1. Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin
- Author
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Titus, Jitto, Wu, Alan HB, Biswal, Siddharth, Burman, Atandra, Sengupta, Shantanu P, and Sengupta, Partho P
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Heart Disease ,Cardiovascular ,4.1 Discovery and preclinical testing of markers and technologies ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Good Health and Well Being ,Cardiac device therapy ,Infrared spectroscopy - Abstract
BackgroundThe levels of circulating troponin are principally required in addition to electrocardiograms for the effective diagnosis of acute coronary syndrome. Current standard-of-care troponin assays provide a snapshot or momentary view of the levels due to the requirement of a blood draw. This modality further restricts the number of measurements given the clinical context of the patient. In this communication, we present the development and early validation of non-invasive transdermal monitoring of cardiac troponin-I to detect its elevated state.MethodsOur device relies on infrared spectroscopic detection of troponin-I through the dermis and is tested in stepwise laboratory, benchtop, and clinical studies. Patients were recruited with suspected acute coronary syndrome.ResultsWe demonstrate a significant correlation (r = 0.7774, P
- Published
- 2022