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Intense sunward (westward) plasma flows, named Subauroral Polarization Stream (SAPS), have been known to occur equatorward of the electron auroras for decades, yet their effect on the upper thermosphere has not been well understood. On the one hand, the large velocity of SAPS results in large momentum exchange upon each ion-neutral collision. On the other hand, the low plasma density associated with SAPS implies a low ion-neutral collision frequency. We investigate the SAPS effect during non-storm time by utilizing a Scanning Doppler Imager (SDI) for monitoring the upper thermosphere, SuperDARN radars for SAPS, all-sky imagers and DMSP Spectrographic Imager for the auroral oval, and GPS receivers for the total electron content. Our observations suggest that SAPS at times drives substantial (>50 m/s) westward winds at subauroral latitudes in the dusk-midnight sector, but not always. The occurrence of the westward winds varies with AE index, plasma content in the trough, and local time. The latitudinally averaged wind speed varies from 60 to 160 m/s, and is statistically 21% of the plasma. These westward winds also shift to lower latitude with increasing AE and increasing MLT. We do not observe SAPS driving poleward wind surges, neutral temperature enhancements, or acoustic-gravity waves, likely due to the somewhat weak forcing of SAPS during the non-storm time.

The intrinsic temporal nature of magnetic reconnection at the magnetopause has been an active area of research. Both temporally steady and intermittent reconnection have been reported. We examine the steadiness of reconnection using space-ground conjunctions under quasi-steady solar wind driving. The spacecraft suggests that reconnection is first inactive, and then activates. The radar further suggests that after activation, reconnection proceeds continuously but unsteadily. The reconnection electric field shows variations at frequencies below 10 mHz with peaks at 3 and 5 mHz. The variation amplitudes are ∼10-30 mV/m in the ionosphere, and 0.3-0.8 mV/m at the equatorial magnetopause. Such amplitudes represent 30%-60% of the peak reconnection electric field. The unsteadiness of reconnection can be plausibly explained by the fluctuating magnetic field in the turbulent magnetosheath. A comparison with a previous global hybrid simulation suggests that it is the foreshock waves that drive the magnetosheath fluctuations, and hence modulate the reconnection.

Tumor-associated macrophages (TAM) in the tumor microenvironment (TME) cooperate with cancer stem cells (CSC) to maintain stemness. We recently identified cluster of differentiation 44 (CD44) as a surface marker defining head and neck squamous cell carcinoma (HNSCC) CSC. PI3K-4EBP1-SOX2 activation and signaling regulate CSC properties, yet the upstream molecular control of this pathway and the mechanisms underlying cross-talk between TAM and CSC in HNSCC remain largely unknown. Because CD44 is a molecular mediator in the TME, we propose here that TAM-influenced CD44 signaling could mediate stemness via the PI3K-4EBP1-SOX2 pathway, possibly by modulating availability of hyaluronic acid (HA), the main CD44 ligand. HNSCC IHC was used to identify TAM/CSC relationships, and in vitro coculture spheroid models and in vivo mouse models were used to identify the influence of TAMs on CSC function via CD44. Patient HNSCC-derived TAMs were positively and negatively associated with CSC marker expression at noninvasive and invasive edge regions, respectively. TAMs increased availability of HA and increased cancer cell invasion. HA binding to CD44 increased PI3K-4EBP1-SOX2 signaling and the CSC fraction, whereas CD44-VCAM-1 binding promoted invasive signaling by ezrin/PI3K. In vivo, targeting CD44 decreased PI3K-4EBP1-SOX2 signaling, tumor growth, and CSC. TAM depletion in syngeneic and humanized mouse models also diminished growth and CSC numbers. Finally, a CD44 isoform switch regulated epithelial-to-mesenchymal plasticity as standard form of CD44 and CD44v8-10 determined invasive and tumorigenic phenotypes, respectively. We have established a mechanistic link between TAMs and CSCs in HNSCC that is mediated by CD44 intracellular signaling in response to extracellular signals. SIGNIFICANCE: These findings establish a mechanistic link between tumor cell CD44, TAM, and CSC properties at the tumor-stroma interface that can serve as a vital area of focus for target and drug discovery.

For accurate modelling of observations of exoplanet atmospheres, quantification of the pressure broadening of infrared absorption lines for and by a variety of gases at elevated temperatures is needed. High-resolution high-temperature H2-pressure-broadened spectra are recorded for the CH4 ν3-band P-branch. Measured linewidths for 143 transitions between 2840 and 3000 cm−1 with temperature and pressures ranging between 300 and 655 K, and 10 and 933 Torr, respectively, were used to find rotation- and tetrahedral-symmetry-dependent coefficients for pressure and temperature broadening and pressure-induced lineshifts. The new pressure-broadening data will be useful in radiative-transfer models for retrieving the properties of observed expolanet atmospheres.

Observations of neutral winds from rocket release experiments within the premidnight and postmidnight substorm recovery phase aurora, show very large E-region neutral winds of several hundred m/s, where winds measured on the dusk side are even larger than those on the dawn side. These large winds are also associated with strong shears, and there is evidence that some of the regions below these shears may be unstable. The mechanisms which generate this strong vertical structure are not well understood. It is also not known whether the acceleration conditions in the pre and post midnight sectors of the aurora may produce significantly different neutral responses on the dawn and dusk sides. Simulations have been performed using a three-dimensional high resolution limited area thermosphere model to try to understand the neutral structure within the dawn and dusk side aurora. When simulations are performed using auroral forcing alone, for equivalent conditions within the dawn and dusk sectors, differences are found in the simulated response on each side. When measured values of auroral forcing parameters, and background winds and tides consistent with recent observations, are used as model inputs, some of the main features of the zonal and meridional wind observations are reproduced in the simulations, but the magnitude of the peak zonal wind around 140 km tends to be too small and the maximum meridional wind around 130 km is overestimated. The winds above 120 km altitude are found to be sensitive to changes in electric fields and ion densities, as was the case for the dawn side, but the effects of background winds and tides on the magnitudes of the winds above 120 km are found to be relatively small on the dusk side. The structure below 120 km appears to be related mainly to background winds and tides rather than auroral forcing, as was found in earlier studies on the dawn side, although the peak magnitudes of simulated wind variations in the 100 to 120 km altitude range are smaller than those observed. The source of the strong shears measured around I 10 km altitude on the dusk side is uncertain, but may be related to different kinds of oscillations, such as gravity waves, non migrating semidiurnal tides, or secondary oscillations produced by non linear interactions between waves.

Measurements of the neutral thermosphere within the postmidnight substorm recovery phase diffuse aurora show very large horizontal winds, and strong vertical structure. Rocket, satellite, and ground based observations during the ARIA (Atmospheric Response in Aurora) campaigns, and earlier dawn side rocket observations, indicate neutral winds of up to 200m/s, and a characteristic jet-like wind maximum around 110 to 120-km altitude, with strong shears above and below. The observed wind magnitudes are found to have a dependence on geomagnetic activity level, but recent modeling studies suggest that tides which propagate up from the troposphere and stratosphere may play an important role in generating the strong vertical variations in the neutral winds. The relative importance of auroral and tidal forcing in producing the measured wind structure is not known, however. Simulations have been performed using a three dimensional (3-D) high resolution limited area thermosphere model to understand the processes which generate the observed neutral structure within the postmidnight diffuse aurora. Parameters measured during the ARIA I observational campaign have been used to provide auroral forcing inputs for the model. Global background winds and tides have been provided by the CTIP (Coupled Thermosphere Ionosphere Plasmasphere) model. The sensitivity of the response of the neutral atmosphere to changes in different parameters has been examined. Variations in the amplitudes and phases of the propagating tides in the background winds are found to have significant effects on the neutral structure in the E region, and the wind structure below around I 10 km is found to be mainly produced by tidal forcing. Changes in the electric field and ion density affect the winds above around 120km, and the importance of auroral forcing is found to depend on background winds. Variations in the orientation of the aurora relative to the background field, which may be caused by changes in the interplanetary magnetic field, are also found to modify the wind structure. When both auroral forcing and propagating tides are included, many of the basic characteristics of the wind structure are displayed, although the great strength of the wind shears is not well reproduced. The strength of the shears may be related to a currently unmodeled process, or to different types of waves.