1. The Year in Human and Medical Genetics
- Author
-
Smith, Moyra
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Prevention ,Stem Cell Research - Embryonic - Human ,Brain Disorders ,Biotechnology ,Human Genome ,Schizophrenia ,Stem Cell Research ,Mental Health ,HIV/AIDS ,Good Health and Well Being ,Animals ,Central Nervous System Diseases ,Epigenesis ,Genetic ,Genetic Variation ,Genetics ,Medical ,Humans ,human genome ,copy number variant or variation ,schizophrenia ,microRNA ,epigenetics ,pluripotent stem cell ,sexual differentiation ,Duffy antigen ,malaria ,HIV-AIDS ,Copy number variant or variation ,Epigenetics ,Human genome ,Malaria ,MicroRNA ,Pluripotent stem cell ,Sexual differentiation ,beta defensin ,Human immunodeficiency virus antigen ,acquired immune deficiency syndrome ,Africa ,antigen function ,blood group Duffy system ,cell nucleus ,central nervous system function ,chromatin ,chromatin assembly and disassembly ,chromosome 22q ,chromosome analysis ,chromosome deletion ,DNA methylation ,DNA polymorphism ,gene expression ,gene locus ,genetic association ,genetic epistasis ,genetic risk ,genetic susceptibility ,genetic variability ,heredity ,human ,human genome project ,Human immunodeficiency virus infection ,immune response ,incidence ,mental patient ,oocyte ,pathogenesis ,psoriasis ,review ,sex differentiation ,somatic cell ,true hermaphroditism ,General Science & Technology - Abstract
The breadth and scope of new information makes difficult a selection of topics to be included in a limited review of highlights of the year. Admittedly, the choices are idiosyncratic. The eight topics presented here are (1) structural and copy number variants in the human genome; (2) progress in defining genetic factors in the etiology of schizophrenia; (3) microRNAs in central nervous system development and function; (4) progress in elucidation of risk factors for complex common disorders through large scale association studies; (5) epigenetics and the epigenomic era; (6) reprogramming of somatic cell nuclei to generate pluripotent stem cells; (7) new concepts regarding factors involved in sexual differentiation; and (8) Duffy blood group antigens: new concepts, and new discoveries on the role of these antigens in malaria and HIV-AIDS.
- Published
- 2009