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4 results on '"Farías, Gonzalo A"'

1. Biomarkers for dementia in Latin American countries: Gaps and opportunities.

Author

Parra, Mario, Orellana, Paulina, Leon, Tomas, Victoria, Cabello, Henriquez, Fernando, Gomez, Rodrigo, Avalos, Constanza, Damian, Andres, Slachevsky, Andrea, Ibañez, Agustin, Zetterberg, Henrik, Tijms, Betty, Yokoyama, Jennifer, Piña-Escudero, Stefanie, Cochran, J, Matallana, Diana, Acosta, Daisy, Allegri, Ricardo, Arias-Suárez, Bianca, Barra, Bernardo, Behrens, Maria, Brucki, Sonia, Busatto, Geraldo, Caramelli, Paulo, Castro-Suarez, Sheila, Contreras, Valeria, Custodio, Nilton, Dansilio, Sergio, la Cruz-Puebla, Myriam, de Souza, Leonardo, Diaz, Monica, Duque, Lissette, Farías, Gonzalo, Ferreira, Sergio, Guimet, Nahuel, Kmaid, Ana, Lira, David, Lopera, Francisco, Meza, Beatriz, Miotto, Eliane, Nitrini, Ricardo, Nuñez, Alberto, ONeill, Santiago, Ochoa, John, Pintado-Caipa, Maritza, Resende, Elisa, Risacher, Shannon, Rojas, Luz, Sabaj, Valentina, Schilling, Lucas, Sellek, Allis, Sosa, Ana, Takada, Leonel, Teixeira, Antonio, Unaucho-Pilalumbo, Martha, and Duran-Aniotz, Claudia

Subjects
Humans, Latin America, Dementia
Abstract

Limited knowledge on dementia biomarkers in Latin American and Caribbean (LAC) countries remains a serious barrier. Here, we reported a survey to explore the ongoing work, needs, interests, potential barriers, and opportunities for future studies related to biomarkers. The results show that neuroimaging is the most used biomarker (73%), followed by genetic studies (40%), peripheral fluids biomarkers (31%), and cerebrospinal fluid biomarkers (29%). Regarding barriers in LAC, lack of funding appears to undermine the implementation of biomarkers in clinical or research settings, followed by insufficient infrastructure and training. The survey revealed that despite the above barriers, the region holds a great potential to advance dementia biomarkers research. Considering the unique contributions that LAC could make to this growing field, we highlight the urgent need to expand biomarker research. These insights allowed us to propose an action plan that addresses the recommendations for a biomarker framework recently proposed by regional experts.

Published
2023

2. Multi-feature computational framework for combined signatures of dementia in underrepresented settings.

Author

Moguilner, Sebastian, Birba, Agustina, Fittipaldi, Sol, Gonzalez-Campo, Cecilia, Tagliazucchi, Enzo, Reyes, Pablo, Matallana, Diana, Parra, Mario, Slachevsky, Andrea, Farías, Gonzalo, Cruzat, Josefina, García, Adolfo, Eyre, Harris, La Joie, Renaud, Rabinovici, Gil, Whelan, Robert, and Ibáñez, Agustín

Subjects
feature selection, harmonization, machine learning, multimodal neuroimaging, neurodegeneration, Alzheimer Disease, Bayes Theorem, Biomarkers, Brain, Frontotemporal Dementia, Humans, Magnetic Resonance Imaging, Neuropsychological Tests
Abstract

Objective.The differential diagnosis of behavioral variant frontotemporal dementia (bvFTD) and Alzheimers disease (AD) remains challenging in underrepresented, underdiagnosed groups, including Latinos, as advanced biomarkers are rarely available. Recent guidelines for the study of dementia highlight the critical role of biomarkers. Thus, novel cost-effective complementary approaches are required in clinical settings.Approach. We developed a novel framework based on a gradient boosting machine learning classifier, tuned by Bayesian optimization, on a multi-feature multimodal approach (combining demographic, neuropsychological, magnetic resonance imaging (MRI), and electroencephalography/functional MRI connectivity data) to characterize neurodegeneration using site harmonization and sequential feature selection. We assessed 54 bvFTD and 76 AD patients and 152 healthy controls (HCs) from a Latin American consortium (ReDLat).Main results. The multimodal model yielded high area under the curve classification values (bvFTD patients vs HCs: 0.93 (±0.01); AD patients vs HCs: 0.95 (±0.01); bvFTD vs AD patients: 0.92 (±0.01)). The feature selection approach successfully filtered non-informative multimodal markers (from thousands to dozens).Results. Proved robust against multimodal heterogeneity, sociodemographic variability, and missing data.Significance. The model accurately identified dementia subtypes using measures readily available in underrepresented settings, with a similar performance than advanced biomarkers. This approach, if confirmed and replicated, may potentially complement clinical assessments in developing countries.

Published
2022

3. Dementia in Latin America: Paving the way toward a regional action plan.

Author

Parra, Mario Alfredo, Baez, Sandra, Sedeño, Lucas, Gonzalez Campo, Cecilia, Santamaría-García, Hernando, Aprahamian, Ivan, Bertolucci, Paulo Hf, Bustin, Julian, Camargos Bicalho, Maria Aparecida, Cano-Gutierrez, Carlos, Caramelli, Paulo, Chaves, Marcia LF, Cogram, Patricia, Beber, Bárbara Costa, Court, Felipe A, de Souza, Leonardo Cruz, Custodio, Nilton, Damian, Andres, de la Cruz, Myriam, Diehl Rodriguez, Roberta, Brucki, Sonia Maria Dozzi, Fajersztajn, Lais, Farías, Gonzalo A, De Felice, Fernanda G, Ferrari, Raffaele, de Oliveira, Fabricio Ferreira, Ferreira, Sergio T, Ferretti, Ceres, Figueredo Balthazar, Marcio Luiz, Ferreira Frota, Norberto Anizio, Fuentes, Patricio, García, Adolfo M, Garcia, Patricia J, de Gobbi Porto, Fábio Henrique, Duque Peñailillo, Lissette, Engler, Henry Willy, Maier, Irene, Mata, Ignacio F, Gonzalez-Billault, Christian, Lopez, Oscar L, Morelli, Laura, Nitrini, Ricardo, Quiroz, Yakeel T, Guerrero Barragan, Alejandra, Huepe, David, Pio, Fabricio Joao, Suemoto, Claudia Kimie, Kochhann, Renata, Kochen, Silvia, Kumfor, Fiona, Lanata, Serggio, Miller, Bruce, Mansur, Leticia Lessa, Hosogi, Mirna Lie, Lillo, Patricia, Llibre Guerra, Jorge, Lira, David, Lopera, Francisco, Comas, Adelina, Avila-Funes, José Alberto, Sosa, Ana Luisa, Ramos, Claudia, Resende, Elisa de Paula França, Snyder, Heather M, Tarnanas, Ioannis, Yokoyama, Jenifer, Llibre, Juan, Cardona, Juan Felipe, Possin, Kate, Kosik, Kenneth S, Montesinos, Rosa, Moguilner, Sebastian, Solis, Patricia Cristina Lourdes, Ferretti-Rebustini, Renata Eloah de Lucena, Ramirez, Jeronimo Martin, Matallana, Diana, Mbakile-Mahlanza, Lingani, Marques Ton, Alyne Mendonça, Tavares, Ronnielly Melo, Miotto, Eliane C, Muniz-Terrera, Graciela, Muñoz-Nevárez, Luis Arnoldo, Orozco, David, Okada de Oliveira, Maira, Piguet, Olivier, Pintado Caipa, Maritza, Piña Escudero, Stefanie Danielle, Schilling, Lucas Porcello, Rodrigues Palmeira, André Luiz, Yassuda, Mônica Sanches, Santacruz-Escudero, Jose Manuel, Serafim, Rodrigo Bernardo, Smid, Jerusa, Slachevsky, Andrea, Serrano, Cecilia, Soto-Añari, Marcio, Takada, Leonel Tadao, Grinberg, Lea Tenenholz, Teixeira, Antonio Lucio, and Barbosa, Maira Tonidandel

Subjects
Latin America, biomarkers, clinical trials, dementia, epidemiology, evidence-based recommendations, genetics, knowledge to action framework, networking and translational research, nonpharmacological interventions, Dementia, Clinical Research, Brain Disorders, Aging, Acquired Cognitive Impairment, Prevention, Neurological, Clinical Sciences, Neurosciences, Geriatrics
Abstract

Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.

Published
2021

4. Dementia in Latin America: Paving the way toward a regional action plan

Author

Parra, Mario Alfredo, Baez, Sandra, Sedeño, Lucas, Campo, Cecilia Gonzalez, Santamaría‐García, Hernando, Aprahamian, Ivan, Bertolucci, Paulo HF, Bustin, Julian, Bicalho, Maria Aparecida Camargos, Cano‐Gutierrez, Carlos, Caramelli, Paulo, Chaves, Marcia LF, Cogram, Patricia, Beber, Bárbara Costa, Court, Felipe A, Souza, Leonardo Cruz, Custodio, Nilton, Damian, Andres, de la Cruz, Myriam, Rodriguez, Roberta Diehl, Brucki, Sonia Maria Dozzi, Fajersztajn, Lais, Farías, Gonzalo A, De Felice, Fernanda G, Ferrari, Raffaele, de Oliveira, Fabricio Ferreira, Ferreira, Sergio T, Ferretti, Ceres, Balthazar, Marcio Luiz Figueredo, Frota, Norberto Anizio Ferreira, Fuentes, Patricio, García, Adolfo M, Garcia, Patricia J, de Gobbi Porto, Fábio Henrique, Peñailillo, Lissette Duque, Engler, Henry Willy, Maier, Irene, Mata, Ignacio F, Gonzalez‐Billault, Christian, Lopez, Oscar L, Morelli, Laura, Nitrini, Ricardo, Quiroz, Yakeel T, Barragan, Alejandra Guerrero, Huepe, David, Pio, Fabricio Joao, Suemoto, Claudia Kimie, Kochhann, Renata, Kochen, Silvia, Kumfor, Fiona, Lanata, Serggio, Miller, Bruce, Mansur, Leticia Lessa, Hosogi, Mirna Lie, Lillo, Patricia, Guerra, Jorge Llibre, Lira, David, Lopera, Francisco, Comas, Adelina, Avila‐Funes, José Alberto, Sosa, Ana Luisa, Ramos, Claudia, de Paula França Resende, Elisa, Snyder, Heather M, Tarnanas, Ioannis, Yokoyama, Jenifer, Llibre, Juan, Cardona, Juan Felipe, Possin, Kate, Kosik, Kenneth S, Montesinos, Rosa, Moguilner, Sebastian, Solis, Patricia Cristina Lourdes, de Lucena Ferretti‐Rebustini, Renata Eloah, Ramirez, Jeronimo Martin, Matallana, Diana, Mbakile‐Mahlanza, Lingani, Ton, Alyne Mendonça Marques, Tavares, Ronnielly Melo, Miotto, Eliane C, Muniz‐Terrera, Graciela, Muñoz‐Nevárez, Luis Arnoldo, Orozco, David, de Oliveira, Maira Okada, Piguet, Olivier, Caipa, Maritza Pintado, Escudero, Stefanie Danielle Piña, Schilling, Lucas Porcello, Palmeira, André Luiz Rodrigues, Yassuda, Mônica Sanches, Santacruz‐Escudero, Jose Manuel, Serafim, Rodrigo Bernardo, Smid, Jerusa, Slachevsky, Andrea, Serrano, Cecilia, Soto‐Añari, Marcio, Takada, Leonel Tadao, Grinberg, Lea Tenenholz, Teixeira, Antonio Lucio, and Barbosa, Maira Tonidandel

Subjects
Aging, Brain Disorders, Dementia, Acquired Cognitive Impairment, Clinical Research, Prevention, Neurological, Biomarkers, Evidence-Based Practice, Humans, Latin America, Socioeconomic Factors, biomarkers, clinical trials, dementia, epidemiology, evidence-based recommendations, genetics, knowledge to action framework, networking and translational research, nonpharmacological interventions, Clinical Sciences, Neurosciences, Geriatrics
Abstract

Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.

Published
2021

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