nach verschiedenen diagnostischen Schwierigkeiten, ist in dieser Form neu. Eindrucksvolle Beispiele sind die Abnahmetechniken von Schuppenmaterial bei mykologischen Untersuchungen oder von Hautbiopsien zur histologischen Diagnostik. Viele Fallbeispiele und eindrucksvolle Illustrationen bieten dem Leser wertvolle Hilfestellung für die tägliche Praxis sowie im Umgang mit Abweichungen von der Norm. Das Buch richtet sich sowohl an Fachärzte der Dermatologie und Kollegen in der Facharztausbildung wie auch an Vertreter anderer Fachgruppen (wie z.B. Allgemeinmediziner), die mit dermatologischen Untersuchungsverfahren konfrontiert sind.

Der vorliegende Band dient den in Klinik und Praxis tätigen Dermatologen und dermatologisch interessierten Ärzten zur kontinuierlichen Fortbildung und als verläßliche Informationsquelle. Die Schwerpunkte dieses Bandes liegen auf den Fortschritten im Bereich der klinischen und operativen Dermatologie, des atopischen Ekzems, der Überlappungsdermatosen, der Erkrankungen des Fettgewebes, AIDS, der angewandten Allergologie, der Mikrobiologie, der Andrologie, der pädiatrischen Dermatologie, der Entwicklungen in der Therapie und der Berichte aus der Forschung für die Therapie.

Atopic eczema is one of the most common dermatologic Altough the etiopathogenesis of the disease has not yet conditions. According to recent data, up to 10% of all been fully elucidated, the large body of data already children may be affected. Particularly in its severe form, available provides important clues for both our atopic eczema is a distressing and even disabling disease. understanding of the disease and for daily patient care. Even the far more frequent minor forms may pose prob­ This Handbook of Atopic Eczema aims to put together lems because of their chronicity or the unpredictable current knowledge on this multifacted disease in the tendency for relapse. Atopic eczema must therefore be most comprehensive way. This volume covers the whole regarded as a major health problem, and it is one that is range of relevant information. Since each topic is dealt today drawing mounting attention, not only from the with by authors expert in that particular field, the up-to­ medical community, but increasingly from the date knowledge provided is not only extensive but also nonmedical public as well. critical. I believe that this Handbook of Atopic Eczema Since atopic eczema first emerged as a disease entity in will not only enhance our ability to treat our patients, but the early decades of this century, it has been the subject will also stimulate our efforts to fully understand this of both extensive research and intense scientific enigmatic disease. controversies.

Hauttumoren – Übersichtliche Infos für die täglichen Praxis und das HautkrebsscreeningWarzen, Nävi, Zysten, Aktinische Keratosen, Malignes Melanom – in der täglichen Praxis begegnet der Arzt einer Vielzahl von Hauttumoren oder tumorartigen Hautveränderungen. Die exakte Diagnose, die Einleitung einer passgenauen Therapie oder auch die Beruhigung eines Patienten mit einem harmlosen Befund setzen eine genaue Kenntnis der häufigsten Hauttumoren voraus. Bei malignen Erkrankungen erhöht eine frühzeitige exakte Diagnose die Chancen auf eine erfolgreiche Heilung.Häufige Hauttumoren in der Praxis bietet übersichtliche Tabellen zur Schnellorientierung, prägnante Darstellung des klinischen Bildes mit hervorragenden Farbfotos, Hinführung zur angemessenen Therapie.Zusätzlich zur praxisrelevanten Darstellung der Hauttumoren finden Sie hier die wesentlichen Informationen für die Durchführung des Hautkrebsscreenings.Für alle Dermatologen in der Praxis oder Weiterbildungund ebenso für Hausärzte, Internisten und Kinderärzte.

There is no doubt among experts that the prevalence of allergic diseases has increased in many industrialized countries in recent years. The rea­ sons for this increase are unknown; only suppositions exist. Many people focus on environmental influences. However, the assumption that air pollution alone is responsible for this increase seems to be too simple: many other influences, including the genetic predisposition of individual patients, allergen exposure, and possibly socioeconomic factors, also have to be taken into consideration. Although our understanding of the complex mechanisms of allergic diseases has considerably improved thanks to the progress made in ex­ perimental immunology and allergology, we still have a long way to go before this scientific knowledge is translated into new therapeutic mo­ dalities. For this reason, the scientific community welcomed the gathering of scientists from very different disciplines and different parts of the world at an international symposium,'New Trends in Allergy IV'together with'Environmental Allergy and Allergotoxicology III'in Hamburg in 1995. This volume contains the invited papers, covering a wide range from basic science to practical clinical diagnosis and therapy. A further unique feature of this event was the concomitant first official workshop of the Environmental Pollution and Allergy Committee of the International Association of Allergy and Clinical Immunology (IAACI), at which the state of scientific knowledge in this field was defined and formulated.

The international symposium'New Trends in Allergy', held in Munich from July 13 to 15, 1990, brought together for the third time since 1980 some of the most experienced researchers working in the field of allergy. This volume comprises the papers presented at this meeting. All over the world, and not merely in the industrialized countries, allergy is becoming a cause of evermore serious diseases. In recent years, research in the field of allergy has provided numerous impor­ tant and fascinating results extending our knowledge considerably. Despite the new insights into basic mechanisms of allergic reactions, improved diagnostic methods, and new therapeutic approaches, how­ ever, many questions remain to be answered, including: Are allergies really increasing in frequency? If so, what are the reasons? Especially, does environmental pollution playa role? Which factors influence IgE synthesis? Can the IgE immune response be switched off? Does the nervous system interact with allergic reactions? If so, what are the mechanisms? Are new approaches in allergy prophylaxis and allergy therapy effi­ cient? What measures have proven useful and deserve to be employed in daily practice? In this volume, these questions and other current topics are dealt with. As each issue is covered by authors competent in the respective fields, the result is an extensive and critical review of the state of the art. Going through these papers, one comes to the conviction that allergy research is a multifacetted, explosively expanding, most stimulating field of work.

New Trends in Allergy V'is the fifth volume of a series focussing on new trends in experimental and clinical allergology. The interdisciplinary character is documented by articles from such different fields as basic immunology, chemistry, molecular biology, pharmacology, epidemiology, pneumology, dermatology, otolaryngology, pediatrics and psychosomatic medicine. Special emphasis is given to the role of both anthropogenic (pollutants) as well as natural environmental factors in the development of allergy. Among new pathophysiological concepts, dendritic cells, lymphocyte interactions, mast cells, eosinophils and neutrophils as well as psycho-neuro-immunological influences are featured. Practical aspects focus on asthma, rhinoconjunctivitis, atopic eczema, occupational and food allergy as well as anaphylaxis. The most recent therapeutic strategies comprise novel pharmacotherapy and allergen-specific as well as unspecific (e. g. anti-IgE) immunotherapy.

Anergic reactions and anergic diseases are found in many fields of medicine. As wen as affecting the skin, allergic diseases occur in internal organs such as the lungs and the kidneys and in the vascular and nervous systems. Interdisciplinary understanding and cooperation thus seem necessary to get a better insight into allergic reactions in the different fields of medicine in order that we may give our patients the best diagnostic and therapeutic care. Allergic diseases are on the increase. Studies from Sweden show that 15% of the population there are atopic, and some people speculate that in Germany about 10%-15% of all adults suffer from one of the many different allergic conditions. We in our clinic also have the impression that the incidence of atopic reactions has increased in recent years. The figure of 15% would mean something like 200 000 people in Munich alone! We all know that a wide variety of environmental factors can induce allergic reactions in the skin, the respiratory system, or internal organs. The most important anergens in our environment are pollen, molds, animal dander, housedust mite, food or food additives, various insects, industrial compounds and drugs. The direct costs of hospital and community medical care, other services, and drugs to help patients with asthma, hay fever, and skin allergies have in­ creased considerably in the last 10 years. The figures should make it clear to everybody that we are dealing with a health and environmental problem of great practical importance.

Atopic eczema (atopic dermatitis, neurodermitis diffusa, endogenous eczema) is one of the most common skin diseases of our time and is still increasing in prevalence dramatically all over the world. The reasons for this increase are not known. It occurs at any age, not only in childhood, approximately 2/3 of children affected will suffer from this disease when they are grown-up. Written by leading experts of their field, this second edition comprises the state of the art in pathophysiology, clinical medicine and therapeutic management. It demonstrates that there is no simple'miracle'cream, pill or diet for this disease, but that a disturbed barrier function can only be repaired by adequate and individualized skin care and it shows how unspecific anti-inflammatory treatment has to be individually tailored according to body area affected, patient age and acuity of skin lesions. All physicians will find this book most helpful in the painstaking search for the individual causal or eliciting factors.

Allergy is one of the major health problems of most modern societies. Although allergic diseases are well-known for almost two hundred years, their prevalence has increased dramatically over the last decades. Allergic reactions manifest in various organs, most commonly in the skin and mucous membranes, the frontier surfaces where the contact between the individual and the environment takes place. In a very concise and practical way this book covers all aspects of allergic reactions from pathophysiology to diagnosis, therapy and prevention with a strong focus on relevant aspects for the everyday work of the practising dermatologist and allergist in the hospital or office. This book reflects the rich personal experience of a German allergist with international training and reputation, who is active in immunology and allergy research and practice for almost 30 years. In this book, not only IgE-mediated allergic reactions are covered but all other kinds of allergies such as atopic eczema, contact dermatitis, drug eruptions, anaphylaxis and food allergies are equally represented as well as psychosomatic aspects and problems of environmental intolerances.