1. Occupational Pesticide Exposure in Parkinson’s Disease Related to GBA and LRRK2 Variants
- Author
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Brown, Ethan G, Goldman, Samuel M, Coffey, Christopher S, Siderowf, Andrew, Simuni, Tanya, Meng, Cheryl, Brumm, Michael C, Caspell-Garcia, Chelsea, Marek, Kenneth, Tanner, Caroline M, and Initiative, The Parkinson’s Progression Markers more...
- Subjects
Biomedical and Clinical Sciences ,Neurosciences ,Aging ,Prevention ,Health Disparities ,Rural Health ,Neurodegenerative ,Brain Disorders ,Clinical Research ,Parkinson's Disease ,2.1 Biological and endogenous factors ,Neurological ,Humans ,Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ,Female ,Parkinson Disease ,Male ,Glucosylceramidase ,Occupational Exposure ,Pesticides ,Aged ,Middle Aged ,Penetrance ,Activities of Daily Living ,Cognitive Dysfunction ,Parkinson's disease ,environmental exposure ,GBAassociated Parkinson's disease ,LRRK2associated Parkinson's ,disease ,pesticide exposure ,Parkinson’s Progression Markers Initiative ,GBA associated Parkinson’s disease ,LRRK2 associated Parkinson’s disease ,Parkinson’s disease ,Biochemistry and Cell Biology - Abstract
BackgroundThe penetrance of common genetic risk variants for Parkinson's disease (PD) is low. Pesticide exposure increases PD risk, but how exposure affects penetrance is not well understood.ObjectiveTo determine the relationship between occupational pesticide exposure and PD in people with LRRK2 and GBA risk variants.MethodsParticipants of the Parkinson's Progression Markers Initiative (PPMI) with a LRRK2-G2019 S or GBA risk variant provided information about occupational pesticide exposure. We compared exposure in carriers with and without PD. Among carriers with PD, we used Cox proportional hazard models to compare time-to impairment in balance, cognition, and activities of daily living (ADLs) between participants with and without prior occupational pesticide exposure.Results378 participants with a risk variant provided exposure information; 176 with LRRK2-G2019 S (54 with and 122 without PD) and 202 with GBA variants (47 with and 155 without PD). Twenty-six participants reported pesticide exposure. People with a GBA variant and occupational pesticide exposure had much higher odds of PD (aOR: 5.4, 95% CI 1.7-18.5, p more...
- Published
- 2024