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1. Population pharmacokinetics of cabotegravir following administration of oral tablet and long‐acting intramuscular injection in adult HIV‐1‐infected and uninfected subjects

Author

Han, Kelong, Baker, Mark, Lovern, Mark, Paul, Prokash, Xiong, Yuan, Patel, Parul, Moore, Katy P, Seal, Ciara S, Cutrell, Amy G, D'Amico, Ronald D, Benn, Paul D, Landovitz, Raphael J, Marzinke, Mark A, Spreen, William R, and Ford, Susan L

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Clinical Research, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Adult, Diketopiperazines, Female, HIV Infections, HIV-1, Humans, Injections, Intramuscular, Likelihood Functions, Pyridones, Tablets, cabotegravir, HIV, integrase inhibitor, long-acting, population pharmacokinetics, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences
Abstract

AimTo characterize cabotegravir population pharmacokinetics using data from phase 1, 2 and 3 studies and evaluate the association of intrinsic and extrinsic factors with pharmacokinetic variability.MethodsAnalyses were implemented in NONMEM and R. Concentrations below the quantitation limit were modelled with likelihood-based approaches. Covariate relationships were evaluated using forward addition (P

Published
2022

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