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This textbook demonstrates new paradigms for the interface between CMOS circuits and the biological world. A deep theoretical description of such an interface is defined and discussed, while various real applications are demonstrated by also discussing several analog CMOS circuits. Electrochemical techniques are proposed in detail to learn how to design integrated biosensors. Biological materials are described to provide devices selectivity. Nanoscale materials are discussed to provide device sensitivity. CMOS circuits are analyzed to provide real applications. Extensive examples with solutions are provided, as well as exercises at the end of each chapter. This book introduces students to the state-of-the-art in Bio/CMOS interfaces, describing leading-edge research in CMOS design and VLSI development for applications requiring intimate integration of biological molecules onto the chip. It provides multidisciplinary content ranging from biochemistry to CMOS design in order to address Bio/CMOS interface co-design in biosensing applications.

This book presents a systematic approach to analyzing the challenging engineering problems posed by the need for security and privacy in implantable medical devices (IMD). It describes in detail new issues termed as lightweight security, due to the associated constraints on metrics such as available power, energy, computing ability, area, execution time, and memory requirements. Coverage includes vulnerabilities and defense across multiple levels, with basic abstractions of cryptographic services and primitives such as public key cryptography, block ciphers and digital signatures. Experts from Computer Security and Cryptography present new research which shows vulnerabilities in existing IMDs and proposes solutions. Experts from Privacy Technology and Policy will discuss the societal, legal and ethical challenges surrounding IMD security as well as technological solutions that build on the latest in Computer Science privacy research, as well as lightweight solutions appropriate for implementation in IMDs.

The application of CMOS circuits and ASIC VLSI systems to problems in medicine and system biology has led to the emergence of Bio/CMOS Interfaces and Co-Design as an exciting and rapidly growing area of research. The mutual inter-relationships between VLSI-CMOS design and the biophysics of molecules interfacing with silicon and/or onto metals has led to the emergence of the interdisciplinary engineering approach to Bio/CMOS interfaces. This new approach, facilitated by 3D circuit design and nanotechnology, has resulted in new concepts and applications for VLSI systems in the bio-world. This book offers an invaluable reference to the state-of-the-art in Bio/CMOS interfaces. It describes leading-edge research in the field of CMOS design and VLSI development for applications requiring integration of biological molecules onto the chip. It provides multidisciplinary content ranging from biochemistry to CMOS design in order to address Bio/CMOS interface co-design in bio-sensing applications.

The application of circuits and systems and engineering principles to problems in the medicine has led to the emergence of biomedical circuits and systems as an exciting and rapidly growing area of research. Nanotechnology provides new nano-structured materials with amazing properties. The properties offered by nanomaterials can be applied to develop advanced instrumentation for biomedical diagnostics and personalized therapy, as well as bio-sensing in the environment. Biotechnology provides new biochemical materials with novel properties to be applied to develop new performances in sensing techniques. These advancements in Nano- and Bio- technologies will lead to new concepts and applications for nano-bio-sensing systems. This book offers an invaluable reference to the state-of-the-art applications of nano-bio-sensing. It brings together expertise of researchers from the fields of nano-electronics and bio-technology, providing multidisciplinary content from nano-structures fabrication to bio-sensing applications.

This book constitutes the proceedings of the 4th International Conference on Nano-Networks, Nano-Net 2009, held in Lucerne, Switherland, in October 2009. The 36 invited and regular papers address the whole spectrum of Nano-Networks and spans topis like modeling, simulation, statdards, architectural aspects, novel information and graph theory aspects, device physics and interconnects, nanorobotics as well as nano-biological systems. The volume also contains the workshop on Nano-Bio-Sensing Paradigms as well as the workshop on Brain Inspired Interconnects and Circuits.