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This book constitutes the proceedings of the 15th Brazilian Symposium on Bioinformatics on Advances in Bioinformatics and Computational Biology, BSB 2022, which took place in Buzios, Brazil, in September 2022. The 10 full papers and 7 short papers presented in this volume were carefully reviewed and selected from 23 submissions. The papers focus on bioinformatics, computational biology, Biological Databases, Biological Networks, Cheminformatics, Evolutionary Genomics, Computational Proteomics, Systems Biology, Drug Design, Genomics, Machine Learning applications in Bioinformatics, Metagenomics, Molecular Docking and Modeling, Molecular Evolution and Phylogenetics, Protein Structure and Modeling, Proteomics, Transcriptomics, Single-Cell Analysis, Workflows in Bioinformatics.

This is a succinct guide to the application and modelling of dependence models or copulas in the financial markets. First applied to credit risk modelling, copulas are now widely used across a range of derivatives transactions, asset pricing techniques and risk models and are a core part of the financial engineer's toolkit.

'Simply put, every local boater should have a dog-eared, well-thumbed copy [of this guide] as a permanent feature in the nautical library.'—48° North A Cruising Guide to Puget Sound and the San Juan Islands has earned an outstanding reputation for the accuracy of its piloting instructions, the clarity of its writing, and the high quality of its information. This second edition includes color photos and nautical chart segments throughout, as well as: Approaches and anchorages for hundreds of bays, harbors, and inlets—many with annotated charts Weather, tides, currents, and commercial traffic patterns Local history and attractions 240 full-color photos 75 color chartlets Larger size and lay-flat binding for ease of use With at-a-glance ratings of every harbor and anchorage, A Cruising Guide to Puget Sound and the San Juan Islands is the definitive resource for Pacific Northwest cruising.'Everything a yachtsman's pilot ought to be: shipshape and workmanlike in its approach, unusually well written, very thoughtfully researched.'—Jonathan Raban, bestselling author, Waxwings: A Novel and Passage to Juneau'All the necessary nuts and bolts about navigating local waters is found in A Cruising Guide to Puget Sound.... A welcome addition to the library of any Puget Sound sail- or powerboat owner.'—Seattle Times'An elegant, beautiful book.... For even those few boaters who think they know all Puget Sound has to offer, this invaluable reference guide will introduce them to hundreds of new places yet to explore.'—48° North'So complete that veteran cruisers will discover cruising grounds they didn't know existed or didn't consider navigable.'—SAIL'An encyclopedic sailing guide to area waters, written with exhaustive first-hand research to almost every cove and inlet, and complemented with a remarkable series of maps, charts, and pictures.'—Seattle Post-Intelligencer'Well written and full of tantalizing places.'—WoodenBoat'A keeper for my'to take cruising'box.'—Sailing'A monumental book that gives minute details on every bay, waterway, and stretch of navigable salt water from Olympia to Port Angeles, including the San Juan Islands. It does an excellent job of explaining navigational hazards and anchoring peculiarities at each point along the way.'—Bellingham Herald

Edwin Mansfield was a research pioneer into the economics of R and D and technological change. As appreciation and remembrance for his scholarly contributions, eminent scholars have contributed original papers for this edited volume. The authors have followed the'Mansfieldian” approach of emphasizing economic insight and intuition over mathematical rigor and as a result are very accessable. Essays in Honor of Edwin Mansfield has the potential to serve as a reader in all advanced undergraduate and graduate classes/seminars in the economics of R and D and technological change. This edited volume will be the definitive work in the field.

In 1700, most composers were employees of noble courts or the church. But by the nineteenth century, Chopin, Schumann, Brahms, Verdi, and many others functioned as freelance artists teaching, performing, and selling their compositions in the private marketplace. While some believe that Mozart's career marks a clean break between these two periods, this book tells the story of a more complex and interesting transition. F. M. Scherer first examines the political, intellectual, and economic roots of the shift from patronage to a freelance market. He describes the eighteenth-century cultural'arms race'among noble courts, the spread of private concert halls and opera houses, the increasing attendance of middle-class music lovers, and the founding of conservatories. He analyzes changing trends in how composers acquired their skills and earned their living, examining such impacts as demographic developments and new modes of transportation. The book offers insight into the diversity of composers'economic aspirations, the strategies through which they pursued success, the burgeoning music publishing industry, and the emergence of copyright protection. Scherer concludes by drawing some parallels to the economic state of music composition in our own times. Written by a leading economist with an unusually broad knowledge of music, this fascinating account is directed toward individuals intrigued by the world of classical composers as well as those interested in economic history or the role of money in art.

This book covers the consolidation and merger of corporations and corporate divestiture in the United States.

'Scherer has demonstrated yet again why he is one of the world's leading antitrust scholars. This book provides a much needed, in-depth study of the role of national antitrust policies in a global economy. The Antitrust Division wrestles with this question daily and this book provides a guide to us and to all those interested in antitrust policy with some important answers.'—Anne K. Bingaman, Assistant Attorney General, Antitrust Division, U.S. Department of Justice.As global markets for goods, services and financial assets have become increasingly integrated, national governments no longer have as much control over economic markets. With the completion of the Uruguay Round of the GATT talks, the world economy has entered a fresh phase requiring different rules and different levels of international cooperation. Policies once thought to be entirely domestic and appropriately determined by national political institutions, are now subject to international constraints. Cogent analysis of this deeper integration of the world economy, and guidelines for government policies, are urgent priorities. This series aims to meet these needs over a range of 21 books by some of the world's leading economists, political scientists, foreign policy specialists and government officials.A volume of Brookings'Integrating National Economies Series