1. Positive follow-up blood cultures identify high mortality risk among patients with Gram-negative bacteraemia
- Author
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Maskarinec, SA, Park, LP, Ruffin, F, Turner, NA, Patel, N, Eichenberger, EM, van Duin, D, Lodise, T, Fowler, VG, and Thaden, JT
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Prevention ,Patient Safety ,Good Health and Well Being ,Aged ,Bacteremia ,Blood Culture ,Female ,Follow-Up Studies ,Gram-Negative Bacterial Infections ,Hospital Mortality ,Humans ,Inpatients ,Male ,Middle Aged ,Prospective Studies ,Survival Analysis ,Blood cultures ,Gram-negative bacteremia ,Persistent bacteremia ,Risk score ,Public Health and Health Services ,Microbiology ,Clinical sciences ,Medical microbiology - Abstract
ObjectivesThe role of follow-up blood cultures (FUBCs) in the management of Gram-negative bacteraemia (GNB) is poorly understood. We aimed to determine the utility of FUBCs in identifying patients with increased mortality risk.MethodsAn observational study with a prospectively enrolled cohort of adult inpatients with GNB was conducted at Duke University Health System from 2002 to 2015. FUBCs were defined as blood cultures performed from 24 hours to 7 days from initial positive blood culture.ResultsAmong 1702 patients with GNB, 1164 (68%) had FUBCs performed. When performed, FUBCs were positive in 20% (228/1113) of cases. FUBC acquisition was associated with lower all-cause in-hospital mortality (108/538, 20%, vs. 176/1164, 15%; p 0.01) and attributable in-hospital mortality (78/538, 15%, vs. 98/1164, 8%; p
- Published
- 2020