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1. Use of Drug-level Testing and Single-genome Sequencing to Unravel a Case of Human Immunodeficiency Virus Seroconversion on Pre-exposure Prophylaxis

Author

Spinelli, Matthew A, Lowery, Brentton, Shuford, Jennifer A, Spindler, Jon, Kearney, Mary F, McFarlane, Jenny R, McDonald, Cheryl, Okochi, Hideaki, Phung, Nhi, Kuncze, Karen, Jee, Kathryn, Johannessen, DeeJay, Anderson, Peter L, Smith, Dawn K, Defechereux, Patricia, Grant, Robert M, and Gandhi, Monica

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Genetics, Human Genome, 2.2 Factors relating to the physical environment, Infection, Good Health and Well Being, Anti-HIV Agents, Emtricitabine, HIV, HIV Infections, Humans, Medication Adherence, Pharmaceutical Preparations, Pre-Exposure Prophylaxis, Seroconversion, Tenofovir, PrEP, HIV seroconversion, adherence, single-genome-sequencing, PrEP failure, Biological Sciences, Medical and Health Sciences, Microbiology, Clinical sciences
Abstract

Cases of seroconversion on pre-exposure prophylaxis (PrEP) should be carefully investigated, given their public health implications and rarity. We report a case of transmitted drug resistance causing seroconversion on PrEP in spite of high adherence, confirmed with dried blood spot and segmental hair drug-level testing and single-genome sequencing.

Published
2021

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