1. Update on PPHN: Mechanisms and treatment
- Author
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Nair, Jayasree and Lakshminrusimha, Satyan
- Subjects
Lung ,Perinatal Period - Conditions Originating in Perinatal Period ,Pediatric ,Infant Mortality ,Neonatal Respiratory Distress ,Preterm ,Low Birth Weight and Health of the Newborn ,Respiratory ,Reproductive health and childbirth ,Good Health and Well Being ,Administration ,Inhalation ,Alprostadil ,Asphyxia Neonatorum ,Endothelium-Dependent Relaxing Factors ,Epoprostenol ,Extracorporeal Membrane Oxygenation ,Hernia ,Diaphragmatic ,Hernias ,Diaphragmatic ,Congenital ,Humans ,Infant ,Newborn ,Meconium Aspiration Syndrome ,Nitric Oxide ,Oxygen Inhalation Therapy ,Persistent Fetal Circulation Syndrome ,Piperazines ,Pulmonary Surfactants ,Purines ,Respiration ,Artificial ,Respiratory Distress Syndrome ,Newborn ,Sildenafil Citrate ,Sulfones ,Vascular Resistance ,Vasodilator Agents ,Pulmonary vascular resistance ,Nitric oxide ,Persistent fetal circulation ,Hypoxic respiratory failure ,Systemic vasodilators ,Clinical Sciences ,Paediatrics and Reproductive Medicine ,Obstetrics & Reproductive Medicine - Abstract
Persistent pulmonary hypertension of the newborn (PPHN) is a syndrome of failed circulatory adaptation at birth, seen in about 2/1000 live born infants. While it is mostly seen in term and near-term infants, it can be recognized in some premature infants with respiratory distress or bronchopulmonary dysplasia. Most commonly, PPHN is secondary to delayed or impaired relaxation of the pulmonary vasculature associated with diverse neonatal pulmonary pathologies, such as meconium aspiration syndrome, congenital diaphragmatic hernia, and respiratory distress syndrome. Gentle ventilation strategies, lung recruitment, inhaled nitric oxide, and surfactant therapy have improved outcome and reduced the need for extracorporeal membrane oxygenation (ECMO) in PPHN. Newer modalities of treatment discussed in this article include systemic and inhaled vasodilators like sildenafil, prostaglandin E1, prostacyclin, and endothelin antagonists. With prompt recognition/treatment and early referral to ECMO centers, the mortality rate for PPHN has significantly decreased. However, the risk of potential neurodevelopmental impairment warrants close follow-up after discharge for infants with PPHN.
- Published
- 2014